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P36124

- SET3_YEAST

UniProt

P36124 - SET3_YEAST

Protein

SET domain-containing protein 3

Gene

SET3

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 121 (01 Oct 2014)
      Sequence version 1 (01 Jun 1994)
      Previous versions | rss
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    Functioni

    Transcriptional regulator that acts via the formation of large multiprotein complexes that modify and/or remodel the chromatin. Required for both gene activation and repression. Part of the Set3C complex, which is required to repress early/middle sporulation genes during meiosis. Required for the transcriptional activation of genes with high activity.1 Publication

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri117 – 16650PHD-typePROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. methylated histone binding Source: SGD
    2. protein binding Source: IntAct
    3. zinc ion binding Source: InterPro

    GO - Biological processi

    1. histone deacetylation Source: SGD
    2. meiotic nuclear division Source: UniProtKB-KW
    3. negative regulation of meiosis Source: SGD
    4. regulation of transcription, DNA-templated Source: SGD
    5. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Activator, Chromatin regulator, Repressor

    Keywords - Biological processi

    Meiosis, Transcription, Transcription regulation

    Keywords - Ligandi

    Metal-binding, Zinc

    Enzyme and pathway databases

    BioCyciYEAST:G3O-32005-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    SET domain-containing protein 3
    Gene namesi
    Name:SET3
    Ordered Locus Names:YKR029C
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome XI

    Organism-specific databases

    CYGDiYKR029c.
    SGDiS000001737. SET3.

    Subcellular locationi

    GO - Cellular componenti

    1. Set3 complex Source: SGD

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 751751SET domain-containing protein 3PRO_0000097696Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei236 – 2361Phosphoserine1 Publication
    Modified residuei684 – 6841Phosphoserine1 Publication
    Modified residuei718 – 7181Phosphoserine1 Publication
    Modified residuei719 – 7191Phosphothreonine1 Publication
    Modified residuei741 – 7411Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiP36124.
    PaxDbiP36124.

    Expressioni

    Gene expression databases

    GenevestigatoriP36124.

    Interactioni

    Subunit structurei

    Identified in the Set3C complex with HOS2, HST1, SNT1, SIF2, CPR1 and HOS4/YIL112W.1 Publication

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    HHF2P023092EBI-16993,EBI-8113
    HHT2P618302EBI-16993,EBI-8098

    Protein-protein interaction databases

    BioGridi34162. 208 interactions.
    DIPiDIP-5632N.
    IntActiP36124. 123 interactions.
    MINTiMINT-548373.
    STRINGi4932.YKR029C.

    Structurei

    3D structure databases

    ProteinModelPortaliP36124.
    SMRiP36124. Positions 117-180.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini313 – 456144SETPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the SET3 family.Curated
    Contains 1 PHD-type zinc finger.PROSITE-ProRule annotation
    Contains 1 SET domain.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri117 – 16650PHD-typePROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Zinc-finger

    Phylogenomic databases

    eggNOGiCOG2940.
    GeneTreeiENSGT00700000105281.
    HOGENOMiHOG000141785.
    KOiK07117.
    OMAiFTIQCDH.
    OrthoDBiEOG793BH2.

    Family and domain databases

    Gene3Di3.30.40.10. 1 hit.
    InterProiIPR001214. SET_dom.
    IPR019786. Zinc_finger_PHD-type_CS.
    IPR011011. Znf_FYVE_PHD.
    IPR001965. Znf_PHD.
    IPR019787. Znf_PHD-finger.
    IPR013083. Znf_RING/FYVE/PHD.
    [Graphical view]
    PfamiPF00628. PHD. 1 hit.
    PF00856. SET. 1 hit.
    [Graphical view]
    SMARTiSM00249. PHD. 1 hit.
    SM00317. SET. 1 hit.
    [Graphical view]
    SUPFAMiSSF57903. SSF57903. 1 hit.
    PROSITEiPS50280. SET. 1 hit.
    PS01359. ZF_PHD_1. 1 hit.
    PS50016. ZF_PHD_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P36124-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSVPNSKEQS LLDDASTLLL FSKGKKRAEE ASKIGSKTDT IEHDESHERE    50
    KKGAIEMAAA ALATASTVSL PLKKATEQSA AEAATSTAAK EETENQPQKQ 100
    PQWPVPDSYI VDPDAGIITC ICDLNDDDGF TIQCDHCNRW QHAICYGIKD 150
    IGMAPDDYLC NSCDPREVDI NLARKIQQER INVKTVEPSS SNNSASNKNN 200
    GRDRASSTTI SDVGDSFSTD QDNTNHRDKR RKRNPSNNSI DSKNESASVN 250
    SSDGLTSMPK KKEHFLSAKD AYGAIYLPLK DNVFKSDLIE PFLNKHMDDN 300
    WVIQYPHKTF KSVSIEVKPY ADIAYSRTYP GFTKLGVYLK KDCIKGDFIQ 350
    EILGELDFYK NYLTDPRNHY RIWGTAKRRV IFHSHWPIYI DARLSGNSTR 400
    YLRRSCQPNV ELVTIKLQDT DNRNDKSSGR KSSRIKFVLR ALRDISEDEE 450
    LYIKWQWDSK HPILKLIKGM TIDSLDDLER YGLINSVETI LSNGECGCGN 500
    NSKDCYLLKV KRYAQSLYKS VKSRGKMNNR YKLNEILNQY NCKKRREPPI 550
    LHRLEEKAQN TIERAPILLN NFYRQKFLNR NNGPKIPQKN TIDSTNNPDD 600
    IAKPFKFALF AQHSSNISVP KKNETSEKPL IITKSTDYDE SHITNIEELP 650
    IPVLLPINKT SRQTANDVEE SQSKNEHKLS RTPSLSNFNK ELSKEAQHSQ 700
    AKTKEIMTEA SVNSRRESTP ESIMHLSDFS SSQLHSKKKL SFADYRKKLL 750
    K 751
    Length:751
    Mass (Da):85,480
    Last modified:June 1, 1994 - v1
    Checksum:i934621768C36230B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z28254 Genomic DNA. Translation: CAA82101.1.
    BK006944 Genomic DNA. Translation: DAA09184.1.
    PIRiS38101.
    RefSeqiNP_012954.3. NM_001179819.3.

    Genome annotation databases

    EnsemblFungiiYKR029C; YKR029C; YKR029C.
    GeneIDi853900.
    KEGGisce:YKR029C.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z28254 Genomic DNA. Translation: CAA82101.1 .
    BK006944 Genomic DNA. Translation: DAA09184.1 .
    PIRi S38101.
    RefSeqi NP_012954.3. NM_001179819.3.

    3D structure databases

    ProteinModelPortali P36124.
    SMRi P36124. Positions 117-180.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 34162. 208 interactions.
    DIPi DIP-5632N.
    IntActi P36124. 123 interactions.
    MINTi MINT-548373.
    STRINGi 4932.YKR029C.

    Proteomic databases

    MaxQBi P36124.
    PaxDbi P36124.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YKR029C ; YKR029C ; YKR029C .
    GeneIDi 853900.
    KEGGi sce:YKR029C.

    Organism-specific databases

    CYGDi YKR029c.
    SGDi S000001737. SET3.

    Phylogenomic databases

    eggNOGi COG2940.
    GeneTreei ENSGT00700000105281.
    HOGENOMi HOG000141785.
    KOi K07117.
    OMAi FTIQCDH.
    OrthoDBi EOG793BH2.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-32005-MONOMER.

    Miscellaneous databases

    NextBioi 975224.
    PROi P36124.

    Gene expression databases

    Genevestigatori P36124.

    Family and domain databases

    Gene3Di 3.30.40.10. 1 hit.
    InterProi IPR001214. SET_dom.
    IPR019786. Zinc_finger_PHD-type_CS.
    IPR011011. Znf_FYVE_PHD.
    IPR001965. Znf_PHD.
    IPR019787. Znf_PHD-finger.
    IPR013083. Znf_RING/FYVE/PHD.
    [Graphical view ]
    Pfami PF00628. PHD. 1 hit.
    PF00856. SET. 1 hit.
    [Graphical view ]
    SMARTi SM00249. PHD. 1 hit.
    SM00317. SET. 1 hit.
    [Graphical view ]
    SUPFAMi SSF57903. SSF57903. 1 hit.
    PROSITEi PS50280. SET. 1 hit.
    PS01359. ZF_PHD_1. 1 hit.
    PS50016. ZF_PHD_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete DNA sequence of yeast chromosome XI."
      Dujon B., Alexandraki D., Andre B., Ansorge W., Baladron V., Ballesta J.P.G., Banrevi A., Bolle P.-A., Bolotin-Fukuhara M., Bossier P., Bou G., Boyer J., Buitrago M.J., Cheret G., Colleaux L., Daignan-Fornier B., del Rey F., Dion C.
      , Domdey H., Duesterhoeft A., Duesterhus S., Entian K.-D., Erfle H., Esteban P.F., Feldmann H., Fernandes L., Fobo G.M., Fritz C., Fukuhara H., Gabel C., Gaillon L., Garcia-Cantalejo J.M., Garcia-Ramirez J.J., Gent M.E., Ghazvini M., Goffeau A., Gonzalez A., Grothues D., Guerreiro P., Hegemann J.H., Hewitt N., Hilger F., Hollenberg C.P., Horaitis O., Indge K.J., Jacquier A., James C.M., Jauniaux J.-C., Jimenez A., Keuchel H., Kirchrath L., Kleine K., Koetter P., Legrain P., Liebl S., Louis E.J., Maia e Silva A., Marck C., Monnier A.-L., Moestl D., Mueller S., Obermaier B., Oliver S.G., Pallier C., Pascolo S., Pfeiffer F., Philippsen P., Planta R.J., Pohl F.M., Pohl T.M., Poehlmann R., Portetelle D., Purnelle B., Puzos V., Ramezani Rad M., Rasmussen S.W., Remacha M.A., Revuelta J.L., Richard G.-F., Rieger M., Rodrigues-Pousada C., Rose M., Rupp T., Santos M.A., Schwager C., Sensen C., Skala J., Soares H., Sor F., Stegemann J., Tettelin H., Thierry A., Tzermia M., Urrestarazu L.A., van Dyck L., van Vliet-Reedijk J.C., Valens M., Vandenbol M., Vilela C., Vissers S., von Wettstein D., Voss H., Wiemann S., Xu G., Zimmermann J., Haasemann M., Becker I., Mewes H.-W.
      Nature 369:371-378(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    2. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    3. "The S. cerevisiae SET3 complex includes two histone deacetylases, Hos2 and Hst1, and is a meiotic-specific repressor of the sporulation gene program."
      Pijnappel W.W.M.P., Schaft D., Roguev A., Shevchenko A., Tekotte H., Wilm M., Rigaut G., Seraphin B., Aasland R., Stewart A.F.
      Genes Dev. 15:2991-3004(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION IN A COMPLEX WITH HOS2; HST1; SNT1; SIF2; CPR1 AND YIL112W.
    4. "Requirement of Hos2 histone deacetylase for gene activity in yeast."
      Wang A., Kurdistani S.K., Grunstein M.
      Science 298:1412-1414(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    5. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
    6. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
      Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
      Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-236 AND SER-741, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    7. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
      Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
      Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-684; SER-718 AND THR-719, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiSET3_YEAST
    AccessioniPrimary (citable) accession number: P36124
    Secondary accession number(s): D6VX94
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 1, 1994
    Last sequence update: June 1, 1994
    Last modified: October 1, 2014
    This is version 121 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Present with 623 molecules/cell in log phase SD medium.1 Publication

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    3. Yeast chromosome XI
      Yeast (Saccharomyces cerevisiae) chromosome XI: entries and gene names

    External Data

    Dasty 3