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P36121

- RPC5_YEAST

UniProt

P36121 - RPC5_YEAST

Protein

DNA-directed RNA polymerase III subunit RPC5

Gene

RPC37

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 103 (01 Oct 2014)
      Sequence version 1 (01 Jun 1994)
      Previous versions | rss
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    Functioni

    DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. The RPC53/RPC4-RPC37/RPC5 subcomplex is required for terminator recognition and reinitiation.1 Publication

    GO - Molecular functioni

    1. DNA-directed RNA polymerase activity Source: UniProtKB-KW

    GO - Biological processi

    1. tRNA transcription from RNA polymerase III promoter Source: SGD

    Keywords - Biological processi

    Transcription

    Enzyme and pathway databases

    BioCyciYEAST:G3O-32001-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    DNA-directed RNA polymerase III subunit RPC5
    Short name:
    RNA polymerase III subunit C5
    Alternative name(s):
    DNA-directed RNA polymerase III 37 kDa polypeptide
    RNA polymerase III subunit C37
    Gene namesi
    Name:RPC37
    Ordered Locus Names:YKR025W
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome XI

    Organism-specific databases

    CYGDiYKR025w.
    SGDiS000001733. RPC37.

    Subcellular locationi

    Nucleus 1 Publication

    GO - Cellular componenti

    1. DNA-directed RNA polymerase III complex Source: SGD

    Keywords - Cellular componenti

    DNA-directed RNA polymerase, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 282282DNA-directed RNA polymerase III subunit RPC5PRO_0000203203Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei61 – 611Phosphothreonine2 Publications

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiP36121.
    PaxDbiP36121.

    Expressioni

    Gene expression databases

    GenevestigatoriP36121.

    Interactioni

    Subunit structurei

    Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits. Interacts with RPC53/RPC4. RPC53/RPC4, RPC37/RPC5 and RPC11/RPC10 probably form a Pol III subcomplex.1 Publication

    Protein-protein interaction databases

    BioGridi34157. 38 interactions.
    DIPiDIP-761N.
    IntActiP36121. 10 interactions.
    MINTiMINT-399243.
    STRINGi4932.YKR025W.

    Structurei

    3D structure databases

    ProteinModelPortaliP36121.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Phylogenomic databases

    eggNOGiNOG276044.
    HOGENOMiHOG000074717.
    KOiK14721.
    OMAiANIELTW.
    OrthoDBiEOG7VDZ0M.

    Family and domain databases

    InterProiIPR006886. RNA_pol_III_Rpc5.
    [Graphical view]
    PfamiPF04801. Sin_N. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P36121-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSIDNKLFVT EEDEEDRTQD RADVEDESND IDMIADENGT NSAIANEQEE    50
    KSEEVKAEDD TGEEEEDDPV IEEFPLKISG EEESLHVFQY ANRPRLVGRK 100
    PAEHPFISAA RYKPKSHLWE IDIPLDEQAF YNKDKAESEW NGVNVQTLKG 150
    VGVENNGQYA AFVKDMQVYL VPIERVAQLK PFFKYIDDAN VTRKQEDARR 200
    NPNPSSQRAQ VVTMSVKSVN DPSQNRLTGS LLAHKVADEE ANIELTWAEG 250
    TFEQFKDTIV KEAEDKTLVA LEKQEDYIDN LV 282
    Length:282
    Mass (Da):32,142
    Last modified:June 1, 1994 - v1
    Checksum:i9E948BDDECE9D15E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z28250 Genomic DNA. Translation: CAA82097.1.
    AY692886 Genomic DNA. Translation: AAT92905.1.
    BK006944 Genomic DNA. Translation: DAA09180.1.
    PIRiS38094.
    RefSeqiNP_012950.3. NM_001179815.3.

    Genome annotation databases

    EnsemblFungiiYKR025W; YKR025W; YKR025W.
    GeneIDi853895.
    KEGGisce:YKR025W.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z28250 Genomic DNA. Translation: CAA82097.1 .
    AY692886 Genomic DNA. Translation: AAT92905.1 .
    BK006944 Genomic DNA. Translation: DAA09180.1 .
    PIRi S38094.
    RefSeqi NP_012950.3. NM_001179815.3.

    3D structure databases

    ProteinModelPortali P36121.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 34157. 38 interactions.
    DIPi DIP-761N.
    IntActi P36121. 10 interactions.
    MINTi MINT-399243.
    STRINGi 4932.YKR025W.

    Proteomic databases

    MaxQBi P36121.
    PaxDbi P36121.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YKR025W ; YKR025W ; YKR025W .
    GeneIDi 853895.
    KEGGi sce:YKR025W.

    Organism-specific databases

    CYGDi YKR025w.
    SGDi S000001733. RPC37.

    Phylogenomic databases

    eggNOGi NOG276044.
    HOGENOMi HOG000074717.
    KOi K14721.
    OMAi ANIELTW.
    OrthoDBi EOG7VDZ0M.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-32001-MONOMER.

    Miscellaneous databases

    NextBioi 975210.
    PROi P36121.

    Gene expression databases

    Genevestigatori P36121.

    Family and domain databases

    InterProi IPR006886. RNA_pol_III_Rpc5.
    [Graphical view ]
    Pfami PF04801. Sin_N. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete DNA sequence of yeast chromosome XI."
      Dujon B., Alexandraki D., Andre B., Ansorge W., Baladron V., Ballesta J.P.G., Banrevi A., Bolle P.-A., Bolotin-Fukuhara M., Bossier P., Bou G., Boyer J., Buitrago M.J., Cheret G., Colleaux L., Daignan-Fornier B., del Rey F., Dion C.
      , Domdey H., Duesterhoeft A., Duesterhus S., Entian K.-D., Erfle H., Esteban P.F., Feldmann H., Fernandes L., Fobo G.M., Fritz C., Fukuhara H., Gabel C., Gaillon L., Garcia-Cantalejo J.M., Garcia-Ramirez J.J., Gent M.E., Ghazvini M., Goffeau A., Gonzalez A., Grothues D., Guerreiro P., Hegemann J.H., Hewitt N., Hilger F., Hollenberg C.P., Horaitis O., Indge K.J., Jacquier A., James C.M., Jauniaux J.-C., Jimenez A., Keuchel H., Kirchrath L., Kleine K., Koetter P., Legrain P., Liebl S., Louis E.J., Maia e Silva A., Marck C., Monnier A.-L., Moestl D., Mueller S., Obermaier B., Oliver S.G., Pallier C., Pascolo S., Pfeiffer F., Philippsen P., Planta R.J., Pohl F.M., Pohl T.M., Poehlmann R., Portetelle D., Purnelle B., Puzos V., Ramezani Rad M., Rasmussen S.W., Remacha M.A., Revuelta J.L., Richard G.-F., Rieger M., Rodrigues-Pousada C., Rose M., Rupp T., Santos M.A., Schwager C., Sensen C., Skala J., Soares H., Sor F., Stegemann J., Tettelin H., Thierry A., Tzermia M., Urrestarazu L.A., van Dyck L., van Vliet-Reedijk J.C., Valens M., Vandenbol M., Vilela C., Vissers S., von Wettstein D., Voss H., Wiemann S., Xu G., Zimmermann J., Haasemann M., Becker I., Mewes H.-W.
      Nature 369:371-378(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    2. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    3. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    4. "The yeast RNA polymerase III transcription machinery: a paradigm for eukaryotic gene activation."
      Chedin S., Ferri M.L., Peyroche G., Andrau J.-C., Jourdain S., Lefebvre O., Werner M., Carles C., Sentenac A.
      Cold Spring Harb. Symp. Quant. Biol. 63:381-389(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: REVIEW ON THE RNA POL III COMPLEX.
    5. Cited for: IDENTIFICATION IN THE RNA POL III COMPLEX, INTERACTION WITH RPC4.
    6. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
    7. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
    8. "A subcomplex of RNA polymerase III subunits involved in transcription termination and reinitiation."
      Landrieux E., Alic N., Ducrot C., Acker J., Riva M., Carles C.
      EMBO J. 25:118-128(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION OF THE RPC53-RPC37 SUBCOMPLEX.
    9. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
      Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
      Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-61, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    10. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
      Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
      Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-61, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiRPC5_YEAST
    AccessioniPrimary (citable) accession number: P36121
    Secondary accession number(s): D6VX90
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 1, 1994
    Last sequence update: June 1, 1994
    Last modified: October 1, 2014
    This is version 103 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Present with 1590 molecules/cell in log phase SD medium.1 Publication

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    2. Yeast chromosome XI
      Yeast (Saccharomyces cerevisiae) chromosome XI: entries and gene names

    External Data

    Dasty 3