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P36106

- BYE1_YEAST

UniProt

P36106 - BYE1_YEAST

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Protein
Transcription factor BYE1
Gene
BYE1, YKL005C, YKL150
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Negative regulator of transcription elongation.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri72 – 13463PHD-type
Add
BLAST

GO - Molecular functioni

  1. chromatin binding Source: SGD
  2. methylated histone binding Source: SGD
  3. zinc ion binding Source: InterPro

GO - Biological processi

  1. negative regulation of transcription from RNA polymerase II promoter Source: SGD
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BioCyciYEAST:G3O-31815-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor BYE1
Alternative name(s):
Bypass of ESS1 protein 1
Gene namesi
Name:BYE1
Ordered Locus Names:YKL005C
ORF Names:YKL150
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome XI

Organism-specific databases

CYGDiYKL005c.
SGDiS000001488. BYE1.

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. nucleus Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 594594Transcription factor BYE1
PRO_0000203191Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei177 – 1771Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP36106.
PaxDbiP36106.

Expressioni

Gene expression databases

GenevestigatoriP36106.

Interactioni

Subunit structurei

Interacts with the RNA polymerase RPB1 subunit and specifically with the trimethylated H3 histone H3K4me3.2 Publications

Protein-protein interaction databases

BioGridi34128. 16 interactions.
MINTiMINT-2493828.
STRINGi4932.YKL005C.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi234 – 25118
Helixi254 – 2585
Helixi272 – 28312
Helixi285 – 2895
Helixi302 – 31413
Beta strandi317 – 3193
Helixi320 – 3278
Helixi332 – 3365
Helixi346 – 35914
Turni360 – 3623

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4BXXX-ray3.28X225-370[»]
4BXZX-ray4.80X1-594[»]
4BY1X-ray3.60X225-370[»]
4BY7X-ray3.15X225-370[»]
ProteinModelPortaliP36106.
SMRiP36106. Positions 232-365.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini254 – 365112TFIIS central
Add
BLAST

Domaini

The PHD domain is involved in the binding to H3K4me3.2 Publications

Sequence similaritiesi

Belongs to the BYE1 family.

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiNOG241623.
HOGENOMiHOG000095286.
OMAiESHEVIA.
OrthoDBiEOG754HZ0.

Family and domain databases

Gene3Di1.10.472.30. 1 hit.
3.30.40.10. 1 hit.
InterProiIPR012921. SPOC_C.
IPR003618. TFIIS_cen_dom.
IPR017890. TFS2M.
IPR019786. Zinc_finger_PHD-type_CS.
IPR011011. Znf_FYVE_PHD.
IPR001965. Znf_PHD.
IPR019787. Znf_PHD-finger.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamiPF00628. PHD. 1 hit.
PF07744. SPOC. 1 hit.
PF07500. TFIIS_M. 1 hit.
[Graphical view]
SMARTiSM00249. PHD. 1 hit.
SM00510. TFS2M. 1 hit.
[Graphical view]
SUPFAMiSSF46942. SSF46942. 1 hit.
SSF57903. SSF57903. 1 hit.
PROSITEiPS51321. TFIIS_CENTRAL. 1 hit.
PS01359. ZF_PHD_1. 1 hit.
PS50016. ZF_PHD_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P36106-1 [UniParc]FASTAAdd to Basket

« Hide

MSVRTSSRSN KGQNKYIEYL LQEETEAPKK KRTKKKVDSA IEKNKKSDSS    50
QEPRKDTENV RTDEVDEADE GYVRCLCGAN NENYDAAEYS HGDMVQCDGC 100
DTWQHIKCMT DGKDTIDGLM SEDSKYYCEL CDPSLYAHLE TSKEAEVSED 150
EDYHDDVYKP VNDHDDNDAD VFLDEESPRK RKRSPDSAKG IHIKSKQVKK 200
SNGSKKRNKS IDAAKSDTAE NEMPTRKDFE SEKEHKLRYN AEKMFSTLFS 250
KFIVPETIEA KLYELPDGKD VISISQEFAH NLEEELYKAC LNVEFGTLDK 300
IYTEKVRSLY SNLKDKKNLE LKAHVVEGKL PLNKLVNMNA SELANPDLQE 350
FKEKRDKIIL ENFIVEVPDK PMYVKTHKGD ELIEDIAEPQ EDILYSKDSI 400
RLHNIDSIDS DKSKIEQTHA ISKEPSPSTI INEESLNCAF LYPGLGLEFT 450
GYLNYIGASQ KLRRDIFKEA IGDGKLYVEG RLPTTTAAPY LKEISCSRAI 500
LVYQLFPSND SESKTTFADV VDSLENKGRI AGIKPKTRYE KDFYIVPSKG 550
GEIPEILKDI LGSHNDERSE RFSRMKSDER TLFAFVVVKQ EFIH 594
Length:594
Mass (Da):67,901
Last modified:June 1, 1994 - v1
Checksum:i1AE16A20E33F21C9
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z28005 Genomic DNA. Translation: CAA81837.1.
X61398 Genomic DNA. No translation available.
S59773 Genomic DNA. Translation: AAC60551.1.
BK006944 Genomic DNA. Translation: DAA09152.1.
PIRiS37816.
RefSeqiNP_012921.3. NM_001179571.3.

Genome annotation databases

EnsemblFungiiYKL005C; YKL005C; YKL005C.
GeneIDi853865.
KEGGisce:YKL005C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z28005 Genomic DNA. Translation: CAA81837.1 .
X61398 Genomic DNA. No translation available.
S59773 Genomic DNA. Translation: AAC60551.1 .
BK006944 Genomic DNA. Translation: DAA09152.1 .
PIRi S37816.
RefSeqi NP_012921.3. NM_001179571.3.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4BXX X-ray 3.28 X 225-370 [» ]
4BXZ X-ray 4.80 X 1-594 [» ]
4BY1 X-ray 3.60 X 225-370 [» ]
4BY7 X-ray 3.15 X 225-370 [» ]
ProteinModelPortali P36106.
SMRi P36106. Positions 232-365.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 34128. 16 interactions.
MINTi MINT-2493828.
STRINGi 4932.YKL005C.

Proteomic databases

MaxQBi P36106.
PaxDbi P36106.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YKL005C ; YKL005C ; YKL005C .
GeneIDi 853865.
KEGGi sce:YKL005C.

Organism-specific databases

CYGDi YKL005c.
SGDi S000001488. BYE1.

Phylogenomic databases

eggNOGi NOG241623.
HOGENOMi HOG000095286.
OMAi ESHEVIA.
OrthoDBi EOG754HZ0.

Enzyme and pathway databases

BioCyci YEAST:G3O-31815-MONOMER.

Miscellaneous databases

NextBioi 975124.

Gene expression databases

Genevestigatori P36106.

Family and domain databases

Gene3Di 1.10.472.30. 1 hit.
3.30.40.10. 1 hit.
InterProi IPR012921. SPOC_C.
IPR003618. TFIIS_cen_dom.
IPR017890. TFS2M.
IPR019786. Zinc_finger_PHD-type_CS.
IPR011011. Znf_FYVE_PHD.
IPR001965. Znf_PHD.
IPR019787. Znf_PHD-finger.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view ]
Pfami PF00628. PHD. 1 hit.
PF07744. SPOC. 1 hit.
PF07500. TFIIS_M. 1 hit.
[Graphical view ]
SMARTi SM00249. PHD. 1 hit.
SM00510. TFS2M. 1 hit.
[Graphical view ]
SUPFAMi SSF46942. SSF46942. 1 hit.
SSF57903. SSF57903. 1 hit.
PROSITEi PS51321. TFIIS_CENTRAL. 1 hit.
PS01359. ZF_PHD_1. 1 hit.
PS50016. ZF_PHD_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Complete DNA sequence of yeast chromosome XI."
    Dujon B., Alexandraki D., Andre B., Ansorge W., Baladron V., Ballesta J.P.G., Banrevi A., Bolle P.-A., Bolotin-Fukuhara M., Bossier P., Bou G., Boyer J., Buitrago M.J., Cheret G., Colleaux L., Daignan-Fornier B., del Rey F., Dion C.
    , Domdey H., Duesterhoeft A., Duesterhus S., Entian K.-D., Erfle H., Esteban P.F., Feldmann H., Fernandes L., Fobo G.M., Fritz C., Fukuhara H., Gabel C., Gaillon L., Garcia-Cantalejo J.M., Garcia-Ramirez J.J., Gent M.E., Ghazvini M., Goffeau A., Gonzalez A., Grothues D., Guerreiro P., Hegemann J.H., Hewitt N., Hilger F., Hollenberg C.P., Horaitis O., Indge K.J., Jacquier A., James C.M., Jauniaux J.-C., Jimenez A., Keuchel H., Kirchrath L., Kleine K., Koetter P., Legrain P., Liebl S., Louis E.J., Maia e Silva A., Marck C., Monnier A.-L., Moestl D., Mueller S., Obermaier B., Oliver S.G., Pallier C., Pascolo S., Pfeiffer F., Philippsen P., Planta R.J., Pohl F.M., Pohl T.M., Poehlmann R., Portetelle D., Purnelle B., Puzos V., Ramezani Rad M., Rasmussen S.W., Remacha M.A., Revuelta J.L., Richard G.-F., Rieger M., Rodrigues-Pousada C., Rose M., Rupp T., Santos M.A., Schwager C., Sensen C., Skala J., Soares H., Sor F., Stegemann J., Tettelin H., Thierry A., Tzermia M., Urrestarazu L.A., van Dyck L., van Vliet-Reedijk J.C., Valens M., Vandenbol M., Vilela C., Vissers S., von Wettstein D., Voss H., Wiemann S., Xu G., Zimmermann J., Haasemann M., Becker I., Mewes H.-W.
    Nature 369:371-378(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. "Sequence of a 7.8 kb segment on the left arm of yeast chromosome XI reveals four open reading frames, including the CAP1 gene, an intron-containing gene and a gene encoding a homolog to the mammalian UOG-1 gene."
    Boyer J., Pascolo S., Richard G.-F., Dujon B.
    Yeast 9:279-287(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 90-594.
  4. "The ESS1 prolyl isomerase and its suppressor BYE1 interact with RNA pol II to inhibit transcription elongation in Saccharomyces cerevisiae."
    Wu X., Rossettini A., Hanes S.D.
    Genetics 165:1687-1702(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, DOMAINS, INTERACTION WITH RPB1.
  5. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  6. "Proteome-wide analysis in Saccharomyces cerevisiae identifies several PHD fingers as novel direct and selective binding modules of histone H3 methylated at either lysine 4 or lysine 36."
    Shi X., Kachirskaia I., Walter K.L., Kuo J.-H.A., Lake A., Davrazou F., Chan S.M., Martin D.G.E., Fingerman I.M., Briggs S.D., Howe L., Utz P.J., Kutateladze T.G., Lugovskoy A.A., Bedford M.T., Gozani O.
    J. Biol. Chem. 282:2450-2455(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: DOMAIN, INTERACTION WITH H3K4ME3.
  7. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
    Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
    Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-177, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiBYE1_YEAST
AccessioniPrimary (citable) accession number: P36106
Secondary accession number(s): D6VXT2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: July 9, 2014
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 892 molecules/cell in log phase SD medium.

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome XI
    Yeast (Saccharomyces cerevisiae) chromosome XI: entries and gene names

External Data

Dasty 3

Similar proteinsi