Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Pre-mRNA-splicing factor NTR2

Gene

NTR2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Involved in pre-mRNA splicing and spliceosome disassembly. Promotes release of excised lariat intron from the spliceosome by acting as a receptor for PRP43. This targeting of PRP43 leads to disassembly of the spliceosome with the separation of the U2, U5, U6 snRNPs and the NTC complex.2 Publications

GO - Biological processi

  • spliceosomal complex disassembly Source: SGD
Complete GO annotation...

Keywords - Biological processi

mRNA processing, mRNA splicing

Enzyme and pathway databases

BioCyciYEAST:G3O-31998-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Pre-mRNA-splicing factor NTR2
Alternative name(s):
Nineteen complex-related protein 2
Short name:
NTC-related protein 2
Gene namesi
Name:NTR2
Ordered Locus Names:YKR022C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XI

Organism-specific databases

EuPathDBiFungiDB:YKR022C.
SGDiS000001730. NTR2.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB-SubCell
  • spliceosomal complex Source: SGD
  • U2-type post-mRNA release spliceosomal complex Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus, Spliceosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002032011 – 322Pre-mRNA-splicing factor NTR2Add BLAST322

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei40PhosphoserineCombined sources1
Modified residuei153PhosphoserineCombined sources1
Modified residuei197PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP36118.
PRIDEiP36118.

PTM databases

iPTMnetiP36118.

Interactioni

Subunit structurei

Component of the NTR complex (NTC-related complex), composed of NTR1, NTR2 and PRP43. Interacts with CLF1, NTR1 and PRP43.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
SPP382Q0641111EBI-26362,EBI-576

Protein-protein interaction databases

BioGridi34154. 62 interactors.
DIPiDIP-1924N.
IntActiP36118. 20 interactors.
MINTiMINT-403676.

Structurei

3D structure databases

ProteinModelPortaliP36118.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

InParanoidiP36118.
OrthoDBiEOG092C3KBI.

Family and domain databases

InterProiIPR028211. Ntr2.
[Graphical view]
PfamiPF15458. NTR2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P36118-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAIKKRNKIR LPSGSPEEVG IDGSAHKPMQ QIKPLVSNDS EDDDNDICVL
60 70 80 90 100
QPIKFKKVPK RDITFDGEQA IKEDNSHYED LYHSKKNTNA STRNKDDLLI
110 120 130 140 150
LNMEDLMEGN HHLLSDSSEA GSSSEGEHIS SIPTRGEIAK LKAQKSLSRR
160 170 180 190 200
KISESDVTTE RDYVKLLDSE DKREIMETIR LNGGLKRNNE KEITNFSDDE
210 220 230 240 250
MQGFQDEMLA LTDNQIAIQK DSKRKIIEKA INEVPYRTNE EWETQLLSKG
260 270 280 290 300
NINKSNEKII TPLPVLFPDD DESGNSIERI NEMVSKICLQ RKKVEMRLQA
310 320
LEKTKIDLEK SKASLINKLI GN
Length:322
Mass (Da):36,647
Last modified:June 1, 1994 - v1
Checksum:iD7A601A46839244C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z28247 Genomic DNA. Translation: CAA82094.1.
BK006944 Genomic DNA. Translation: DAA09177.1.
PIRiS38091.
RefSeqiNP_012947.1. NM_001179812.1.

Genome annotation databases

EnsemblFungiiYKR022C; YKR022C; YKR022C.
GeneIDi853892.
KEGGisce:YKR022C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z28247 Genomic DNA. Translation: CAA82094.1.
BK006944 Genomic DNA. Translation: DAA09177.1.
PIRiS38091.
RefSeqiNP_012947.1. NM_001179812.1.

3D structure databases

ProteinModelPortaliP36118.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi34154. 62 interactors.
DIPiDIP-1924N.
IntActiP36118. 20 interactors.
MINTiMINT-403676.

PTM databases

iPTMnetiP36118.

Proteomic databases

MaxQBiP36118.
PRIDEiP36118.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYKR022C; YKR022C; YKR022C.
GeneIDi853892.
KEGGisce:YKR022C.

Organism-specific databases

EuPathDBiFungiDB:YKR022C.
SGDiS000001730. NTR2.

Phylogenomic databases

InParanoidiP36118.
OrthoDBiEOG092C3KBI.

Enzyme and pathway databases

BioCyciYEAST:G3O-31998-MONOMER.

Miscellaneous databases

PROiP36118.

Family and domain databases

InterProiIPR028211. Ntr2.
[Graphical view]
PfamiPF15458. NTR2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNTR2_YEAST
AccessioniPrimary (citable) accession number: P36118
Secondary accession number(s): D6VX87
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: November 2, 2016
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 892 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome XI
    Yeast (Saccharomyces cerevisiae) chromosome XI: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.