Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P36105

- RL14A_YEAST

UniProt

P36105 - RL14A_YEAST

Protein

60S ribosomal protein L14-A

Gene

RPL14A

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 102 (01 Oct 2014)
      Sequence version 1 (01 Jun 1994)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    GO - Molecular functioni

    1. RNA binding Source: SGD
    2. structural constituent of ribosome Source: SGD

    GO - Biological processi

    1. cytoplasmic translation Source: SGD

    Keywords - Molecular functioni

    Ribonucleoprotein, Ribosomal protein

    Enzyme and pathway databases

    BioCyciYEAST:G3O-31816-MONOMER.
    ReactomeiREACT_188965. SRP-dependent cotranslational protein targeting to membrane.
    REACT_189050. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
    REACT_189183. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
    REACT_217188. Formation of a pool of free 40S subunits.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    60S ribosomal protein L14-A
    Gene namesi
    Name:RPL14A
    Ordered Locus Names:YKL006W
    ORF Names:YKL153
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome XI

    Organism-specific databases

    CYGDiYKL006w.
    SGDiS000001489. RPL14A.

    Subcellular locationi

    Cytoplasm 1 Publication

    GO - Cellular componenti

    1. cytosolic large ribosomal subunit Source: SGD

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed1 Publication
    Chaini2 – 13813760S ribosomal protein L14-APRO_0000132043Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylserine1 Publication

    Post-translational modificationi

    N-terminally acetylated by acetyltransferase NatA.1 Publication

    Keywords - PTMi

    Acetylation

    Proteomic databases

    MaxQBiP36105.
    PeptideAtlasiP36105.

    Expressioni

    Gene expression databases

    GenevestigatoriP36105.

    Interactioni

    Subunit structurei

    Component of the large ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains 32 different proteins (encoded by 56 genes) and 1 molecule of RNA (18S). The 60S subunit contains 46 different proteins (encoded by 81 genes) and 3 molecules of RNA (25S, 5.8S and 5S).1 Publication

    Protein-protein interaction databases

    BioGridi34127. 166 interactions.
    IntActiP36105. 18 interactions.
    MINTiMINT-4492283.
    STRINGi4932.YKL006W.

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1VW8electron microscopy6.10N1-138[»]
    1VWUelectron microscopy6.10N1-138[»]
    3IZSelectron microscopy-N1-138[»]
    3J65electron microscopy8.70M1-138[»]
    3O58X-ray4.00N1-138[»]
    3O5HX-ray4.00N1-138[»]
    3U5EX-ray3.00M1-138[»]
    3U5IX-ray3.00M1-138[»]
    4B6Aelectron microscopy8.10M1-138[»]
    ProteinModelPortaliP36105.
    SMRiP36105. Positions 2-138.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ribosomal protein L14e family.Curated

    Phylogenomic databases

    GeneTreeiENSGT00390000007888.
    HOGENOMiHOG000201693.
    KOiK02875.
    OMAiAVCEKWA.
    OrthoDBiEOG7GFBHZ.

    Family and domain databases

    Gene3Di2.30.30.30. 1 hit.
    InterProiIPR014722. Rib_L2_dom2.
    IPR002784. Ribosomal_L14.
    IPR008991. Translation_prot_SH3-like.
    [Graphical view]
    PfamiPF01929. Ribosomal_L14e. 1 hit.
    [Graphical view]
    SUPFAMiSSF50104. SSF50104. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P36105-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSTDSIVKAS NWRLVEVGRV VLIKKGQSAG KLAAIVEIID QKKVLIDGPK    50
    AGVPRQAINL GQVVLTPLTF ALPRGARTAT VSKKWAAAAV CEKWAASSWA 100
    KKIAQRERRA ALTDFERFQV MVLRKQKRYT VKKALAKA 138
    Length:138
    Mass (Da):15,167
    Last modified:June 1, 1994 - v1
    Checksum:iF8F2A346ABB395BC
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X61398 Genomic DNA. No translation available.
    Z28006 Genomic DNA. Translation: CAA81839.1.
    Z28005 Genomic DNA. Translation: CAA81838.1.
    S59773 Genomic DNA. Translation: AAC60550.1.
    BK006944 Genomic DNA. Translation: DAA09151.1.
    PIRiS30133.
    RefSeqiNP_012920.1. NM_001179572.1.

    Genome annotation databases

    EnsemblFungiiYKL006W; YKL006W; YKL006W.
    GeneIDi853864.
    KEGGisce:YKL006W.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X61398 Genomic DNA. No translation available.
    Z28006 Genomic DNA. Translation: CAA81839.1 .
    Z28005 Genomic DNA. Translation: CAA81838.1 .
    S59773 Genomic DNA. Translation: AAC60550.1 .
    BK006944 Genomic DNA. Translation: DAA09151.1 .
    PIRi S30133.
    RefSeqi NP_012920.1. NM_001179572.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1VW8 electron microscopy 6.10 N 1-138 [» ]
    1VWU electron microscopy 6.10 N 1-138 [» ]
    3IZS electron microscopy - N 1-138 [» ]
    3J65 electron microscopy 8.70 M 1-138 [» ]
    3O58 X-ray 4.00 N 1-138 [» ]
    3O5H X-ray 4.00 N 1-138 [» ]
    3U5E X-ray 3.00 M 1-138 [» ]
    3U5I X-ray 3.00 M 1-138 [» ]
    4B6A electron microscopy 8.10 M 1-138 [» ]
    ProteinModelPortali P36105.
    SMRi P36105. Positions 2-138.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 34127. 166 interactions.
    IntActi P36105. 18 interactions.
    MINTi MINT-4492283.
    STRINGi 4932.YKL006W.

    Proteomic databases

    MaxQBi P36105.
    PeptideAtlasi P36105.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YKL006W ; YKL006W ; YKL006W .
    GeneIDi 853864.
    KEGGi sce:YKL006W.

    Organism-specific databases

    CYGDi YKL006w.
    SGDi S000001489. RPL14A.

    Phylogenomic databases

    GeneTreei ENSGT00390000007888.
    HOGENOMi HOG000201693.
    KOi K02875.
    OMAi AVCEKWA.
    OrthoDBi EOG7GFBHZ.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-31816-MONOMER.
    Reactomei REACT_188965. SRP-dependent cotranslational protein targeting to membrane.
    REACT_189050. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
    REACT_189183. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
    REACT_217188. Formation of a pool of free 40S subunits.

    Miscellaneous databases

    NextBioi 975121.

    Gene expression databases

    Genevestigatori P36105.

    Family and domain databases

    Gene3Di 2.30.30.30. 1 hit.
    InterProi IPR014722. Rib_L2_dom2.
    IPR002784. Ribosomal_L14.
    IPR008991. Translation_prot_SH3-like.
    [Graphical view ]
    Pfami PF01929. Ribosomal_L14e. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50104. SSF50104. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Sequence of a 7.8 kb segment on the left arm of yeast chromosome XI reveals four open reading frames, including the CAP1 gene, an intron-containing gene and a gene encoding a homolog to the mammalian UOG-1 gene."
      Boyer J., Pascolo S., Richard G.-F., Dujon B.
      Yeast 9:279-287(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "Complete DNA sequence of yeast chromosome XI."
      Dujon B., Alexandraki D., Andre B., Ansorge W., Baladron V., Ballesta J.P.G., Banrevi A., Bolle P.-A., Bolotin-Fukuhara M., Bossier P., Bou G., Boyer J., Buitrago M.J., Cheret G., Colleaux L., Daignan-Fornier B., del Rey F., Dion C.
      , Domdey H., Duesterhoeft A., Duesterhus S., Entian K.-D., Erfle H., Esteban P.F., Feldmann H., Fernandes L., Fobo G.M., Fritz C., Fukuhara H., Gabel C., Gaillon L., Garcia-Cantalejo J.M., Garcia-Ramirez J.J., Gent M.E., Ghazvini M., Goffeau A., Gonzalez A., Grothues D., Guerreiro P., Hegemann J.H., Hewitt N., Hilger F., Hollenberg C.P., Horaitis O., Indge K.J., Jacquier A., James C.M., Jauniaux J.-C., Jimenez A., Keuchel H., Kirchrath L., Kleine K., Koetter P., Legrain P., Liebl S., Louis E.J., Maia e Silva A., Marck C., Monnier A.-L., Moestl D., Mueller S., Obermaier B., Oliver S.G., Pallier C., Pascolo S., Pfeiffer F., Philippsen P., Planta R.J., Pohl F.M., Pohl T.M., Poehlmann R., Portetelle D., Purnelle B., Puzos V., Ramezani Rad M., Rasmussen S.W., Remacha M.A., Revuelta J.L., Richard G.-F., Rieger M., Rodrigues-Pousada C., Rose M., Rupp T., Santos M.A., Schwager C., Sensen C., Skala J., Soares H., Sor F., Stegemann J., Tettelin H., Thierry A., Tzermia M., Urrestarazu L.A., van Dyck L., van Vliet-Reedijk J.C., Valens M., Vandenbol M., Vilela C., Vissers S., von Wettstein D., Voss H., Wiemann S., Xu G., Zimmermann J., Haasemann M., Becker I., Mewes H.-W.
      Nature 369:371-378(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    3. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    4. "The list of cytoplasmic ribosomal proteins of Saccharomyces cerevisiae."
      Planta R.J., Mager W.H.
      Yeast 14:471-477(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NOMENCLATURE, SUBUNIT.
    5. "The action of N-terminal acetyltransferases on yeast ribosomal proteins."
      Arnold R.J., Polevoda B., Reilly J.P., Sherman F.
      J. Biol. Chem. 274:37035-37040(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: CLEAVAGE OF INITIATOR METHIONINE, ACETYLATION AT SER-2 BY NATA.
    6. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
    7. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
    8. "Crystal structure of the eukaryotic ribosome."
      Ben-Shem A., Jenner L., Yusupova G., Yusupov M.
      Science 330:1203-1209(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (4.0 ANGSTROMS) OF 80S RIBOSOME.
    9. Cited for: X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS) OF 80S RIBOSOME.

    Entry informationi

    Entry nameiRL14A_YEAST
    AccessioniPrimary (citable) accession number: P36105
    Secondary accession number(s): D6VXT1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 1, 1994
    Last sequence update: June 1, 1994
    Last modified: October 1, 2014
    This is version 102 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Present with 45300 molecules/cell in log phase SD medium.1 Publication
    There are 2 genes for L14 in yeast.

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. Ribosomal proteins
      Ribosomal proteins families and list of entries
    3. SIMILARITY comments
      Index of protein domains and families
    4. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    5. Yeast chromosome XI
      Yeast (Saccharomyces cerevisiae) chromosome XI: entries and gene names

    External Data

    Dasty 3