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P36121

- RPC5_YEAST

UniProt

P36121 - RPC5_YEAST

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Protein

DNA-directed RNA polymerase III subunit RPC5

Gene

RPC37

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. The RPC53/RPC4-RPC37/RPC5 subcomplex is required for terminator recognition and reinitiation.1 Publication

GO - Molecular functioni

  1. DNA-directed RNA polymerase activity Source: UniProtKB-KW

GO - Biological processi

  1. tRNA transcription from RNA polymerase III promoter Source: SGD
Complete GO annotation...

Keywords - Biological processi

Transcription

Enzyme and pathway databases

BioCyciYEAST:G3O-32001-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
DNA-directed RNA polymerase III subunit RPC5
Short name:
RNA polymerase III subunit C5
Alternative name(s):
DNA-directed RNA polymerase III 37 kDa polypeptide
RNA polymerase III subunit C37
Gene namesi
Name:RPC37
Ordered Locus Names:YKR025W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome XI

Organism-specific databases

CYGDiYKR025w.
SGDiS000001733. RPC37.

Subcellular locationi

Nucleus 1 Publication

GO - Cellular componenti

  1. DNA-directed RNA polymerase III complex Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

DNA-directed RNA polymerase, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 282282DNA-directed RNA polymerase III subunit RPC5PRO_0000203203Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei61 – 611Phosphothreonine2 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP36121.
PaxDbiP36121.

Expressioni

Gene expression databases

GenevestigatoriP36121.

Interactioni

Subunit structurei

Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits. Interacts with RPC53/RPC4. RPC53/RPC4, RPC37/RPC5 and RPC11/RPC10 probably form a Pol III subcomplex.1 Publication

Protein-protein interaction databases

BioGridi34157. 38 interactions.
DIPiDIP-761N.
IntActiP36121. 10 interactions.
MINTiMINT-399243.
STRINGi4932.YKR025W.

Structurei

3D structure databases

ProteinModelPortaliP36121.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiNOG276044.
HOGENOMiHOG000074717.
InParanoidiP36121.
KOiK14721.
OMAiANIELTW.
OrthoDBiEOG7VDZ0M.

Family and domain databases

InterProiIPR006886. RNA_pol_III_Rpc5.
[Graphical view]
PfamiPF04801. Sin_N. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P36121-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSIDNKLFVT EEDEEDRTQD RADVEDESND IDMIADENGT NSAIANEQEE
60 70 80 90 100
KSEEVKAEDD TGEEEEDDPV IEEFPLKISG EEESLHVFQY ANRPRLVGRK
110 120 130 140 150
PAEHPFISAA RYKPKSHLWE IDIPLDEQAF YNKDKAESEW NGVNVQTLKG
160 170 180 190 200
VGVENNGQYA AFVKDMQVYL VPIERVAQLK PFFKYIDDAN VTRKQEDARR
210 220 230 240 250
NPNPSSQRAQ VVTMSVKSVN DPSQNRLTGS LLAHKVADEE ANIELTWAEG
260 270 280
TFEQFKDTIV KEAEDKTLVA LEKQEDYIDN LV
Length:282
Mass (Da):32,142
Last modified:June 1, 1994 - v1
Checksum:i9E948BDDECE9D15E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z28250 Genomic DNA. Translation: CAA82097.1.
AY692886 Genomic DNA. Translation: AAT92905.1.
BK006944 Genomic DNA. Translation: DAA09180.1.
PIRiS38094.
RefSeqiNP_012950.3. NM_001179815.3.

Genome annotation databases

EnsemblFungiiYKR025W; YKR025W; YKR025W.
GeneIDi853895.
KEGGisce:YKR025W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z28250 Genomic DNA. Translation: CAA82097.1 .
AY692886 Genomic DNA. Translation: AAT92905.1 .
BK006944 Genomic DNA. Translation: DAA09180.1 .
PIRi S38094.
RefSeqi NP_012950.3. NM_001179815.3.

3D structure databases

ProteinModelPortali P36121.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 34157. 38 interactions.
DIPi DIP-761N.
IntActi P36121. 10 interactions.
MINTi MINT-399243.
STRINGi 4932.YKR025W.

Proteomic databases

MaxQBi P36121.
PaxDbi P36121.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YKR025W ; YKR025W ; YKR025W .
GeneIDi 853895.
KEGGi sce:YKR025W.

Organism-specific databases

CYGDi YKR025w.
SGDi S000001733. RPC37.

Phylogenomic databases

eggNOGi NOG276044.
HOGENOMi HOG000074717.
InParanoidi P36121.
KOi K14721.
OMAi ANIELTW.
OrthoDBi EOG7VDZ0M.

Enzyme and pathway databases

BioCyci YEAST:G3O-32001-MONOMER.

Miscellaneous databases

NextBioi 975210.
PROi P36121.

Gene expression databases

Genevestigatori P36121.

Family and domain databases

InterProi IPR006886. RNA_pol_III_Rpc5.
[Graphical view ]
Pfami PF04801. Sin_N. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Complete DNA sequence of yeast chromosome XI."
    Dujon B., Alexandraki D., Andre B., Ansorge W., Baladron V., Ballesta J.P.G., Banrevi A., Bolle P.-A., Bolotin-Fukuhara M., Bossier P., Bou G., Boyer J., Buitrago M.J., Cheret G., Colleaux L., Daignan-Fornier B., del Rey F., Dion C.
    , Domdey H., Duesterhoeft A., Duesterhus S., Entian K.-D., Erfle H., Esteban P.F., Feldmann H., Fernandes L., Fobo G.M., Fritz C., Fukuhara H., Gabel C., Gaillon L., Garcia-Cantalejo J.M., Garcia-Ramirez J.J., Gent M.E., Ghazvini M., Goffeau A., Gonzalez A., Grothues D., Guerreiro P., Hegemann J.H., Hewitt N., Hilger F., Hollenberg C.P., Horaitis O., Indge K.J., Jacquier A., James C.M., Jauniaux J.-C., Jimenez A., Keuchel H., Kirchrath L., Kleine K., Koetter P., Legrain P., Liebl S., Louis E.J., Maia e Silva A., Marck C., Monnier A.-L., Moestl D., Mueller S., Obermaier B., Oliver S.G., Pallier C., Pascolo S., Pfeiffer F., Philippsen P., Planta R.J., Pohl F.M., Pohl T.M., Poehlmann R., Portetelle D., Purnelle B., Puzos V., Ramezani Rad M., Rasmussen S.W., Remacha M.A., Revuelta J.L., Richard G.-F., Rieger M., Rodrigues-Pousada C., Rose M., Rupp T., Santos M.A., Schwager C., Sensen C., Skala J., Soares H., Sor F., Stegemann J., Tettelin H., Thierry A., Tzermia M., Urrestarazu L.A., van Dyck L., van Vliet-Reedijk J.C., Valens M., Vandenbol M., Vilela C., Vissers S., von Wettstein D., Voss H., Wiemann S., Xu G., Zimmermann J., Haasemann M., Becker I., Mewes H.-W.
    Nature 369:371-378(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  4. "The yeast RNA polymerase III transcription machinery: a paradigm for eukaryotic gene activation."
    Chedin S., Ferri M.L., Peyroche G., Andrau J.-C., Jourdain S., Lefebvre O., Werner M., Carles C., Sentenac A.
    Cold Spring Harb. Symp. Quant. Biol. 63:381-389(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW ON THE RNA POL III COMPLEX.
  5. Cited for: IDENTIFICATION IN THE RNA POL III COMPLEX, INTERACTION WITH RPC4.
  6. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
  7. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  8. "A subcomplex of RNA polymerase III subunits involved in transcription termination and reinitiation."
    Landrieux E., Alic N., Ducrot C., Acker J., Riva M., Carles C.
    EMBO J. 25:118-128(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION OF THE RPC53-RPC37 SUBCOMPLEX.
  9. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
    Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
    Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-61, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  10. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
    Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
    Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-61, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiRPC5_YEAST
AccessioniPrimary (citable) accession number: P36121
Secondary accession number(s): D6VX90
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: October 29, 2014
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 1590 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome XI
    Yeast (Saccharomyces cerevisiae) chromosome XI: entries and gene names

External Data

Dasty 3