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Protein

60S ribosomal protein L14-A

Gene

RPL14A

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • RNA binding Source: SGD
  • structural constituent of ribosome Source: SGD

GO - Biological processi

  • cytoplasmic translation Source: SGD
  • macroautophagy Source: SGD
  • ribosomal large subunit biogenesis Source: GO_Central
  • translation Source: GO_Central
Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Enzyme and pathway databases

BioCyciYEAST:G3O-31816-MONOMER.
ReactomeiR-SCE-156827. L13a-mediated translational silencing of Ceruloplasmin expression.
R-SCE-1799339. SRP-dependent cotranslational protein targeting to membrane.
R-SCE-72689. Formation of a pool of free 40S subunits.
R-SCE-72706. GTP hydrolysis and joining of the 60S ribosomal subunit.
R-SCE-975956. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
R-SCE-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Names & Taxonomyi

Protein namesi
Recommended name:
60S ribosomal protein L14-A
Gene namesi
Name:RPL14A
Ordered Locus Names:YKL006W
ORF Names:YKL153
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XI

Organism-specific databases

EuPathDBiFungiDB:YKL006W.
SGDiS000001489. RPL14A.

Subcellular locationi

GO - Cellular componenti

  • cytosolic large ribosomal subunit Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00001320432 – 13860S ribosomal protein L14-AAdd BLAST137

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserine1 Publication1

Post-translational modificationi

N-terminally acetylated by acetyltransferase NatA.1 Publication

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiP36105.
PRIDEiP36105.

PTM databases

iPTMnetiP36105.

Interactioni

Subunit structurei

Component of the large ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains 32 different proteins (encoded by 56 genes) and 1 molecule of RNA (18S). The 60S subunit contains 46 different proteins (encoded by 81 genes) and 3 molecules of RNA (25S, 5.8S and 5S).1 Publication

Protein-protein interaction databases

BioGridi34127. 170 interactors.
DIPiDIP-8081N.
IntActiP36105. 18 interactors.
MINTiMINT-4492283.

Structurei

Secondary structure

1138
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi19 – 23Combined sources5
Beta strandi25 – 28Combined sources4
Beta strandi32 – 38Combined sources7
Beta strandi40 – 48Combined sources9
Helixi49 – 51Combined sources3
Beta strandi53 – 59Combined sources7
Helixi60 – 62Combined sources3
Beta strandi63 – 69Combined sources7
Helixi78 – 88Combined sources11
Helixi90 – 95Combined sources6
Helixi98 – 111Combined sources14
Helixi114 – 134Combined sources21
Turni135 – 137Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3J6Xelectron microscopy6.10541-138[»]
3J6Yelectron microscopy6.10541-138[»]
3J77electron microscopy6.20641-138[»]
3J78electron microscopy6.30641-138[»]
3JCTelectron microscopy3.08M1-138[»]
4U3MX-ray3.00M4/m42-138[»]
4U3NX-ray3.20M4/m42-138[»]
4U3UX-ray2.90M4/m42-138[»]
4U4NX-ray3.10M4/m42-138[»]
4U4OX-ray3.60M4/m42-138[»]
4U4QX-ray3.00M4/m42-138[»]
4U4RX-ray2.80M4/m42-138[»]
4U4UX-ray3.00M4/m42-138[»]
4U4YX-ray3.20M4/m42-138[»]
4U4ZX-ray3.10M4/m42-138[»]
4U50X-ray3.20M4/m42-138[»]
4U51X-ray3.20M4/m42-138[»]
4U52X-ray3.00M4/m42-138[»]
4U53X-ray3.30M4/m42-138[»]
4U55X-ray3.20M4/m42-138[»]
4U56X-ray3.45M4/m42-138[»]
4U6FX-ray3.10M4/m42-138[»]
4V6Ielectron microscopy8.80BN1-138[»]
4V7Felectron microscopy8.70M1-138[»]
4V7RX-ray4.00BN/DN1-138[»]
4V88X-ray3.00BM/DM1-138[»]
4V8Telectron microscopy8.10M1-138[»]
5APNelectron microscopy3.91M1-138[»]
5APOelectron microscopy3.41M1-138[»]
5DATX-ray3.15M4/m42-138[»]
5DC3X-ray3.25M4/m42-138[»]
5FCIX-ray3.40M4/m42-138[»]
5FCJX-ray3.10M4/m42-138[»]
5FL8electron microscopy9.50M1-138[»]
5GAKelectron microscopy3.88O1-138[»]
5I4LX-ray3.10M4/m42-138[»]
5JUOelectron microscopy4.00R1-138[»]
5JUPelectron microscopy3.50R1-138[»]
5JUSelectron microscopy4.20R1-138[»]
5JUTelectron microscopy4.00R1-138[»]
5JUUelectron microscopy4.00R1-138[»]
ProteinModelPortaliP36105.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ribosomal protein L14e family.Curated

Phylogenomic databases

HOGENOMiHOG000201693.
InParanoidiP36105.
KOiK02875.
OMAiIINQTRV.
OrthoDBiEOG092C5GEN.

Family and domain databases

Gene3Di2.30.30.30. 1 hit.
InterProiIPR014722. Rib_L2_dom2.
IPR002784. Ribosomal_L14e_dom.
IPR008991. Translation_prot_SH3-like.
[Graphical view]
PfamiPF01929. Ribosomal_L14e. 1 hit.
[Graphical view]
SUPFAMiSSF50104. SSF50104. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P36105-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTDSIVKAS NWRLVEVGRV VLIKKGQSAG KLAAIVEIID QKKVLIDGPK
60 70 80 90 100
AGVPRQAINL GQVVLTPLTF ALPRGARTAT VSKKWAAAAV CEKWAASSWA
110 120 130
KKIAQRERRA ALTDFERFQV MVLRKQKRYT VKKALAKA
Length:138
Mass (Da):15,167
Last modified:June 1, 1994 - v1
Checksum:iF8F2A346ABB395BC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X61398 Genomic DNA. No translation available.
Z28006 Genomic DNA. Translation: CAA81839.1.
Z28005 Genomic DNA. Translation: CAA81838.1.
S59773 Genomic DNA. Translation: AAC60550.1.
BK006944 Genomic DNA. Translation: DAA09151.1.
PIRiS30133.
RefSeqiNP_012920.1. NM_001179572.1.

Genome annotation databases

EnsemblFungiiYKL006W; YKL006W; YKL006W.
GeneIDi853864.
KEGGisce:YKL006W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X61398 Genomic DNA. No translation available.
Z28006 Genomic DNA. Translation: CAA81839.1.
Z28005 Genomic DNA. Translation: CAA81838.1.
S59773 Genomic DNA. Translation: AAC60550.1.
BK006944 Genomic DNA. Translation: DAA09151.1.
PIRiS30133.
RefSeqiNP_012920.1. NM_001179572.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3J6Xelectron microscopy6.10541-138[»]
3J6Yelectron microscopy6.10541-138[»]
3J77electron microscopy6.20641-138[»]
3J78electron microscopy6.30641-138[»]
3JCTelectron microscopy3.08M1-138[»]
4U3MX-ray3.00M4/m42-138[»]
4U3NX-ray3.20M4/m42-138[»]
4U3UX-ray2.90M4/m42-138[»]
4U4NX-ray3.10M4/m42-138[»]
4U4OX-ray3.60M4/m42-138[»]
4U4QX-ray3.00M4/m42-138[»]
4U4RX-ray2.80M4/m42-138[»]
4U4UX-ray3.00M4/m42-138[»]
4U4YX-ray3.20M4/m42-138[»]
4U4ZX-ray3.10M4/m42-138[»]
4U50X-ray3.20M4/m42-138[»]
4U51X-ray3.20M4/m42-138[»]
4U52X-ray3.00M4/m42-138[»]
4U53X-ray3.30M4/m42-138[»]
4U55X-ray3.20M4/m42-138[»]
4U56X-ray3.45M4/m42-138[»]
4U6FX-ray3.10M4/m42-138[»]
4V6Ielectron microscopy8.80BN1-138[»]
4V7Felectron microscopy8.70M1-138[»]
4V7RX-ray4.00BN/DN1-138[»]
4V88X-ray3.00BM/DM1-138[»]
4V8Telectron microscopy8.10M1-138[»]
5APNelectron microscopy3.91M1-138[»]
5APOelectron microscopy3.41M1-138[»]
5DATX-ray3.15M4/m42-138[»]
5DC3X-ray3.25M4/m42-138[»]
5FCIX-ray3.40M4/m42-138[»]
5FCJX-ray3.10M4/m42-138[»]
5FL8electron microscopy9.50M1-138[»]
5GAKelectron microscopy3.88O1-138[»]
5I4LX-ray3.10M4/m42-138[»]
5JUOelectron microscopy4.00R1-138[»]
5JUPelectron microscopy3.50R1-138[»]
5JUSelectron microscopy4.20R1-138[»]
5JUTelectron microscopy4.00R1-138[»]
5JUUelectron microscopy4.00R1-138[»]
ProteinModelPortaliP36105.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi34127. 170 interactors.
DIPiDIP-8081N.
IntActiP36105. 18 interactors.
MINTiMINT-4492283.

PTM databases

iPTMnetiP36105.

Proteomic databases

MaxQBiP36105.
PRIDEiP36105.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYKL006W; YKL006W; YKL006W.
GeneIDi853864.
KEGGisce:YKL006W.

Organism-specific databases

EuPathDBiFungiDB:YKL006W.
SGDiS000001489. RPL14A.

Phylogenomic databases

HOGENOMiHOG000201693.
InParanoidiP36105.
KOiK02875.
OMAiIINQTRV.
OrthoDBiEOG092C5GEN.

Enzyme and pathway databases

BioCyciYEAST:G3O-31816-MONOMER.
ReactomeiR-SCE-156827. L13a-mediated translational silencing of Ceruloplasmin expression.
R-SCE-1799339. SRP-dependent cotranslational protein targeting to membrane.
R-SCE-72689. Formation of a pool of free 40S subunits.
R-SCE-72706. GTP hydrolysis and joining of the 60S ribosomal subunit.
R-SCE-975956. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
R-SCE-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Miscellaneous databases

PROiP36105.

Family and domain databases

Gene3Di2.30.30.30. 1 hit.
InterProiIPR014722. Rib_L2_dom2.
IPR002784. Ribosomal_L14e_dom.
IPR008991. Translation_prot_SH3-like.
[Graphical view]
PfamiPF01929. Ribosomal_L14e. 1 hit.
[Graphical view]
SUPFAMiSSF50104. SSF50104. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiRL14A_YEAST
AccessioniPrimary (citable) accession number: P36105
Secondary accession number(s): D6VXT1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: November 30, 2016
This is version 125 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 45300 molecules/cell in log phase SD medium.1 Publication
There are 2 genes for L14 in yeast.

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Ribosomal proteins
    Ribosomal proteins families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families
  4. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  5. Yeast chromosome XI
    Yeast (Saccharomyces cerevisiae) chromosome XI: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.