Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Transcription factor BYE1

Gene

BYE1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Negative regulator of transcription elongation.1 Publication

Miscellaneous

Present with 892 molecules/cell in log phase SD medium.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri72 – 134PHD-typePROSITE-ProRule annotationAdd BLAST63

GO - Molecular functioni

  • chromatin binding Source: SGD
  • metal ion binding Source: UniProtKB-KW
  • methylated histone binding Source: SGD

GO - Biological processi

  • negative regulation of transcription by RNA polymerase II Source: SGD
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionRepressor
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

BioCyciYEAST:G3O-31815-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor BYE1
Alternative name(s):
Bypass of ESS1 protein 1
Gene namesi
Name:BYE1
Ordered Locus Names:YKL005C
ORF Names:YKL150
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XI

Organism-specific databases

EuPathDBiFungiDB:YKL005C
SGDiS000001488 BYE1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002031911 – 594Transcription factor BYE1Add BLAST594

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei177PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP36106
PaxDbiP36106
PRIDEiP36106

PTM databases

iPTMnetiP36106

Interactioni

Subunit structurei

Interacts with the RNA polymerase RPB1 subunit and specifically with the trimethylated H3 histone H3K4me3.2 Publications

GO - Molecular functioni

  • methylated histone binding Source: SGD

Protein-protein interaction databases

BioGridi34128, 105 interactors
MINTiP36106
STRINGi4932.YKL005C

Structurei

Secondary structure

1594
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi234 – 251Combined sources18
Helixi254 – 258Combined sources5
Helixi272 – 283Combined sources12
Helixi285 – 289Combined sources5
Helixi302 – 314Combined sources13
Beta strandi317 – 319Combined sources3
Helixi320 – 327Combined sources8
Helixi332 – 336Combined sources5
Helixi346 – 359Combined sources14
Turni360 – 362Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4BXXX-ray3.28X225-370[»]
4BXZX-ray4.80X1-594[»]
4BY1X-ray3.60X225-370[»]
4BY7X-ray3.15X225-370[»]
ProteinModelPortaliP36106
SMRiP36106
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini254 – 365TFIIS centralPROSITE-ProRule annotationAdd BLAST112

Domaini

The PHD domain is involved in the binding to H3K4me3.2 Publications

Sequence similaritiesi

Belongs to the BYE1 family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri72 – 134PHD-typePROSITE-ProRule annotationAdd BLAST63

Keywords - Domaini

Zinc-finger

Phylogenomic databases

HOGENOMiHOG000095286
InParanoidiP36106
OMAiHGDMVQC
OrthoDBiEOG092C4I9X

Family and domain databases

Gene3Di1.10.472.30, 1 hit
3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR012921 SPOC_C
IPR003618 TFIIS_cen_dom
IPR036575 TFIIS_cen_dom_sf
IPR019786 Zinc_finger_PHD-type_CS
IPR011011 Znf_FYVE_PHD
IPR001965 Znf_PHD
IPR019787 Znf_PHD-finger
IPR013083 Znf_RING/FYVE/PHD
PfamiView protein in Pfam
PF00628 PHD, 1 hit
PF07744 SPOC, 1 hit
PF07500 TFIIS_M, 1 hit
SMARTiView protein in SMART
SM00249 PHD, 1 hit
SM00510 TFS2M, 1 hit
SUPFAMiSSF46942 SSF46942, 1 hit
SSF57903 SSF57903, 1 hit
PROSITEiView protein in PROSITE
PS51321 TFIIS_CENTRAL, 1 hit
PS01359 ZF_PHD_1, 1 hit
PS50016 ZF_PHD_2, 1 hit

Sequencei

Sequence statusi: Complete.

P36106-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSVRTSSRSN KGQNKYIEYL LQEETEAPKK KRTKKKVDSA IEKNKKSDSS
60 70 80 90 100
QEPRKDTENV RTDEVDEADE GYVRCLCGAN NENYDAAEYS HGDMVQCDGC
110 120 130 140 150
DTWQHIKCMT DGKDTIDGLM SEDSKYYCEL CDPSLYAHLE TSKEAEVSED
160 170 180 190 200
EDYHDDVYKP VNDHDDNDAD VFLDEESPRK RKRSPDSAKG IHIKSKQVKK
210 220 230 240 250
SNGSKKRNKS IDAAKSDTAE NEMPTRKDFE SEKEHKLRYN AEKMFSTLFS
260 270 280 290 300
KFIVPETIEA KLYELPDGKD VISISQEFAH NLEEELYKAC LNVEFGTLDK
310 320 330 340 350
IYTEKVRSLY SNLKDKKNLE LKAHVVEGKL PLNKLVNMNA SELANPDLQE
360 370 380 390 400
FKEKRDKIIL ENFIVEVPDK PMYVKTHKGD ELIEDIAEPQ EDILYSKDSI
410 420 430 440 450
RLHNIDSIDS DKSKIEQTHA ISKEPSPSTI INEESLNCAF LYPGLGLEFT
460 470 480 490 500
GYLNYIGASQ KLRRDIFKEA IGDGKLYVEG RLPTTTAAPY LKEISCSRAI
510 520 530 540 550
LVYQLFPSND SESKTTFADV VDSLENKGRI AGIKPKTRYE KDFYIVPSKG
560 570 580 590
GEIPEILKDI LGSHNDERSE RFSRMKSDER TLFAFVVVKQ EFIH
Length:594
Mass (Da):67,901
Last modified:June 1, 1994 - v1
Checksum:i1AE16A20E33F21C9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z28005 Genomic DNA Translation: CAA81837.1
X61398 Genomic DNA No translation available.
S59773 Genomic DNA Translation: AAC60551.1
BK006944 Genomic DNA Translation: DAA09152.1
PIRiS37816
RefSeqiNP_012921.3, NM_001179571.3

Genome annotation databases

EnsemblFungiiYKL005C; YKL005C; YKL005C
GeneIDi853865
KEGGisce:YKL005C

Similar proteinsi

Entry informationi

Entry nameiBYE1_YEAST
AccessioniPrimary (citable) accession number: P36106
Secondary accession number(s): D6VXT2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: May 23, 2018
This is version 140 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome XI
    Yeast (Saccharomyces cerevisiae) chromosome XI: entries and gene names

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health