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P36135 (UTH1_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 105. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable secreted beta-glucosidase UTH1

EC=3.2.1.-
Alternative name(s):
Youth protein 1
Gene names
Name:UTH1
Ordered Locus Names:YKR042W
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length365 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Involved in aging, oxidative stress response, and in the regulation of mitochondrial biogenesis. Inactivation of UTH1 increases life span, leads to higher resistance to heat stress and against hydrogen peroxide, and increases sensitivity to the superoxide radical-generating drug paraquat and to copper. Also required for the selective autophagic degradation of mitochondria (mitophagy) in response to nitrogen starvation. Involved in the remodeling of the cell wall during the various phases of yeast culture development and under various environmental conditions and plays a role in septation. Involved in cell sensitivity to boric acid. Ref.4 Ref.5 Ref.6 Ref.7 Ref.9 Ref.12 Ref.14 Ref.15

Subcellular location

Mitochondrion outer membrane; Peripheral membrane protein. Secretedcell wall. Note: Non-covalently bound to the cell wall. Ref.8 Ref.15

Induction

Induced by hydrogen peroxide. Repressed by superoxide radicals and anoxia. Ref.4 Ref.15

Disruption phenotype

Leads to increased resistance to zymolyase treatment and to boric acid. Ref.15

Miscellaneous

Present with 56900 molecules/cell in log phase SD medium.

Sequence similarities

Belongs to the SUN family.

Sequence caution

The sequence CAA82118.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1717 Potential
Chain18 – 365348Probable secreted beta-glucosidase UTH1
PRO_0000194002

Regions

Compositional bias89 – 10315Poly-Ser

Sequences

Sequence LengthMass (Da)Tools
P36135 [UniParc].

Last modified June 16, 2009. Version 2.
Checksum: 5DBAB73510FA6F84

FASTA36536,955
        10         20         30         40         50         60 
MKLSALLALS ASTAVLAAPA VHHSDNHHHN DKRAVVTVTQ YVNADGAVVI PAATTATSAA 

        70         80         90        100        110        120 
ADGKVESVAA ATTTLSSTAA AATTSAAASS SSSSSSSSSS SSSVGSGDFE DGTISCSDFP 

       130        140        150        160        170        180 
SGQGAVSLDW LGLGGWASIM DMNGNTATSC QDGYYCSYAC SPGYAKTQWP SEQPSDGRSV 

       190        200        210        220        230        240 
GGLYCKNGKL YRSNTDTNSL CVEGQGSAQA VNKVSGSIAI CGTDYPGSEN MVVPTVVGAG 

       250        260        270        280        290        300 
SSQPINVIKE DSYYQWQGKK TSAQYYVNNA GVSVEDGCIW GTEGSGVGNW APVVLGAGYT 

       310        320        330        340        350        360 
DGITYLSIIP NPNNKEAPNF NIKIVATDGS TVNGACSYEN GVYSGSGSDG CTVSVTSGSA 


NFVFY 

« Hide

References

« Hide 'large scale' references
[1]"Complete DNA sequence of yeast chromosome XI."
Dujon B., Alexandraki D., Andre B., Ansorge W., Baladron V., Ballesta J.P.G., Banrevi A., Bolle P.-A., Bolotin-Fukuhara M., Bossier P., Bou G., Boyer J., Buitrago M.J., Cheret G., Colleaux L., Daignan-Fornier B., del Rey F., Dion C. expand/collapse author list , Domdey H., Duesterhoeft A., Duesterhus S., Entian K.-D., Erfle H., Esteban P.F., Feldmann H., Fernandes L., Fobo G.M., Fritz C., Fukuhara H., Gabel C., Gaillon L., Garcia-Cantalejo J.M., Garcia-Ramirez J.J., Gent M.E., Ghazvini M., Goffeau A., Gonzalez A., Grothues D., Guerreiro P., Hegemann J.H., Hewitt N., Hilger F., Hollenberg C.P., Horaitis O., Indge K.J., Jacquier A., James C.M., Jauniaux J.-C., Jimenez A., Keuchel H., Kirchrath L., Kleine K., Koetter P., Legrain P., Liebl S., Louis E.J., Maia e Silva A., Marck C., Monnier A.-L., Moestl D., Mueller S., Obermaier B., Oliver S.G., Pallier C., Pascolo S., Pfeiffer F., Philippsen P., Planta R.J., Pohl F.M., Pohl T.M., Poehlmann R., Portetelle D., Purnelle B., Puzos V., Ramezani Rad M., Rasmussen S.W., Remacha M.A., Revuelta J.L., Richard G.-F., Rieger M., Rodrigues-Pousada C., Rose M., Rupp T., Santos M.A., Schwager C., Sensen C., Skala J., Soares H., Sor F., Stegemann J., Tettelin H., Thierry A., Tzermia M., Urrestarazu L.A., van Dyck L., van Vliet-Reedijk J.C., Valens M., Vandenbol M., Vilela C., Vissers S., von Wettstein D., Voss H., Wiemann S., Xu G., Zimmermann J., Haasemann M., Becker I., Mewes H.-W.
Nature 369:371-378(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[2]Saccharomyces Genome Database
Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[3]"Mutation in the silencing gene SIR4 can delay aging in S.cerevisiae."
Kennedy B.K., Austriaco N.R. Jr., Zhang J., Guarente L.
Cell 80:485-496(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION.
[4]"Involvement of the Saccharomyces cerevisiae UTH1 gene in the oxidative-stress response."
Bandara P.D.S., Flattery-O'Brien J.A., Grant C.M., Dawes I.W.
Curr. Genet. 34:259-268(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION, INDUCTION, FUNCTION.
[5]"The 'SUN' family: UTH1, an ageing gene, is also involved in the regulation of mitochondria biogenesis in Saccharomyces cerevisiae."
Camougrand N.M., Mouassite M., Velours G.M., Guerin M.G.
Arch. Biochem. Biophys. 375:154-160(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[6]"The SUN family of Saccharomyces cerevisiae: the double knock-out of UTH1 and SIM1 promotes defects in nucleus migration and increased drug sensitivity."
Mouassite M., Guerin M.G., Camougrand N.M.
FEMS Microbiol. Lett. 182:137-141(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[7]"The 'SUN' family: yeast SUN4/SCW3 is involved in cell septation."
Mouassite M., Camougrand N.M., Schwob E., Demaison G., Laclau M., Guerin M.G.
Yeast 16:905-919(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[8]"Dual cell wall/mitochondria localization of the 'SUN' family proteins."
Velours G.M., Boucheron C., Manon S., Camougrand N.M.
FEMS Microbiol. Lett. 207:165-172(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION.
[9]"The product of the UTH1 gene, required for Bax-induced cell death in yeast, is involved in the response to rapamycin."
Camougrand N.M., Grelaud-Coq A., Marza E., Priault M., Bessoule J.-J., Manon S.
Mol. Microbiol. 47:495-506(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[10]"Sequencing and comparison of yeast species to identify genes and regulatory elements."
Kellis M., Patterson N., Endrizzi M., Birren B.W., Lander E.S.
Nature 423:241-254(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION OF PROBABLE INITIATION SITE.
[11]"Global analysis of protein expression in yeast."
Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S.
Nature 425:737-741(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
[12]"Uth1p is involved in the autophagic degradation of mitochondria."
Kissova I., Deffieu M., Manon S., Camougrand N.M.
J. Biol. Chem. 279:39068-39074(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[13]"Mapping of transcription start sites in Saccharomyces cerevisiae using 5' SAGE."
Zhang Z., Dietrich F.S.
Nucleic Acids Res. 33:2838-2851(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION OF PROBABLE INITIATION SITE.
[14]"Selective and non-selective autophagic degradation of mitochondria in yeast."
Kissova I., Salin B., Schaeffer J., Bhatia S., Manon S., Camougrand N.M.
Autophagy 3:329-336(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[15]"SUN family proteins Sun4p, Uth1p and Sim1p are secreted from Saccharomyces cerevisiae and produced dependently on oxygen level."
Kuznetsov E., Kucerova H., Vachova L., Palkova Z.
PLoS ONE 8:E73882-E73882(2013) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION, INDUCTION, DISRUPTION PHENOTYPE, FUNCTION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Z28267 Genomic DNA. Translation: CAA82118.1. Different initiation.
BK006944 Genomic DNA. Translation: DAA09194.1.
PIRS38114.
RefSeqNP_012968.4. NM_001179832.3.

3D structure databases

ProteinModelPortalP36135.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid34174. 123 interactions.
MINTMINT-2782317.
STRING4932.YKR042W.

Proteomic databases

PaxDbP36135.
PeptideAtlasP36135.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYKR042W; YKR042W; YKR042W.
GeneID853916.
KEGGsce:YKR042W.

Organism-specific databases

SGDS000001750. UTH1.

Phylogenomic databases

eggNOGNOG83991.
GeneTreeENSGT00390000002934.
HOGENOMHOG000180870.
OMAGCIWGTD.
OrthoDBEOG79PK14.

Enzyme and pathway databases

BioCycYEAST:G3O-32013-MONOMER.

Gene expression databases

GenevestigatorP36135.

Family and domain databases

InterProIPR005556. SUN.
[Graphical view]
PfamPF03856. SUN. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio975258.
PMAP-CutDBP36135.

Entry information

Entry nameUTH1_YEAST
AccessionPrimary (citable) accession number: P36135
Secondary accession number(s): D6VXA4
Entry history
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 16, 2009
Last modified: February 19, 2014
This is version 105 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast chromosome XI

Yeast (Saccharomyces cerevisiae) chromosome XI: entries and gene names

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

SIMILARITY comments

Index of protein domains and families

Glycosyl hydrolases

Classification of glycosyl hydrolase families and list of entries