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Protein

DNA-directed RNA polymerase III subunit RPC5

Gene

RPC37

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. The RPC53/RPC4-RPC37/RPC5 subcomplex is required for terminator recognition and reinitiation.1 Publication

Miscellaneous

Present with 1590 molecules/cell in log phase SD medium.1 Publication

GO - Molecular functioni

GO - Biological processi

  • tRNA transcription by RNA polymerase III Source: SGD

Keywordsi

Biological processTranscription

Enzyme and pathway databases

BioCyciYEAST:G3O-32001-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
DNA-directed RNA polymerase III subunit RPC5
Short name:
RNA polymerase III subunit C5
Alternative name(s):
DNA-directed RNA polymerase III 37 kDa polypeptide
RNA polymerase III subunit C37
Gene namesi
Name:RPC37
Ordered Locus Names:YKR025W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XI

Organism-specific databases

EuPathDBiFungiDB:YKR025W
SGDiS000001733 RPC37

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

DNA-directed RNA polymerase, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002032031 – 282DNA-directed RNA polymerase III subunit RPC5Add BLAST282

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei61PhosphothreonineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP36121
PaxDbiP36121
PRIDEiP36121

PTM databases

iPTMnetiP36121

Interactioni

Subunit structurei

Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits. Interacts with RPC53/RPC4. RPC53/RPC4, RPC37/RPC5 and RPC11/RPC10 probably form a Pol III subcomplex.1 Publication

Protein-protein interaction databases

BioGridi34157, 61 interactors
DIPiDIP-761N
IntActiP36121, 10 interactors
MINTiP36121
STRINGi4932.YKR025W

Structurei

Secondary structure

1282
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi83 – 87Combined sources5
Beta strandi90 – 92Combined sources3
Beta strandi98 – 100Combined sources3
Beta strandi114 – 116Combined sources3
Beta strandi122 – 124Combined sources3
Beta strandi127 – 130Combined sources4
Helixi133 – 136Combined sources4
Turni137 – 139Combined sources3
Beta strandi145 – 147Combined sources3
Beta strandi156 – 164Combined sources9
Beta strandi167 – 172Combined sources6
Helixi185 – 192Combined sources8
Beta strandi229 – 231Combined sources3
Helixi232 – 235Combined sources4
Beta strandi236 – 239Combined sources4
Beta strandi251 – 254Combined sources4
Turni255 – 257Combined sources3
Beta strandi258 – 260Combined sources3
Turni262 – 264Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5FJ8electron microscopy3.90M1-282[»]
5FJ9electron microscopy4.60M1-282[»]
5FJAelectron microscopy4.65M1-282[»]
6EU0electron microscopy4.00M1-282[»]
6EU1electron microscopy3.40M1-282[»]
6EU2electron microscopy3.40M1-282[»]
6EU3electron microscopy3.30M1-282[»]
6F40electron microscopy3.70M1-282[»]
6F41electron microscopy4.30M1-282[»]
6F42electron microscopy5.50M1-282[»]
6F44electron microscopy4.20M1-282[»]
ProteinModelPortaliP36121
SMRiP36121
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

HOGENOMiHOG000074717
InParanoidiP36121
KOiK14721
OMAiNCHASIK
OrthoDBiEOG092C3VNF

Family and domain databases

InterProiView protein in InterPro
IPR006886 RNA_pol_III_Rpc5
PANTHERiPTHR12069 PTHR12069, 1 hit
PfamiView protein in Pfam
PF04801 Sin_N, 1 hit

Sequencei

Sequence statusi: Complete.

P36121-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSIDNKLFVT EEDEEDRTQD RADVEDESND IDMIADENGT NSAIANEQEE
60 70 80 90 100
KSEEVKAEDD TGEEEEDDPV IEEFPLKISG EEESLHVFQY ANRPRLVGRK
110 120 130 140 150
PAEHPFISAA RYKPKSHLWE IDIPLDEQAF YNKDKAESEW NGVNVQTLKG
160 170 180 190 200
VGVENNGQYA AFVKDMQVYL VPIERVAQLK PFFKYIDDAN VTRKQEDARR
210 220 230 240 250
NPNPSSQRAQ VVTMSVKSVN DPSQNRLTGS LLAHKVADEE ANIELTWAEG
260 270 280
TFEQFKDTIV KEAEDKTLVA LEKQEDYIDN LV
Length:282
Mass (Da):32,142
Last modified:June 1, 1994 - v1
Checksum:i9E948BDDECE9D15E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z28250 Genomic DNA Translation: CAA82097.1
AY692886 Genomic DNA Translation: AAT92905.1
BK006944 Genomic DNA Translation: DAA09180.1
PIRiS38094
RefSeqiNP_012950.3, NM_001179815.3

Genome annotation databases

EnsemblFungiiYKR025W; YKR025W; YKR025W
GeneIDi853895
KEGGisce:YKR025W

Similar proteinsi

Entry informationi

Entry nameiRPC5_YEAST
AccessioniPrimary (citable) accession number: P36121
Secondary accession number(s): D6VX90
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: May 23, 2018
This is version 131 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XI
    Yeast (Saccharomyces cerevisiae) chromosome XI: entries and gene names

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