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P36147 (PAM17_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 73. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Presequence translocated-associated motor subunit PAM17, mitochondrial
Gene names
Name:PAM17
Synonyms:FMP18
Ordered Locus Names:YKR065C
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length197 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. In the complex, it is required to organize PAM16-PAM18 (TIM16-TIM14) heterodimer. Ref.5

Subunit structure

Component of the PAM complex, at least composed of mtHsp70, MGE1, TIM44, PAM16, PAM17 and PAM18/TIM14.

Subcellular location

Mitochondrion inner membrane; Multi-pass membrane protein Potential Ref.3 Ref.5.

Miscellaneous

Present with 3000 molecules/cell in log phase SD medium. Ref.4

Sequence similarities

Belongs to the PAM17 family.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

ECM4P361561EBI-26467,EBI-2042717

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – 1414Mitochondrion Potential
Chain15 – 197183Presequence translocated-associated motor subunit PAM17, mitochondrial
PRO_0000043179

Regions

Transmembrane64 – 8421Helical; Potential
Transmembrane103 – 12321Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
P36147 [UniParc].

Last modified June 1, 1994. Version 1.
Checksum: 633C74D569E51603

FASTA19721,968
        10         20         30         40         50         60 
MFTSAIRLSS QRLFASQPSV TAAALRSTAT TLPLRSYSQP ASLQDSSILT WSDFFKLRKQ 

        70         80         90        100        110        120 
QRRINVGSSL FTALLGCNVS WAYLSTMEID PTQMLFGFDP LTVISAGIIA SGALGYLLGP 

       130        140        150        160        170        180 
IVGSQVFKLS HNQQLAQFNN KNKEFLKHII NNRVDASSQS FSNPVPDYYG EKIGSLKEYK 

       190 
QWLRDCHAYA KKAKEFL 

« Hide

References

« Hide 'large scale' references
[1]"Complete DNA sequence of yeast chromosome XI."
Dujon B., Alexandraki D., Andre B., Ansorge W., Baladron V., Ballesta J.P.G., Banrevi A., Bolle P.-A., Bolotin-Fukuhara M., Bossier P., Bou G., Boyer J., Buitrago M.J., Cheret G., Colleaux L., Daignan-Fornier B., del Rey F., Dion C. expand/collapse author list , Domdey H., Duesterhoeft A., Duesterhus S., Entian K.-D., Erfle H., Esteban P.F., Feldmann H., Fernandes L., Fobo G.M., Fritz C., Fukuhara H., Gabel C., Gaillon L., Garcia-Cantalejo J.M., Garcia-Ramirez J.J., Gent M.E., Ghazvini M., Goffeau A., Gonzalez A., Grothues D., Guerreiro P., Hegemann J.H., Hewitt N., Hilger F., Hollenberg C.P., Horaitis O., Indge K.J., Jacquier A., James C.M., Jauniaux J.-C., Jimenez A., Keuchel H., Kirchrath L., Kleine K., Koetter P., Legrain P., Liebl S., Louis E.J., Maia e Silva A., Marck C., Monnier A.-L., Moestl D., Mueller S., Obermaier B., Oliver S.G., Pallier C., Pascolo S., Pfeiffer F., Philippsen P., Planta R.J., Pohl F.M., Pohl T.M., Poehlmann R., Portetelle D., Purnelle B., Puzos V., Ramezani Rad M., Rasmussen S.W., Remacha M.A., Revuelta J.L., Richard G.-F., Rieger M., Rodrigues-Pousada C., Rose M., Rupp T., Santos M.A., Schwager C., Sensen C., Skala J., Soares H., Sor F., Stegemann J., Tettelin H., Thierry A., Tzermia M., Urrestarazu L.A., van Dyck L., van Vliet-Reedijk J.C., Valens M., Vandenbol M., Vilela C., Vissers S., von Wettstein D., Voss H., Wiemann S., Xu G., Zimmermann J., Haasemann M., Becker I., Mewes H.-W.
Nature 369:371-378(1994) [PubMed: 8196765] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[2]Saccharomyces Genome Database
Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[3]"Global analysis of protein localization in budding yeast."
Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W., Weissman J.S., O'Shea E.K.
Nature 425:686-691(2003) [PubMed: 14562095] [Abstract]
Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
[4]"Global analysis of protein expression in yeast."
Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S.
Nature 425:737-741(2003) [PubMed: 14562106] [Abstract]
Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
[5]"Pam17 is required for architecture and translocation activity of the mitochondrial protein import motor."
van der Laan M., Chacinska A., Lind M., Perschil I., Sickmann A., Meyer H.E., Guiard B., Meisinger C., Pfanner N., Rehling P.
Mol. Cell. Biol. 25:7449-7458(2005) [PubMed: 16107694] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY, IDENTIFICATION IN THE PAM COMPLEX, FUNCTION, SUBCELLULAR LOCATION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Z28290 Genomic DNA. Translation: CAA82144.1.
BK006944 Genomic DNA. Translation: DAA09216.1.
PIRS38141.
RefSeqNP_012991.1. NM_001179855.1.

3D structure databases

ProteinModelPortalP36147.
ModBaseSearch...

Protein-protein interaction databases

DIPDIP-2128N.
IntActP36147. 2 interactions.
MINTMINT-547403.
STRINGP36147.

Proteomic databases

PeptideAtlasP36147.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYKR065C; YKR065C; YKR065C.
GeneID853939.
KEGGsce:YKR065C.
NMPDRfig|4932.3.peg.3977.

Organism-specific databases

CYGDYKR065c.
SGDS000001773. PAM17.

Phylogenomic databases

eggNOGfuNOG09299.
GeneTreeEFGT00050000003497.
HOGENOMHBG396609.
OMADVEKPIM.
OrthoDBEOG46T6B1.

Gene expression databases

ArrayExpressP36147.
GenevestigatorP36147.
GermOnlineYKR065C. Saccharomyces cerevisiae.

Family and domain databases

InterProIPR013875. Pam17.
[Graphical view]
PfamPF08566. Pam17. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio975324.

Entry information

Entry namePAM17_YEAST
AccessionPrimary (citable) accession number: P36147
Secondary accession number(s): D6VXC6
Entry history
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: December 14, 2011
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

Yeast chromosome XI

Yeast (Saccharomyces cerevisiae) chromosome XI: entries and gene names

SIMILARITY comments

Index of protein domains and families