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P36135

- UTH1_YEAST

UniProt

P36135 - UTH1_YEAST

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Protein
Probable secreted beta-glucosidase UTH1
Gene
UTH1, YKR042W
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Involved in aging, oxidative stress response, and in the regulation of mitochondrial biogenesis. Inactivation of UTH1 increases life span, leads to higher resistance to heat stress and against hydrogen peroxide, and increases sensitivity to the superoxide radical-generating drug paraquat and to copper. Also required for the selective autophagic degradation of mitochondria (mitophagy) in response to nitrogen starvation. Involved in the remodeling of the cell wall during the various phases of yeast culture development and under various environmental conditions and plays a role in septation. Involved in cell sensitivity to boric acid.8 Publications

GO - Molecular functioni

  1. hydrolase activity, acting on glycosyl bonds Source: UniProtKB-KW

GO - Biological processi

  1. barrier septum assembly Source: UniProtKB-KW
  2. fungal-type cell wall biogenesis Source: SGD
  3. mitochondrion degradation Source: SGD
  4. negative regulation of chromatin silencing involved in replicative cell aging Source: SGD
  5. polysaccharide catabolic process Source: UniProtKB-KW
  6. response to stress Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Keywords - Biological processi

Autophagy, Carbohydrate metabolism, Cell cycle, Cell division, Cell wall biogenesis/degradation, Polysaccharide degradation, Septation, Stress response

Enzyme and pathway databases

BioCyciYEAST:G3O-32013-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable secreted beta-glucosidase UTH1 (EC:3.2.1.-)
Alternative name(s):
Youth protein 1
Gene namesi
Name:UTH1
Ordered Locus Names:YKR042W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome XI

Organism-specific databases

SGDiS000001750. UTH1.

Subcellular locationi

Mitochondrion outer membrane; Peripheral membrane protein. Secretedcell wall
Note: Non-covalently bound to the cell wall.2 Publications

GO - Cellular componenti

  1. cell wall Source: UniProtKB-SubCell
  2. extracellular region Source: UniProtKB-KW
  3. extrinsic component of mitochondrial inner membrane Source: SGD
  4. mitochondrial outer membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell wall, Membrane, Mitochondrion, Mitochondrion outer membrane, Secreted

Pathology & Biotechi

Disruption phenotypei

Leads to increased resistance to zymolyase treatment and to boric acid.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1717 Reviewed prediction
Add
BLAST
Chaini18 – 365348Probable secreted beta-glucosidase UTH1
PRO_0000194002Add
BLAST

Proteomic databases

MaxQBiP36135.
PaxDbiP36135.
PeptideAtlasiP36135.

Miscellaneous databases

PMAP-CutDBP36135.

Expressioni

Inductioni

Induced by hydrogen peroxide. Repressed by superoxide radicals and anoxia.2 Publications

Gene expression databases

GenevestigatoriP36135.

Interactioni

Protein-protein interaction databases

BioGridi34174. 123 interactions.
MINTiMINT-2782317.
STRINGi4932.YKR042W.

Structurei

3D structure databases

ProteinModelPortaliP36135.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi89 – 10315Poly-Ser
Add
BLAST

Sequence similaritiesi

Belongs to the SUN family.

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG83991.
GeneTreeiENSGT00390000002934.
HOGENOMiHOG000180870.
OMAiGCIWGTD.
OrthoDBiEOG79PK14.

Family and domain databases

InterProiIPR005556. SUN.
[Graphical view]
PfamiPF03856. SUN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P36135-1 [UniParc]FASTAAdd to Basket

« Hide

MKLSALLALS ASTAVLAAPA VHHSDNHHHN DKRAVVTVTQ YVNADGAVVI    50
PAATTATSAA ADGKVESVAA ATTTLSSTAA AATTSAAASS SSSSSSSSSS 100
SSSVGSGDFE DGTISCSDFP SGQGAVSLDW LGLGGWASIM DMNGNTATSC 150
QDGYYCSYAC SPGYAKTQWP SEQPSDGRSV GGLYCKNGKL YRSNTDTNSL 200
CVEGQGSAQA VNKVSGSIAI CGTDYPGSEN MVVPTVVGAG SSQPINVIKE 250
DSYYQWQGKK TSAQYYVNNA GVSVEDGCIW GTEGSGVGNW APVVLGAGYT 300
DGITYLSIIP NPNNKEAPNF NIKIVATDGS TVNGACSYEN GVYSGSGSDG 350
CTVSVTSGSA NFVFY 365
Length:365
Mass (Da):36,955
Last modified:June 16, 2009 - v2
Checksum:i5DBAB73510FA6F84
GO

Sequence cautioni

The sequence CAA82118.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z28267 Genomic DNA. Translation: CAA82118.1. Different initiation.
BK006944 Genomic DNA. Translation: DAA09194.1.
PIRiS38114.
RefSeqiNP_012968.4. NM_001179832.3.

Genome annotation databases

EnsemblFungiiYKR042W; YKR042W; YKR042W.
GeneIDi853916.
KEGGisce:YKR042W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z28267 Genomic DNA. Translation: CAA82118.1 . Different initiation.
BK006944 Genomic DNA. Translation: DAA09194.1 .
PIRi S38114.
RefSeqi NP_012968.4. NM_001179832.3.

3D structure databases

ProteinModelPortali P36135.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 34174. 123 interactions.
MINTi MINT-2782317.
STRINGi 4932.YKR042W.

Proteomic databases

MaxQBi P36135.
PaxDbi P36135.
PeptideAtlasi P36135.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YKR042W ; YKR042W ; YKR042W .
GeneIDi 853916.
KEGGi sce:YKR042W.

Organism-specific databases

SGDi S000001750. UTH1.

Phylogenomic databases

eggNOGi NOG83991.
GeneTreei ENSGT00390000002934.
HOGENOMi HOG000180870.
OMAi GCIWGTD.
OrthoDBi EOG79PK14.

Enzyme and pathway databases

BioCyci YEAST:G3O-32013-MONOMER.

Miscellaneous databases

NextBioi 975258.
PMAP-CutDB P36135.

Gene expression databases

Genevestigatori P36135.

Family and domain databases

InterProi IPR005556. SUN.
[Graphical view ]
Pfami PF03856. SUN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Complete DNA sequence of yeast chromosome XI."
    Dujon B., Alexandraki D., Andre B., Ansorge W., Baladron V., Ballesta J.P.G., Banrevi A., Bolle P.-A., Bolotin-Fukuhara M., Bossier P., Bou G., Boyer J., Buitrago M.J., Cheret G., Colleaux L., Daignan-Fornier B., del Rey F., Dion C.
    , Domdey H., Duesterhoeft A., Duesterhus S., Entian K.-D., Erfle H., Esteban P.F., Feldmann H., Fernandes L., Fobo G.M., Fritz C., Fukuhara H., Gabel C., Gaillon L., Garcia-Cantalejo J.M., Garcia-Ramirez J.J., Gent M.E., Ghazvini M., Goffeau A., Gonzalez A., Grothues D., Guerreiro P., Hegemann J.H., Hewitt N., Hilger F., Hollenberg C.P., Horaitis O., Indge K.J., Jacquier A., James C.M., Jauniaux J.-C., Jimenez A., Keuchel H., Kirchrath L., Kleine K., Koetter P., Legrain P., Liebl S., Louis E.J., Maia e Silva A., Marck C., Monnier A.-L., Moestl D., Mueller S., Obermaier B., Oliver S.G., Pallier C., Pascolo S., Pfeiffer F., Philippsen P., Planta R.J., Pohl F.M., Pohl T.M., Poehlmann R., Portetelle D., Purnelle B., Puzos V., Ramezani Rad M., Rasmussen S.W., Remacha M.A., Revuelta J.L., Richard G.-F., Rieger M., Rodrigues-Pousada C., Rose M., Rupp T., Santos M.A., Schwager C., Sensen C., Skala J., Soares H., Sor F., Stegemann J., Tettelin H., Thierry A., Tzermia M., Urrestarazu L.A., van Dyck L., van Vliet-Reedijk J.C., Valens M., Vandenbol M., Vilela C., Vissers S., von Wettstein D., Voss H., Wiemann S., Xu G., Zimmermann J., Haasemann M., Becker I., Mewes H.-W.
    Nature 369:371-378(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. "Mutation in the silencing gene SIR4 can delay aging in S.cerevisiae."
    Kennedy B.K., Austriaco N.R. Jr., Zhang J., Guarente L.
    Cell 80:485-496(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION.
  4. "Involvement of the Saccharomyces cerevisiae UTH1 gene in the oxidative-stress response."
    Bandara P.D.S., Flattery-O'Brien J.A., Grant C.M., Dawes I.W.
    Curr. Genet. 34:259-268(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION, INDUCTION, FUNCTION.
  5. "The 'SUN' family: UTH1, an ageing gene, is also involved in the regulation of mitochondria biogenesis in Saccharomyces cerevisiae."
    Camougrand N.M., Mouassite M., Velours G.M., Guerin M.G.
    Arch. Biochem. Biophys. 375:154-160(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  6. "The SUN family of Saccharomyces cerevisiae: the double knock-out of UTH1 and SIM1 promotes defects in nucleus migration and increased drug sensitivity."
    Mouassite M., Guerin M.G., Camougrand N.M.
    FEMS Microbiol. Lett. 182:137-141(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  7. "The 'SUN' family: yeast SUN4/SCW3 is involved in cell septation."
    Mouassite M., Camougrand N.M., Schwob E., Demaison G., Laclau M., Guerin M.G.
    Yeast 16:905-919(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  8. "Dual cell wall/mitochondria localization of the 'SUN' family proteins."
    Velours G.M., Boucheron C., Manon S., Camougrand N.M.
    FEMS Microbiol. Lett. 207:165-172(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.
  9. "The product of the UTH1 gene, required for Bax-induced cell death in yeast, is involved in the response to rapamycin."
    Camougrand N.M., Grelaud-Coq A., Marza E., Priault M., Bessoule J.-J., Manon S.
    Mol. Microbiol. 47:495-506(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  10. "Sequencing and comparison of yeast species to identify genes and regulatory elements."
    Kellis M., Patterson N., Endrizzi M., Birren B.W., Lander E.S.
    Nature 423:241-254(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION OF PROBABLE INITIATION SITE.
  11. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  12. "Uth1p is involved in the autophagic degradation of mitochondria."
    Kissova I., Deffieu M., Manon S., Camougrand N.M.
    J. Biol. Chem. 279:39068-39074(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  13. "Mapping of transcription start sites in Saccharomyces cerevisiae using 5' SAGE."
    Zhang Z., Dietrich F.S.
    Nucleic Acids Res. 33:2838-2851(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION OF PROBABLE INITIATION SITE.
  14. "Selective and non-selective autophagic degradation of mitochondria in yeast."
    Kissova I., Salin B., Schaeffer J., Bhatia S., Manon S., Camougrand N.M.
    Autophagy 3:329-336(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  15. "SUN family proteins Sun4p, Uth1p and Sim1p are secreted from Saccharomyces cerevisiae and produced dependently on oxygen level."
    Kuznetsov E., Kucerova H., Vachova L., Palkova Z.
    PLoS ONE 8:E73882-E73882(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, INDUCTION, DISRUPTION PHENOTYPE, FUNCTION.

Entry informationi

Entry nameiUTH1_YEAST
AccessioniPrimary (citable) accession number: P36135
Secondary accession number(s): D6VXA4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 16, 2009
Last modified: May 14, 2014
This is version 106 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 56900 molecules/cell in log phase SD medium.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome XI
    Yeast (Saccharomyces cerevisiae) chromosome XI: entries and gene names

External Data

Dasty 3

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