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Protein

Probable secreted beta-glucosidase UTH1

Gene

UTH1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in aging, oxidative stress response, and in the regulation of mitochondrial biogenesis. Inactivation of UTH1 increases life span, leads to higher resistance to heat stress and against hydrogen peroxide, and increases sensitivity to the superoxide radical-generating drug paraquat and to copper. Also required for the selective autophagic degradation of mitochondria (mitophagy) in response to nitrogen starvation. Involved in the remodeling of the cell wall during the various phases of yeast culture development and under various environmental conditions and plays a role in septation. Involved in cell sensitivity to boric acid.8 Publications

GO - Molecular functioni

GO - Biological processi

  • barrier septum assembly Source: UniProtKB-KW
  • fungal-type cell wall biogenesis Source: SGD
  • fungal-type cell wall organization Source: GO_Central
  • mitophagy Source: SGD
  • negative regulation of chromatin silencing involved in replicative cell aging Source: SGD
  • polysaccharide catabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Keywords - Biological processi

Autophagy, Carbohydrate metabolism, Cell cycle, Cell division, Cell wall biogenesis/degradation, Polysaccharide degradation, Septation, Stress response

Enzyme and pathway databases

BioCyciYEAST:G3O-32013-MONOMER.

Protein family/group databases

CAZyiGH132. Glycoside Hydrolase Family 132.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable secreted beta-glucosidase UTH1 (EC:3.2.1.-)
Alternative name(s):
Youth protein 1
Gene namesi
Name:UTH1
Ordered Locus Names:YKR042W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XI

Organism-specific databases

EuPathDBiFungiDB:YKR042W.
SGDiS000001750. UTH1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell wall, Membrane, Mitochondrion, Mitochondrion outer membrane, Secreted

Pathology & Biotechi

Disruption phenotypei

Leads to increased resistance to zymolyase treatment and to boric acid.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 17Sequence analysisAdd BLAST17
ChainiPRO_000019400218 – 365Probable secreted beta-glucosidase UTH1Add BLAST348

Proteomic databases

MaxQBiP36135.
PRIDEiP36135.

Miscellaneous databases

PMAP-CutDBP36135.

Expressioni

Inductioni

Induced by hydrogen peroxide. Repressed by superoxide radicals and anoxia.2 Publications

Interactioni

Protein-protein interaction databases

BioGridi34174. 123 interactors.
MINTiMINT-2782317.

Structurei

3D structure databases

ProteinModelPortaliP36135.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi89 – 103Poly-SerAdd BLAST15

Sequence similaritiesi

Belongs to the SUN family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

GeneTreeiENSGT00390000002934.
HOGENOMiHOG000180870.
InParanoidiP36135.
KOiK01238.
OMAiGCIWGTD.
OrthoDBiEOG092C3CJQ.

Family and domain databases

InterProiIPR005556. SUN.
[Graphical view]
PfamiPF03856. SUN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P36135-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLSALLALS ASTAVLAAPA VHHSDNHHHN DKRAVVTVTQ YVNADGAVVI
60 70 80 90 100
PAATTATSAA ADGKVESVAA ATTTLSSTAA AATTSAAASS SSSSSSSSSS
110 120 130 140 150
SSSVGSGDFE DGTISCSDFP SGQGAVSLDW LGLGGWASIM DMNGNTATSC
160 170 180 190 200
QDGYYCSYAC SPGYAKTQWP SEQPSDGRSV GGLYCKNGKL YRSNTDTNSL
210 220 230 240 250
CVEGQGSAQA VNKVSGSIAI CGTDYPGSEN MVVPTVVGAG SSQPINVIKE
260 270 280 290 300
DSYYQWQGKK TSAQYYVNNA GVSVEDGCIW GTEGSGVGNW APVVLGAGYT
310 320 330 340 350
DGITYLSIIP NPNNKEAPNF NIKIVATDGS TVNGACSYEN GVYSGSGSDG
360
CTVSVTSGSA NFVFY
Length:365
Mass (Da):36,955
Last modified:June 16, 2009 - v2
Checksum:i5DBAB73510FA6F84
GO

Sequence cautioni

The sequence CAA82118 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z28267 Genomic DNA. Translation: CAA82118.1. Different initiation.
BK006944 Genomic DNA. Translation: DAA09194.1.
PIRiS38114.
RefSeqiNP_012968.4. NM_001179832.3.

Genome annotation databases

EnsemblFungiiYKR042W; YKR042W; YKR042W.
GeneIDi853916.
KEGGisce:YKR042W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z28267 Genomic DNA. Translation: CAA82118.1. Different initiation.
BK006944 Genomic DNA. Translation: DAA09194.1.
PIRiS38114.
RefSeqiNP_012968.4. NM_001179832.3.

3D structure databases

ProteinModelPortaliP36135.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi34174. 123 interactors.
MINTiMINT-2782317.

Protein family/group databases

CAZyiGH132. Glycoside Hydrolase Family 132.

Proteomic databases

MaxQBiP36135.
PRIDEiP36135.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYKR042W; YKR042W; YKR042W.
GeneIDi853916.
KEGGisce:YKR042W.

Organism-specific databases

EuPathDBiFungiDB:YKR042W.
SGDiS000001750. UTH1.

Phylogenomic databases

GeneTreeiENSGT00390000002934.
HOGENOMiHOG000180870.
InParanoidiP36135.
KOiK01238.
OMAiGCIWGTD.
OrthoDBiEOG092C3CJQ.

Enzyme and pathway databases

BioCyciYEAST:G3O-32013-MONOMER.

Miscellaneous databases

PMAP-CutDBP36135.
PROiP36135.

Family and domain databases

InterProiIPR005556. SUN.
[Graphical view]
PfamiPF03856. SUN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiUTH1_YEAST
AccessioniPrimary (citable) accession number: P36135
Secondary accession number(s): D6VXA4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 16, 2009
Last modified: November 2, 2016
This is version 123 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 56900 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome XI
    Yeast (Saccharomyces cerevisiae) chromosome XI: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.