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Protein

Coenzyme A biosynthesis protein 3

Gene

CAB3

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the phosphopantothenoylcysteine decarboxylase (PPCDC) involved in the coenzyme A synthesis.2 Publications

Miscellaneous

Present with 2940 molecules/cell in log phase SD medium.1 Publication

GO - Molecular functioni

  • identical protein binding Source: IntAct
  • phosphopantothenoylcysteine decarboxylase activity Source: SGD
  • purine nucleotide binding Source: SGD

GO - Biological processi

  • coenzyme A biosynthetic process Source: SGD
  • response to salt stress Source: SGD

Keywordsi

Biological processCoenzyme A biosynthesis

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER3O-299
YEAST:MONOMER3O-299
ReactomeiR-SCE-196783 Coenzyme A biosynthesis

Names & Taxonomyi

Protein namesi
Recommended name:
Coenzyme A biosynthesis protein 3
Gene namesi
Name:CAB3
Ordered Locus Names:YKL088W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XI

Organism-specific databases

EuPathDBiFungiDB:YKL088W
SGDiS000001571 CAB3

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi478C → S: Abolishes PPCDC activity. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001820391 – 571Coenzyme A biosynthesis protein 3Add BLAST571

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei42PhosphoserineCombined sources1
Modified residuei116PhosphoserineCombined sources1
Modified residuei121PhosphoserineCombined sources1
Modified residuei124PhosphoserineCombined sources1
Modified residuei264PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP36076
PaxDbiP36076
PRIDEiP36076

PTM databases

iPTMnetiP36076

Interactioni

Subunit structurei

Component of the phosphopantothenoylcysteine decarboxylase (PPCDC) complex, a heterotrimer composed of CAB3, HAL3 and VHS3.

Binary interactionsi

Show more details

GO - Molecular functioni

  • identical protein binding Source: IntAct

Protein-protein interaction databases

BioGridi34045, 34 interactors
DIPiDIP-4475N
IntActiP36076, 74 interactors
MINTiP36076
STRINGi4932.YKL088W

Structurei

3D structure databases

ProteinModelPortaliP36076
SMRiP36076
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi508 – 570Asp/Glu-rich (highly acidic)Add BLAST63

Sequence similaritiesi

Phylogenomic databases

GeneTreeiENSGT00440000038107
InParanoidiP36076
KOiK01598
OrthoDBiEOG092C4QKO

Family and domain databases

Gene3Di3.40.50.1950, 1 hit
InterProiView protein in InterPro
IPR036551 Flavin_trans-like
IPR003382 Flavoprotein
PfamiView protein in Pfam
PF02441 Flavoprotein, 1 hit
SUPFAMiSSF52507 SSF52507, 1 hit

Sequencei

Sequence statusi: Complete.

P36076-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTDEKVNSDQ NMNGKQGVNL ISSLPTTQVP VSILTNKERR KSIHDESNFE
60 70 80 90 100
RSDSHEDQSK SNSNRRNIYK NDYSTNLRDF SFANLKQNSE RNKDGHEIQI
110 120 130 140 150
NTSMPANTNG QQKRFSPSLP SAVSFTVPEV ERLPYHRYSI SNKPGKQQQQ
160 170 180 190 200
QEQLQQNQQQ EEQQKAQLQE QNQRAKQQEE VKQIQEQVQK KQTERQQLID
210 220 230 240 250
EKERIANAIF KENTTNDGTD IRKHSVSSGT SNSEDEVDSP SMEKNSIVHM
260 270 280 290 300
PGDFIYFNPK SNASKPITAK AAPLSANNST HKNKEVITAP TGPRVPFTEF
310 320 330 340 350
FQKEDDKKFH ILIGATGSVA TIKVPLIIDK LFKIYGPEKI SIQLIVTKPA
360 370 380 390 400
EHFLKGLKMS THVKIWREED AWVFDAVNKN DTSLSLNLIL HHELRKWADI
410 420 430 440 450
FLIAPLSANT LAKLANGICN NLLTSVMRDW SPLTPVLIAP AMNTFMYINP
460 470 480 490 500
MTKKHLTSLV QDYPFIQVLK PVEKVLICGD IGMGGMREWT DIVEIVRRRI
510 520 530 540 550
NEIRKARDEE TGDKEQEQEE QEGADNEDDD DEDDEEDEED EEEEEALNET
560 570
ASDESNDEED EEDEEDVKTE V
Length:571
Mass (Da):65,238
Last modified:June 1, 1994 - v1
Checksum:i9C674C2394EFCEAB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z28088 Genomic DNA Translation: CAA81926.1
BK006944 Genomic DNA Translation: DAA09070.1
PIRiS37913
RefSeqiNP_012835.1, NM_001179654.1

Genome annotation databases

EnsemblFungiiYKL088W; YKL088W; YKL088W
GeneIDi853774
KEGGisce:YKL088W

Similar proteinsi

Entry informationi

Entry nameiCAB3_YEAST
AccessioniPrimary (citable) accession number: P36076
Secondary accession number(s): D6VXK0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: May 23, 2018
This is version 138 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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