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P36124 (SET3_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 120. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
SET domain-containing protein 3
Gene names
Name:SET3
Ordered Locus Names:YKR029C
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length751 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Transcriptional regulator that acts via the formation of large multiprotein complexes that modify and/or remodel the chromatin. Required for both gene activation and repression. Part of the Set3C complex, which is required to repress early/middle sporulation genes during meiosis. Required for the transcriptional activation of genes with high activity. Ref.4

Subunit structure

Identified in the Set3C complex with HOS2, HST1, SNT1, SIF2, CPR1 and HOS4/YIL112W. Ref.3

Miscellaneous

Present with 623 molecules/cell in log phase SD medium.

Sequence similarities

Belongs to the SET3 family.

Contains 1 PHD-type zinc finger.

Contains 1 SET domain.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

HHF2P023092EBI-16993,EBI-8113
HHT2P618302EBI-16993,EBI-8098

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 751751SET domain-containing protein 3
PRO_0000097696

Regions

Domain313 – 456144SET
Zinc finger117 – 16650PHD-type

Amino acid modifications

Modified residue2361Phosphoserine Ref.6
Modified residue6841Phosphoserine Ref.7
Modified residue7181Phosphoserine Ref.7
Modified residue7191Phosphothreonine Ref.7
Modified residue7411Phosphoserine Ref.6

Sequences

Sequence LengthMass (Da)Tools
P36124 [UniParc].

Last modified June 1, 1994. Version 1.
Checksum: 934621768C36230B

FASTA75185,480
        10         20         30         40         50         60 
MSVPNSKEQS LLDDASTLLL FSKGKKRAEE ASKIGSKTDT IEHDESHERE KKGAIEMAAA 

        70         80         90        100        110        120 
ALATASTVSL PLKKATEQSA AEAATSTAAK EETENQPQKQ PQWPVPDSYI VDPDAGIITC 

       130        140        150        160        170        180 
ICDLNDDDGF TIQCDHCNRW QHAICYGIKD IGMAPDDYLC NSCDPREVDI NLARKIQQER 

       190        200        210        220        230        240 
INVKTVEPSS SNNSASNKNN GRDRASSTTI SDVGDSFSTD QDNTNHRDKR RKRNPSNNSI 

       250        260        270        280        290        300 
DSKNESASVN SSDGLTSMPK KKEHFLSAKD AYGAIYLPLK DNVFKSDLIE PFLNKHMDDN 

       310        320        330        340        350        360 
WVIQYPHKTF KSVSIEVKPY ADIAYSRTYP GFTKLGVYLK KDCIKGDFIQ EILGELDFYK 

       370        380        390        400        410        420 
NYLTDPRNHY RIWGTAKRRV IFHSHWPIYI DARLSGNSTR YLRRSCQPNV ELVTIKLQDT 

       430        440        450        460        470        480 
DNRNDKSSGR KSSRIKFVLR ALRDISEDEE LYIKWQWDSK HPILKLIKGM TIDSLDDLER 

       490        500        510        520        530        540 
YGLINSVETI LSNGECGCGN NSKDCYLLKV KRYAQSLYKS VKSRGKMNNR YKLNEILNQY 

       550        560        570        580        590        600 
NCKKRREPPI LHRLEEKAQN TIERAPILLN NFYRQKFLNR NNGPKIPQKN TIDSTNNPDD 

       610        620        630        640        650        660 
IAKPFKFALF AQHSSNISVP KKNETSEKPL IITKSTDYDE SHITNIEELP IPVLLPINKT 

       670        680        690        700        710        720 
SRQTANDVEE SQSKNEHKLS RTPSLSNFNK ELSKEAQHSQ AKTKEIMTEA SVNSRRESTP 

       730        740        750 
ESIMHLSDFS SSQLHSKKKL SFADYRKKLL K 

« Hide

References

« Hide 'large scale' references
[1]"Complete DNA sequence of yeast chromosome XI."
Dujon B., Alexandraki D., Andre B., Ansorge W., Baladron V., Ballesta J.P.G., Banrevi A., Bolle P.-A., Bolotin-Fukuhara M., Bossier P., Bou G., Boyer J., Buitrago M.J., Cheret G., Colleaux L., Daignan-Fornier B., del Rey F., Dion C. expand/collapse author list , Domdey H., Duesterhoeft A., Duesterhus S., Entian K.-D., Erfle H., Esteban P.F., Feldmann H., Fernandes L., Fobo G.M., Fritz C., Fukuhara H., Gabel C., Gaillon L., Garcia-Cantalejo J.M., Garcia-Ramirez J.J., Gent M.E., Ghazvini M., Goffeau A., Gonzalez A., Grothues D., Guerreiro P., Hegemann J.H., Hewitt N., Hilger F., Hollenberg C.P., Horaitis O., Indge K.J., Jacquier A., James C.M., Jauniaux J.-C., Jimenez A., Keuchel H., Kirchrath L., Kleine K., Koetter P., Legrain P., Liebl S., Louis E.J., Maia e Silva A., Marck C., Monnier A.-L., Moestl D., Mueller S., Obermaier B., Oliver S.G., Pallier C., Pascolo S., Pfeiffer F., Philippsen P., Planta R.J., Pohl F.M., Pohl T.M., Poehlmann R., Portetelle D., Purnelle B., Puzos V., Ramezani Rad M., Rasmussen S.W., Remacha M.A., Revuelta J.L., Richard G.-F., Rieger M., Rodrigues-Pousada C., Rose M., Rupp T., Santos M.A., Schwager C., Sensen C., Skala J., Soares H., Sor F., Stegemann J., Tettelin H., Thierry A., Tzermia M., Urrestarazu L.A., van Dyck L., van Vliet-Reedijk J.C., Valens M., Vandenbol M., Vilela C., Vissers S., von Wettstein D., Voss H., Wiemann S., Xu G., Zimmermann J., Haasemann M., Becker I., Mewes H.-W.
Nature 369:371-378(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[2]"The reference genome sequence of Saccharomyces cerevisiae: Then and now."
Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R., Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S., Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.
G3 (Bethesda) 4:389-398(2014) [PubMed] [Europe PMC] [Abstract]
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[3]"The S. cerevisiae SET3 complex includes two histone deacetylases, Hos2 and Hst1, and is a meiotic-specific repressor of the sporulation gene program."
Pijnappel W.W.M.P., Schaft D., Roguev A., Shevchenko A., Tekotte H., Wilm M., Rigaut G., Seraphin B., Aasland R., Stewart A.F.
Genes Dev. 15:2991-3004(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION IN A COMPLEX WITH HOS2; HST1; SNT1; SIF2; CPR1 AND YIL112W.
[4]"Requirement of Hos2 histone deacetylase for gene activity in yeast."
Wang A., Kurdistani S.K., Grunstein M.
Science 298:1412-1414(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[5]"Global analysis of protein expression in yeast."
Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S.
Nature 425:737-741(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
[6]"A multidimensional chromatography technology for in-depth phosphoproteome analysis."
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-236 AND SER-741, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[7]"Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-684; SER-718 AND THR-719, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Z28254 Genomic DNA. Translation: CAA82101.1.
BK006944 Genomic DNA. Translation: DAA09184.1.
PIRS38101.
RefSeqNP_012954.3. NM_001179819.3.

3D structure databases

ProteinModelPortalP36124.
SMRP36124. Positions 117-180.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid34162. 208 interactions.
DIPDIP-5632N.
IntActP36124. 123 interactions.
MINTMINT-548373.
STRING4932.YKR029C.

Proteomic databases

MaxQBP36124.
PaxDbP36124.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYKR029C; YKR029C; YKR029C.
GeneID853900.
KEGGsce:YKR029C.

Organism-specific databases

CYGDYKR029c.
SGDS000001737. SET3.

Phylogenomic databases

eggNOGCOG2940.
GeneTreeENSGT00700000105281.
HOGENOMHOG000141785.
KOK07117.
OMAFTIQCDH.
OrthoDBEOG793BH2.

Enzyme and pathway databases

BioCycYEAST:G3O-32005-MONOMER.

Gene expression databases

GenevestigatorP36124.

Family and domain databases

Gene3D3.30.40.10. 1 hit.
InterProIPR001214. SET_dom.
IPR019786. Zinc_finger_PHD-type_CS.
IPR011011. Znf_FYVE_PHD.
IPR001965. Znf_PHD.
IPR019787. Znf_PHD-finger.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamPF00628. PHD. 1 hit.
PF00856. SET. 1 hit.
[Graphical view]
SMARTSM00249. PHD. 1 hit.
SM00317. SET. 1 hit.
[Graphical view]
SUPFAMSSF57903. SSF57903. 1 hit.
PROSITEPS50280. SET. 1 hit.
PS01359. ZF_PHD_1. 1 hit.
PS50016. ZF_PHD_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio975224.
PROP36124.

Entry information

Entry nameSET3_YEAST
AccessionPrimary (citable) accession number: P36124
Secondary accession number(s): D6VX94
Entry history
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: July 9, 2014
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast chromosome XI

Yeast (Saccharomyces cerevisiae) chromosome XI: entries and gene names

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

SIMILARITY comments

Index of protein domains and families