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P36118

- NTR2_YEAST

UniProt

P36118 - NTR2_YEAST

Protein

Pre-mRNA-splicing factor NTR2

Gene

NTR2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 98 (01 Oct 2014)
      Sequence version 1 (01 Jun 1994)
      Previous versions | rss
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    Functioni

    Involved in pre-mRNA splicing and spliceosome disassembly. Promotes release of excised lariat intron from the spliceosome by acting as a receptor for PRP43. This targeting of PRP43 leads to disassembly of the spliceosome with the separation of the U2, U5, U6 snRNPs and the NTC complex.2 Publications

    GO - Molecular functioni

    1. protein binding Source: IntAct

    GO - Biological processi

    1. spliceosomal complex disassembly Source: SGD

    Keywords - Biological processi

    mRNA processing, mRNA splicing

    Enzyme and pathway databases

    BioCyciYEAST:G3O-31998-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Pre-mRNA-splicing factor NTR2
    Alternative name(s):
    Nineteen complex-related protein 2
    Short name:
    NTC-related protein 2
    Gene namesi
    Name:NTR2
    Ordered Locus Names:YKR022C
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome XI

    Organism-specific databases

    CYGDiYKR022c.
    SGDiS000001730. NTR2.

    Subcellular locationi

    Cytoplasm 1 Publication. Nucleus 1 Publication

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. spliceosomal complex Source: SGD
    3. U2-type post-mRNA release spliceosomal complex Source: SGD

    Keywords - Cellular componenti

    Cytoplasm, Nucleus, Spliceosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 322322Pre-mRNA-splicing factor NTR2PRO_0000203201Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei40 – 401Phosphoserine2 Publications
    Modified residuei153 – 1531Phosphoserine1 Publication
    Modified residuei197 – 1971Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiP36118.
    PaxDbiP36118.
    PeptideAtlasiP36118.

    Expressioni

    Gene expression databases

    GenevestigatoriP36118.

    Interactioni

    Subunit structurei

    Component of the NTR complex (NTC-related complex), composed of NTR1, NTR2 and PRP43. Interacts with CLF1, NTR1 and PRP43.2 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    SPP382Q0641111EBI-26362,EBI-576

    Protein-protein interaction databases

    BioGridi34154. 61 interactions.
    DIPiDIP-1924N.
    IntActiP36118. 20 interactions.
    MINTiMINT-403676.
    STRINGi4932.YKR022C.

    Structurei

    3D structure databases

    ProteinModelPortaliP36118.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Phylogenomic databases

    eggNOGiNOG244380.
    OMAiEHISSIP.
    OrthoDBiEOG7CG796.

    Family and domain databases

    InterProiIPR028211. Ntr2.
    [Graphical view]
    PfamiPF15458. NTR2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P36118-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAIKKRNKIR LPSGSPEEVG IDGSAHKPMQ QIKPLVSNDS EDDDNDICVL    50
    QPIKFKKVPK RDITFDGEQA IKEDNSHYED LYHSKKNTNA STRNKDDLLI 100
    LNMEDLMEGN HHLLSDSSEA GSSSEGEHIS SIPTRGEIAK LKAQKSLSRR 150
    KISESDVTTE RDYVKLLDSE DKREIMETIR LNGGLKRNNE KEITNFSDDE 200
    MQGFQDEMLA LTDNQIAIQK DSKRKIIEKA INEVPYRTNE EWETQLLSKG 250
    NINKSNEKII TPLPVLFPDD DESGNSIERI NEMVSKICLQ RKKVEMRLQA 300
    LEKTKIDLEK SKASLINKLI GN 322
    Length:322
    Mass (Da):36,647
    Last modified:June 1, 1994 - v1
    Checksum:iD7A601A46839244C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z28247 Genomic DNA. Translation: CAA82094.1.
    BK006944 Genomic DNA. Translation: DAA09177.1.
    PIRiS38091.
    RefSeqiNP_012947.1. NM_001179812.1.

    Genome annotation databases

    EnsemblFungiiYKR022C; YKR022C; YKR022C.
    GeneIDi853892.
    KEGGisce:YKR022C.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z28247 Genomic DNA. Translation: CAA82094.1 .
    BK006944 Genomic DNA. Translation: DAA09177.1 .
    PIRi S38091.
    RefSeqi NP_012947.1. NM_001179812.1.

    3D structure databases

    ProteinModelPortali P36118.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 34154. 61 interactions.
    DIPi DIP-1924N.
    IntActi P36118. 20 interactions.
    MINTi MINT-403676.
    STRINGi 4932.YKR022C.

    Proteomic databases

    MaxQBi P36118.
    PaxDbi P36118.
    PeptideAtlasi P36118.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YKR022C ; YKR022C ; YKR022C .
    GeneIDi 853892.
    KEGGi sce:YKR022C.

    Organism-specific databases

    CYGDi YKR022c.
    SGDi S000001730. NTR2.

    Phylogenomic databases

    eggNOGi NOG244380.
    OMAi EHISSIP.
    OrthoDBi EOG7CG796.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-31998-MONOMER.

    Miscellaneous databases

    NextBioi 975201.

    Gene expression databases

    Genevestigatori P36118.

    Family and domain databases

    InterProi IPR028211. Ntr2.
    [Graphical view ]
    Pfami PF15458. NTR2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete DNA sequence of yeast chromosome XI."
      Dujon B., Alexandraki D., Andre B., Ansorge W., Baladron V., Ballesta J.P.G., Banrevi A., Bolle P.-A., Bolotin-Fukuhara M., Bossier P., Bou G., Boyer J., Buitrago M.J., Cheret G., Colleaux L., Daignan-Fornier B., del Rey F., Dion C.
      , Domdey H., Duesterhoeft A., Duesterhus S., Entian K.-D., Erfle H., Esteban P.F., Feldmann H., Fernandes L., Fobo G.M., Fritz C., Fukuhara H., Gabel C., Gaillon L., Garcia-Cantalejo J.M., Garcia-Ramirez J.J., Gent M.E., Ghazvini M., Goffeau A., Gonzalez A., Grothues D., Guerreiro P., Hegemann J.H., Hewitt N., Hilger F., Hollenberg C.P., Horaitis O., Indge K.J., Jacquier A., James C.M., Jauniaux J.-C., Jimenez A., Keuchel H., Kirchrath L., Kleine K., Koetter P., Legrain P., Liebl S., Louis E.J., Maia e Silva A., Marck C., Monnier A.-L., Moestl D., Mueller S., Obermaier B., Oliver S.G., Pallier C., Pascolo S., Pfeiffer F., Philippsen P., Planta R.J., Pohl F.M., Pohl T.M., Poehlmann R., Portetelle D., Purnelle B., Puzos V., Ramezani Rad M., Rasmussen S.W., Remacha M.A., Revuelta J.L., Richard G.-F., Rieger M., Rodrigues-Pousada C., Rose M., Rupp T., Santos M.A., Schwager C., Sensen C., Skala J., Soares H., Sor F., Stegemann J., Tettelin H., Thierry A., Tzermia M., Urrestarazu L.A., van Dyck L., van Vliet-Reedijk J.C., Valens M., Vandenbol M., Vilela C., Vissers S., von Wettstein D., Voss H., Wiemann S., Xu G., Zimmermann J., Haasemann M., Becker I., Mewes H.-W.
      Nature 369:371-378(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    2. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    3. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
    4. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
    5. "Spliceosome disassembly catalyzed by Prp43 and its associated components Ntr1 and Ntr2."
      Tsai R.-T., Fu R.-H., Yeh F.-L., Tseng C.-K., Lin Y.-C., Huang Y.-H., Cheng S.-C.
      Genes Dev. 19:2991-3003(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, IDENTIFICATION IN THE NTC-RELATED COMPLEX, INTERACTION WITH CLF1; NTR1 AND PRP43.
    6. Cited for: FUNCTION, INTERACTION WITH NTR1 AND PRP43.
    7. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
      Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
      Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-40 AND SER-153, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    8. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
      Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
      Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-40 AND SER-197, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiNTR2_YEAST
    AccessioniPrimary (citable) accession number: P36118
    Secondary accession number(s): D6VX87
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 1, 1994
    Last sequence update: June 1, 1994
    Last modified: October 1, 2014
    This is version 98 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Present with 892 molecules/cell in log phase SD medium.1 Publication

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    2. Yeast chromosome XI
      Yeast (Saccharomyces cerevisiae) chromosome XI: entries and gene names

    External Data

    Dasty 3