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P36106 (BYE1_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 106. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Transcription factor BYE1
Alternative name(s):
Bypass of ESS1 protein 1
Gene names
Name:BYE1
Ordered Locus Names:YKL005C
ORF Names:YKL150
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length594 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Negative regulator of transcription elongation. Ref.4

Subunit structure

Interacts with the RNA polymerase RPB1 subunit and specifically with the trimethylated H3 histone H3K4me3. Ref.4 Ref.6

Subcellular location

Nucleus By similarity.

Domain

The PHD domain is involved in the binding to H3K4me3. Ref.4 Ref.6

Miscellaneous

Present with 892 molecules/cell in log phase SD medium.

Sequence similarities

Belongs to the BYE1 family.

Contains 1 PHD-type zinc finger.

Contains 1 TFIIS central domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 594594Transcription factor BYE1
PRO_0000203191

Regions

Domain254 – 365112TFIIS central
Zinc finger72 – 13463PHD-type

Amino acid modifications

Modified residue1771Phosphoserine Ref.7

Secondary structure

................... 594
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P36106 [UniParc].

Last modified June 1, 1994. Version 1.
Checksum: 1AE16A20E33F21C9

FASTA59467,901
        10         20         30         40         50         60 
MSVRTSSRSN KGQNKYIEYL LQEETEAPKK KRTKKKVDSA IEKNKKSDSS QEPRKDTENV 

        70         80         90        100        110        120 
RTDEVDEADE GYVRCLCGAN NENYDAAEYS HGDMVQCDGC DTWQHIKCMT DGKDTIDGLM 

       130        140        150        160        170        180 
SEDSKYYCEL CDPSLYAHLE TSKEAEVSED EDYHDDVYKP VNDHDDNDAD VFLDEESPRK 

       190        200        210        220        230        240 
RKRSPDSAKG IHIKSKQVKK SNGSKKRNKS IDAAKSDTAE NEMPTRKDFE SEKEHKLRYN 

       250        260        270        280        290        300 
AEKMFSTLFS KFIVPETIEA KLYELPDGKD VISISQEFAH NLEEELYKAC LNVEFGTLDK 

       310        320        330        340        350        360 
IYTEKVRSLY SNLKDKKNLE LKAHVVEGKL PLNKLVNMNA SELANPDLQE FKEKRDKIIL 

       370        380        390        400        410        420 
ENFIVEVPDK PMYVKTHKGD ELIEDIAEPQ EDILYSKDSI RLHNIDSIDS DKSKIEQTHA 

       430        440        450        460        470        480 
ISKEPSPSTI INEESLNCAF LYPGLGLEFT GYLNYIGASQ KLRRDIFKEA IGDGKLYVEG 

       490        500        510        520        530        540 
RLPTTTAAPY LKEISCSRAI LVYQLFPSND SESKTTFADV VDSLENKGRI AGIKPKTRYE 

       550        560        570        580        590 
KDFYIVPSKG GEIPEILKDI LGSHNDERSE RFSRMKSDER TLFAFVVVKQ EFIH 

« Hide

References

« Hide 'large scale' references
[1]"Complete DNA sequence of yeast chromosome XI."
Dujon B., Alexandraki D., Andre B., Ansorge W., Baladron V., Ballesta J.P.G., Banrevi A., Bolle P.-A., Bolotin-Fukuhara M., Bossier P., Bou G., Boyer J., Buitrago M.J., Cheret G., Colleaux L., Daignan-Fornier B., del Rey F., Dion C. expand/collapse author list , Domdey H., Duesterhoeft A., Duesterhus S., Entian K.-D., Erfle H., Esteban P.F., Feldmann H., Fernandes L., Fobo G.M., Fritz C., Fukuhara H., Gabel C., Gaillon L., Garcia-Cantalejo J.M., Garcia-Ramirez J.J., Gent M.E., Ghazvini M., Goffeau A., Gonzalez A., Grothues D., Guerreiro P., Hegemann J.H., Hewitt N., Hilger F., Hollenberg C.P., Horaitis O., Indge K.J., Jacquier A., James C.M., Jauniaux J.-C., Jimenez A., Keuchel H., Kirchrath L., Kleine K., Koetter P., Legrain P., Liebl S., Louis E.J., Maia e Silva A., Marck C., Monnier A.-L., Moestl D., Mueller S., Obermaier B., Oliver S.G., Pallier C., Pascolo S., Pfeiffer F., Philippsen P., Planta R.J., Pohl F.M., Pohl T.M., Poehlmann R., Portetelle D., Purnelle B., Puzos V., Ramezani Rad M., Rasmussen S.W., Remacha M.A., Revuelta J.L., Richard G.-F., Rieger M., Rodrigues-Pousada C., Rose M., Rupp T., Santos M.A., Schwager C., Sensen C., Skala J., Soares H., Sor F., Stegemann J., Tettelin H., Thierry A., Tzermia M., Urrestarazu L.A., van Dyck L., van Vliet-Reedijk J.C., Valens M., Vandenbol M., Vilela C., Vissers S., von Wettstein D., Voss H., Wiemann S., Xu G., Zimmermann J., Haasemann M., Becker I., Mewes H.-W.
Nature 369:371-378(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[2]Saccharomyces Genome Database
Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[3]"Sequence of a 7.8 kb segment on the left arm of yeast chromosome XI reveals four open reading frames, including the CAP1 gene, an intron-containing gene and a gene encoding a homolog to the mammalian UOG-1 gene."
Boyer J., Pascolo S., Richard G.-F., Dujon B.
Yeast 9:279-287(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 90-594.
[4]"The ESS1 prolyl isomerase and its suppressor BYE1 interact with RNA pol II to inhibit transcription elongation in Saccharomyces cerevisiae."
Wu X., Rossettini A., Hanes S.D.
Genetics 165:1687-1702(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, DOMAINS, INTERACTION WITH RPB1.
[5]"Global analysis of protein expression in yeast."
Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S.
Nature 425:737-741(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
[6]"Proteome-wide analysis in Saccharomyces cerevisiae identifies several PHD fingers as novel direct and selective binding modules of histone H3 methylated at either lysine 4 or lysine 36."
Shi X., Kachirskaia I., Walter K.L., Kuo J.-H.A., Lake A., Davrazou F., Chan S.M., Martin D.G.E., Fingerman I.M., Briggs S.D., Howe L., Utz P.J., Kutateladze T.G., Lugovskoy A.A., Bedford M.T., Gozani O.
J. Biol. Chem. 282:2450-2455(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: DOMAIN, INTERACTION WITH H3K4ME3.
[7]"Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-177, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Z28005 Genomic DNA. Translation: CAA81837.1.
X61398 Genomic DNA. No translation available.
S59773 Genomic DNA. Translation: AAC60551.1.
BK006944 Genomic DNA. Translation: DAA09152.1.
PIRS37816.
RefSeqNP_012921.3. NM_001179571.3.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
4BXXX-ray3.28X225-370[»]
4BXZX-ray4.80X1-594[»]
4BY1X-ray3.60X225-370[»]
4BY7X-ray3.15X225-370[»]
ProteinModelPortalP36106.
SMRP36106. Positions 91-131, 232-365.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid34128. 16 interactions.
MINTMINT-2493828.
STRING4932.YKL005C.

Proteomic databases

PaxDbP36106.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYKL005C; YKL005C; YKL005C.
GeneID853865.
KEGGsce:YKL005C.

Organism-specific databases

CYGDYKL005c.
SGDS000001488. BYE1.

Phylogenomic databases

eggNOGNOG241623.
HOGENOMHOG000095286.
OMATIINEES.
OrthoDBEOG754HZ0.

Enzyme and pathway databases

BioCycYEAST:G3O-31815-MONOMER.

Gene expression databases

GenevestigatorP36106.

Family and domain databases

Gene3D1.10.472.30. 1 hit.
3.30.40.10. 1 hit.
InterProIPR012921. SPOC_C.
IPR003618. TFIIS_cen_dom.
IPR017890. TFS2M.
IPR019786. Zinc_finger_PHD-type_CS.
IPR011011. Znf_FYVE_PHD.
IPR001965. Znf_PHD.
IPR019787. Znf_PHD-finger.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamPF00628. PHD. 1 hit.
PF07744. SPOC. 1 hit.
PF07500. TFIIS_M. 1 hit.
[Graphical view]
SMARTSM00249. PHD. 1 hit.
SM00510. TFS2M. 1 hit.
[Graphical view]
SUPFAMSSF46942. SSF46942. 1 hit.
SSF57903. SSF57903. 1 hit.
PROSITEPS51321. TFIIS_CENTRAL. 1 hit.
PS01359. ZF_PHD_1. 1 hit.
PS50016. ZF_PHD_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio975124.

Entry information

Entry nameBYE1_YEAST
AccessionPrimary (citable) accession number: P36106
Secondary accession number(s): D6VXT2
Entry history
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: March 19, 2014
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast chromosome XI

Yeast (Saccharomyces cerevisiae) chromosome XI: entries and gene names

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references