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Protein

SET domain-containing protein 3

Gene

SET3

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transcriptional regulator that acts via the formation of large multiprotein complexes that modify and/or remodel the chromatin. Required for both gene activation and repression. Part of the Set3C complex, which is required to repress early/middle sporulation genes during meiosis. Required for the transcriptional activation of genes with high activity.1 Publication

Miscellaneous

Present with 623 molecules/cell in log phase SD medium.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri117 – 166PHD-typePROSITE-ProRule annotationAdd BLAST50

GO - Molecular functioni

  • metal ion binding Source: UniProtKB-KW
  • methylated histone binding Source: SGD

GO - Biological processi

  • histone deacetylation Source: SGD
  • meiotic cell cycle Source: UniProtKB-KW
  • negative regulation of meiotic nuclear division Source: SGD
  • regulation of transcription, DNA-templated Source: SGD
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionActivator, Chromatin regulator, Repressor
Biological processMeiosis, Transcription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

BioCyciYEAST:G3O-32005-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
SET domain-containing protein 3
Gene namesi
Name:SET3
Ordered Locus Names:YKR029C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XI

Organism-specific databases

EuPathDBiFungiDB:YKR029C
SGDiS000001737 SET3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000976961 – 751SET domain-containing protein 3Add BLAST751

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei236PhosphoserineCombined sources1
Modified residuei684PhosphoserineCombined sources1
Modified residuei718PhosphoserineCombined sources1
Modified residuei719PhosphothreonineCombined sources1
Modified residuei741PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP36124
PaxDbiP36124
PRIDEiP36124

PTM databases

iPTMnetiP36124

Interactioni

Subunit structurei

Identified in the Set3C complex with HOS2, HST1, SNT1, SIF2, CPR1 and HOS4/YIL112W.1 Publication

Binary interactionsi

Show more details

GO - Molecular functioni

  • methylated histone binding Source: SGD

Protein-protein interaction databases

BioGridi34162, 402 interactors
ComplexPortaliCPX-1342 SET3C histone deacetylase complex
DIPiDIP-5632N
IntActiP36124, 125 interactors
MINTiP36124
STRINGi4932.YKR029C

Structurei

Secondary structure

1751
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi129 – 133Combined sources5
Turni135 – 137Combined sources3
Beta strandi140 – 142Combined sources3
Helixi143 – 146Combined sources4
Helixi151 – 153Combined sources3
Turni161 – 163Combined sources3
Helixi170 – 183Combined sources14

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5TDRX-ray1.42A116-184[»]
5TDWX-ray1.70A116-184[»]
ProteinModelPortaliP36124
SMRiP36124
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini313 – 456SETPROSITE-ProRule annotationAdd BLAST144

Sequence similaritiesi

Belongs to the SET3 family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri117 – 166PHD-typePROSITE-ProRule annotationAdd BLAST50

Keywords - Domaini

Zinc-finger

Phylogenomic databases

GeneTreeiENSGT00700000105281
HOGENOMiHOG000141785
InParanoidiP36124
KOiK07117
OMAiFTIQCDH
OrthoDBiEOG092C2WZB

Family and domain databases

Gene3Di3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR001214 SET_dom
IPR019786 Zinc_finger_PHD-type_CS
IPR011011 Znf_FYVE_PHD
IPR001965 Znf_PHD
IPR019787 Znf_PHD-finger
IPR013083 Znf_RING/FYVE/PHD
PfamiView protein in Pfam
PF00628 PHD, 1 hit
SMARTiView protein in SMART
SM00249 PHD, 1 hit
SM00317 SET, 1 hit
SUPFAMiSSF57903 SSF57903, 1 hit
PROSITEiView protein in PROSITE
PS50280 SET, 1 hit
PS01359 ZF_PHD_1, 1 hit
PS50016 ZF_PHD_2, 1 hit

Sequencei

Sequence statusi: Complete.

P36124-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSVPNSKEQS LLDDASTLLL FSKGKKRAEE ASKIGSKTDT IEHDESHERE
60 70 80 90 100
KKGAIEMAAA ALATASTVSL PLKKATEQSA AEAATSTAAK EETENQPQKQ
110 120 130 140 150
PQWPVPDSYI VDPDAGIITC ICDLNDDDGF TIQCDHCNRW QHAICYGIKD
160 170 180 190 200
IGMAPDDYLC NSCDPREVDI NLARKIQQER INVKTVEPSS SNNSASNKNN
210 220 230 240 250
GRDRASSTTI SDVGDSFSTD QDNTNHRDKR RKRNPSNNSI DSKNESASVN
260 270 280 290 300
SSDGLTSMPK KKEHFLSAKD AYGAIYLPLK DNVFKSDLIE PFLNKHMDDN
310 320 330 340 350
WVIQYPHKTF KSVSIEVKPY ADIAYSRTYP GFTKLGVYLK KDCIKGDFIQ
360 370 380 390 400
EILGELDFYK NYLTDPRNHY RIWGTAKRRV IFHSHWPIYI DARLSGNSTR
410 420 430 440 450
YLRRSCQPNV ELVTIKLQDT DNRNDKSSGR KSSRIKFVLR ALRDISEDEE
460 470 480 490 500
LYIKWQWDSK HPILKLIKGM TIDSLDDLER YGLINSVETI LSNGECGCGN
510 520 530 540 550
NSKDCYLLKV KRYAQSLYKS VKSRGKMNNR YKLNEILNQY NCKKRREPPI
560 570 580 590 600
LHRLEEKAQN TIERAPILLN NFYRQKFLNR NNGPKIPQKN TIDSTNNPDD
610 620 630 640 650
IAKPFKFALF AQHSSNISVP KKNETSEKPL IITKSTDYDE SHITNIEELP
660 670 680 690 700
IPVLLPINKT SRQTANDVEE SQSKNEHKLS RTPSLSNFNK ELSKEAQHSQ
710 720 730 740 750
AKTKEIMTEA SVNSRRESTP ESIMHLSDFS SSQLHSKKKL SFADYRKKLL

K
Length:751
Mass (Da):85,480
Last modified:June 1, 1994 - v1
Checksum:i934621768C36230B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z28254 Genomic DNA Translation: CAA82101.1
BK006944 Genomic DNA Translation: DAA09184.1
PIRiS38101
RefSeqiNP_012954.3, NM_001179819.3

Genome annotation databases

EnsemblFungiiYKR029C; YKR029C; YKR029C
GeneIDi853900
KEGGisce:YKR029C

Similar proteinsi

Entry informationi

Entry nameiSET3_YEAST
AccessioniPrimary (citable) accession number: P36124
Secondary accession number(s): D6VX94
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: June 20, 2018
This is version 152 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

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