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P36118

- NTR2_YEAST

UniProt

P36118 - NTR2_YEAST

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Protein

Pre-mRNA-splicing factor NTR2

Gene

NTR2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Involved in pre-mRNA splicing and spliceosome disassembly. Promotes release of excised lariat intron from the spliceosome by acting as a receptor for PRP43. This targeting of PRP43 leads to disassembly of the spliceosome with the separation of the U2, U5, U6 snRNPs and the NTC complex.2 Publications

GO - Biological processi

  1. spliceosomal complex disassembly Source: SGD
Complete GO annotation...

Keywords - Biological processi

mRNA processing, mRNA splicing

Enzyme and pathway databases

BioCyciYEAST:G3O-31998-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Pre-mRNA-splicing factor NTR2
Alternative name(s):
Nineteen complex-related protein 2
Short name:
NTC-related protein 2
Gene namesi
Name:NTR2
Ordered Locus Names:YKR022C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome XI

Organism-specific databases

CYGDiYKR022c.
SGDiS000001730. NTR2.

Subcellular locationi

Cytoplasm 1 Publication. Nucleus 1 Publication

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
  2. spliceosomal complex Source: SGD
  3. U2-type post-mRNA release spliceosomal complex Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus, Spliceosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 322322Pre-mRNA-splicing factor NTR2PRO_0000203201Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei40 – 401Phosphoserine2 Publications
Modified residuei153 – 1531Phosphoserine1 Publication
Modified residuei197 – 1971Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP36118.
PaxDbiP36118.
PeptideAtlasiP36118.

Expressioni

Gene expression databases

GenevestigatoriP36118.

Interactioni

Subunit structurei

Component of the NTR complex (NTC-related complex), composed of NTR1, NTR2 and PRP43. Interacts with CLF1, NTR1 and PRP43.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
SPP382Q0641111EBI-26362,EBI-576

Protein-protein interaction databases

BioGridi34154. 62 interactions.
DIPiDIP-1924N.
IntActiP36118. 20 interactions.
MINTiMINT-403676.
STRINGi4932.YKR022C.

Structurei

3D structure databases

ProteinModelPortaliP36118.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiNOG244380.
InParanoidiP36118.
OMAiEHISSIP.
OrthoDBiEOG7CG796.

Family and domain databases

InterProiIPR028211. Ntr2.
[Graphical view]
PfamiPF15458. NTR2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P36118-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAIKKRNKIR LPSGSPEEVG IDGSAHKPMQ QIKPLVSNDS EDDDNDICVL
60 70 80 90 100
QPIKFKKVPK RDITFDGEQA IKEDNSHYED LYHSKKNTNA STRNKDDLLI
110 120 130 140 150
LNMEDLMEGN HHLLSDSSEA GSSSEGEHIS SIPTRGEIAK LKAQKSLSRR
160 170 180 190 200
KISESDVTTE RDYVKLLDSE DKREIMETIR LNGGLKRNNE KEITNFSDDE
210 220 230 240 250
MQGFQDEMLA LTDNQIAIQK DSKRKIIEKA INEVPYRTNE EWETQLLSKG
260 270 280 290 300
NINKSNEKII TPLPVLFPDD DESGNSIERI NEMVSKICLQ RKKVEMRLQA
310 320
LEKTKIDLEK SKASLINKLI GN
Length:322
Mass (Da):36,647
Last modified:June 1, 1994 - v1
Checksum:iD7A601A46839244C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z28247 Genomic DNA. Translation: CAA82094.1.
BK006944 Genomic DNA. Translation: DAA09177.1.
PIRiS38091.
RefSeqiNP_012947.1. NM_001179812.1.

Genome annotation databases

EnsemblFungiiYKR022C; YKR022C; YKR022C.
GeneIDi853892.
KEGGisce:YKR022C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z28247 Genomic DNA. Translation: CAA82094.1 .
BK006944 Genomic DNA. Translation: DAA09177.1 .
PIRi S38091.
RefSeqi NP_012947.1. NM_001179812.1.

3D structure databases

ProteinModelPortali P36118.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 34154. 62 interactions.
DIPi DIP-1924N.
IntActi P36118. 20 interactions.
MINTi MINT-403676.
STRINGi 4932.YKR022C.

Proteomic databases

MaxQBi P36118.
PaxDbi P36118.
PeptideAtlasi P36118.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YKR022C ; YKR022C ; YKR022C .
GeneIDi 853892.
KEGGi sce:YKR022C.

Organism-specific databases

CYGDi YKR022c.
SGDi S000001730. NTR2.

Phylogenomic databases

eggNOGi NOG244380.
InParanoidi P36118.
OMAi EHISSIP.
OrthoDBi EOG7CG796.

Enzyme and pathway databases

BioCyci YEAST:G3O-31998-MONOMER.

Miscellaneous databases

NextBioi 975201.

Gene expression databases

Genevestigatori P36118.

Family and domain databases

InterProi IPR028211. Ntr2.
[Graphical view ]
Pfami PF15458. NTR2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Complete DNA sequence of yeast chromosome XI."
    Dujon B., Alexandraki D., Andre B., Ansorge W., Baladron V., Ballesta J.P.G., Banrevi A., Bolle P.-A., Bolotin-Fukuhara M., Bossier P., Bou G., Boyer J., Buitrago M.J., Cheret G., Colleaux L., Daignan-Fornier B., del Rey F., Dion C.
    , Domdey H., Duesterhoeft A., Duesterhus S., Entian K.-D., Erfle H., Esteban P.F., Feldmann H., Fernandes L., Fobo G.M., Fritz C., Fukuhara H., Gabel C., Gaillon L., Garcia-Cantalejo J.M., Garcia-Ramirez J.J., Gent M.E., Ghazvini M., Goffeau A., Gonzalez A., Grothues D., Guerreiro P., Hegemann J.H., Hewitt N., Hilger F., Hollenberg C.P., Horaitis O., Indge K.J., Jacquier A., James C.M., Jauniaux J.-C., Jimenez A., Keuchel H., Kirchrath L., Kleine K., Koetter P., Legrain P., Liebl S., Louis E.J., Maia e Silva A., Marck C., Monnier A.-L., Moestl D., Mueller S., Obermaier B., Oliver S.G., Pallier C., Pascolo S., Pfeiffer F., Philippsen P., Planta R.J., Pohl F.M., Pohl T.M., Poehlmann R., Portetelle D., Purnelle B., Puzos V., Ramezani Rad M., Rasmussen S.W., Remacha M.A., Revuelta J.L., Richard G.-F., Rieger M., Rodrigues-Pousada C., Rose M., Rupp T., Santos M.A., Schwager C., Sensen C., Skala J., Soares H., Sor F., Stegemann J., Tettelin H., Thierry A., Tzermia M., Urrestarazu L.A., van Dyck L., van Vliet-Reedijk J.C., Valens M., Vandenbol M., Vilela C., Vissers S., von Wettstein D., Voss H., Wiemann S., Xu G., Zimmermann J., Haasemann M., Becker I., Mewes H.-W.
    Nature 369:371-378(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
  4. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  5. "Spliceosome disassembly catalyzed by Prp43 and its associated components Ntr1 and Ntr2."
    Tsai R.-T., Fu R.-H., Yeh F.-L., Tseng C.-K., Lin Y.-C., Huang Y.-H., Cheng S.-C.
    Genes Dev. 19:2991-3003(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, IDENTIFICATION IN THE NTC-RELATED COMPLEX, INTERACTION WITH CLF1; NTR1 AND PRP43.
  6. Cited for: FUNCTION, INTERACTION WITH NTR1 AND PRP43.
  7. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
    Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
    Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-40 AND SER-153, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  8. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
    Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
    Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-40 AND SER-197, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiNTR2_YEAST
AccessioniPrimary (citable) accession number: P36118
Secondary accession number(s): D6VX87
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: October 29, 2014
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 892 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome XI
    Yeast (Saccharomyces cerevisiae) chromosome XI: entries and gene names

External Data

Dasty 3