ID   UIP5_YEAST              Reviewed;         443 AA.
AC   P36137; D6VXA6;
DT   01-JUN-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-1994, sequence version 1.
DT   24-JAN-2024, entry version 147.
DE   RecName: Full=Protein UIP5;
DE   AltName: Full=ULP1-interacting protein 5;
DE   Flags: Precursor;
GN   Name=UIP5; OrderedLocusNames=YKR044W;
OS   Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX   NCBI_TaxID=559292;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=8196765; DOI=10.1038/369371a0;
RA   Dujon B., Alexandraki D., Andre B., Ansorge W., Baladron V.,
RA   Ballesta J.P.G., Banrevi A., Bolle P.-A., Bolotin-Fukuhara M., Bossier P.,
RA   Bou G., Boyer J., Buitrago M.J., Cheret G., Colleaux L.,
RA   Daignan-Fornier B., del Rey F., Dion C., Domdey H., Duesterhoeft A.,
RA   Duesterhus S., Entian K.-D., Erfle H., Esteban P.F., Feldmann H.,
RA   Fernandes L., Fobo G.M., Fritz C., Fukuhara H., Gabel C., Gaillon L.,
RA   Garcia-Cantalejo J.M., Garcia-Ramirez J.J., Gent M.E., Ghazvini M.,
RA   Goffeau A., Gonzalez A., Grothues D., Guerreiro P., Hegemann J.H.,
RA   Hewitt N., Hilger F., Hollenberg C.P., Horaitis O., Indge K.J.,
RA   Jacquier A., James C.M., Jauniaux J.-C., Jimenez A., Keuchel H.,
RA   Kirchrath L., Kleine K., Koetter P., Legrain P., Liebl S., Louis E.J.,
RA   Maia e Silva A., Marck C., Monnier A.-L., Moestl D., Mueller S.,
RA   Obermaier B., Oliver S.G., Pallier C., Pascolo S., Pfeiffer F.,
RA   Philippsen P., Planta R.J., Pohl F.M., Pohl T.M., Poehlmann R.,
RA   Portetelle D., Purnelle B., Puzos V., Ramezani Rad M., Rasmussen S.W.,
RA   Remacha M.A., Revuelta J.L., Richard G.-F., Rieger M.,
RA   Rodrigues-Pousada C., Rose M., Rupp T., Santos M.A., Schwager C.,
RA   Sensen C., Skala J., Soares H., Sor F., Stegemann J., Tettelin H.,
RA   Thierry A., Tzermia M., Urrestarazu L.A., van Dyck L.,
RA   van Vliet-Reedijk J.C., Valens M., Vandenbol M., Vilela C., Vissers S.,
RA   von Wettstein D., Voss H., Wiemann S., Xu G., Zimmermann J., Haasemann M.,
RA   Becker I., Mewes H.-W.;
RT   "Complete DNA sequence of yeast chromosome XI.";
RL   Nature 369:371-378(1994).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=24374639; DOI=10.1534/g3.113.008995;
RA   Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA   Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA   Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT   "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL   G3 (Bethesda) 4:389-398(2014).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=17322287; DOI=10.1101/gr.6037607;
RA   Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F.,
RA   Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J.,
RA   Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J.,
RA   Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D.,
RA   LaBaer J.;
RT   "Approaching a complete repository of sequence-verified protein-encoding
RT   clones for Saccharomyces cerevisiae.";
RL   Genome Res. 17:536-543(2007).
RN   [4]
RP   LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
RX   PubMed=14562106; DOI=10.1038/nature02046;
RA   Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N.,
RA   O'Shea E.K., Weissman J.S.;
RT   "Global analysis of protein expression in yeast.";
RL   Nature 425:737-741(2003).
RN   [5]
RP   TOPOLOGY [LARGE SCALE ANALYSIS].
RC   STRAIN=ATCC 208353 / W303-1A;
RX   PubMed=16847258; DOI=10.1073/pnas.0604075103;
RA   Kim H., Melen K., Oesterberg M., von Heijne G.;
RT   "A global topology map of the Saccharomyces cerevisiae membrane proteome.";
RL   Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006).
CC   -!- SUBCELLULAR LOCATION: Nucleus membrane; Single-pass type I membrane
CC       protein.
CC   -!- MISCELLANEOUS: Present with 319 molecules/cell in log phase SD medium.
CC       {ECO:0000269|PubMed:14562106}.
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DR   EMBL; Z28269; CAA82120.1; -; Genomic_DNA.
DR   EMBL; AY723841; AAU09758.1; -; Genomic_DNA.
DR   EMBL; BK006944; DAA09196.1; -; Genomic_DNA.
DR   PIR; S38116; S38116.
DR   RefSeq; NP_012970.3; NM_001179834.3.
DR   AlphaFoldDB; P36137; -.
DR   SMR; P36137; -.
DR   BioGRID; 34176; 34.
DR   DIP; DIP-4845N; -.
DR   IntAct; P36137; 1.
DR   STRING; 4932.YKR044W; -.
DR   iPTMnet; P36137; -.
DR   PaxDb; 4932-YKR044W; -.
DR   PeptideAtlas; P36137; -.
DR   EnsemblFungi; YKR044W_mRNA; YKR044W; YKR044W.
DR   GeneID; 853918; -.
DR   KEGG; sce:YKR044W; -.
DR   AGR; SGD:S000001752; -.
DR   SGD; S000001752; UIP5.
DR   VEuPathDB; FungiDB:YKR044W; -.
DR   eggNOG; ENOG502QVEK; Eukaryota.
DR   GeneTree; ENSGT00940000171755; -.
DR   HOGENOM; CLU_050744_0_0_1; -.
DR   InParanoid; P36137; -.
DR   OMA; MGFPKNL; -.
DR   OrthoDB; 2010345at2759; -.
DR   BioCyc; YEAST:G3O-32015-MONOMER; -.
DR   BioGRID-ORCS; 853918; 2 hits in 10 CRISPR screens.
DR   PRO; PR:P36137; -.
DR   Proteomes; UP000002311; Chromosome XI.
DR   RNAct; P36137; Protein.
DR   GO; GO:0030134; C:COPII-coated ER to Golgi transport vesicle; IBA:GO_Central.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IBA:GO_Central.
DR   GO; GO:0005793; C:endoplasmic reticulum-Golgi intermediate compartment; IBA:GO_Central.
DR   GO; GO:0000324; C:fungal-type vacuole; HDA:SGD.
DR   GO; GO:0000139; C:Golgi membrane; IBA:GO_Central.
DR   GO; GO:0005635; C:nuclear envelope; IDA:SGD.
DR   GO; GO:0031965; C:nuclear membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005537; F:mannose binding; IBA:GO_Central.
DR   GO; GO:0006888; P:endoplasmic reticulum to Golgi vesicle-mediated transport; IBA:GO_Central.
DR   CDD; cd07308; lectin_leg-like; 1.
DR   Gene3D; 2.60.120.200; -; 1.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR005052; Lectin_leg.
DR   PANTHER; PTHR12223:SF28; RE50040P; 1.
DR   PANTHER; PTHR12223; VESICULAR MANNOSE-BINDING LECTIN; 1.
DR   Pfam; PF03388; Lectin_leg-like; 1.
DR   SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
PE   1: Evidence at protein level;
KW   Membrane; Nucleus; Reference proteome; Signal; Transmembrane;
KW   Transmembrane helix.
FT   SIGNAL          1..27
FT                   /evidence="ECO:0000255"
FT   CHAIN           28..443
FT                   /note="Protein UIP5"
FT                   /id="PRO_0000203212"
FT   TOPO_DOM        28..398
FT                   /note="Perinuclear space"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        399..420
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        421..443
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   443 AA;  50981 MW;  360A0117AC2667A2 CRC64;
     MSRDVRAEKL AISLLILSLF LIFQLVAEIY LNNGDQYHTE TSPFTRGRSH VTRVPNHDAS
     LSIPFLDKIN QFWHVGGATQ IRNIQSIKLT QDRDQDKHGL VLSNGIGDNT INDFEIVFTF
     RISHDPTTQL TGDGMCFAIT PENGFLTQNL QSSYAKKQYM MNSQGVIADN TDLMGFPKNL
     PGLFIVLDTY RNQGHDHKEV PFMDVFINVA PESDWYDINS DGELSTSLRL NSRGHIKLKK
     NALWNRVTKL RIIYLESISF LKIDVQYAKE GNYWIELFQT TENLYLPKNM HTGQRYIGCS
     ALNGQLTETV ELLDVSTSEF HWNDMDASIE DTYDYAKEAE LFLEQEFGEV LDREPDEFTK
     WKMIKAQPNI KTGSQSAEQK TSNNPHSRLF KVVLTIWHYS EILLLIMGIY LFSACIRVFQ
     RRFKKIRSRR KRAGSHSVGL LPM
//