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P36125 (GMH1_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 87. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein GMH1
Alternative name(s):
GEA1-6 membrane-associated high-copy suppressor protein 1
Gene names
Name:GMH1
Synonyms:MSG1
Ordered Locus Names:YKR030W
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length273 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Subunit structure

Interacts with GEA1 and GEA2. Ref.3

Subcellular location

Golgi apparatus membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Note: Recycles between Golgi apparatus and endoplasmic reticulum. Ref.3

Sequence similarities

Belongs to the unc-50 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed Ref.5
Chain2 – 273272Protein GMH1
PRO_0000203205

Regions

Topological domain2 – 8988Cytoplasmic Potential
Transmembrane90 – 11021Helical; Potential
Topological domain111 – 13424Lumenal Potential
Transmembrane135 – 15521Helical; Potential
Topological domain156 – 17520Cytoplasmic Potential
Transmembrane176 – 19621Helical; Potential
Topological domain197 – 21620Lumenal Potential
Transmembrane217 – 23721Helical; Potential
Topological domain238 – 2425Cytoplasmic Potential
Transmembrane243 – 26321Helical; Potential
Topological domain264 – 27310Lumenal Potential

Amino acid modifications

Modified residue21N-acetylserine Ref.5

Sequences

Sequence LengthMass (Da)Tools
P36125 [UniParc].

Last modified June 1, 1994. Version 1.
Checksum: 94E991416D7630F2

FASTA27331,993
        10         20         30         40         50         60 
MSYLPTYSND LPAGPQGQRR RNNGNENDAR QGYGQQSVPM VIRRLFKTPK NLDLETASWE 

        70         80         90        100        110        120 
MFHLIFHPRK AYRSIYYQRQ TKNQWARDDP SFFIFQIALI SLSSIIWSIY NSGFNNDSDM 

       130        140        150        160        170        180 
GALSIIGHFF KSLVMMVILD FFIFGFIMAT IFYLLLNRSH FKFKSSQNSV VEWAYCFDVH 

       190        200        210        220        230        240 
CNSFLIILLC LYFIQFLLLP IINLQNWISL LIGNSLYCFA IGHYFILTFY GYNQLPFLKN 

       250        260        270 
LNFILLPTLG LSIIYLISLF GIDLSKKLSF YNY 

« Hide

References

« Hide 'large scale' references
[1]"Complete DNA sequence of yeast chromosome XI."
Dujon B., Alexandraki D., Andre B., Ansorge W., Baladron V., Ballesta J.P.G., Banrevi A., Bolle P.-A., Bolotin-Fukuhara M., Bossier P., Bou G., Boyer J., Buitrago M.J., Cheret G., Colleaux L., Daignan-Fornier B., del Rey F., Dion C. expand/collapse author list , Domdey H., Duesterhoeft A., Duesterhus S., Entian K.-D., Erfle H., Esteban P.F., Feldmann H., Fernandes L., Fobo G.M., Fritz C., Fukuhara H., Gabel C., Gaillon L., Garcia-Cantalejo J.M., Garcia-Ramirez J.J., Gent M.E., Ghazvini M., Goffeau A., Gonzalez A., Grothues D., Guerreiro P., Hegemann J.H., Hewitt N., Hilger F., Hollenberg C.P., Horaitis O., Indge K.J., Jacquier A., James C.M., Jauniaux J.-C., Jimenez A., Keuchel H., Kirchrath L., Kleine K., Koetter P., Legrain P., Liebl S., Louis E.J., Maia e Silva A., Marck C., Monnier A.-L., Moestl D., Mueller S., Obermaier B., Oliver S.G., Pallier C., Pascolo S., Pfeiffer F., Philippsen P., Planta R.J., Pohl F.M., Pohl T.M., Poehlmann R., Portetelle D., Purnelle B., Puzos V., Ramezani Rad M., Rasmussen S.W., Remacha M.A., Revuelta J.L., Richard G.-F., Rieger M., Rodrigues-Pousada C., Rose M., Rupp T., Santos M.A., Schwager C., Sensen C., Skala J., Soares H., Sor F., Stegemann J., Tettelin H., Thierry A., Tzermia M., Urrestarazu L.A., van Dyck L., van Vliet-Reedijk J.C., Valens M., Vandenbol M., Vilela C., Vissers S., von Wettstein D., Voss H., Wiemann S., Xu G., Zimmermann J., Haasemann M., Becker I., Mewes H.-W.
Nature 369:371-378(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[2]"The reference genome sequence of Saccharomyces cerevisiae: Then and now."
Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R., Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S., Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.
G3 (Bethesda) 4:389-398(2014) [PubMed] [Europe PMC] [Abstract]
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[3]"A novel Golgi membrane protein is a partner of the ARF exchange factors Gea1p and Gea2p."
Chantalat S., Courbeyrette R., Senic-Matuglia F., Jackson C.L., Goud B., Peyroche A.
Mol. Biol. Cell 14:2357-2371(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION, SUBCELLULAR LOCATION, TOPOLOGY, INTERACTION WITH GEA1 AND GEA2.
[4]"A global topology map of the Saccharomyces cerevisiae membrane proteome."
Kim H., Melen K., Oesterberg M., von Heijne G.
Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
Strain: ATCC 208353 / W303-1A.
[5]"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."
Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A., Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E., Timmerman E., Prieto J., Arnesen T., Sherman F., Gevaert K., Aldabe R.
Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Z28255 Genomic DNA. Translation: CAA82102.1.
BK006944 Genomic DNA. Translation: DAA09185.1.
PIRS38102.
RefSeqNP_012955.1. NM_001179820.1.

3D structure databases

ProteinModelPortalP36125.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid34163. 33 interactions.
DIPDIP-2023N.
IntActP36125. 9 interactions.
MINTMINT-386053.
STRING4932.YKR030W.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYKR030W; YKR030W; YKR030W.
GeneID853901.
KEGGsce:YKR030W.

Organism-specific databases

CYGDYKR030w.
SGDS000001738. GMH1.

Phylogenomic databases

eggNOGNOG262379.
GeneTreeENSGT00390000018553.
HOGENOMHOG000193563.
OMANYRKQTK.
OrthoDBEOG76QFTZ.

Enzyme and pathway databases

BioCycYEAST:G3O-32006-MONOMER.

Gene expression databases

GenevestigatorP36125.

Family and domain databases

InterProIPR007881. UNC-50.
[Graphical view]
PANTHERPTHR12841. PTHR12841. 1 hit.
PfamPF05216. UNC-50. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio975227.
PROP36125.

Entry information

Entry nameGMH1_YEAST
AccessionPrimary (citable) accession number: P36125
Secondary accession number(s): D6VX95
Entry history
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: May 14, 2014
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast chromosome XI

Yeast (Saccharomyces cerevisiae) chromosome XI: entries and gene names

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

SIMILARITY comments

Index of protein domains and families