Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Sulfiredoxin

Gene

SRX1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Contributes to oxidative stress resistance by reducing cysteine-sulfinic acid formed under exposure to oxidants in the peroxiredoxin TSA1. May catalyze the reduction in a multi-step process by acting both as a specific phosphotransferase and as thioltransferase.1 Publication

Catalytic activityi

Peroxiredoxin-(S-hydroxy-S-oxocysteine) + ATP + 2 R-SH = peroxiredoxin-(S-hydroxycysteine) + ADP + phosphate + R-S-S-R.

Cofactori

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • sulfiredoxin activity Source: SGD

GO - Biological processi

  • cellular response to oxidative stress Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Antioxidant, Oxidoreductase

Keywords - Ligandi

ATP-binding, Magnesium, Nucleotide-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-31879-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Sulfiredoxin (EC:1.8.98.2)
Alternative name(s):
Sulphiredoxin
Gene namesi
Name:SRX1
Ordered Locus Names:YKL086W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XI

Organism-specific databases

EuPathDBiFungiDB:YKL086W.
SGDiS000001569. SRX1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi48C → S: Minor effect on formation of disulfide bond with TSA1 and reduction of cysteine-sulfinic acid. 1 Publication1
Mutagenesisi84C → S: Abolishes formation of disulfide bond with TSA1 and reduction of cysteine-sulfinic acid. 1 Publication1
Mutagenesisi106C → S: No effect on formation of disulfide bond with TSA1 and reduction of cysteine-sulfinic acid. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002114351 – 127SulfiredoxinAdd BLAST127

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi84Interchain (with C-48 in TSA1); transient1 Publication

Post-translational modificationi

Forms a transient disulfide bond with TSA1 during the reduction of cysteine sulfinic acid (-SO2H).

Keywords - PTMi

Disulfide bond

Proteomic databases

MaxQBiP36077.
PRIDEiP36077.

Expressioni

Inductioni

By hydrogen peroxide.1 Publication

Interactioni

Protein-protein interaction databases

BioGridi34047. 6 interactors.
DIPiDIP-4344N.
IntActiP36077. 2 interactors.
MINTiMINT-537334.

Structurei

3D structure databases

ProteinModelPortaliP36077.
SMRiP36077.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the sulfiredoxin family.Curated

Phylogenomic databases

GeneTreeiENSGT00390000007832.
HOGENOMiHOG000231799.
InParanoidiP36077.
KOiK12260.
OMAiYQKIDAM.
OrthoDBiEOG092C1W6S.

Family and domain databases

InterProiIPR003115. ParB/Sulfiredoxin_dom.
IPR016692. Sulfiredoxin.
[Graphical view]
PANTHERiPTHR21348. PTHR21348. 2 hits.
PfamiPF02195. ParBc. 1 hit.
[Graphical view]
PIRSFiPIRSF017267. Sulfiredoxin. 1 hit.
SMARTiSM00470. ParB. 1 hit.
[Graphical view]
SUPFAMiSSF110849. SSF110849. 1 hit.

Sequencei

Sequence statusi: Complete.

P36077-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLQSNSVKP TEIPLSEIRR PLAPVLDPQK IDAMVATMKG IPTASKTCSL
60 70 80 90 100
EQAEAAASAG ELPPVDVLGV RVKGQTLYYA FGGCHRLQAY DRRARETQNA
110 120
AFPVRCRVLP ATPRQIRMYL GSSLDIE
Length:127
Mass (Da):13,854
Last modified:June 1, 1994 - v1
Checksum:iAC15AFD2F6CBC9A0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z28086 Genomic DNA. Translation: CAA81924.1.
AY558350 Genomic DNA. Translation: AAS56676.1.
BK006944 Genomic DNA. Translation: DAA09072.1.
PIRiS37911.
RefSeqiNP_012837.1. NM_001179652.1.

Genome annotation databases

EnsemblFungiiYKL086W; YKL086W; YKL086W.
GeneIDi853776.
KEGGisce:YKL086W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z28086 Genomic DNA. Translation: CAA81924.1.
AY558350 Genomic DNA. Translation: AAS56676.1.
BK006944 Genomic DNA. Translation: DAA09072.1.
PIRiS37911.
RefSeqiNP_012837.1. NM_001179652.1.

3D structure databases

ProteinModelPortaliP36077.
SMRiP36077.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi34047. 6 interactors.
DIPiDIP-4344N.
IntActiP36077. 2 interactors.
MINTiMINT-537334.

Proteomic databases

MaxQBiP36077.
PRIDEiP36077.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYKL086W; YKL086W; YKL086W.
GeneIDi853776.
KEGGisce:YKL086W.

Organism-specific databases

EuPathDBiFungiDB:YKL086W.
SGDiS000001569. SRX1.

Phylogenomic databases

GeneTreeiENSGT00390000007832.
HOGENOMiHOG000231799.
InParanoidiP36077.
KOiK12260.
OMAiYQKIDAM.
OrthoDBiEOG092C1W6S.

Enzyme and pathway databases

BioCyciYEAST:G3O-31879-MONOMER.

Miscellaneous databases

PROiP36077.

Family and domain databases

InterProiIPR003115. ParB/Sulfiredoxin_dom.
IPR016692. Sulfiredoxin.
[Graphical view]
PANTHERiPTHR21348. PTHR21348. 2 hits.
PfamiPF02195. ParBc. 1 hit.
[Graphical view]
PIRSFiPIRSF017267. Sulfiredoxin. 1 hit.
SMARTiSM00470. ParB. 1 hit.
[Graphical view]
SUPFAMiSSF110849. SSF110849. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiSRX1_YEAST
AccessioniPrimary (citable) accession number: P36077
Secondary accession number(s): D6VXK2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: November 2, 2016
This is version 127 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 538 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome XI
    Yeast (Saccharomyces cerevisiae) chromosome XI: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.