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Protein

Putative redox protein FMP46, mitochondrial

Gene

FMP46

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Putative mitochondrial redox protein which could be involved in the reduction of small toxic molecules.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei97 – 971Curated

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Enzyme and pathway databases

BioCyciYEAST:G3O-32019-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative redox protein FMP46, mitochondrial (EC:1.-.-.-)
Alternative name(s):
Found in mitochondrial proteome protein 46
Gene namesi
Name:FMP46
Ordered Locus Names:YKR049C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XI

Organism-specific databases

EuPathDBiFungiDB:YKR049C.
SGDiS000001757. FMP46.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 2121MitochondrionSequence analysisAdd
BLAST
Chaini22 – 133112Putative redox protein FMP46, mitochondrialPRO_0000203215Add
BLAST

Proteomic databases

MaxQBiP36141.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
RSP5P399402EBI-26445,EBI-16219

Protein-protein interaction databases

BioGridi34180. 30 interactions.
IntActiP36141. 1 interaction.
MINTiMINT-2493865.

Structurei

Secondary structure

1
133
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi13 – 186Combined sources
Beta strandi22 – 243Combined sources
Helixi27 – 315Combined sources
Turni32 – 354Combined sources
Beta strandi41 – 488Combined sources
Helixi53 – 619Combined sources
Beta strandi62 – 654Combined sources
Helixi66 – 738Combined sources
Beta strandi74 – 763Combined sources
Helixi77 – 804Combined sources
Turni81 – 855Combined sources
Helixi86 – 905Combined sources
Helixi95 – 984Combined sources
Beta strandi109 – 1157Combined sources
Beta strandi118 – 1225Combined sources
Helixi123 – 1297Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1WPINMR-A1-133[»]
ProteinModelPortaliP36141.
SMRiP36141. Positions 1-133.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP36141.

Family & Domainsi

Sequence similaritiesi

Belongs to the FMP46 family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

HOGENOMiHOG000001095.
InParanoidiP36141.
OMAiLWVDWEK.
OrthoDBiEOG7DVDPQ.

Family and domain databases

InterProiIPR012882. DUF1687_fun.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF07955. DUF1687. 1 hit.
[Graphical view]
SUPFAMiSSF52833. SSF52833. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P36141-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSFWKTLQRQ PRTISLFTND IASNIKSQKC LQLLKGDVSH RFDVEIANRF
60 70 80 90 100
PTWDQLQYMR TSCPQGPVSL QRQIPKLDSV LKYKHTDPTF GMDLQKCVQR
110 120 130
GLWNPKEALW VDWENKLVGN EPADIDKYII QRK
Length:133
Mass (Da):15,650
Last modified:June 1, 1994 - v1
Checksum:i188F530D3E00FE57
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z28274 Genomic DNA. Translation: CAA82127.1.
AY558316 Genomic DNA. Translation: AAS56642.1.
BK006944 Genomic DNA. Translation: DAA09200.1.
PIRiS38123.
RefSeqiNP_012975.3. NM_001179839.3.

Genome annotation databases

EnsemblFungiiYKR049C; YKR049C; YKR049C.
GeneIDi853923.
KEGGisce:YKR049C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z28274 Genomic DNA. Translation: CAA82127.1.
AY558316 Genomic DNA. Translation: AAS56642.1.
BK006944 Genomic DNA. Translation: DAA09200.1.
PIRiS38123.
RefSeqiNP_012975.3. NM_001179839.3.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1WPINMR-A1-133[»]
ProteinModelPortaliP36141.
SMRiP36141. Positions 1-133.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi34180. 30 interactions.
IntActiP36141. 1 interaction.
MINTiMINT-2493865.

Proteomic databases

MaxQBiP36141.

Protocols and materials databases

DNASUi853923.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYKR049C; YKR049C; YKR049C.
GeneIDi853923.
KEGGisce:YKR049C.

Organism-specific databases

EuPathDBiFungiDB:YKR049C.
SGDiS000001757. FMP46.

Phylogenomic databases

HOGENOMiHOG000001095.
InParanoidiP36141.
OMAiLWVDWEK.
OrthoDBiEOG7DVDPQ.

Enzyme and pathway databases

BioCyciYEAST:G3O-32019-MONOMER.

Miscellaneous databases

EvolutionaryTraceiP36141.
NextBioi975276.
PROiP36141.

Family and domain databases

InterProiIPR012882. DUF1687_fun.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF07955. DUF1687. 1 hit.
[Graphical view]
SUPFAMiSSF52833. SSF52833. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Complete DNA sequence of yeast chromosome XI."
    Dujon B., Alexandraki D., Andre B., Ansorge W., Baladron V., Ballesta J.P.G., Banrevi A., Bolle P.-A., Bolotin-Fukuhara M., Bossier P., Bou G., Boyer J., Buitrago M.J., Cheret G., Colleaux L., Daignan-Fornier B., del Rey F., Dion C.
    , Domdey H., Duesterhoeft A., Duesterhus S., Entian K.-D., Erfle H., Esteban P.F., Feldmann H., Fernandes L., Fobo G.M., Fritz C., Fukuhara H., Gabel C., Gaillon L., Garcia-Cantalejo J.M., Garcia-Ramirez J.J., Gent M.E., Ghazvini M., Goffeau A., Gonzalez A., Grothues D., Guerreiro P., Hegemann J.H., Hewitt N., Hilger F., Hollenberg C.P., Horaitis O., Indge K.J., Jacquier A., James C.M., Jauniaux J.-C., Jimenez A., Keuchel H., Kirchrath L., Kleine K., Koetter P., Legrain P., Liebl S., Louis E.J., Maia e Silva A., Marck C., Monnier A.-L., Moestl D., Mueller S., Obermaier B., Oliver S.G., Pallier C., Pascolo S., Pfeiffer F., Philippsen P., Planta R.J., Pohl F.M., Pohl T.M., Poehlmann R., Portetelle D., Purnelle B., Puzos V., Ramezani Rad M., Rasmussen S.W., Remacha M.A., Revuelta J.L., Richard G.-F., Rieger M., Rodrigues-Pousada C., Rose M., Rupp T., Santos M.A., Schwager C., Sensen C., Skala J., Soares H., Sor F., Stegemann J., Tettelin H., Thierry A., Tzermia M., Urrestarazu L.A., van Dyck L., van Vliet-Reedijk J.C., Valens M., Vandenbol M., Vilela C., Vissers S., von Wettstein D., Voss H., Wiemann S., Xu G., Zimmermann J., Haasemann M., Becker I., Mewes H.-W.
    Nature 369:371-378(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  4. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
  5. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  6. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
    Strain: ATCC 76625 / YPH499.
  7. "Solution structure of YKR049C, a putative redox protein from Saccharomyces cerevisiae."
    Jung J.-W., Yee A., Wu B., Arrowsmith C.H., Lee W.
    J. Biochem. Mol. Biol. 38:550-554(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY NMR, PUTATIVE FUNCTION.

Entry informationi

Entry nameiFMP46_YEAST
AccessioniPrimary (citable) accession number: P36141
Secondary accession number(s): D6VXB0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: May 11, 2016
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 1240 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome XI
    Yeast (Saccharomyces cerevisiae) chromosome XI: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.