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P36076

- CAB3_YEAST

UniProt

P36076 - CAB3_YEAST

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Protein
Coenzyme A biosynthesis protein 3
Gene
CAB3, YKL088W
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Component of the phosphopantothenoylcysteine decarboxylase (PPCDC) involved in the coenzyme A synthesis.2 Publications

GO - Molecular functioni

  1. phosphopantothenoylcysteine decarboxylase activity Source: SGD
  2. protein binding Source: IntAct
  3. purine nucleotide binding Source: SGD

GO - Biological processi

  1. coenzyme A biosynthetic process Source: SGD
  2. response to salt stress Source: SGD
Complete GO annotation...

Keywords - Biological processi

Coenzyme A biosynthesis

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER3O-299.
YEAST:MONOMER3O-299.

Names & Taxonomyi

Protein namesi
Recommended name:
Coenzyme A biosynthesis protein 3
Gene namesi
Name:CAB3
Ordered Locus Names:YKL088W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome XI

Organism-specific databases

CYGDiYKL088w.
SGDiS000001571. CAB3.

Subcellular locationi

Cytoplasm 1 Publication

GO - Cellular componenti

  1. phosphopantothenoylcysteine decarboxylase complex Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi478 – 4781C → S: Abolishes PPCDC activity. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 571571Coenzyme A biosynthesis protein 3
PRO_0000182039Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei42 – 421Phosphoserine3 Publications
Modified residuei116 – 1161Phosphoserine2 Publications
Modified residuei121 – 1211Phosphoserine2 Publications
Modified residuei124 – 1241Phosphoserine1 Publication
Modified residuei264 – 2641Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP36076.
PaxDbiP36076.

Expressioni

Gene expression databases

GenevestigatoriP36076.

Interactioni

Subunit structurei

Component of the phosphopantothenoylcysteine decarboxylase (PPCDC) complex, a heterotrimer composed of CAB3, HAL3 and VHS3.

Binary interactionsi

WithEntry#Exp.IntActNotes
PPZ1P265706EBI-26778,EBI-13807
PPZ2P333294EBI-26778,EBI-13815
SIS2P360243EBI-26778,EBI-17250
VHS3Q084384EBI-26778,EBI-30482

Protein-protein interaction databases

BioGridi34045. 28 interactions.
DIPiDIP-4475N.
IntActiP36076. 67 interactions.
MINTiMINT-541287.
STRINGi4932.YKL088W.

Structurei

3D structure databases

ProteinModelPortaliP36076.
SMRiP36076. Positions 307-497.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi508 – 57063Asp/Glu-rich (highly acidic)
Add
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0452.
GeneTreeiENSGT00440000038107.
KOiK01598.
OMAiISIQLIV.
OrthoDBiEOG7N906N.

Family and domain databases

Gene3Di3.40.50.1950. 1 hit.
InterProiIPR003382. Flavoprotein.
[Graphical view]
PfamiPF02441. Flavoprotein. 1 hit.
[Graphical view]
SUPFAMiSSF52507. SSF52507. 1 hit.

Sequencei

Sequence statusi: Complete.

P36076-1 [UniParc]FASTAAdd to Basket

« Hide

MTDEKVNSDQ NMNGKQGVNL ISSLPTTQVP VSILTNKERR KSIHDESNFE    50
RSDSHEDQSK SNSNRRNIYK NDYSTNLRDF SFANLKQNSE RNKDGHEIQI 100
NTSMPANTNG QQKRFSPSLP SAVSFTVPEV ERLPYHRYSI SNKPGKQQQQ 150
QEQLQQNQQQ EEQQKAQLQE QNQRAKQQEE VKQIQEQVQK KQTERQQLID 200
EKERIANAIF KENTTNDGTD IRKHSVSSGT SNSEDEVDSP SMEKNSIVHM 250
PGDFIYFNPK SNASKPITAK AAPLSANNST HKNKEVITAP TGPRVPFTEF 300
FQKEDDKKFH ILIGATGSVA TIKVPLIIDK LFKIYGPEKI SIQLIVTKPA 350
EHFLKGLKMS THVKIWREED AWVFDAVNKN DTSLSLNLIL HHELRKWADI 400
FLIAPLSANT LAKLANGICN NLLTSVMRDW SPLTPVLIAP AMNTFMYINP 450
MTKKHLTSLV QDYPFIQVLK PVEKVLICGD IGMGGMREWT DIVEIVRRRI 500
NEIRKARDEE TGDKEQEQEE QEGADNEDDD DEDDEEDEED EEEEEALNET 550
ASDESNDEED EEDEEDVKTE V 571
Length:571
Mass (Da):65,238
Last modified:June 1, 1994 - v1
Checksum:i9C674C2394EFCEAB
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z28088 Genomic DNA. Translation: CAA81926.1.
BK006944 Genomic DNA. Translation: DAA09070.1.
PIRiS37913.
RefSeqiNP_012835.1. NM_001179654.1.

Genome annotation databases

EnsemblFungiiYKL088W; YKL088W; YKL088W.
GeneIDi853774.
KEGGisce:YKL088W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z28088 Genomic DNA. Translation: CAA81926.1 .
BK006944 Genomic DNA. Translation: DAA09070.1 .
PIRi S37913.
RefSeqi NP_012835.1. NM_001179654.1.

3D structure databases

ProteinModelPortali P36076.
SMRi P36076. Positions 307-497.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 34045. 28 interactions.
DIPi DIP-4475N.
IntActi P36076. 67 interactions.
MINTi MINT-541287.
STRINGi 4932.YKL088W.

Proteomic databases

MaxQBi P36076.
PaxDbi P36076.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YKL088W ; YKL088W ; YKL088W .
GeneIDi 853774.
KEGGi sce:YKL088W.

Organism-specific databases

CYGDi YKL088w.
SGDi S000001571. CAB3.

Phylogenomic databases

eggNOGi COG0452.
GeneTreei ENSGT00440000038107.
KOi K01598.
OMAi ISIQLIV.
OrthoDBi EOG7N906N.

Enzyme and pathway databases

BioCyci MetaCyc:MONOMER3O-299.
YEAST:MONOMER3O-299.

Miscellaneous databases

NextBioi 974879.

Gene expression databases

Genevestigatori P36076.

Family and domain databases

Gene3Di 3.40.50.1950. 1 hit.
InterProi IPR003382. Flavoprotein.
[Graphical view ]
Pfami PF02441. Flavoprotein. 1 hit.
[Graphical view ]
SUPFAMi SSF52507. SSF52507. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Complete DNA sequence of yeast chromosome XI."
    Dujon B., Alexandraki D., Andre B., Ansorge W., Baladron V., Ballesta J.P.G., Banrevi A., Bolle P.-A., Bolotin-Fukuhara M., Bossier P., Bou G., Boyer J., Buitrago M.J., Cheret G., Colleaux L., Daignan-Fornier B., del Rey F., Dion C.
    , Domdey H., Duesterhoeft A., Duesterhus S., Entian K.-D., Erfle H., Esteban P.F., Feldmann H., Fernandes L., Fobo G.M., Fritz C., Fukuhara H., Gabel C., Gaillon L., Garcia-Cantalejo J.M., Garcia-Ramirez J.J., Gent M.E., Ghazvini M., Goffeau A., Gonzalez A., Grothues D., Guerreiro P., Hegemann J.H., Hewitt N., Hilger F., Hollenberg C.P., Horaitis O., Indge K.J., Jacquier A., James C.M., Jauniaux J.-C., Jimenez A., Keuchel H., Kirchrath L., Kleine K., Koetter P., Legrain P., Liebl S., Louis E.J., Maia e Silva A., Marck C., Monnier A.-L., Moestl D., Mueller S., Obermaier B., Oliver S.G., Pallier C., Pascolo S., Pfeiffer F., Philippsen P., Planta R.J., Pohl F.M., Pohl T.M., Poehlmann R., Portetelle D., Purnelle B., Puzos V., Ramezani Rad M., Rasmussen S.W., Remacha M.A., Revuelta J.L., Richard G.-F., Rieger M., Rodrigues-Pousada C., Rose M., Rupp T., Santos M.A., Schwager C., Sensen C., Skala J., Soares H., Sor F., Stegemann J., Tettelin H., Thierry A., Tzermia M., Urrestarazu L.A., van Dyck L., van Vliet-Reedijk J.C., Valens M., Vandenbol M., Vilela C., Vissers S., von Wettstein D., Voss H., Wiemann S., Xu G., Zimmermann J., Haasemann M., Becker I., Mewes H.-W.
    Nature 369:371-378(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
  4. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  5. "Large-scale phosphorylation analysis of alpha-factor-arrested Saccharomyces cerevisiae."
    Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J., Elias J.E., Gygi S.P.
    J. Proteome Res. 6:1190-1197(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-42; SER-116; SER-121 AND SER-124, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Strain: ADR376.
  6. "Analysis of phosphorylation sites on proteins from Saccharomyces cerevisiae by electron transfer dissociation (ETD) mass spectrometry."
    Chi A., Huttenhower C., Geer L.Y., Coon J.J., Syka J.E.P., Bai D.L., Shabanowitz J., Burke D.J., Troyanskaya O.G., Hunt D.F.
    Proc. Natl. Acad. Sci. U.S.A. 104:2193-2198(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-42, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  7. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
    Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
    Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-42 AND SER-264, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  8. "Genetic analysis of coenzyme A biosynthesis in the yeast Saccharomyces cerevisiae: identification of a conditional mutation in the pantothenate kinase gene CAB1."
    Olzhausen J., Schuebbe S., Schueller H.-J.
    Curr. Genet. 55:163-173(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  9. "Moonlighting proteins Hal3 and Vhs3 form a heteromeric PPCDC with Ykl088w in yeast CoA biosynthesis."
    Ruiz A., Gonzalez A., Munoz I., Serrano R., Abrie J.A., Strauss E., Arino J.
    Nat. Chem. Biol. 5:920-928(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, MUTAGENESIS OF CYS-478, INTERACTION WITH HAL3 AND VHS3.
  10. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
    Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
    Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-116 AND SER-121, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiCAB3_YEAST
AccessioniPrimary (citable) accession number: P36076
Secondary accession number(s): D6VXK0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: June 11, 2014
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 2940 molecules/cell in log phase SD medium.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XI
    Yeast (Saccharomyces cerevisiae) chromosome XI: entries and gene names

External Data

Dasty 3

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