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Protein

Presequence translocated-associated motor subunit PAM17, mitochondrial

Gene

PAM17

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. In the complex, it is required to organize PAM16-PAM18 (TIM16-TIM14) heterodimer.1 Publication

Miscellaneous

Present with 3000 molecules/cell in log phase SD medium.1 Publication

GO - Biological processi

  • protein import into mitochondrial matrix Source: SGD

Keywordsi

Biological processProtein transport, Translocation, Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-32033-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Presequence translocated-associated motor subunit PAM17, mitochondrial
Gene namesi
Name:PAM17
Synonyms:FMP18
Ordered Locus Names:YKR065C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XI

Organism-specific databases

EuPathDBiFungiDB:YKR065C
SGDiS000001773 PAM17

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei64 – 84HelicalSequence analysisAdd BLAST21
Transmembranei103 – 123HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 14MitochondrionSequence analysisAdd BLAST14
ChainiPRO_000004317915 – 197Presequence translocated-associated motor subunit PAM17, mitochondrialAdd BLAST183

Proteomic databases

MaxQBiP36147
PaxDbiP36147
PRIDEiP36147

Interactioni

Subunit structurei

Component of the PAM complex, at least composed of mtHsp70, MGE1, TIM44, PAM16, PAM17 and PAM18/TIM14.1 Publication

Protein-protein interaction databases

BioGridi34196, 256 interactors
DIPiDIP-2128N
IntActiP36147, 5 interactors
MINTiP36147
STRINGi4932.YKR065C

Structurei

3D structure databases

ProteinModelPortaliP36147
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PAM17 family.Curated

Keywords - Domaini

Transit peptide, Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000213138
InParanoidiP36147
KOiK17806
OMAiNRVDPTA
OrthoDBiEOG092C4LIK

Family and domain databases

InterProiView protein in InterPro
IPR013875 Pam17
PANTHERiPTHR28021 PTHR28021, 1 hit
PfamiView protein in Pfam
PF08566 Pam17, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P36147-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFTSAIRLSS QRLFASQPSV TAAALRSTAT TLPLRSYSQP ASLQDSSILT
60 70 80 90 100
WSDFFKLRKQ QRRINVGSSL FTALLGCNVS WAYLSTMEID PTQMLFGFDP
110 120 130 140 150
LTVISAGIIA SGALGYLLGP IVGSQVFKLS HNQQLAQFNN KNKEFLKHII
160 170 180 190
NNRVDASSQS FSNPVPDYYG EKIGSLKEYK QWLRDCHAYA KKAKEFL
Length:197
Mass (Da):21,968
Last modified:June 1, 1994 - v1
Checksum:i633C74D569E51603
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z28290 Genomic DNA Translation: CAA82144.1
BK006944 Genomic DNA Translation: DAA09216.1
PIRiS38141
RefSeqiNP_012991.3, NM_001179855.3

Genome annotation databases

EnsemblFungiiYKR065C; YKR065C; YKR065C
GeneIDi853939
KEGGisce:YKR065C

Similar proteinsi

Entry informationi

Entry nameiPAM17_YEAST
AccessioniPrimary (citable) accession number: P36147
Secondary accession number(s): D6VXC6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: June 20, 2018
This is version 121 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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