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Protein

Coenzyme A biosynthesis protein 3

Gene

CAB3

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Component of the phosphopantothenoylcysteine decarboxylase (PPCDC) involved in the coenzyme A synthesis.2 Publications

GO - Molecular functioni

  • phosphopantothenoylcysteine decarboxylase activity Source: SGD
  • purine nucleotide binding Source: SGD

GO - Biological processi

  • coenzyme A biosynthetic process Source: SGD
  • response to salt stress Source: SGD
Complete GO annotation...

Keywords - Biological processi

Coenzyme A biosynthesis

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER3O-299.
YEAST:MONOMER3O-299.
ReactomeiR-SCE-196783. Coenzyme A biosynthesis.

Names & Taxonomyi

Protein namesi
Recommended name:
Coenzyme A biosynthesis protein 3
Gene namesi
Name:CAB3
Ordered Locus Names:YKL088W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XI

Organism-specific databases

EuPathDBiFungiDB:YKL088W.
SGDiS000001571. CAB3.

Subcellular locationi

GO - Cellular componenti

  • CoA-synthesizing protein complex Source: SGD
  • phosphopantothenoylcysteine decarboxylase complex Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi478C → S: Abolishes PPCDC activity. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001820391 – 571Coenzyme A biosynthesis protein 3Add BLAST571

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei42PhosphoserineCombined sources1
Modified residuei116PhosphoserineCombined sources1
Modified residuei121PhosphoserineCombined sources1
Modified residuei124PhosphoserineCombined sources1
Modified residuei264PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP36076.
PRIDEiP36076.

PTM databases

iPTMnetiP36076.

Interactioni

Subunit structurei

Component of the phosphopantothenoylcysteine decarboxylase (PPCDC) complex, a heterotrimer composed of CAB3, HAL3 and VHS3.

Binary interactionsi

WithEntry#Exp.IntActNotes
itself3EBI-26778,EBI-26778
CAB2P405066EBI-26778,EBI-25089
CAB4P533325EBI-26778,EBI-23648
CAB5Q039417EBI-26778,EBI-22174
PPZ1P265706EBI-26778,EBI-13807
PPZ2P333294EBI-26778,EBI-13815
SIS2P360248EBI-26778,EBI-17250
VHS3Q084389EBI-26778,EBI-30482

Protein-protein interaction databases

BioGridi34045. 30 interactors.
DIPiDIP-4475N.
IntActiP36076. 71 interactors.
MINTiMINT-541287.

Structurei

3D structure databases

ProteinModelPortaliP36076.
SMRiP36076.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi508 – 570Asp/Glu-rich (highly acidic)Add BLAST63

Sequence similaritiesi

Phylogenomic databases

GeneTreeiENSGT00440000038107.
InParanoidiP36076.
KOiK01598.
OMAiISIQLIV.
OrthoDBiEOG092C4QKO.

Family and domain databases

Gene3Di3.40.50.1950. 1 hit.
InterProiIPR003382. Flavoprotein.
[Graphical view]
PfamiPF02441. Flavoprotein. 1 hit.
[Graphical view]
SUPFAMiSSF52507. SSF52507. 1 hit.

Sequencei

Sequence statusi: Complete.

P36076-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTDEKVNSDQ NMNGKQGVNL ISSLPTTQVP VSILTNKERR KSIHDESNFE
60 70 80 90 100
RSDSHEDQSK SNSNRRNIYK NDYSTNLRDF SFANLKQNSE RNKDGHEIQI
110 120 130 140 150
NTSMPANTNG QQKRFSPSLP SAVSFTVPEV ERLPYHRYSI SNKPGKQQQQ
160 170 180 190 200
QEQLQQNQQQ EEQQKAQLQE QNQRAKQQEE VKQIQEQVQK KQTERQQLID
210 220 230 240 250
EKERIANAIF KENTTNDGTD IRKHSVSSGT SNSEDEVDSP SMEKNSIVHM
260 270 280 290 300
PGDFIYFNPK SNASKPITAK AAPLSANNST HKNKEVITAP TGPRVPFTEF
310 320 330 340 350
FQKEDDKKFH ILIGATGSVA TIKVPLIIDK LFKIYGPEKI SIQLIVTKPA
360 370 380 390 400
EHFLKGLKMS THVKIWREED AWVFDAVNKN DTSLSLNLIL HHELRKWADI
410 420 430 440 450
FLIAPLSANT LAKLANGICN NLLTSVMRDW SPLTPVLIAP AMNTFMYINP
460 470 480 490 500
MTKKHLTSLV QDYPFIQVLK PVEKVLICGD IGMGGMREWT DIVEIVRRRI
510 520 530 540 550
NEIRKARDEE TGDKEQEQEE QEGADNEDDD DEDDEEDEED EEEEEALNET
560 570
ASDESNDEED EEDEEDVKTE V
Length:571
Mass (Da):65,238
Last modified:June 1, 1994 - v1
Checksum:i9C674C2394EFCEAB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z28088 Genomic DNA. Translation: CAA81926.1.
BK006944 Genomic DNA. Translation: DAA09070.1.
PIRiS37913.
RefSeqiNP_012835.1. NM_001179654.1.

Genome annotation databases

EnsemblFungiiYKL088W; YKL088W; YKL088W.
GeneIDi853774.
KEGGisce:YKL088W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z28088 Genomic DNA. Translation: CAA81926.1.
BK006944 Genomic DNA. Translation: DAA09070.1.
PIRiS37913.
RefSeqiNP_012835.1. NM_001179654.1.

3D structure databases

ProteinModelPortaliP36076.
SMRiP36076.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi34045. 30 interactors.
DIPiDIP-4475N.
IntActiP36076. 71 interactors.
MINTiMINT-541287.

PTM databases

iPTMnetiP36076.

Proteomic databases

MaxQBiP36076.
PRIDEiP36076.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYKL088W; YKL088W; YKL088W.
GeneIDi853774.
KEGGisce:YKL088W.

Organism-specific databases

EuPathDBiFungiDB:YKL088W.
SGDiS000001571. CAB3.

Phylogenomic databases

GeneTreeiENSGT00440000038107.
InParanoidiP36076.
KOiK01598.
OMAiISIQLIV.
OrthoDBiEOG092C4QKO.

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER3O-299.
YEAST:MONOMER3O-299.
ReactomeiR-SCE-196783. Coenzyme A biosynthesis.

Miscellaneous databases

PROiP36076.

Family and domain databases

Gene3Di3.40.50.1950. 1 hit.
InterProiIPR003382. Flavoprotein.
[Graphical view]
PfamiPF02441. Flavoprotein. 1 hit.
[Graphical view]
SUPFAMiSSF52507. SSF52507. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiCAB3_YEAST
AccessioniPrimary (citable) accession number: P36076
Secondary accession number(s): D6VXK0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: November 2, 2016
This is version 126 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 2940 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XI
    Yeast (Saccharomyces cerevisiae) chromosome XI: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.