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P36124

- SET3_YEAST

UniProt

P36124 - SET3_YEAST

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Protein

SET domain-containing protein 3

Gene

SET3

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Transcriptional regulator that acts via the formation of large multiprotein complexes that modify and/or remodel the chromatin. Required for both gene activation and repression. Part of the Set3C complex, which is required to repress early/middle sporulation genes during meiosis. Required for the transcriptional activation of genes with high activity.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri117 – 16650PHD-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. methylated histone binding Source: SGD
  2. zinc ion binding Source: InterPro

GO - Biological processi

  1. histone deacetylation Source: SGD
  2. meiotic nuclear division Source: UniProtKB-KW
  3. negative regulation of meiosis Source: SGD
  4. regulation of transcription, DNA-templated Source: SGD
  5. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator, Chromatin regulator, Repressor

Keywords - Biological processi

Meiosis, Transcription, Transcription regulation

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BioCyciYEAST:G3O-32005-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
SET domain-containing protein 3
Gene namesi
Name:SET3
Ordered Locus Names:YKR029C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome XI

Organism-specific databases

CYGDiYKR029c.
SGDiS000001737. SET3.

Subcellular locationi

GO - Cellular componenti

  1. Set3 complex Source: SGD
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 751751SET domain-containing protein 3PRO_0000097696Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei236 – 2361Phosphoserine1 Publication
Modified residuei684 – 6841Phosphoserine1 Publication
Modified residuei718 – 7181Phosphoserine1 Publication
Modified residuei719 – 7191Phosphothreonine1 Publication
Modified residuei741 – 7411Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP36124.
PaxDbiP36124.

Expressioni

Gene expression databases

GenevestigatoriP36124.

Interactioni

Subunit structurei

Identified in the Set3C complex with HOS2, HST1, SNT1, SIF2, CPR1 and HOS4/YIL112W.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
HHF2P023092EBI-16993,EBI-8113
HHT2P618302EBI-16993,EBI-8098

Protein-protein interaction databases

BioGridi34162. 208 interactions.
DIPiDIP-5632N.
IntActiP36124. 123 interactions.
MINTiMINT-548373.
STRINGi4932.YKR029C.

Structurei

3D structure databases

ProteinModelPortaliP36124.
SMRiP36124. Positions 117-180.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini313 – 456144SETPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the SET3 family.Curated
Contains 1 PHD-type zinc finger.PROSITE-ProRule annotation
Contains 1 SET domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri117 – 16650PHD-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiCOG2940.
GeneTreeiENSGT00700000105281.
HOGENOMiHOG000141785.
InParanoidiP36124.
KOiK07117.
OMAiFTIQCDH.
OrthoDBiEOG793BH2.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiIPR001214. SET_dom.
IPR019786. Zinc_finger_PHD-type_CS.
IPR011011. Znf_FYVE_PHD.
IPR001965. Znf_PHD.
IPR019787. Znf_PHD-finger.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamiPF00628. PHD. 1 hit.
PF00856. SET. 1 hit.
[Graphical view]
SMARTiSM00249. PHD. 1 hit.
SM00317. SET. 1 hit.
[Graphical view]
SUPFAMiSSF57903. SSF57903. 1 hit.
PROSITEiPS50280. SET. 1 hit.
PS01359. ZF_PHD_1. 1 hit.
PS50016. ZF_PHD_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P36124-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSVPNSKEQS LLDDASTLLL FSKGKKRAEE ASKIGSKTDT IEHDESHERE
60 70 80 90 100
KKGAIEMAAA ALATASTVSL PLKKATEQSA AEAATSTAAK EETENQPQKQ
110 120 130 140 150
PQWPVPDSYI VDPDAGIITC ICDLNDDDGF TIQCDHCNRW QHAICYGIKD
160 170 180 190 200
IGMAPDDYLC NSCDPREVDI NLARKIQQER INVKTVEPSS SNNSASNKNN
210 220 230 240 250
GRDRASSTTI SDVGDSFSTD QDNTNHRDKR RKRNPSNNSI DSKNESASVN
260 270 280 290 300
SSDGLTSMPK KKEHFLSAKD AYGAIYLPLK DNVFKSDLIE PFLNKHMDDN
310 320 330 340 350
WVIQYPHKTF KSVSIEVKPY ADIAYSRTYP GFTKLGVYLK KDCIKGDFIQ
360 370 380 390 400
EILGELDFYK NYLTDPRNHY RIWGTAKRRV IFHSHWPIYI DARLSGNSTR
410 420 430 440 450
YLRRSCQPNV ELVTIKLQDT DNRNDKSSGR KSSRIKFVLR ALRDISEDEE
460 470 480 490 500
LYIKWQWDSK HPILKLIKGM TIDSLDDLER YGLINSVETI LSNGECGCGN
510 520 530 540 550
NSKDCYLLKV KRYAQSLYKS VKSRGKMNNR YKLNEILNQY NCKKRREPPI
560 570 580 590 600
LHRLEEKAQN TIERAPILLN NFYRQKFLNR NNGPKIPQKN TIDSTNNPDD
610 620 630 640 650
IAKPFKFALF AQHSSNISVP KKNETSEKPL IITKSTDYDE SHITNIEELP
660 670 680 690 700
IPVLLPINKT SRQTANDVEE SQSKNEHKLS RTPSLSNFNK ELSKEAQHSQ
710 720 730 740 750
AKTKEIMTEA SVNSRRESTP ESIMHLSDFS SSQLHSKKKL SFADYRKKLL

K
Length:751
Mass (Da):85,480
Last modified:June 1, 1994 - v1
Checksum:i934621768C36230B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z28254 Genomic DNA. Translation: CAA82101.1.
BK006944 Genomic DNA. Translation: DAA09184.1.
PIRiS38101.
RefSeqiNP_012954.3. NM_001179819.3.

Genome annotation databases

EnsemblFungiiYKR029C; YKR029C; YKR029C.
GeneIDi853900.
KEGGisce:YKR029C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z28254 Genomic DNA. Translation: CAA82101.1 .
BK006944 Genomic DNA. Translation: DAA09184.1 .
PIRi S38101.
RefSeqi NP_012954.3. NM_001179819.3.

3D structure databases

ProteinModelPortali P36124.
SMRi P36124. Positions 117-180.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 34162. 208 interactions.
DIPi DIP-5632N.
IntActi P36124. 123 interactions.
MINTi MINT-548373.
STRINGi 4932.YKR029C.

Proteomic databases

MaxQBi P36124.
PaxDbi P36124.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YKR029C ; YKR029C ; YKR029C .
GeneIDi 853900.
KEGGi sce:YKR029C.

Organism-specific databases

CYGDi YKR029c.
SGDi S000001737. SET3.

Phylogenomic databases

eggNOGi COG2940.
GeneTreei ENSGT00700000105281.
HOGENOMi HOG000141785.
InParanoidi P36124.
KOi K07117.
OMAi FTIQCDH.
OrthoDBi EOG793BH2.

Enzyme and pathway databases

BioCyci YEAST:G3O-32005-MONOMER.

Miscellaneous databases

NextBioi 975224.
PROi P36124.

Gene expression databases

Genevestigatori P36124.

Family and domain databases

Gene3Di 3.30.40.10. 1 hit.
InterProi IPR001214. SET_dom.
IPR019786. Zinc_finger_PHD-type_CS.
IPR011011. Znf_FYVE_PHD.
IPR001965. Znf_PHD.
IPR019787. Znf_PHD-finger.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view ]
Pfami PF00628. PHD. 1 hit.
PF00856. SET. 1 hit.
[Graphical view ]
SMARTi SM00249. PHD. 1 hit.
SM00317. SET. 1 hit.
[Graphical view ]
SUPFAMi SSF57903. SSF57903. 1 hit.
PROSITEi PS50280. SET. 1 hit.
PS01359. ZF_PHD_1. 1 hit.
PS50016. ZF_PHD_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Complete DNA sequence of yeast chromosome XI."
    Dujon B., Alexandraki D., Andre B., Ansorge W., Baladron V., Ballesta J.P.G., Banrevi A., Bolle P.-A., Bolotin-Fukuhara M., Bossier P., Bou G., Boyer J., Buitrago M.J., Cheret G., Colleaux L., Daignan-Fornier B., del Rey F., Dion C.
    , Domdey H., Duesterhoeft A., Duesterhus S., Entian K.-D., Erfle H., Esteban P.F., Feldmann H., Fernandes L., Fobo G.M., Fritz C., Fukuhara H., Gabel C., Gaillon L., Garcia-Cantalejo J.M., Garcia-Ramirez J.J., Gent M.E., Ghazvini M., Goffeau A., Gonzalez A., Grothues D., Guerreiro P., Hegemann J.H., Hewitt N., Hilger F., Hollenberg C.P., Horaitis O., Indge K.J., Jacquier A., James C.M., Jauniaux J.-C., Jimenez A., Keuchel H., Kirchrath L., Kleine K., Koetter P., Legrain P., Liebl S., Louis E.J., Maia e Silva A., Marck C., Monnier A.-L., Moestl D., Mueller S., Obermaier B., Oliver S.G., Pallier C., Pascolo S., Pfeiffer F., Philippsen P., Planta R.J., Pohl F.M., Pohl T.M., Poehlmann R., Portetelle D., Purnelle B., Puzos V., Ramezani Rad M., Rasmussen S.W., Remacha M.A., Revuelta J.L., Richard G.-F., Rieger M., Rodrigues-Pousada C., Rose M., Rupp T., Santos M.A., Schwager C., Sensen C., Skala J., Soares H., Sor F., Stegemann J., Tettelin H., Thierry A., Tzermia M., Urrestarazu L.A., van Dyck L., van Vliet-Reedijk J.C., Valens M., Vandenbol M., Vilela C., Vissers S., von Wettstein D., Voss H., Wiemann S., Xu G., Zimmermann J., Haasemann M., Becker I., Mewes H.-W.
    Nature 369:371-378(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. "The S. cerevisiae SET3 complex includes two histone deacetylases, Hos2 and Hst1, and is a meiotic-specific repressor of the sporulation gene program."
    Pijnappel W.W.M.P., Schaft D., Roguev A., Shevchenko A., Tekotte H., Wilm M., Rigaut G., Seraphin B., Aasland R., Stewart A.F.
    Genes Dev. 15:2991-3004(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION IN A COMPLEX WITH HOS2; HST1; SNT1; SIF2; CPR1 AND YIL112W.
  4. "Requirement of Hos2 histone deacetylase for gene activity in yeast."
    Wang A., Kurdistani S.K., Grunstein M.
    Science 298:1412-1414(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  5. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  6. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
    Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
    Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-236 AND SER-741, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  7. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
    Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
    Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-684; SER-718 AND THR-719, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiSET3_YEAST
AccessioniPrimary (citable) accession number: P36124
Secondary accession number(s): D6VX94
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: October 29, 2014
This is version 122 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 623 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XI
    Yeast (Saccharomyces cerevisiae) chromosome XI: entries and gene names

External Data

Dasty 3