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Protein

Increased rDNA silencing protein 4

Gene

IRS4

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

With TAX4, acts as a positive regulator of INP51 activity and phosphatidylinositol 4,5-bisphosphate turnover. Negatively regulates signaling through the cell integrity pathway, including the MAP kinase SLT2. Seems also to be involved in rDNA silencing.2 Publications

GO - Biological processi

  • autophagy Source: SGD
  • cellular response to starvation Source: SGD
  • chromatin silencing at rDNA Source: SGD
  • fungal-type cell wall organization Source: SGD
  • inositol lipid-mediated signaling Source: SGD
  • lipid metabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Lipid metabolism

Enzyme and pathway databases

BioCyciYEAST:G3O-31995-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Increased rDNA silencing protein 4
Gene namesi
Name:IRS4
Ordered Locus Names:YKR019C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XI

Organism-specific databases

EuPathDBiFungiDB:YKR019C.
SGDiS000001727. IRS4.

Subcellular locationi

GO - Cellular componenti

  • pre-autophagosomal structure Source: SGD
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 615615Increased rDNA silencing protein 4PRO_0000203199Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei180 – 1801PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP36115.

PTM databases

iPTMnetiP36115.

Interactioni

Subunit structurei

Interacts with INP51.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
INP51P405593EBI-27090,EBI-24915

Protein-protein interaction databases

BioGridi34151. 116 interactions.
IntActiP36115. 2 interactions.
MINTiMINT-524061.

Structurei

3D structure databases

ProteinModelPortaliP36115.
SMRiP36115. Positions 495-562.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini460 – 571112EHAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi122 – 282161Ser-richAdd
BLAST

Sequence similaritiesi

Belongs to the IRS4 family.Curated
Contains 1 EH domain.Curated

Phylogenomic databases

GeneTreeiENSGT00530000068452.
InParanoidiP36115.
OrthoDBiEOG092C2VMY.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR000261. EH_dom.
[Graphical view]
SMARTiSM00027. EH. 1 hit.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.

Sequencei

Sequence statusi: Complete.

P36115-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRLSFGKQRY HGGTTVTLTE QGASDSLRAA QAIFQNHSNE VSSPCPPVTV
60 70 80 90 100
SRNPQTRLSE PSLQKSGRKQ EQKKARIRTK QVPKIKTTAP NDVELSKKHR
110 120 130 140 150
SSPAGKDNVS STAQMAAALA HSQSKLSSDN NSSHSSALDT LKVLETPNLN
160 170 180 190 200
GLLGIHSRSS SRNGSNESLT PGQRTPDNRS QENLLTSFSS GRRLSSSSME
210 220 230 240 250
PATNKDSNKA LPKRRPSPPL QSSLVGSGQL HENENLSSIS IDSRHSLNPD
260 270 280 290 300
TSDVISNRSQ TSLSQTINQL SLCESEPSIA SSNTTTTTSN QGSGLPNLVP
310 320 330 340 350
NYSSDMRKKK LVNKFKRKVF GSKPKHLSSQ YEMDASSEEL GQHEQQPSMR
360 370 380 390 400
FKTTLRKTSV STNAENDHAS SLHEGNLRYK YNPSNDTYDV YDDTDSDSES
410 420 430 440 450
DQNQDALTKP RKRDRIKRKI RNSANKTAHH RPIHRTRDRK FNEDKPWKSH
460 470 480 490 500
TDITFVTDNE RKRYESMWVS NRHRHLNLLS WWPSITGDSG AINTLPEDGL
510 520 530 540 550
ILGIIVRDIW KRSNLPNSLL AEIYTKVDTR KDGTLDRKSF IVGMWLVDQC
560 570 580 590 600
LYGRKLPNVV EQCVWDSVDR YASTTVVPVS TLKAMAKQKR KQMKEEIKNI
610
KKENRVVLVD HNSSS
Length:615
Mass (Da):68,880
Last modified:June 1, 1994 - v1
Checksum:i242EBE45978068FD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z28244 Genomic DNA. Translation: CAA82091.1.
BK006944 Genomic DNA. Translation: DAA09174.1.
PIRiS38088.
RefSeqiNP_012944.3. NM_001179809.3.

Genome annotation databases

EnsemblFungiiYKR019C; YKR019C; YKR019C.
GeneIDi853889.
KEGGisce:YKR019C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z28244 Genomic DNA. Translation: CAA82091.1.
BK006944 Genomic DNA. Translation: DAA09174.1.
PIRiS38088.
RefSeqiNP_012944.3. NM_001179809.3.

3D structure databases

ProteinModelPortaliP36115.
SMRiP36115. Positions 495-562.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi34151. 116 interactions.
IntActiP36115. 2 interactions.
MINTiMINT-524061.

PTM databases

iPTMnetiP36115.

Proteomic databases

MaxQBiP36115.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYKR019C; YKR019C; YKR019C.
GeneIDi853889.
KEGGisce:YKR019C.

Organism-specific databases

EuPathDBiFungiDB:YKR019C.
SGDiS000001727. IRS4.

Phylogenomic databases

GeneTreeiENSGT00530000068452.
InParanoidiP36115.
OrthoDBiEOG092C2VMY.

Enzyme and pathway databases

BioCyciYEAST:G3O-31995-MONOMER.

Miscellaneous databases

PROiP36115.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR000261. EH_dom.
[Graphical view]
SMARTiSM00027. EH. 1 hit.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiIRS4_YEAST
AccessioniPrimary (citable) accession number: P36115
Secondary accession number(s): D6VX84
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: September 7, 2016
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XI
    Yeast (Saccharomyces cerevisiae) chromosome XI: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.