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Protein

Sulfiredoxin

Gene

SRX1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Contributes to oxidative stress resistance by reducing cysteine-sulfinic acid formed under exposure to oxidants in the peroxiredoxin TSA1. May catalyze the reduction in a multi-step process by acting both as a specific phosphotransferase and as thioltransferase.1 Publication

Miscellaneous

Present with 538 molecules/cell in log phase SD medium.1 Publication

Catalytic activityi

Peroxiredoxin-(S-hydroxy-S-oxocysteine) + ATP + 2 R-SH = peroxiredoxin-(S-hydroxycysteine) + ADP + phosphate + R-S-S-R.

Cofactori

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • sulfiredoxin activity Source: SGD

GO - Biological processi

  • cellular response to oxidative stress Source: SGD
  • negative regulation of protein polymerization Source: CAFA

Keywordsi

Molecular functionAntioxidant, Oxidoreductase
LigandATP-binding, Magnesium, Nucleotide-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-31879-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Sulfiredoxin (EC:1.8.98.2)
Alternative name(s):
Sulphiredoxin
Gene namesi
Name:SRX1
Ordered Locus Names:YKL086W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XI

Organism-specific databases

EuPathDBiFungiDB:YKL086W
SGDiS000001569 SRX1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi48C → S: Minor effect on formation of disulfide bond with TSA1 and reduction of cysteine-sulfinic acid. 1 Publication1
Mutagenesisi84C → S: Abolishes formation of disulfide bond with TSA1 and reduction of cysteine-sulfinic acid. 1 Publication1
Mutagenesisi106C → S: No effect on formation of disulfide bond with TSA1 and reduction of cysteine-sulfinic acid. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002114351 – 127SulfiredoxinAdd BLAST127

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi84Interchain (with C-48 in TSA1); transient1 Publication

Post-translational modificationi

Forms a transient disulfide bond with TSA1 during the reduction of cysteine sulfinic acid (-SO2H).

Keywords - PTMi

Disulfide bond

Proteomic databases

MaxQBiP36077
PaxDbiP36077
PRIDEiP36077

PTM databases

CarbonylDBiP36077

Expressioni

Inductioni

By hydrogen peroxide.1 Publication

Interactioni

Protein-protein interaction databases

BioGridi34047, 45 interactors
DIPiDIP-4344N
IntActiP36077, 4 interactors
STRINGi4932.YKL086W

Structurei

3D structure databases

ProteinModelPortaliP36077
SMRiP36077
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the sulfiredoxin family.Curated

Phylogenomic databases

GeneTreeiENSGT00390000007832
HOGENOMiHOG000231799
InParanoidiP36077
KOiK12260
OMAiGGCHRFA
OrthoDBiEOG092C1W6S

Family and domain databases

InterProiView protein in InterPro
IPR003115 ParB/Sulfiredoxin_dom
IPR036086 ParB/Sulfiredoxin_sf
IPR016692 Sulfiredoxin
PANTHERiPTHR21348 PTHR21348, 1 hit
PfamiView protein in Pfam
PF02195 ParBc, 1 hit
PIRSFiPIRSF017267 Sulfiredoxin, 1 hit
SMARTiView protein in SMART
SM00470 ParB, 1 hit
SUPFAMiSSF110849 SSF110849, 1 hit

Sequencei

Sequence statusi: Complete.

P36077-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLQSNSVKP TEIPLSEIRR PLAPVLDPQK IDAMVATMKG IPTASKTCSL
60 70 80 90 100
EQAEAAASAG ELPPVDVLGV RVKGQTLYYA FGGCHRLQAY DRRARETQNA
110 120
AFPVRCRVLP ATPRQIRMYL GSSLDIE
Length:127
Mass (Da):13,854
Last modified:June 1, 1994 - v1
Checksum:iAC15AFD2F6CBC9A0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z28086 Genomic DNA Translation: CAA81924.1
AY558350 Genomic DNA Translation: AAS56676.1
BK006944 Genomic DNA Translation: DAA09072.1
PIRiS37911
RefSeqiNP_012837.1, NM_001179652.1

Genome annotation databases

EnsemblFungiiYKL086W; YKL086W; YKL086W
GeneIDi853776
KEGGisce:YKL086W

Similar proteinsi

Entry informationi

Entry nameiSRX1_YEAST
AccessioniPrimary (citable) accession number: P36077
Secondary accession number(s): D6VXK2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: March 28, 2018
This is version 137 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health