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Protein

Glycogenin-1

Gene

GLG1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Self-glucosylating initiator of glycogen synthesis. Catalyzes the formation of a short alpha (1,4)-glucosyl chain covalently attached via a glucose 1-O-tyrosyl linkage to internal tyrosine residues. These chains act as primers for the elongation reaction catalyzed by glycogen synthase. Capable of transferring glucosyl residues to unbound acceptors such as free oligoglucans or oligoglucan derivatives.2 Publications

Catalytic activityi

UDP-alpha-D-glucose + glycogenin = UDP + alpha-D-glucosylglycogenin.

GO - Molecular functioni

  • glycogenin glucosyltransferase activity Source: SGD
  • UDP-alpha-D-glucose:glucosyl-glycogenin alpha-D-glucosyltransferase activity Source: UniProtKB-EC

GO - Biological processi

  • glycogen biosynthetic process Source: SGD

Keywordsi

Molecular functionTransferase
Biological processGlycogen biosynthesis

Enzyme and pathway databases

BioCyciYEAST:MONOMER3O-4054
ReactomeiR-SCE-3322077 Glycogen synthesis
R-SCE-6798695 Neutrophil degranulation
R-SCE-70221 Glycogen breakdown (glycogenolysis)

Protein family/group databases

CAZyiGT8 Glycosyltransferase Family 8

Names & Taxonomyi

Protein namesi
Recommended name:
Glycogenin-1 (EC:2.4.1.186)
Alternative name(s):
Glycogen synthesis initiator protein 1
Glycogenin glucosyltransferase 1
Gene namesi
Name:GLG1
Ordered Locus Names:YKR058W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XI

Organism-specific databases

EuPathDBiFungiDB:YKR058W
SGDiS000001766 GLG1

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi230Y → F: Eliminates glycogen accumulation; when associated with F-598. 1 Publication1
Mutagenesisi598Y → F: Eliminates glycogen accumulation; when associated with F-230. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002151811 – 616Glycogenin-1Add BLAST616

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi230O-linked (Glc...) tyrosineBy similarity1
Glycosylationi598O-linked (Glc...) tyrosineCurated1

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiP36143
PaxDbiP36143
PRIDEiP36143

Expressioni

Inductioni

Induced during the diauxic transition.1 Publication

Interactioni

Protein-protein interaction databases

BioGridi34189, 62 interactors
IntActiP36143, 2 interactors
MINTiP36143
STRINGi4932.YKR058W

Structurei

3D structure databases

ProteinModelPortaliP36143
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

GeneTreeiENSGT00390000004721
HOGENOMiHOG000112734
InParanoidiP36143
KOiK00750
OMAiDECEEHI
OrthoDBiEOG092C395N

Family and domain databases

Gene3Di3.90.550.10, 1 hit
InterProiView protein in InterPro
IPR002495 Glyco_trans_8
IPR029044 Nucleotide-diphossugar_trans
PfamiView protein in Pfam
PF01501 Glyco_transf_8, 1 hit
SUPFAMiSSF53448 SSF53448, 1 hit

Sequencei

Sequence statusi: Complete.

P36143-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYKKLAIATL LYSADYLPGV FALGHQVNKL LEEAGKKGDI ETCLIVTTSL
60 70 80 90 100
FNGTLSELAK NILQSIYTKI VLVEPLNCQE ESIQKNSENL ALLERPELSF
110 120 130 140 150
ALIKARLWEL TQFEQVLYLD SDTLPLNKEF LKLFDIMSKQ TTSQVGAIAD
160 170 180 190 200
IGWPDMFNSG VMMLIPDADT ASVLQNYIFE NTSIDGSDQG ILNQFFNQNC
210 220 230 240 250
CTDELVKDSF SREWVQLSFT YNVTIPNLGY QSSPAMNYFK PSIKLIHFIG
260 270 280 290 300
KHKPWSLWSQ KNFIKNEYHD QWNEVYEEFK EEHQLNNEVS KPKISDSDKT
310 320 330 340 350
ETPETITPVD APPSNEPTTN QEIDTISTVE ENVDNQNAEP VPNSDHSPAP
360 370 380 390 400
NPVPLDFTKW LTTFINKDHL TNQPVNESRE YSKENDNNII NSSSNRDQES
410 420 430 440 450
PPNSTQELNS SYSVVSTQAD SDEHQNAEEE DSTTDNASNS GEESHLDDIS
460 470 480 490 500
TAASSNNNVS NQPDGKNFSN SKENNISVES SPSNPEQKRS TDNIQKPSVS
510 520 530 540 550
TNDLPDDVEP HTSVDDNIQY LEKDKEGYEE FLPDVYESNA IDNEEEFFDD
560 570 580 590 600
DARDATEGET KTSAVADKQE DMKLTAEETN QPQQEMPNFK FDWEDSDYLS
610
KVERCFPDDI FEYAVE
Length:616
Mass (Da):69,724
Last modified:May 20, 2008 - v4
Checksum:i35DFF4A1E043FC8B
GO

Sequence cautioni

The sequence AAA91646 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAA82136 differs from that shown. Reason: Frameshift at positions 6 and 38.Curated
The sequence CAA82136 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U25546 Genomic DNA Translation: AAA91646.1 Different initiation.
Z28283 Genomic DNA Translation: CAA82136.1 Sequence problems.
BK006944 Genomic DNA Translation: DAA09209.1
PIRiS38134
RefSeqiNP_012984.2, NM_001179848.1

Genome annotation databases

EnsemblFungiiYKR058W; YKR058W; YKR058W
GeneIDi853932
KEGGisce:YKR058W

Similar proteinsi

Entry informationi

Entry nameiGLG1_YEAST
AccessioniPrimary (citable) accession number: P36143
Secondary accession number(s): D6VXB9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: May 20, 2008
Last modified: May 23, 2018
This is version 125 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XI
    Yeast (Saccharomyces cerevisiae) chromosome XI: entries and gene names

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