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P36106

- BYE1_YEAST

UniProt

P36106 - BYE1_YEAST

Protein

Transcription factor BYE1

Gene

BYE1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 110 (01 Oct 2014)
      Sequence version 1 (01 Jun 1994)
      Previous versions | rss
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    Functioni

    Negative regulator of transcription elongation.1 Publication

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri72 – 13463PHD-typePROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. chromatin binding Source: SGD
    2. methylated histone binding Source: SGD
    3. zinc ion binding Source: InterPro

    GO - Biological processi

    1. negative regulation of transcription from RNA polymerase II promoter Source: SGD
    2. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Repressor

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    Metal-binding, Zinc

    Enzyme and pathway databases

    BioCyciYEAST:G3O-31815-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Transcription factor BYE1
    Alternative name(s):
    Bypass of ESS1 protein 1
    Gene namesi
    Name:BYE1
    Ordered Locus Names:YKL005C
    ORF Names:YKL150
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome XI

    Organism-specific databases

    CYGDiYKL005c.
    SGDiS000001488. BYE1.

    Subcellular locationi

    Nucleus PROSITE-ProRule annotation

    GO - Cellular componenti

    1. nucleus Source: SGD

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 594594Transcription factor BYE1PRO_0000203191Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei177 – 1771Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiP36106.
    PaxDbiP36106.

    Expressioni

    Gene expression databases

    GenevestigatoriP36106.

    Interactioni

    Subunit structurei

    Interacts with the RNA polymerase RPB1 subunit and specifically with the trimethylated H3 histone H3K4me3.2 Publications

    Protein-protein interaction databases

    BioGridi34128. 16 interactions.
    MINTiMINT-2493828.
    STRINGi4932.YKL005C.

    Structurei

    Secondary structure

    1
    594
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi234 – 25118
    Helixi254 – 2585
    Helixi272 – 28312
    Helixi285 – 2895
    Helixi302 – 31413
    Beta strandi317 – 3193
    Helixi320 – 3278
    Helixi332 – 3365
    Helixi346 – 35914
    Turni360 – 3623

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    4BXXX-ray3.28X225-370[»]
    4BXZX-ray4.80X1-594[»]
    4BY1X-ray3.60X225-370[»]
    4BY7X-ray3.15X225-370[»]
    ProteinModelPortaliP36106.
    SMRiP36106. Positions 232-365.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini254 – 365112TFIIS centralPROSITE-ProRule annotationAdd
    BLAST

    Domaini

    The PHD domain is involved in the binding to H3K4me3.2 Publications

    Sequence similaritiesi

    Belongs to the BYE1 family.Curated
    Contains 1 PHD-type zinc finger.PROSITE-ProRule annotation
    Contains 1 TFIIS central domain.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri72 – 13463PHD-typePROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Zinc-finger

    Phylogenomic databases

    eggNOGiNOG241623.
    HOGENOMiHOG000095286.
    OMAiESHEVIA.
    OrthoDBiEOG754HZ0.

    Family and domain databases

    Gene3Di1.10.472.30. 1 hit.
    3.30.40.10. 1 hit.
    InterProiIPR012921. SPOC_C.
    IPR003618. TFIIS_cen_dom.
    IPR017890. TFS2M.
    IPR019786. Zinc_finger_PHD-type_CS.
    IPR011011. Znf_FYVE_PHD.
    IPR001965. Znf_PHD.
    IPR019787. Znf_PHD-finger.
    IPR013083. Znf_RING/FYVE/PHD.
    [Graphical view]
    PfamiPF00628. PHD. 1 hit.
    PF07744. SPOC. 1 hit.
    PF07500. TFIIS_M. 1 hit.
    [Graphical view]
    SMARTiSM00249. PHD. 1 hit.
    SM00510. TFS2M. 1 hit.
    [Graphical view]
    SUPFAMiSSF46942. SSF46942. 1 hit.
    SSF57903. SSF57903. 1 hit.
    PROSITEiPS51321. TFIIS_CENTRAL. 1 hit.
    PS01359. ZF_PHD_1. 1 hit.
    PS50016. ZF_PHD_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P36106-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSVRTSSRSN KGQNKYIEYL LQEETEAPKK KRTKKKVDSA IEKNKKSDSS    50
    QEPRKDTENV RTDEVDEADE GYVRCLCGAN NENYDAAEYS HGDMVQCDGC 100
    DTWQHIKCMT DGKDTIDGLM SEDSKYYCEL CDPSLYAHLE TSKEAEVSED 150
    EDYHDDVYKP VNDHDDNDAD VFLDEESPRK RKRSPDSAKG IHIKSKQVKK 200
    SNGSKKRNKS IDAAKSDTAE NEMPTRKDFE SEKEHKLRYN AEKMFSTLFS 250
    KFIVPETIEA KLYELPDGKD VISISQEFAH NLEEELYKAC LNVEFGTLDK 300
    IYTEKVRSLY SNLKDKKNLE LKAHVVEGKL PLNKLVNMNA SELANPDLQE 350
    FKEKRDKIIL ENFIVEVPDK PMYVKTHKGD ELIEDIAEPQ EDILYSKDSI 400
    RLHNIDSIDS DKSKIEQTHA ISKEPSPSTI INEESLNCAF LYPGLGLEFT 450
    GYLNYIGASQ KLRRDIFKEA IGDGKLYVEG RLPTTTAAPY LKEISCSRAI 500
    LVYQLFPSND SESKTTFADV VDSLENKGRI AGIKPKTRYE KDFYIVPSKG 550
    GEIPEILKDI LGSHNDERSE RFSRMKSDER TLFAFVVVKQ EFIH 594
    Length:594
    Mass (Da):67,901
    Last modified:June 1, 1994 - v1
    Checksum:i1AE16A20E33F21C9
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z28005 Genomic DNA. Translation: CAA81837.1.
    X61398 Genomic DNA. No translation available.
    S59773 Genomic DNA. Translation: AAC60551.1.
    BK006944 Genomic DNA. Translation: DAA09152.1.
    PIRiS37816.
    RefSeqiNP_012921.3. NM_001179571.3.

    Genome annotation databases

    EnsemblFungiiYKL005C; YKL005C; YKL005C.
    GeneIDi853865.
    KEGGisce:YKL005C.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z28005 Genomic DNA. Translation: CAA81837.1 .
    X61398 Genomic DNA. No translation available.
    S59773 Genomic DNA. Translation: AAC60551.1 .
    BK006944 Genomic DNA. Translation: DAA09152.1 .
    PIRi S37816.
    RefSeqi NP_012921.3. NM_001179571.3.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    4BXX X-ray 3.28 X 225-370 [» ]
    4BXZ X-ray 4.80 X 1-594 [» ]
    4BY1 X-ray 3.60 X 225-370 [» ]
    4BY7 X-ray 3.15 X 225-370 [» ]
    ProteinModelPortali P36106.
    SMRi P36106. Positions 232-365.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 34128. 16 interactions.
    MINTi MINT-2493828.
    STRINGi 4932.YKL005C.

    Proteomic databases

    MaxQBi P36106.
    PaxDbi P36106.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YKL005C ; YKL005C ; YKL005C .
    GeneIDi 853865.
    KEGGi sce:YKL005C.

    Organism-specific databases

    CYGDi YKL005c.
    SGDi S000001488. BYE1.

    Phylogenomic databases

    eggNOGi NOG241623.
    HOGENOMi HOG000095286.
    OMAi ESHEVIA.
    OrthoDBi EOG754HZ0.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-31815-MONOMER.

    Miscellaneous databases

    NextBioi 975124.

    Gene expression databases

    Genevestigatori P36106.

    Family and domain databases

    Gene3Di 1.10.472.30. 1 hit.
    3.30.40.10. 1 hit.
    InterProi IPR012921. SPOC_C.
    IPR003618. TFIIS_cen_dom.
    IPR017890. TFS2M.
    IPR019786. Zinc_finger_PHD-type_CS.
    IPR011011. Znf_FYVE_PHD.
    IPR001965. Znf_PHD.
    IPR019787. Znf_PHD-finger.
    IPR013083. Znf_RING/FYVE/PHD.
    [Graphical view ]
    Pfami PF00628. PHD. 1 hit.
    PF07744. SPOC. 1 hit.
    PF07500. TFIIS_M. 1 hit.
    [Graphical view ]
    SMARTi SM00249. PHD. 1 hit.
    SM00510. TFS2M. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46942. SSF46942. 1 hit.
    SSF57903. SSF57903. 1 hit.
    PROSITEi PS51321. TFIIS_CENTRAL. 1 hit.
    PS01359. ZF_PHD_1. 1 hit.
    PS50016. ZF_PHD_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete DNA sequence of yeast chromosome XI."
      Dujon B., Alexandraki D., Andre B., Ansorge W., Baladron V., Ballesta J.P.G., Banrevi A., Bolle P.-A., Bolotin-Fukuhara M., Bossier P., Bou G., Boyer J., Buitrago M.J., Cheret G., Colleaux L., Daignan-Fornier B., del Rey F., Dion C.
      , Domdey H., Duesterhoeft A., Duesterhus S., Entian K.-D., Erfle H., Esteban P.F., Feldmann H., Fernandes L., Fobo G.M., Fritz C., Fukuhara H., Gabel C., Gaillon L., Garcia-Cantalejo J.M., Garcia-Ramirez J.J., Gent M.E., Ghazvini M., Goffeau A., Gonzalez A., Grothues D., Guerreiro P., Hegemann J.H., Hewitt N., Hilger F., Hollenberg C.P., Horaitis O., Indge K.J., Jacquier A., James C.M., Jauniaux J.-C., Jimenez A., Keuchel H., Kirchrath L., Kleine K., Koetter P., Legrain P., Liebl S., Louis E.J., Maia e Silva A., Marck C., Monnier A.-L., Moestl D., Mueller S., Obermaier B., Oliver S.G., Pallier C., Pascolo S., Pfeiffer F., Philippsen P., Planta R.J., Pohl F.M., Pohl T.M., Poehlmann R., Portetelle D., Purnelle B., Puzos V., Ramezani Rad M., Rasmussen S.W., Remacha M.A., Revuelta J.L., Richard G.-F., Rieger M., Rodrigues-Pousada C., Rose M., Rupp T., Santos M.A., Schwager C., Sensen C., Skala J., Soares H., Sor F., Stegemann J., Tettelin H., Thierry A., Tzermia M., Urrestarazu L.A., van Dyck L., van Vliet-Reedijk J.C., Valens M., Vandenbol M., Vilela C., Vissers S., von Wettstein D., Voss H., Wiemann S., Xu G., Zimmermann J., Haasemann M., Becker I., Mewes H.-W.
      Nature 369:371-378(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    2. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    3. "Sequence of a 7.8 kb segment on the left arm of yeast chromosome XI reveals four open reading frames, including the CAP1 gene, an intron-containing gene and a gene encoding a homolog to the mammalian UOG-1 gene."
      Boyer J., Pascolo S., Richard G.-F., Dujon B.
      Yeast 9:279-287(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 90-594.
    4. "The ESS1 prolyl isomerase and its suppressor BYE1 interact with RNA pol II to inhibit transcription elongation in Saccharomyces cerevisiae."
      Wu X., Rossettini A., Hanes S.D.
      Genetics 165:1687-1702(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, DOMAINS, INTERACTION WITH RPB1.
    5. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
    6. "Proteome-wide analysis in Saccharomyces cerevisiae identifies several PHD fingers as novel direct and selective binding modules of histone H3 methylated at either lysine 4 or lysine 36."
      Shi X., Kachirskaia I., Walter K.L., Kuo J.-H.A., Lake A., Davrazou F., Chan S.M., Martin D.G.E., Fingerman I.M., Briggs S.D., Howe L., Utz P.J., Kutateladze T.G., Lugovskoy A.A., Bedford M.T., Gozani O.
      J. Biol. Chem. 282:2450-2455(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: DOMAIN, INTERACTION WITH H3K4ME3.
    7. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
      Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
      Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-177, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiBYE1_YEAST
    AccessioniPrimary (citable) accession number: P36106
    Secondary accession number(s): D6VXT2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 1, 1994
    Last sequence update: June 1, 1994
    Last modified: October 1, 2014
    This is version 110 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Present with 892 molecules/cell in log phase SD medium.1 Publication

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families
    3. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    4. Yeast chromosome XI
      Yeast (Saccharomyces cerevisiae) chromosome XI: entries and gene names

    External Data

    Dasty 3