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P36125

- GMH1_YEAST

UniProt

P36125 - GMH1_YEAST

Protein

Protein GMH1

Gene

GMH1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 89 (01 Oct 2014)
      Sequence version 1 (01 Jun 1994)
      Previous versions | rss
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    Functioni

    GO - Biological processi

    1. transport Source: SGD

    Enzyme and pathway databases

    BioCyciYEAST:G3O-32006-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein GMH1
    Alternative name(s):
    GEA1-6 membrane-associated high-copy suppressor protein 1
    Gene namesi
    Name:GMH1
    Synonyms:MSG1
    Ordered Locus Names:YKR030W
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome XI

    Organism-specific databases

    CYGDiYKR030w.
    SGDiS000001738. GMH1.

    Subcellular locationi

    Golgi apparatus membrane 1 Publication; Multi-pass membrane protein 1 Publication. Endoplasmic reticulum membrane 1 Publication; Multi-pass membrane protein 1 Publication
    Note: Recycles between Golgi apparatus and endoplasmic reticulum.

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
    2. integral component of Golgi membrane Source: SGD

    Keywords - Cellular componenti

    Endoplasmic reticulum, Golgi apparatus, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed1 Publication
    Chaini2 – 273272Protein GMH1PRO_0000203205Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylserine1 Publication

    Keywords - PTMi

    Acetylation

    Expressioni

    Gene expression databases

    GenevestigatoriP36125.

    Interactioni

    Subunit structurei

    Interacts with GEA1 and GEA2.1 Publication

    Protein-protein interaction databases

    BioGridi34163. 34 interactions.
    DIPiDIP-2023N.
    IntActiP36125. 9 interactions.
    MINTiMINT-386053.
    STRINGi4932.YKR030W.

    Structurei

    3D structure databases

    ProteinModelPortaliP36125.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini2 – 8988CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini111 – 13424LumenalSequence AnalysisAdd
    BLAST
    Topological domaini156 – 17520CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini197 – 21620LumenalSequence AnalysisAdd
    BLAST
    Topological domaini238 – 2425CytoplasmicSequence Analysis
    Topological domaini264 – 27310LumenalSequence Analysis

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei90 – 11021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei135 – 15521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei176 – 19621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei217 – 23721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei243 – 26321HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the unc-50 family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG262379.
    GeneTreeiENSGT00390000018553.
    HOGENOMiHOG000193563.
    OMAiNYRKQTK.
    OrthoDBiEOG76QFTZ.

    Family and domain databases

    InterProiIPR007881. UNC-50.
    [Graphical view]
    PANTHERiPTHR12841. PTHR12841. 1 hit.
    PfamiPF05216. UNC-50. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P36125-1 [UniParc]FASTAAdd to Basket

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    MSYLPTYSND LPAGPQGQRR RNNGNENDAR QGYGQQSVPM VIRRLFKTPK    50
    NLDLETASWE MFHLIFHPRK AYRSIYYQRQ TKNQWARDDP SFFIFQIALI 100
    SLSSIIWSIY NSGFNNDSDM GALSIIGHFF KSLVMMVILD FFIFGFIMAT 150
    IFYLLLNRSH FKFKSSQNSV VEWAYCFDVH CNSFLIILLC LYFIQFLLLP 200
    IINLQNWISL LIGNSLYCFA IGHYFILTFY GYNQLPFLKN LNFILLPTLG 250
    LSIIYLISLF GIDLSKKLSF YNY 273
    Length:273
    Mass (Da):31,993
    Last modified:June 1, 1994 - v1
    Checksum:i94E991416D7630F2
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z28255 Genomic DNA. Translation: CAA82102.1.
    BK006944 Genomic DNA. Translation: DAA09185.1.
    PIRiS38102.
    RefSeqiNP_012955.1. NM_001179820.1.

    Genome annotation databases

    EnsemblFungiiYKR030W; YKR030W; YKR030W.
    GeneIDi853901.
    KEGGisce:YKR030W.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z28255 Genomic DNA. Translation: CAA82102.1 .
    BK006944 Genomic DNA. Translation: DAA09185.1 .
    PIRi S38102.
    RefSeqi NP_012955.1. NM_001179820.1.

    3D structure databases

    ProteinModelPortali P36125.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 34163. 34 interactions.
    DIPi DIP-2023N.
    IntActi P36125. 9 interactions.
    MINTi MINT-386053.
    STRINGi 4932.YKR030W.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YKR030W ; YKR030W ; YKR030W .
    GeneIDi 853901.
    KEGGi sce:YKR030W.

    Organism-specific databases

    CYGDi YKR030w.
    SGDi S000001738. GMH1.

    Phylogenomic databases

    eggNOGi NOG262379.
    GeneTreei ENSGT00390000018553.
    HOGENOMi HOG000193563.
    OMAi NYRKQTK.
    OrthoDBi EOG76QFTZ.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-32006-MONOMER.

    Miscellaneous databases

    NextBioi 975227.
    PROi P36125.

    Gene expression databases

    Genevestigatori P36125.

    Family and domain databases

    InterProi IPR007881. UNC-50.
    [Graphical view ]
    PANTHERi PTHR12841. PTHR12841. 1 hit.
    Pfami PF05216. UNC-50. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete DNA sequence of yeast chromosome XI."
      Dujon B., Alexandraki D., Andre B., Ansorge W., Baladron V., Ballesta J.P.G., Banrevi A., Bolle P.-A., Bolotin-Fukuhara M., Bossier P., Bou G., Boyer J., Buitrago M.J., Cheret G., Colleaux L., Daignan-Fornier B., del Rey F., Dion C.
      , Domdey H., Duesterhoeft A., Duesterhus S., Entian K.-D., Erfle H., Esteban P.F., Feldmann H., Fernandes L., Fobo G.M., Fritz C., Fukuhara H., Gabel C., Gaillon L., Garcia-Cantalejo J.M., Garcia-Ramirez J.J., Gent M.E., Ghazvini M., Goffeau A., Gonzalez A., Grothues D., Guerreiro P., Hegemann J.H., Hewitt N., Hilger F., Hollenberg C.P., Horaitis O., Indge K.J., Jacquier A., James C.M., Jauniaux J.-C., Jimenez A., Keuchel H., Kirchrath L., Kleine K., Koetter P., Legrain P., Liebl S., Louis E.J., Maia e Silva A., Marck C., Monnier A.-L., Moestl D., Mueller S., Obermaier B., Oliver S.G., Pallier C., Pascolo S., Pfeiffer F., Philippsen P., Planta R.J., Pohl F.M., Pohl T.M., Poehlmann R., Portetelle D., Purnelle B., Puzos V., Ramezani Rad M., Rasmussen S.W., Remacha M.A., Revuelta J.L., Richard G.-F., Rieger M., Rodrigues-Pousada C., Rose M., Rupp T., Santos M.A., Schwager C., Sensen C., Skala J., Soares H., Sor F., Stegemann J., Tettelin H., Thierry A., Tzermia M., Urrestarazu L.A., van Dyck L., van Vliet-Reedijk J.C., Valens M., Vandenbol M., Vilela C., Vissers S., von Wettstein D., Voss H., Wiemann S., Xu G., Zimmermann J., Haasemann M., Becker I., Mewes H.-W.
      Nature 369:371-378(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    2. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    3. "A novel Golgi membrane protein is a partner of the ARF exchange factors Gea1p and Gea2p."
      Chantalat S., Courbeyrette R., Senic-Matuglia F., Jackson C.L., Goud B., Peyroche A.
      Mol. Biol. Cell 14:2357-2371(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION, SUBCELLULAR LOCATION, TOPOLOGY, INTERACTION WITH GEA1 AND GEA2.
    4. "A global topology map of the Saccharomyces cerevisiae membrane proteome."
      Kim H., Melen K., Oesterberg M., von Heijne G.
      Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
      Strain: ATCC 208353 / W303-1A.
    5. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiGMH1_YEAST
    AccessioniPrimary (citable) accession number: P36125
    Secondary accession number(s): D6VX95
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 1, 1994
    Last sequence update: June 1, 1994
    Last modified: October 1, 2014
    This is version 89 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    3. Yeast chromosome XI
      Yeast (Saccharomyces cerevisiae) chromosome XI: entries and gene names

    External Data

    Dasty 3