P36137 (UIP5_YEAST) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protein UIP5

Alternative name(s):
ULP1-interacting protein 5

Gene names

Name:	UIP5
Ordered Locus Names:	YKR044W

Organism

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]

Taxonomic identifier

559292 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › Saccharomyces cerevisiae

Protein attributes

Sequence length	443 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Subcellular location	Nucleus membrane; Single-pass type I membrane protein.
Miscellaneous	Present with 319 molecules/cell in log phase SD medium.

Ontologies

Keywords
Cellular component	Membrane Nucleus
Domain	Signal Transmembrane Transmembrane helix
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW nuclear envelope Inferred from direct assay PubMed 11056382. Source: SGD nuclear membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 27	27	Potential
	Chain	28 – 443	416	Protein UIP5		PRO_0000203212
Regions
	Topological domain	28 – 398	371	Perinuclear space Potential
	Transmembrane	399 – 420	22	Helical; Potential
	Topological domain	421 – 443	23	Cytoplasmic Potential

Sequences

	Sequence		Length	Mass (Da)
	P36137 [UniParc]. Last modified June 1, 1994. Version 1. Checksum: 360A0117AC2667A2	FASTA	443	50,981
	10 20 30 40 50 60 MSRDVRAEKL AISLLILSLF LIFQLVAEIY LNNGDQYHTE TSPFTRGRSH VTRVPNHDAS 70 80 90 100 110 120 LSIPFLDKIN QFWHVGGATQ IRNIQSIKLT QDRDQDKHGL VLSNGIGDNT INDFEIVFTF 130 140 150 160 170 180 RISHDPTTQL TGDGMCFAIT PENGFLTQNL QSSYAKKQYM MNSQGVIADN TDLMGFPKNL 190 200 210 220 230 240 PGLFIVLDTY RNQGHDHKEV PFMDVFINVA PESDWYDINS DGELSTSLRL NSRGHIKLKK 250 260 270 280 290 300 NALWNRVTKL RIIYLESISF LKIDVQYAKE GNYWIELFQT TENLYLPKNM HTGQRYIGCS 310 320 330 340 350 360 ALNGQLTETV ELLDVSTSEF HWNDMDASIE DTYDYAKEAE LFLEQEFGEV LDREPDEFTK 370 380 390 400 410 420 WKMIKAQPNI KTGSQSAEQK TSNNPHSRLF KVVLTIWHYS EILLLIMGIY LFSACIRVFQ 430 440 RRFKKIRSRR KRAGSHSVGL LPM

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Complete DNA sequence of yeast chromosome XI." Dujon B., Alexandraki D., Andre B., Ansorge W., Baladron V., Ballesta J.P.G., Banrevi A., Bolle P.-A., Bolotin-Fukuhara M., Bossier P., Bou G., Boyer J., Buitrago M.J., Cheret G., Colleaux L., Daignan-Fornier B., del Rey F., Dion C. , Domdey H., Duesterhoeft A., Duesterhus S., Entian K.-D., Erfle H., Esteban P.F., Feldmann H., Fernandes L., Fobo G.M., Fritz C., Fukuhara H., Gabel C., Gaillon L., Garcia-Cantalejo J.M., Garcia-Ramirez J.J., Gent M.E., Ghazvini M., Goffeau A., Gonzalez A., Grothues D., Guerreiro P., Hegemann J.H., Hewitt N., Hilger F., Hollenberg C.P., Horaitis O., Indge K.J., Jacquier A., James C.M., Jauniaux J.-C., Jimenez A., Keuchel H., Kirchrath L., Kleine K., Koetter P., Legrain P., Liebl S., Louis E.J., Maia e Silva A., Marck C., Monnier A.-L., Moestl D., Mueller S., Obermaier B., Oliver S.G., Pallier C., Pascolo S., Pfeiffer F., Philippsen P., Planta R.J., Pohl F.M., Pohl T.M., Poehlmann R., Portetelle D., Purnelle B., Puzos V., Ramezani Rad M., Rasmussen S.W., Remacha M.A., Revuelta J.L., Richard G.-F., Rieger M., Rodrigues-Pousada C., Rose M., Rupp T., Santos M.A., Schwager C., Sensen C., Skala J., Soares H., Sor F., Stegemann J., Tettelin H., Thierry A., Tzermia M., Urrestarazu L.A., van Dyck L., van Vliet-Reedijk J.C., Valens M., Vandenbol M., Vilela C., Vissers S., von Wettstein D., Voss H., Wiemann S., Xu G., Zimmermann J., Haasemann M., Becker I., Mewes H.-W. Nature 369:371-378(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 96604 / S288c / FY1679.
[2]	Saccharomyces Genome Database Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: ATCC 204508 / S288c.
[3]	"Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae." Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F., Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J., Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J. , Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D., LaBaer J. Genome Res. 17:536-543(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 204508 / S288c.
[4]	"Global analysis of protein expression in yeast." Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S. Nature 425:737-741(2003) [PubMed] [Europe PMC] [Abstract] Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
[5]	"A global topology map of the Saccharomyces cerevisiae membrane proteome." Kim H., Melen K., Oesterberg M., von Heijne G. Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006) [PubMed] [Europe PMC] [Abstract] Cited for: TOPOLOGY [LARGE SCALE ANALYSIS]. Strain: ATCC 208353 / W303-1A.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	Z28269 Genomic DNA. Translation: CAA82120.1. AY723841 Genomic DNA. Translation: AAU09758.1. BK006944 Genomic DNA. Translation: DAA09196.1.
PIR	S38116.
RefSeq	NP_012970.3. NM_001179834.3.
3D structure databases
ProteinModelPortal	P36137.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-4845N.
IntAct	P36137. 1 interaction.
MINT	MINT-564407.
STRING	4932.YKR044W.
Proteomic databases
PaxDb	P36137.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	YKR044W; YKR044W; YKR044W.
GeneID	853918.
KEGG	sce:YKR044W.
Organism-specific databases
CYGD	YKR044w.
SGD	S000001752. UIP5.
Phylogenomic databases
eggNOG	NOG44364.
HOGENOM	HOG000154773.
OMA	NGIGDNT.
OrthoDB	EOG4HDX3S.
Enzyme and pathway databases
BioCyc	YEAST:G3O-32015-MONOMER.
Gene expression databases
Genevestigator	P36137.
GermOnline	YKR044W. Saccharomyces cerevisiae.
Family and domain databases
Gene3D	2.60.120.200. 1 hit.
InterPro	IPR008985. ConA-like_lec_gl_sf. IPR013320. ConA-like_subgrp. IPR005052. Lectin_leg. [Graphical view]
PANTHER	PTHR12223. PTHR12223. 1 hit.
Pfam	PF03388. Lectin_leg-like. 2 hits. [Graphical view]
SUPFAM	SSF49899. ConA_like_lec_gl. 1 hit.
ProtoNet	Search...
Other
NextBio	975264.

Entry information

Entry name

UIP5_YEAST

Accession

Primary (citable) accession number: P36137
Secondary accession number(s): D6VXA6

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 1, 1994
Last sequence update:	June 1, 1994
Last modified:	May 29, 2013
This is version 91 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program