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Protein

Protein GMH1

Gene

GMH1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

  • transport Source: SGD
Complete GO annotation...

Enzyme and pathway databases

BioCyciYEAST:G3O-32006-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein GMH1
Alternative name(s):
GEA1-6 membrane-associated high-copy suppressor protein 1
Gene namesi
Name:GMH1
Synonyms:MSG1
Ordered Locus Names:YKR030W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311 Componenti: Chromosome XI

Organism-specific databases

CYGDiYKR030w.
EuPathDBiFungiDB:YKR030W.
SGDiS000001738. GMH1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini2 – 8988CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei90 – 11021HelicalSequence AnalysisAdd
BLAST
Topological domaini111 – 13424LumenalSequence AnalysisAdd
BLAST
Transmembranei135 – 15521HelicalSequence AnalysisAdd
BLAST
Topological domaini156 – 17520CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei176 – 19621HelicalSequence AnalysisAdd
BLAST
Topological domaini197 – 21620LumenalSequence AnalysisAdd
BLAST
Transmembranei217 – 23721HelicalSequence AnalysisAdd
BLAST
Topological domaini238 – 2425CytoplasmicSequence Analysis
Transmembranei243 – 26321HelicalSequence AnalysisAdd
BLAST
Topological domaini264 – 27310LumenalSequence Analysis

GO - Cellular componenti

  • endoplasmic reticulum membrane Source: UniProtKB-SubCell
  • integral component of Golgi membrane Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed1 Publication
Chaini2 – 273272Protein GMH1PRO_0000203205Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserine1 Publication

Keywords - PTMi

Acetylation

Interactioni

Subunit structurei

Interacts with GEA1 and GEA2.1 Publication

Protein-protein interaction databases

BioGridi34163. 34 interactions.
DIPiDIP-2023N.
IntActiP36125. 9 interactions.
MINTiMINT-386053.
STRINGi4932.YKR030W.

Structurei

3D structure databases

ProteinModelPortaliP36125.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the unc-50 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG262379.
GeneTreeiENSGT00390000018553.
HOGENOMiHOG000193563.
InParanoidiP36125.
OMAiISQTWFI.
OrthoDBiEOG76QFTZ.

Family and domain databases

InterProiIPR007881. UNC-50.
[Graphical view]
PANTHERiPTHR12841. PTHR12841. 1 hit.
PfamiPF05216. UNC-50. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P36125-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSYLPTYSND LPAGPQGQRR RNNGNENDAR QGYGQQSVPM VIRRLFKTPK
60 70 80 90 100
NLDLETASWE MFHLIFHPRK AYRSIYYQRQ TKNQWARDDP SFFIFQIALI
110 120 130 140 150
SLSSIIWSIY NSGFNNDSDM GALSIIGHFF KSLVMMVILD FFIFGFIMAT
160 170 180 190 200
IFYLLLNRSH FKFKSSQNSV VEWAYCFDVH CNSFLIILLC LYFIQFLLLP
210 220 230 240 250
IINLQNWISL LIGNSLYCFA IGHYFILTFY GYNQLPFLKN LNFILLPTLG
260 270
LSIIYLISLF GIDLSKKLSF YNY
Length:273
Mass (Da):31,993
Last modified:June 1, 1994 - v1
Checksum:i94E991416D7630F2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z28255 Genomic DNA. Translation: CAA82102.1.
BK006944 Genomic DNA. Translation: DAA09185.1.
PIRiS38102.
RefSeqiNP_012955.1. NM_001179820.1.

Genome annotation databases

EnsemblFungiiYKR030W; YKR030W; YKR030W.
GeneIDi853901.
KEGGisce:YKR030W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z28255 Genomic DNA. Translation: CAA82102.1.
BK006944 Genomic DNA. Translation: DAA09185.1.
PIRiS38102.
RefSeqiNP_012955.1. NM_001179820.1.

3D structure databases

ProteinModelPortaliP36125.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi34163. 34 interactions.
DIPiDIP-2023N.
IntActiP36125. 9 interactions.
MINTiMINT-386053.
STRINGi4932.YKR030W.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYKR030W; YKR030W; YKR030W.
GeneIDi853901.
KEGGisce:YKR030W.

Organism-specific databases

CYGDiYKR030w.
EuPathDBiFungiDB:YKR030W.
SGDiS000001738. GMH1.

Phylogenomic databases

eggNOGiNOG262379.
GeneTreeiENSGT00390000018553.
HOGENOMiHOG000193563.
InParanoidiP36125.
OMAiISQTWFI.
OrthoDBiEOG76QFTZ.

Enzyme and pathway databases

BioCyciYEAST:G3O-32006-MONOMER.

Miscellaneous databases

NextBioi975227.
PROiP36125.

Family and domain databases

InterProiIPR007881. UNC-50.
[Graphical view]
PANTHERiPTHR12841. PTHR12841. 1 hit.
PfamiPF05216. UNC-50. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Complete DNA sequence of yeast chromosome XI."
    Dujon B., Alexandraki D., Andre B., Ansorge W., Baladron V., Ballesta J.P.G., Banrevi A., Bolle P.-A., Bolotin-Fukuhara M., Bossier P., Bou G., Boyer J., Buitrago M.J., Cheret G., Colleaux L., Daignan-Fornier B., del Rey F., Dion C.
    , Domdey H., Duesterhoeft A., Duesterhus S., Entian K.-D., Erfle H., Esteban P.F., Feldmann H., Fernandes L., Fobo G.M., Fritz C., Fukuhara H., Gabel C., Gaillon L., Garcia-Cantalejo J.M., Garcia-Ramirez J.J., Gent M.E., Ghazvini M., Goffeau A., Gonzalez A., Grothues D., Guerreiro P., Hegemann J.H., Hewitt N., Hilger F., Hollenberg C.P., Horaitis O., Indge K.J., Jacquier A., James C.M., Jauniaux J.-C., Jimenez A., Keuchel H., Kirchrath L., Kleine K., Koetter P., Legrain P., Liebl S., Louis E.J., Maia e Silva A., Marck C., Monnier A.-L., Moestl D., Mueller S., Obermaier B., Oliver S.G., Pallier C., Pascolo S., Pfeiffer F., Philippsen P., Planta R.J., Pohl F.M., Pohl T.M., Poehlmann R., Portetelle D., Purnelle B., Puzos V., Ramezani Rad M., Rasmussen S.W., Remacha M.A., Revuelta J.L., Richard G.-F., Rieger M., Rodrigues-Pousada C., Rose M., Rupp T., Santos M.A., Schwager C., Sensen C., Skala J., Soares H., Sor F., Stegemann J., Tettelin H., Thierry A., Tzermia M., Urrestarazu L.A., van Dyck L., van Vliet-Reedijk J.C., Valens M., Vandenbol M., Vilela C., Vissers S., von Wettstein D., Voss H., Wiemann S., Xu G., Zimmermann J., Haasemann M., Becker I., Mewes H.-W.
    Nature 369:371-378(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. "A novel Golgi membrane protein is a partner of the ARF exchange factors Gea1p and Gea2p."
    Chantalat S., Courbeyrette R., Senic-Matuglia F., Jackson C.L., Goud B., Peyroche A.
    Mol. Biol. Cell 14:2357-2371(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION, SUBCELLULAR LOCATION, TOPOLOGY, INTERACTION WITH GEA1 AND GEA2.
  4. "A global topology map of the Saccharomyces cerevisiae membrane proteome."
    Kim H., Melen K., Oesterberg M., von Heijne G.
    Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
    Strain: ATCC 208353 / W303-1A.
  5. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiGMH1_YEAST
AccessioniPrimary (citable) accession number: P36125
Secondary accession number(s): D6VX95
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: June 24, 2015
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XI
    Yeast (Saccharomyces cerevisiae) chromosome XI: entries and gene names

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.