P36093 (PHD1_YEAST) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Putative transcription factor PHD1

Gene names

Name:	PHD1
Ordered Locus Names:	YKL043W
ORF Names:	YKL256

Organism

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]

Taxonomic identifier

559292 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › Saccharomyces cerevisiae

Protein attributes

Sequence length	366 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Putative transcription factor that functions in pseudohyphal growth.
Subcellular location	Nucleus.
Miscellaneous	Present with 1420 molecules/cell in log phase SD medium.
Sequence similarities	Belongs to the EFG1/PHD1/stuA family. Contains 1 HTH APSES-type DNA-binding domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Ligand	DNA-binding
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	positive regulation of transcription from RNA polymerase II promoter Inferred from mutant phenotype Ref.1. Source: SGD pseudohyphal growth Inferred from mutant phenotype Ref.1. Source: SGD transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	nucleus Inferred from direct assay Ref.1. Source: SGD
Molecular_function	sequence-specific DNA binding Inferred from direct assay PubMed 19111667PubMed 19158363. Source: SGD sequence-specific DNA binding transcription factor activity Inferred from mutant phenotype PubMed 16449570. Source: SGD
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 366	366	Putative transcription factor PHD1		PRO_0000058377
Regions
	Domain	186 – 292	107	HTH APSES-type
	DNA binding	220 – 241	22	H-T-H motif By similarity

Sequences

	Sequence		Length	Mass (Da)
	P36093 [UniParc]. Last modified June 1, 1994. Version 1. Checksum: 22B6FA0D505D8654	FASTA	366	40,646
	10 20 30 40 50 60 MYHVPEMRLH YPLVNTQSNA AITPTRSYDN TLPSFNELSH QSTINLPFVQ RETPNAYANV 70 80 90 100 110 120 AQLATSPTQA KSGYYCRYYA VPFPTYPQQP QSPYQQAVLP YATIPNSNFQ PSSFPVMAVM 130 140 150 160 170 180 PPEVQFDGSF LNTLHPHTEL PPIIQNTNDT SVARPNNLKS IAAASPTVTA TTRTPGVSST 190 200 210 220 230 240 SVLKPRVITT MWEDENTICY QVEANGISVV RRADNNMING TKLLNVTKMT RGRRDGILRS 250 260 270 280 290 300 EKVREVVKIG SMHLKGVWIP FERAYILAQR EQILDHLYPL FVKDIESIVD ARKPSNKASL 310 320 330 340 350 360 TPKSSPAPIK QEPSDNKHEI ATEIKPKSID ALSNGASTQG AGELPHLKIN HIDTEAQTSR AKNELS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Induction of pseudohyphal growth by overexpression of PHD1, a Saccharomyces cerevisiae gene related to transcriptional regulators of fungal development." Gimeno C.J., Fink G.R. Mol. Cell. Biol. 14:2100-2112(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: S288c / YPH1.
[2]	"The sequence of a 17.5 kb DNA fragment on the left arm of yeast chromosome XI identifies the protein kinase gene ELM1, the DNA primase gene PRI2, a new gene encoding a putative histone and seven new open reading frames." Purnelle B., Tettelin H., van Dyck L., Skala J., Goffeau A. Yeast 9:1379-1384(1993) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 204508 / S288c.
[3]	"Complete DNA sequence of yeast chromosome XI." Dujon B., Alexandraki D., Andre B., Ansorge W., Baladron V., Ballesta J.P.G., Banrevi A., Bolle P.-A., Bolotin-Fukuhara M., Bossier P., Bou G., Boyer J., Buitrago M.J., Cheret G., Colleaux L., Daignan-Fornier B., del Rey F., Dion C. , Domdey H., Duesterhoeft A., Duesterhus S., Entian K.-D., Erfle H., Esteban P.F., Feldmann H., Fernandes L., Fobo G.M., Fritz C., Fukuhara H., Gabel C., Gaillon L., Garcia-Cantalejo J.M., Garcia-Ramirez J.J., Gent M.E., Ghazvini M., Goffeau A., Gonzalez A., Grothues D., Guerreiro P., Hegemann J.H., Hewitt N., Hilger F., Hollenberg C.P., Horaitis O., Indge K.J., Jacquier A., James C.M., Jauniaux J.-C., Jimenez A., Keuchel H., Kirchrath L., Kleine K., Koetter P., Legrain P., Liebl S., Louis E.J., Maia e Silva A., Marck C., Monnier A.-L., Moestl D., Mueller S., Obermaier B., Oliver S.G., Pallier C., Pascolo S., Pfeiffer F., Philippsen P., Planta R.J., Pohl F.M., Pohl T.M., Poehlmann R., Portetelle D., Purnelle B., Puzos V., Ramezani Rad M., Rasmussen S.W., Remacha M.A., Revuelta J.L., Richard G.-F., Rieger M., Rodrigues-Pousada C., Rose M., Rupp T., Santos M.A., Schwager C., Sensen C., Skala J., Soares H., Sor F., Stegemann J., Tettelin H., Thierry A., Tzermia M., Urrestarazu L.A., van Dyck L., van Vliet-Reedijk J.C., Valens M., Vandenbol M., Vilela C., Vissers S., von Wettstein D., Voss H., Wiemann S., Xu G., Zimmermann J., Haasemann M., Becker I., Mewes H.-W. Nature 369:371-378(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 204508 / S288c.
[4]	Saccharomyces Genome Database Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: ATCC 204508 / S288c.
[5]	"Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae." Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F., Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J., Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J. , Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D., LaBaer J. Genome Res. 17:536-543(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 204508 / S288c.
[6]	"Population structure of the wine yeast Saccharomyces cerevisiae." Townsend J.P., Aa E., Taylor J.W. Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 76625 / YPH499, YPS396, YPS400, YPS598, YPS600, YPS602, YPS604, YPS606, YPS608 and YPS610.
[7]	"Global analysis of protein expression in yeast." Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S. Nature 425:737-741(2003) [PubMed] [Europe PMC] [Abstract] Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U05241 Unassigned DNA. Translation: AAA18358.1. X71621 Genomic DNA. Translation: CAA50629.1. Z28043 Genomic DNA. Translation: CAA81878.1. AY557923 Genomic DNA. Translation: AAS56249.1. AY949939 Genomic DNA. Translation: AAY27341.1. AY949940 Genomic DNA. Translation: AAY27342.1. AY949941 Genomic DNA. Translation: AAY27343.1. AY949942 Genomic DNA. Translation: AAY27344.1. AY949943 Genomic DNA. Translation: AAY27345.1. AY949944 Genomic DNA. Translation: AAY27346.1. AY949945 Genomic DNA. Translation: AAY27347.1. AY949946 Genomic DNA. Translation: AAY27348.1. AY949947 Genomic DNA. Translation: AAY27349.1. AY949948 Genomic DNA. Translation: AAY27350.1. BK006944 Genomic DNA. Translation: DAA09113.1.
PIR	S37864.
RefSeq	NP_012881.1. NM_001179609.1.
3D structure databases
ProteinModelPortal	P36093.
SMR	P36093. Positions 186-281.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-4868N.
IntAct	P36093. 2 interactions.
MINT	MINT-495993.
Proteomic databases
PaxDb	P36093.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	YKL043W; YKL043W; YKL043W.
GeneID	853823.
KEGG	sce:YKL043W.
Organism-specific databases
CYGD	YKL043w.
SGD	S000001526. PHD1.
Phylogenomic databases
eggNOG	NOG41372.
GeneTree	ENSGT00530000067611.
OrthoDB	EOG4D565W.
Gene expression databases
ArrayExpress	P36093.
Genevestigator	P36093.
GermOnline	YKL043W. Saccharomyces cerevisiae.
Family and domain databases
Gene3D	3.10.260.10. 1 hit.
InterPro	IPR018004. KilA_N/APSES_HTH. IPR003163. Tscrpt_reg_HTH_APSES-type. [Graphical view]
Pfam	PF04383. KilA-N. 1 hit. [Graphical view]
SUPFAM	SSF54616. Mlu1-box-bd_prot_DNA-bd. 1 hit.
PROSITE	PS51299. HTH_APSES. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	975008.

Entry information

Entry name

PHD1_YEAST

Accession

Primary (citable) accession number: P36093
Secondary accession number(s): D6VXP3, Q2VQ88

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 1, 1994
Last sequence update:	June 1, 1994
Last modified:	May 1, 2013
This is version 99 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program