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P36105

- RL14A_YEAST

UniProt

P36105 - RL14A_YEAST

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Protein
60S ribosomal protein L14-A
Gene
RPL14A, YKL006W, YKL153
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. RNA binding Source: SGD
  2. structural constituent of ribosome Source: SGD
Complete GO annotation...

GO - Biological processi

  1. cytoplasmic translation Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Enzyme and pathway databases

BioCyciYEAST:G3O-31816-MONOMER.
ReactomeiREACT_188965. SRP-dependent cotranslational protein targeting to membrane.
REACT_189050. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
REACT_189183. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
REACT_217188. Formation of a pool of free 40S subunits.

Names & Taxonomyi

Protein namesi
Recommended name:
60S ribosomal protein L14-A
Gene namesi
Name:RPL14A
Ordered Locus Names:YKL006W
ORF Names:YKL153
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome XI

Organism-specific databases

CYGDiYKL006w.
SGDiS000001489. RPL14A.

Subcellular locationi

Cytoplasm 1 Publication

GO - Cellular componenti

  1. cytosolic large ribosomal subunit Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed1 Publication
Chaini2 – 13813760S ribosomal protein L14-A
PRO_0000132043Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserine1 Publication

Post-translational modificationi

N-terminally acetylated by acetyltransferase NatA.1 Publication

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiP36105.
PeptideAtlasiP36105.

Expressioni

Gene expression databases

GenevestigatoriP36105.

Interactioni

Subunit structurei

Component of the large ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains 32 different proteins (encoded by 56 genes) and 1 molecule of RNA (18S). The 60S subunit contains 46 different proteins (encoded by 81 genes) and 3 molecules of RNA (25S, 5.8S and 5S).1 Publication

Protein-protein interaction databases

BioGridi34127. 166 interactions.
IntActiP36105. 18 interactions.
MINTiMINT-4492283.
STRINGi4932.YKL006W.

Structurei

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1VW8electron microscopy6.10N1-138[»]
1VWUelectron microscopy6.10N1-138[»]
3IZSelectron microscopy-N1-138[»]
3J65electron microscopy8.70M1-138[»]
3O58X-ray4.00N1-138[»]
3O5HX-ray4.00N1-138[»]
3U5EX-ray3.00M1-138[»]
3U5IX-ray3.00M1-138[»]
4B6Aelectron microscopy8.10M1-138[»]
ProteinModelPortaliP36105.
SMRiP36105. Positions 2-138.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

GeneTreeiENSGT00390000007888.
HOGENOMiHOG000201693.
KOiK02875.
OMAiAVCEKWA.
OrthoDBiEOG7GFBHZ.

Family and domain databases

Gene3Di2.30.30.30. 1 hit.
InterProiIPR014722. Rib_L2_dom2.
IPR002784. Ribosomal_L14.
IPR008991. Translation_prot_SH3-like.
[Graphical view]
PfamiPF01929. Ribosomal_L14e. 1 hit.
[Graphical view]
SUPFAMiSSF50104. SSF50104. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P36105-1 [UniParc]FASTAAdd to Basket

« Hide

MSTDSIVKAS NWRLVEVGRV VLIKKGQSAG KLAAIVEIID QKKVLIDGPK    50
AGVPRQAINL GQVVLTPLTF ALPRGARTAT VSKKWAAAAV CEKWAASSWA 100
KKIAQRERRA ALTDFERFQV MVLRKQKRYT VKKALAKA 138
Length:138
Mass (Da):15,167
Last modified:June 1, 1994 - v1
Checksum:iF8F2A346ABB395BC
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X61398 Genomic DNA. No translation available.
Z28006 Genomic DNA. Translation: CAA81839.1.
Z28005 Genomic DNA. Translation: CAA81838.1.
S59773 Genomic DNA. Translation: AAC60550.1.
BK006944 Genomic DNA. Translation: DAA09151.1.
PIRiS30133.
RefSeqiNP_012920.1. NM_001179572.1.

Genome annotation databases

EnsemblFungiiYKL006W; YKL006W; YKL006W.
GeneIDi853864.
KEGGisce:YKL006W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X61398 Genomic DNA. No translation available.
Z28006 Genomic DNA. Translation: CAA81839.1 .
Z28005 Genomic DNA. Translation: CAA81838.1 .
S59773 Genomic DNA. Translation: AAC60550.1 .
BK006944 Genomic DNA. Translation: DAA09151.1 .
PIRi S30133.
RefSeqi NP_012920.1. NM_001179572.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1VW8 electron microscopy 6.10 N 1-138 [» ]
1VWU electron microscopy 6.10 N 1-138 [» ]
3IZS electron microscopy - N 1-138 [» ]
3J65 electron microscopy 8.70 M 1-138 [» ]
3O58 X-ray 4.00 N 1-138 [» ]
3O5H X-ray 4.00 N 1-138 [» ]
3U5E X-ray 3.00 M 1-138 [» ]
3U5I X-ray 3.00 M 1-138 [» ]
4B6A electron microscopy 8.10 M 1-138 [» ]
ProteinModelPortali P36105.
SMRi P36105. Positions 2-138.
ModBasei Search...

Protein-protein interaction databases

BioGridi 34127. 166 interactions.
IntActi P36105. 18 interactions.
MINTi MINT-4492283.
STRINGi 4932.YKL006W.

Proteomic databases

MaxQBi P36105.
PeptideAtlasi P36105.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YKL006W ; YKL006W ; YKL006W .
GeneIDi 853864.
KEGGi sce:YKL006W.

Organism-specific databases

CYGDi YKL006w.
SGDi S000001489. RPL14A.

Phylogenomic databases

GeneTreei ENSGT00390000007888.
HOGENOMi HOG000201693.
KOi K02875.
OMAi AVCEKWA.
OrthoDBi EOG7GFBHZ.

Enzyme and pathway databases

BioCyci YEAST:G3O-31816-MONOMER.
Reactomei REACT_188965. SRP-dependent cotranslational protein targeting to membrane.
REACT_189050. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
REACT_189183. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
REACT_217188. Formation of a pool of free 40S subunits.

Miscellaneous databases

NextBioi 975121.

Gene expression databases

Genevestigatori P36105.

Family and domain databases

Gene3Di 2.30.30.30. 1 hit.
InterProi IPR014722. Rib_L2_dom2.
IPR002784. Ribosomal_L14.
IPR008991. Translation_prot_SH3-like.
[Graphical view ]
Pfami PF01929. Ribosomal_L14e. 1 hit.
[Graphical view ]
SUPFAMi SSF50104. SSF50104. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence of a 7.8 kb segment on the left arm of yeast chromosome XI reveals four open reading frames, including the CAP1 gene, an intron-containing gene and a gene encoding a homolog to the mammalian UOG-1 gene."
    Boyer J., Pascolo S., Richard G.-F., Dujon B.
    Yeast 9:279-287(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Complete DNA sequence of yeast chromosome XI."
    Dujon B., Alexandraki D., Andre B., Ansorge W., Baladron V., Ballesta J.P.G., Banrevi A., Bolle P.-A., Bolotin-Fukuhara M., Bossier P., Bou G., Boyer J., Buitrago M.J., Cheret G., Colleaux L., Daignan-Fornier B., del Rey F., Dion C.
    , Domdey H., Duesterhoeft A., Duesterhus S., Entian K.-D., Erfle H., Esteban P.F., Feldmann H., Fernandes L., Fobo G.M., Fritz C., Fukuhara H., Gabel C., Gaillon L., Garcia-Cantalejo J.M., Garcia-Ramirez J.J., Gent M.E., Ghazvini M., Goffeau A., Gonzalez A., Grothues D., Guerreiro P., Hegemann J.H., Hewitt N., Hilger F., Hollenberg C.P., Horaitis O., Indge K.J., Jacquier A., James C.M., Jauniaux J.-C., Jimenez A., Keuchel H., Kirchrath L., Kleine K., Koetter P., Legrain P., Liebl S., Louis E.J., Maia e Silva A., Marck C., Monnier A.-L., Moestl D., Mueller S., Obermaier B., Oliver S.G., Pallier C., Pascolo S., Pfeiffer F., Philippsen P., Planta R.J., Pohl F.M., Pohl T.M., Poehlmann R., Portetelle D., Purnelle B., Puzos V., Ramezani Rad M., Rasmussen S.W., Remacha M.A., Revuelta J.L., Richard G.-F., Rieger M., Rodrigues-Pousada C., Rose M., Rupp T., Santos M.A., Schwager C., Sensen C., Skala J., Soares H., Sor F., Stegemann J., Tettelin H., Thierry A., Tzermia M., Urrestarazu L.A., van Dyck L., van Vliet-Reedijk J.C., Valens M., Vandenbol M., Vilela C., Vissers S., von Wettstein D., Voss H., Wiemann S., Xu G., Zimmermann J., Haasemann M., Becker I., Mewes H.-W.
    Nature 369:371-378(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  4. "The list of cytoplasmic ribosomal proteins of Saccharomyces cerevisiae."
    Planta R.J., Mager W.H.
    Yeast 14:471-477(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NOMENCLATURE, SUBUNIT.
  5. "The action of N-terminal acetyltransferases on yeast ribosomal proteins."
    Arnold R.J., Polevoda B., Reilly J.P., Sherman F.
    J. Biol. Chem. 274:37035-37040(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: CLEAVAGE OF INITIATOR METHIONINE, ACETYLATION AT SER-2 BY NATA.
  6. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
  7. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  8. "Crystal structure of the eukaryotic ribosome."
    Ben-Shem A., Jenner L., Yusupova G., Yusupov M.
    Science 330:1203-1209(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (4.0 ANGSTROMS) OF 80S RIBOSOME.
  9. Cited for: X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS) OF 80S RIBOSOME.

Entry informationi

Entry nameiRL14A_YEAST
AccessioniPrimary (citable) accession number: P36105
Secondary accession number(s): D6VXT1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: September 3, 2014
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 45300 molecules/cell in log phase SD medium.
There are 2 genes for L14 in yeast.

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Ribosomal proteins
    Ribosomal proteins families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families
  4. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  5. Yeast chromosome XI
    Yeast (Saccharomyces cerevisiae) chromosome XI: entries and gene names

External Data

Dasty 3

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