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Protein

E3 ubiquitin-protein ligase HEL2

Gene

HEL1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Probable ubiquitin-protein ligase involved in the degradation-related ubiquitination of histones. Contributes to the post-translational regulation of histone protein levels by polyubiquitination of excess histones for subsequent degradation.1 Publication

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.Curated
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri179 – 22345RING-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri242 – 31473IBR-typeSequence analysisAdd
BLAST
Zinc fingeri341 – 37030RING-type 2PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

  • histone catabolic process Source: SGD
  • histone ubiquitination Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Ubl conjugation pathway

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BioCyciYEAST:G3O-31993-MONOMER.
ReactomeiR-SCE-1169408. ISG15 antiviral mechanism.
UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
E3 ubiquitin-protein ligase HEL21 Publication (EC:6.3.2.-1 Publication)
Alternative name(s):
Histone E3 ligase 21 Publication
Gene namesi
Name:HEL11 Publication
Ordered Locus Names:YKR017CImported
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XI

Organism-specific databases

EuPathDBiFungiDB:YKR017C.
SGDiS000001725. HEL1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 551551E3 ubiquitin-protein ligase HEL2PRO_0000056339Add
BLAST

Proteomic databases

MaxQBiP36113.

Interactioni

Subunit structurei

Interacts with the E2 ubiquitin-conjugating enzyme UBC4 and histones H3 and H4.1 Publication

Protein-protein interaction databases

BioGridi34149. 11 interactions.
DIPiDIP-4082N.
IntActiP36113. 1 interaction.
MINTiMINT-509668.

Structurei

3D structure databases

ProteinModelPortaliP36113.
SMRiP36113. Positions 91-536.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the RBR family.Curated
Contains 1 IBR-type zinc finger.Sequence analysis
Contains 2 RING-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri179 – 22345RING-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri242 – 31473IBR-typeSequence analysisAdd
BLAST
Zinc fingeri341 – 37030RING-type 2PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

GeneTreeiENSGT00840000129790.
HOGENOMiHOG000001091.
InParanoidiP36113.
KOiK11968.
OMAiMDSEEEY.
OrthoDBiEOG7N9059.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiIPR031127. E3_UB_ligase_RBR.
IPR002867. IBR_dom.
IPR018957. Znf_C3HC4_RING-type.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
[Graphical view]
PANTHERiPTHR11685. PTHR11685. 1 hit.
PfamiPF01485. IBR. 2 hits.
PF00097. zf-C3HC4. 1 hit.
[Graphical view]
SMARTiSM00647. IBR. 2 hits.
SM00184. RING. 1 hit.
[Graphical view]
PROSITEiPS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P36113-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSGTENDQF YSFDESDSSS IELYESHNTS EFTIHGLVFP KLISVTSQDS
60 70 80 90 100
EFDINEDEDG VDTIYEGMLD APLTKNNKRI LCEGSVPNLS YECLTTKGIF
110 120 130 140 150
ERMLQRVDHL QPIFAIPSAD ILILLQHYDW NEERLLEVWT EKMDELLVEL
160 170 180 190 200
GLSTTANIKK DNDYNSHFRE VEFKNDFTCI ICCDKKDTET FALECGHEYC
210 220 230 240 250
INCYRHYIKD KLHEGNIITC MDCSLALKNE DIDKVMGHPS SSKLMDSSIK
260 270 280 290 300
SFVQKHNRNY KWCPFADCKS IVHLRDTSSL PEYTRLHYSP FVKCNSFHRF
310 320 330 340 350
CFNCGFEVHS PADCKITTAW VKKARKESEI LNWVLSHTKE CPKCSVNIEK
360 370 380 390 400
NGGCNHMVCS SCKYEFCWIC EGPWAPHGKN FFQCTMYKNN EDNKSKNPQD
410 420 430 440 450
ANKTLKKYTF YYRLFNEHEV SAKLDWNLGQ TLGTKVHALQ ERIGISWIDG
460 470 480 490 500
QFLSESLKVL NEGRTVLKWS FAVAYYSDAS HNLTKIFVDN QMLLANAVES
510 520 530 540 550
LSELLQIKTP EVIMKRRPEF YNKAGYVENR TTALMECGRE LLCKGICKAA

E
Length:551
Mass (Da):63,569
Last modified:June 1, 1994 - v1
Checksum:iC044D520D228D618
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z28242 Genomic DNA. Translation: CAA82089.1.
BK006944 Genomic DNA. Translation: DAA09172.1.
PIRiS38086.
RefSeqiNP_012942.3. NM_001179807.3.

Genome annotation databases

EnsemblFungiiYKR017C; YKR017C; YKR017C.
GeneIDi853887.
KEGGisce:YKR017C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z28242 Genomic DNA. Translation: CAA82089.1.
BK006944 Genomic DNA. Translation: DAA09172.1.
PIRiS38086.
RefSeqiNP_012942.3. NM_001179807.3.

3D structure databases

ProteinModelPortaliP36113.
SMRiP36113. Positions 91-536.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi34149. 11 interactions.
DIPiDIP-4082N.
IntActiP36113. 1 interaction.
MINTiMINT-509668.

Proteomic databases

MaxQBiP36113.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYKR017C; YKR017C; YKR017C.
GeneIDi853887.
KEGGisce:YKR017C.

Organism-specific databases

EuPathDBiFungiDB:YKR017C.
SGDiS000001725. HEL1.

Phylogenomic databases

GeneTreeiENSGT00840000129790.
HOGENOMiHOG000001091.
InParanoidiP36113.
KOiK11968.
OMAiMDSEEEY.
OrthoDBiEOG7N9059.

Enzyme and pathway databases

UniPathwayiUPA00143.
BioCyciYEAST:G3O-31993-MONOMER.
ReactomeiR-SCE-1169408. ISG15 antiviral mechanism.

Miscellaneous databases

NextBioi975186.
PROiP36113.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiIPR031127. E3_UB_ligase_RBR.
IPR002867. IBR_dom.
IPR018957. Znf_C3HC4_RING-type.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
[Graphical view]
PANTHERiPTHR11685. PTHR11685. 1 hit.
PfamiPF01485. IBR. 2 hits.
PF00097. zf-C3HC4. 1 hit.
[Graphical view]
SMARTiSM00647. IBR. 2 hits.
SM00184. RING. 1 hit.
[Graphical view]
PROSITEiPS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Complete DNA sequence of yeast chromosome XI."
    Dujon B., Alexandraki D., Andre B., Ansorge W., Baladron V., Ballesta J.P.G., Banrevi A., Bolle P.-A., Bolotin-Fukuhara M., Bossier P., Bou G., Boyer J., Buitrago M.J., Cheret G., Colleaux L., Daignan-Fornier B., del Rey F., Dion C.
    , Domdey H., Duesterhoeft A., Duesterhus S., Entian K.-D., Erfle H., Esteban P.F., Feldmann H., Fernandes L., Fobo G.M., Fritz C., Fukuhara H., Gabel C., Gaillon L., Garcia-Cantalejo J.M., Garcia-Ramirez J.J., Gent M.E., Ghazvini M., Goffeau A., Gonzalez A., Grothues D., Guerreiro P., Hegemann J.H., Hewitt N., Hilger F., Hollenberg C.P., Horaitis O., Indge K.J., Jacquier A., James C.M., Jauniaux J.-C., Jimenez A., Keuchel H., Kirchrath L., Kleine K., Koetter P., Legrain P., Liebl S., Louis E.J., Maia e Silva A., Marck C., Monnier A.-L., Moestl D., Mueller S., Obermaier B., Oliver S.G., Pallier C., Pascolo S., Pfeiffer F., Philippsen P., Planta R.J., Pohl F.M., Pohl T.M., Poehlmann R., Portetelle D., Purnelle B., Puzos V., Ramezani Rad M., Rasmussen S.W., Remacha M.A., Revuelta J.L., Richard G.-F., Rieger M., Rodrigues-Pousada C., Rose M., Rupp T., Santos M.A., Schwager C., Sensen C., Skala J., Soares H., Sor F., Stegemann J., Tettelin H., Thierry A., Tzermia M., Urrestarazu L.A., van Dyck L., van Vliet-Reedijk J.C., Valens M., Vandenbol M., Vilela C., Vissers S., von Wettstein D., Voss H., Wiemann S., Xu G., Zimmermann J., Haasemann M., Becker I., Mewes H.-W.
    Nature 369:371-378(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  4. "Novel E3 ubiquitin ligases that regulate histone protein levels in the budding yeast Saccharomyces cerevisiae."
    Singh R.K., Gonzalez M., Kabbaj M.H., Gunjan A.
    PLoS ONE 7:E36295-E36295(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH UBC4, INTERACTION WITH HISTONES H3 AND H4.

Entry informationi

Entry nameiHEL1_YEAST
AccessioniPrimary (citable) accession number: P36113
Secondary accession number(s): D6VX82
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: May 11, 2016
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 2250 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome XI
    Yeast (Saccharomyces cerevisiae) chromosome XI: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.