Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Presequence translocated-associated motor subunit PAM17, mitochondrial

Gene

PAM17

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. In the complex, it is required to organize PAM16-PAM18 (TIM16-TIM14) heterodimer.1 Publication

GO - Biological processi

  • protein import into mitochondrial matrix Source: SGD
  • protein targeting to mitochondrion Source: Reactome

Keywordsi

Biological processProtein transport, Translocation, Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-32033-MONOMER.
ReactomeiR-SCE-1268020. Mitochondrial protein import.

Names & Taxonomyi

Protein namesi
Recommended name:
Presequence translocated-associated motor subunit PAM17, mitochondrial
Gene namesi
Name:PAM17
Synonyms:FMP18
Ordered Locus Names:YKR065C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XI

Organism-specific databases

EuPathDBiFungiDB:YKR065C.
SGDiS000001773. PAM17.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei64 – 84HelicalSequence analysisAdd BLAST21
Transmembranei103 – 123HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 14MitochondrionSequence analysisAdd BLAST14
ChainiPRO_000004317915 – 197Presequence translocated-associated motor subunit PAM17, mitochondrialAdd BLAST183

Proteomic databases

MaxQBiP36147.
PRIDEiP36147.

Interactioni

Subunit structurei

Component of the PAM complex, at least composed of mtHsp70, MGE1, TIM44, PAM16, PAM17 and PAM18/TIM14.1 Publication

Protein-protein interaction databases

BioGridi34196. 253 interactors.
DIPiDIP-2128N.
IntActiP36147. 5 interactors.
MINTiMINT-547403.

Structurei

3D structure databases

ProteinModelPortaliP36147.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PAM17 family.Curated

Keywords - Domaini

Transit peptide, Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000213138.
InParanoidiP36147.
KOiK17806.
OMAiPLFQCCQ.
OrthoDBiEOG092C4LIK.

Family and domain databases

InterProiView protein in InterPro
IPR013875. Pam17.
PfamiView protein in Pfam
PF08566. Pam17. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P36147-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFTSAIRLSS QRLFASQPSV TAAALRSTAT TLPLRSYSQP ASLQDSSILT
60 70 80 90 100
WSDFFKLRKQ QRRINVGSSL FTALLGCNVS WAYLSTMEID PTQMLFGFDP
110 120 130 140 150
LTVISAGIIA SGALGYLLGP IVGSQVFKLS HNQQLAQFNN KNKEFLKHII
160 170 180 190
NNRVDASSQS FSNPVPDYYG EKIGSLKEYK QWLRDCHAYA KKAKEFL
Length:197
Mass (Da):21,968
Last modified:June 1, 1994 - v1
Checksum:i633C74D569E51603
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z28290 Genomic DNA. Translation: CAA82144.1.
BK006944 Genomic DNA. Translation: DAA09216.1.
PIRiS38141.
RefSeqiNP_012991.3. NM_001179855.3.

Genome annotation databases

EnsemblFungiiYKR065C; YKR065C; YKR065C.
GeneIDi853939.
KEGGisce:YKR065C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z28290 Genomic DNA. Translation: CAA82144.1.
BK006944 Genomic DNA. Translation: DAA09216.1.
PIRiS38141.
RefSeqiNP_012991.3. NM_001179855.3.

3D structure databases

ProteinModelPortaliP36147.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi34196. 253 interactors.
DIPiDIP-2128N.
IntActiP36147. 5 interactors.
MINTiMINT-547403.

Proteomic databases

MaxQBiP36147.
PRIDEiP36147.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYKR065C; YKR065C; YKR065C.
GeneIDi853939.
KEGGisce:YKR065C.

Organism-specific databases

EuPathDBiFungiDB:YKR065C.
SGDiS000001773. PAM17.

Phylogenomic databases

HOGENOMiHOG000213138.
InParanoidiP36147.
KOiK17806.
OMAiPLFQCCQ.
OrthoDBiEOG092C4LIK.

Enzyme and pathway databases

BioCyciYEAST:G3O-32033-MONOMER.
ReactomeiR-SCE-1268020. Mitochondrial protein import.

Miscellaneous databases

PROiP36147.

Family and domain databases

InterProiView protein in InterPro
IPR013875. Pam17.
PfamiView protein in Pfam
PF08566. Pam17. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiPAM17_YEAST
AccessioniPrimary (citable) accession number: P36147
Secondary accession number(s): D6VXC6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: March 15, 2017
This is version 112 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 3000 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XI
    Yeast (Saccharomyces cerevisiae) chromosome XI: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.