Protein UTH1 precursor - Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)

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P36135 (UTH1_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified May 29, 2013. Version 99. History...

Clusters with 100%, 90%, 50% identity |

Documents (3) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Protein UTH1

Alternative name(s):
Youth protein 1

Gene names

Name:	UTH1
Ordered Locus Names:	YKR042W

Organism

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]

Taxonomic identifier

559292 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces ›

Protein attributes

Sequence length	365 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Involved in aging, oxidative stress response, and in the regulation of mitochondrial biogenesis. Inactivation of UTH1 increases life span, leads to higher resistance to heat stress and against hydrogen peroxide, and increases sensitivity to the superoxide radical-generating drug paraquat and to copper. Also required for the selective autophagic degradation of mitochondria (mitophagy) in response to nitrogen starvation. May play a role in cell wall morphogenesis and septation. Ref.4 Ref.5 Ref.6 Ref.7 Ref.9 Ref.12 Ref.14
Subcellular location	Mitochondrion outer membrane; Peripheral membrane protein. Secreted › cell wall. Note: Non-covalently bound to the cell wall. Ref.8
Induction	Induced by hydrogen peroxide. Repressed by superoxide radicals. Ref.4
Miscellaneous	Present with 56900 molecules/cell in log phase SD medium.
Sequence similarities	Belongs to the SUN family.
Sequence caution	The sequence CAA82118.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Autophagy Cell cycle Cell division Cell wall biogenesis/degradation Septation Stress response
Cellular component	Cell wall Membrane Mitochondrion Mitochondrion outer membrane Secreted
Domain	Signal
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	barrier septum assembly Inferred from electronic annotation. Source: UniProtKB-KW cell cycle Inferred from electronic annotation. Source: UniProtKB-KW fungal-type cell wall biogenesis Inferred from mutant phenotype PubMed 20070376. Source: SGD mitochondrion degradation Inferred from mutant phenotype Ref.12. Source: SGD negative regulation of chromatin silencing involved in replicative cell aging Traceable author statement PubMed 12966141. Source: SGD response to stress Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	extracellular region Inferred from electronic annotation. Source: UniProtKB-KW fungal-type cell wall Inferred from direct assay Ref.8. Source: SGD mitochondrial outer membrane Traceable author statement Ref.8. Source: SGD
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

1 – 17

Potential

Chain

18 – 365

348

Protein UTH1

PRO_0000194002

Regions

Compositional bias

89 – 103

Poly-Ser

Sequences

Sequence

Length

Mass (Da)

Tools

P36135 [UniParc].

Last modified June 16, 2009. Version 2.
Checksum: 5DBAB73510FA6F84
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FASTA

365

36,955

        10         20         30         40         50         60 
MKLSALLALS ASTAVLAAPA VHHSDNHHHN DKRAVVTVTQ YVNADGAVVI PAATTATSAA 

        70         80         90        100        110        120 
ADGKVESVAA ATTTLSSTAA AATTSAAASS SSSSSSSSSS SSSVGSGDFE DGTISCSDFP 

       130        140        150        160        170        180 
SGQGAVSLDW LGLGGWASIM DMNGNTATSC QDGYYCSYAC SPGYAKTQWP SEQPSDGRSV 

       190        200        210        220        230        240 
GGLYCKNGKL YRSNTDTNSL CVEGQGSAQA VNKVSGSIAI CGTDYPGSEN MVVPTVVGAG 

       250        260        270        280        290        300 
SSQPINVIKE DSYYQWQGKK TSAQYYVNNA GVSVEDGCIW GTEGSGVGNW APVVLGAGYT 

       310        320        330        340        350        360 
DGITYLSIIP NPNNKEAPNF NIKIVATDGS TVNGACSYEN GVYSGSGSDG CTVSVTSGSA 


NFVFY

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Complete DNA sequence of yeast chromosome XI." Dujon B., Alexandraki D., Andre B., Ansorge W., Baladron V., Ballesta J.P.G., Banrevi A., Bolle P.-A., Bolotin-Fukuhara M., Bossier P., Bou G., Boyer J., Buitrago M.J., Cheret G., Colleaux L., Daignan-Fornier B., del Rey F., Dion C. Mewes H.-W. Nature 369:371-378(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 96604 / S288c / FY1679.
[2]	Saccharomyces Genome Database Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: ATCC 204508 / S288c.
[3]	"Mutation in the silencing gene SIR4 can delay aging in S.cerevisiae." Kennedy B.K., Austriaco N.R. Jr., Zhang J., Guarente L. Cell 80:485-496(1995) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION.
[4]	"Involvement of the Saccharomyces cerevisiae UTH1 gene in the oxidative-stress response." Bandara P.D.S., Flattery-O'Brien J.A., Grant C.M., Dawes I.W. Curr. Genet. 34:259-268(1998) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION, INDUCTION, FUNCTION.
[5]	"The 'SUN' family: UTH1, an ageing gene, is also involved in the regulation of mitochondria biogenesis in Saccharomyces cerevisiae." Camougrand N.M., Mouassite M., Velours G.M., Guerin M.G. Arch. Biochem. Biophys. 375:154-160(2000) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION.
[6]	"The SUN family of Saccharomyces cerevisiae: the double knock-out of UTH1 and SIM1 promotes defects in nucleus migration and increased drug sensitivity." Mouassite M., Guerin M.G., Camougrand N.M. FEMS Microbiol. Lett. 182:137-141(2000) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION.
[7]	"The 'SUN' family: yeast SUN4/SCW3 is involved in cell septation." Mouassite M., Camougrand N.M., Schwob E., Demaison G., Laclau M., Guerin M.G. Yeast 16:905-919(2000) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION.
[8]	"Dual cell wall/mitochondria localization of the 'SUN' family proteins." Velours G.M., Boucheron C., Manon S., Camougrand N.M. FEMS Microbiol. Lett. 207:165-172(2002) [PubMed] [Europe PMC] [Abstract] Cited for: SUBCELLULAR LOCATION.
[9]	"The product of the UTH1 gene, required for Bax-induced cell death in yeast, is involved in the response to rapamycin." Camougrand N.M., Grelaud-Coq A., Marza E., Priault M., Bessoule J.-J., Manon S. Mol. Microbiol. 47:495-506(2003) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION.
[10]	"Sequencing and comparison of yeast species to identify genes and regulatory elements." Kellis M., Patterson N., Endrizzi M., Birren B.W., Lander E.S. Nature 423:241-254(2003) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION OF PROBABLE INITIATION SITE.
[11]	"Global analysis of protein expression in yeast." Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S. Nature 425:737-741(2003) [PubMed] [Europe PMC] [Abstract] Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
[12]	"Uth1p is involved in the autophagic degradation of mitochondria." Kissova I., Deffieu M., Manon S., Camougrand N.M. J. Biol. Chem. 279:39068-39074(2004) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION.
[13]	"Mapping of transcription start sites in Saccharomyces cerevisiae using 5' SAGE." Zhang Z., Dietrich F.S. Nucleic Acids Res. 33:2838-2851(2005) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION OF PROBABLE INITIATION SITE.
[14]	"Selective and non-selective autophagic degradation of mitochondria in yeast." Kissova I., Salin B., Schaeffer J., Bhatia S., Manon S., Camougrand N.M. Autophagy 3:329-336(2007) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	Z28267 Genomic DNA. Translation: CAA82118.1. Different initiation. BK006944 Genomic DNA. Translation: DAA09194.1.
PIR	S38114.
RefSeq	NP_012968.4. NM_001179832.3.
3D structure databases
ProteinModelPortal	P36135.
ModBase	Search...
Protein-protein interaction databases
MINT	MINT-2782317.
STRING	4932.YKR042W.
Proteomic databases
PaxDb	P36135.
PeptideAtlas	P36135.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	YKR042W; YKR042W; YKR042W.
GeneID	853916.
KEGG	sce:YKR042W.
Organism-specific databases
SGD	S000001750. UTH1.
Phylogenomic databases
eggNOG	NOG83991.
GeneTree	ENSGT00390000002934.
HOGENOM	HOG000180870.
OMA	SENMNIP.
OrthoDB	EOG4RNFJ8.
Enzyme and pathway databases
BioCyc	YEAST:G3O-32013-MONOMER.
Gene expression databases
Genevestigator	P36135.
GermOnline	YKR042W. Saccharomyces cerevisiae.
Family and domain databases
InterPro	IPR005556. SUN. [Graphical view]
Pfam	PF03856. SUN. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	975258.
PMAP-CutDB	P36135.

Entry information

Entry name

UTH1_YEAST

Accession

Primary (citable) accession number: P36135
Secondary accession number(s): D6VXA4

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 1, 1994
Last sequence update:	June 16, 2009
Last modified:	May 29, 2013
This is version 99 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program

Relevant documents

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

Yeast chromosome XI

Yeast (Saccharomyces cerevisiae) chromosome XI: entries and gene names

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents