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P36078

- HOT13_YEAST

UniProt

P36078 - HOT13_YEAST

Protein

Helper of Tim protein 13

Gene

HOT13

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Required for the assembly or recycling of the small Tim proteins in the mitochondrial intermembrane, thereby participating in the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. Probably acts by facilitating the formation of disulfide bonds in small Tim proteins.1 Publication

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri10 – 9485CHY-typePROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. zinc ion binding Source: SGD

    GO - Biological processi

    1. protein import into mitochondrial intermembrane space Source: SGD

    Keywords - Biological processi

    Protein transport, Translocation, Transport

    Keywords - Ligandi

    Metal-binding, Zinc

    Enzyme and pathway databases

    BioCyciYEAST:G3O-31878-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Helper of Tim protein 13
    Gene namesi
    Name:HOT13
    Ordered Locus Names:YKL084W
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome XI

    Organism-specific databases

    CYGDiYKL084w.
    SGDiS000001567. HOT13.

    Subcellular locationi

    Mitochondrion intermembrane space 1 Publication. Mitochondrion membrane 1 Publication; Peripheral membrane protein 1 Publication

    GO - Cellular componenti

    1. mitochondrial intermembrane space Source: SGD
    2. mitochondrial membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Membrane, Mitochondrion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 116116Helper of Tim protein 13PRO_0000203165Add
    BLAST

    Proteomic databases

    MaxQBiP36078.
    PaxDbiP36078.

    Expressioni

    Gene expression databases

    GenevestigatoriP36078.

    Interactioni

    Subunit structurei

    Interacts with the small Tim proteins TIM8, TIM9, TIM10, TIM12, and TIM13.

    Protein-protein interaction databases

    BioGridi34049. 3 interactions.
    IntActiP36078. 2 interactions.
    STRINGi4932.YKL084W.

    Structurei

    3D structure databases

    ProteinModelPortaliP36078.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Contains 1 CHY-type zinc finger.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri10 – 9485CHY-typePROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Zinc-finger

    Phylogenomic databases

    eggNOGiCOG4357.
    HOGENOMiHOG000235148.
    OMAiCHRCHEE.
    OrthoDBiEOG7V4BBM.

    Family and domain databases

    InterProiIPR016694. UCP017292.
    IPR008913. Znf_CHY.
    [Graphical view]
    PfamiPF05495. zf-CHY. 1 hit.
    [Graphical view]
    PIRSFiPIRSF017292. UCP017292_Znf_CHY. 1 hit.
    PROSITEiPS51266. ZF_CHY. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P36078-1 [UniParc]FASTAAdd to Basket

    « Hide

    MIETAIYGKT VDDQSRCVHW HLPKDVIAIR FKCCDKYYAC FECHQELSSH    50
    PLEKYDLLDD ANKHLIICGV CRHEMTFAEY YDYNSNLICP NCRSPFNPGC 100
    KLHYHLYFQN PPPAMC 116
    Length:116
    Mass (Da):13,641
    Last modified:June 1, 1994 - v1
    Checksum:i57464E5FD9A591F8
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti71 – 711C → R in AAS56591. (PubMed:17322287)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z28084 Genomic DNA. Translation: CAA81922.1.
    AY558265 Genomic DNA. Translation: AAS56591.1.
    BK006944 Genomic DNA. Translation: DAA09074.1.
    PIRiS37909.
    RefSeqiNP_012839.1. NM_001179650.1.

    Genome annotation databases

    EnsemblFungiiYKL084W; YKL084W; YKL084W.
    GeneIDi853778.
    KEGGisce:YKL084W.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z28084 Genomic DNA. Translation: CAA81922.1 .
    AY558265 Genomic DNA. Translation: AAS56591.1 .
    BK006944 Genomic DNA. Translation: DAA09074.1 .
    PIRi S37909.
    RefSeqi NP_012839.1. NM_001179650.1.

    3D structure databases

    ProteinModelPortali P36078.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 34049. 3 interactions.
    IntActi P36078. 2 interactions.
    STRINGi 4932.YKL084W.

    Proteomic databases

    MaxQBi P36078.
    PaxDbi P36078.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YKL084W ; YKL084W ; YKL084W .
    GeneIDi 853778.
    KEGGi sce:YKL084W.

    Organism-specific databases

    CYGDi YKL084w.
    SGDi S000001567. HOT13.

    Phylogenomic databases

    eggNOGi COG4357.
    HOGENOMi HOG000235148.
    OMAi CHRCHEE.
    OrthoDBi EOG7V4BBM.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-31878-MONOMER.

    Miscellaneous databases

    NextBioi 974891.

    Gene expression databases

    Genevestigatori P36078.

    Family and domain databases

    InterProi IPR016694. UCP017292.
    IPR008913. Znf_CHY.
    [Graphical view ]
    Pfami PF05495. zf-CHY. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF017292. UCP017292_Znf_CHY. 1 hit.
    PROSITEi PS51266. ZF_CHY. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete DNA sequence of yeast chromosome XI."
      Dujon B., Alexandraki D., Andre B., Ansorge W., Baladron V., Ballesta J.P.G., Banrevi A., Bolle P.-A., Bolotin-Fukuhara M., Bossier P., Bou G., Boyer J., Buitrago M.J., Cheret G., Colleaux L., Daignan-Fornier B., del Rey F., Dion C.
      , Domdey H., Duesterhoeft A., Duesterhus S., Entian K.-D., Erfle H., Esteban P.F., Feldmann H., Fernandes L., Fobo G.M., Fritz C., Fukuhara H., Gabel C., Gaillon L., Garcia-Cantalejo J.M., Garcia-Ramirez J.J., Gent M.E., Ghazvini M., Goffeau A., Gonzalez A., Grothues D., Guerreiro P., Hegemann J.H., Hewitt N., Hilger F., Hollenberg C.P., Horaitis O., Indge K.J., Jacquier A., James C.M., Jauniaux J.-C., Jimenez A., Keuchel H., Kirchrath L., Kleine K., Koetter P., Legrain P., Liebl S., Louis E.J., Maia e Silva A., Marck C., Monnier A.-L., Moestl D., Mueller S., Obermaier B., Oliver S.G., Pallier C., Pascolo S., Pfeiffer F., Philippsen P., Planta R.J., Pohl F.M., Pohl T.M., Poehlmann R., Portetelle D., Purnelle B., Puzos V., Ramezani Rad M., Rasmussen S.W., Remacha M.A., Revuelta J.L., Richard G.-F., Rieger M., Rodrigues-Pousada C., Rose M., Rupp T., Santos M.A., Schwager C., Sensen C., Skala J., Soares H., Sor F., Stegemann J., Tettelin H., Thierry A., Tzermia M., Urrestarazu L.A., van Dyck L., van Vliet-Reedijk J.C., Valens M., Vandenbol M., Vilela C., Vissers S., von Wettstein D., Voss H., Wiemann S., Xu G., Zimmermann J., Haasemann M., Becker I., Mewes H.-W.
      Nature 369:371-378(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    2. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    3. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    4. "The role of Hot13p and redox chemistry in the mitochondrial TIM22 import pathway."
      Curran S.P., Leuenberger D., Leverich E.P., Hwang D.K., Beverly K.N., Koehler C.M.
      J. Biol. Chem. 279:43744-43751(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY, FUNCTION, SUBCELLULAR LOCATION.
    5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiHOT13_YEAST
    AccessioniPrimary (citable) accession number: P36078
    Secondary accession number(s): D6VXK4, Q6Q598
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 1, 1994
    Last sequence update: June 1, 1994
    Last modified: October 1, 2014
    This is version 94 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    3. Yeast chromosome XI
      Yeast (Saccharomyces cerevisiae) chromosome XI: entries and gene names

    External Data

    Dasty 3