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Reviewed, UniProtKB/Swiss-Prot P36147 (PAM17_YEAST)

Last modified January 19, 2010. Version 60. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Presequence translocated-associated motor subunit PAM17, mitochondrial
Gene names
Name: PAM17
Synonyms: FMP18
Ordered Locus Names: YKR065C
OrganismSaccharomyces cerevisiae (Baker's yeast) [Complete proteome]
Taxonomic identifier4932 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length197 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level.

General annotation (Comments)

Function

Component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. In the complex, it is required to organize PAM16-PAM18 (TIM16-TIM14) heterodimer. Ref.4

Subunit structure

Component of the PAM complex, at least composed of mtHsp70, MGE1, TIM44, PAM16, PAM17 and PAM18/TIM14.

Subcellular location

Mitochondrion inner membrane; Multi-pass membrane protein Potential Ref.4 Ref.2.

Miscellaneous

Present with 3000 molecules/cell in log phase SD medium. Ref.3

Sequence similarities

Belongs to the PAM17 family.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

ECM4P361561EBI-26467,EBI-2042717

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – 1414Mitochondrion Potential
Chain15 – 197183Presequence translocated-associated motor subunit PAM17, mitochondrial
PRO_0000043179

Regions

Transmembrane64 – 8421 Potential
Transmembrane103 – 12321 Potential

Sequences

Sequence LengthMass (Da)Tools
P36147-1 [UniParc].

Last modified June 1, 1994. Version 1.
Checksum: 633C74D569E51603

FASTA19721,968
        10         20         30         40         50         60 
MFTSAIRLSS QRLFASQPSV TAAALRSTAT TLPLRSYSQP ASLQDSSILT WSDFFKLRKQ 

        70         80         90        100        110        120 
QRRINVGSSL FTALLGCNVS WAYLSTMEID PTQMLFGFDP LTVISAGIIA SGALGYLLGP 

       130        140        150        160        170        180 
IVGSQVFKLS HNQQLAQFNN KNKEFLKHII NNRVDASSQS FSNPVPDYYG EKIGSLKEYK 

       190 
QWLRDCHAYA KKAKEFL 

« Hide

References

« Hide 'large scale' references
[1]"Complete DNA sequence of yeast chromosome XI."
Dujon B., Alexandraki D., Andre B., Ansorge W., Baladron V., Ballesta J.P.G., Banrevi A., Bolle P.-A., Bolotin-Fukuhara M., Bossier P., Bou G., Boyer J., Buitrago M.J., Cheret G., Colleaux L., Daignan-Fornier B., del Rey F., Dion C. expand/collapse author list , Domdey H., Duesterhoeft A., Duesterhus S., Entian K.-D., Erfle H., Esteban P.F., Feldmann H., Fernandes L., Fobo G.M., Fritz C., Fukuhara H., Gabel C., Gaillon L., Garcia-Cantalejo J.M., Garcia-Ramirez J.J., Gent M.E., Ghazvini M., Goffeau A., Gonzalez A., Grothues D., Guerreiro P., Hegemann J.H., Hewitt N., Hilger F., Hollenberg C.P., Horaitis O., Indge K.J., Jacquier A., James C.M., Jauniaux J.-C., Jimenez A., Keuchel H., Kirchrath L., Kleine K., Koetter P., Legrain P., Liebl S., Louis E.J., Maia e Silva A., Marck C., Monnier A.-L., Moestl D., Mueller S., Obermaier B., Oliver S.G., Pallier C., Pascolo S., Pfeiffer F., Philippsen P., Planta R.J., Pohl F.M., Pohl T.M., Poehlmann R., Portetelle D., Purnelle B., Puzos V., Ramezani Rad M., Rasmussen S.W., Remacha M.A., Revuelta J.L., Richard G.-F., Rieger M., Rodrigues-Pousada C., Rose M., Rupp T., Santos M.A., Schwager C., Sensen C., Skala J., Soares H., Sor F., Stegemann J., Tettelin H., Thierry A., Tzermia M., Urrestarazu L.A., van Dyck L., van Vliet-Reedijk J.C., Valens M., Vandenbol M., Vilela C., Vissers S., von Wettstein D., Voss H., Wiemann S., Xu G., Zimmermann J., Haasemann M., Becker I., Mewes H.-W.
Nature 369:371-378(1994) [PubMed: 8196765] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[2]"Global analysis of protein localization in budding yeast."
Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W., Weissman J.S., O'Shea E.K.
Nature 425:686-691(2003) [PubMed: 14562095] [Abstract]
Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
[3]"Global analysis of protein expression in yeast."
Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S.
Nature 425:737-741(2003) [PubMed: 14562106] [Abstract]
Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
[4]"Pam17 is required for architecture and translocation activity of the mitochondrial protein import motor."
van der Laan M., Chacinska A., Lind M., Perschil I., Sickmann A., Meyer H.E., Guiard B., Meisinger C., Pfanner N., Rehling P.
Mol. Cell. Biol. 25:7449-7458(2005) [PubMed: 16107694] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY, IDENTIFICATION IN THE PAM COMPLEX, FUNCTION, SUBCELLULAR LOCATION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Z28290 Genomic DNA. Translation: CAA82144.1.
PIRS38141.
RefSeqNP_012991.1.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

DIPDIP-2128N.
IntActP36147. 4 interactions.
STRINGP36147.

Proteomic databases

PeptideAtlasP36147.

Genome annotation databases

EnsemblYKR065C; YKR065C; YKR065C; Saccharomyces cerevisiae. [Genome view]
GeneID853939.
KEGGsce:YKR065C.
NMPDRfig|4932.3.peg.3977.

Organism-specific databases

CYGDYKR065c.
SGDS000001773. PAM17.

Phylogenomic databases

eggNOGfuNOG09299.
HOGENOMHBG396609.
OMACNAFRRK.
OrthoDBEOG9QZ93D.
PhylomeDBP36147.

Gene expression databases

ArrayExpressP36147.
GenevestigatorP36147.
GermOnlineYKR065C. Saccharomyces cerevisiae.

Family and domain databases

InterProIPR013875. Pam17.
[Graphical view]
PfamPF08566. Pam17. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio975324.

Entry information

Entry namePAM17_YEAST
AccessionPrimary (citable) accession number: P36147
Entry history
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: January 19, 2010
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectFPAP (Fungal Proteome Annotation Project)

Relevant documents

SIMILARITY comments

Index of protein domains and families

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

Yeast chromosome XI

Yeast (Saccharomyces cerevisiae) chromosome XI: entries and gene names

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents