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P36075

- CUE2_YEAST

UniProt

P36075 - CUE2_YEAST

Protein

Ubiquitin-binding protein CUE2

Gene

CUE2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 112 (01 Oct 2014)
      Sequence version 1 (01 Jun 1994)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. ubiquitin binding Source: SGD

    Keywords - Biological processi

    Ubl conjugation pathway

    Enzyme and pathway databases

    BioCyciYEAST:G3O-31881-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ubiquitin-binding protein CUE2
    Alternative name(s):
    Coupling of ubiquitin conjugation to ER degradation protein 2
    Gene namesi
    Name:CUE2
    Ordered Locus Names:YKL090W
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome XI

    Organism-specific databases

    CYGDiYKL090w.
    SGDiS000001573. CUE2.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 443443Ubiquitin-binding protein CUE2PRO_0000079558Add
    BLAST

    Proteomic databases

    MaxQBiP36075.
    PaxDbiP36075.

    Expressioni

    Gene expression databases

    GenevestigatoriP36075.

    Interactioni

    Subunit structurei

    Binds to ubiquitin.1 Publication

    Protein-protein interaction databases

    BioGridi34043. 11 interactions.
    DIPiDIP-1917N.
    IntActiP36075. 4 interactions.
    MINTiMINT-394365.
    STRINGi4932.YKL090W.

    Structurei

    Secondary structure

    1
    443
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi9 – 1911
    Beta strandi21 – 233
    Helixi25 – 3410
    Turni35 – 373
    Helixi40 – 4910

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1OTRNMR-A6-54[»]
    ProteinModelPortaliP36075.
    SMRiP36075. Positions 6-54.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP36075.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini8 – 5144CUE 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini55 – 9844CUE 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini347 – 44397SmrPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 2 CUE domains.PROSITE-ProRule annotation
    Contains 1 Smr domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiNOG262951.
    OMAiNDINLAC.
    OrthoDBiEOG7M98RQ.

    Family and domain databases

    InterProiIPR003892. CUE.
    IPR002625. Smr/MutS2_C.
    IPR009060. UBA-like.
    [Graphical view]
    PfamiPF02845. CUE. 2 hits.
    PF01713. Smr. 1 hit.
    [Graphical view]
    SMARTiSM00546. CUE. 2 hits.
    SM00463. SMR. 1 hit.
    [Graphical view]
    SUPFAMiSSF46934. SSF46934. 2 hits.
    PROSITEiPS51140. CUE. 2 hits.
    PS50828. SMR. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P36075-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSMDNNDDHE SKLSILMDMF PAISKSKLQV HLLENNNDLD LTIGLLLKEN    50
    DDKSTVDNEL HQLYDMFPQL DCSVIKDQFV INEKSVESTI SDLLNYETLQ 100
    KLKDNQANSP DSVKRNEKKN NWESTNDHIE SIIKFTDAPK NIAQEYLAEN 150
    GFDTVKAIIK IILDYYDKRD FKKDVDTFKV KRSPNTTVRG GRVQSSTGLA 200
    HVLKKGKESA NVAQESLKRP RSYKHSLDSP QMVELNELVA DNRDLKAINH 250
    EFLQKCLQFY DGDVVKVLNI SSLLIEDDKN ITKTWNFDEG FTLTSRDNCK 300
    QHLPKFSTPQ ISRRNEVGNT YKLPLHDKET PEGAVPVINN LFQTYRLDFH 350
    GFLPSEAVST LKLALNKWWS KEVAERELNS HNINSYGSKV QFVSPLIVVT 400
    GRGIHSIGGI SKVRLQVKSF LEKNHYIFWE ESSYFRIEGK KKK 443
    Length:443
    Mass (Da):50,874
    Last modified:June 1, 1994 - v1
    Checksum:i8B7BB872C2BDC734
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z28090 Genomic DNA. Translation: CAA81928.1.
    BK006944 Genomic DNA. Translation: DAA09068.1.
    PIRiS37915.
    RefSeqiNP_012833.1. NM_001179656.1.

    Genome annotation databases

    EnsemblFungiiYKL090W; YKL090W; YKL090W.
    GeneIDi853772.
    KEGGisce:YKL090W.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z28090 Genomic DNA. Translation: CAA81928.1 .
    BK006944 Genomic DNA. Translation: DAA09068.1 .
    PIRi S37915.
    RefSeqi NP_012833.1. NM_001179656.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1OTR NMR - A 6-54 [» ]
    ProteinModelPortali P36075.
    SMRi P36075. Positions 6-54.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 34043. 11 interactions.
    DIPi DIP-1917N.
    IntActi P36075. 4 interactions.
    MINTi MINT-394365.
    STRINGi 4932.YKL090W.

    Proteomic databases

    MaxQBi P36075.
    PaxDbi P36075.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YKL090W ; YKL090W ; YKL090W .
    GeneIDi 853772.
    KEGGi sce:YKL090W.

    Organism-specific databases

    CYGDi YKL090w.
    SGDi S000001573. CUE2.

    Phylogenomic databases

    eggNOGi NOG262951.
    OMAi NDINLAC.
    OrthoDBi EOG7M98RQ.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-31881-MONOMER.

    Miscellaneous databases

    EvolutionaryTracei P36075.
    NextBioi 974873.

    Gene expression databases

    Genevestigatori P36075.

    Family and domain databases

    InterProi IPR003892. CUE.
    IPR002625. Smr/MutS2_C.
    IPR009060. UBA-like.
    [Graphical view ]
    Pfami PF02845. CUE. 2 hits.
    PF01713. Smr. 1 hit.
    [Graphical view ]
    SMARTi SM00546. CUE. 2 hits.
    SM00463. SMR. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46934. SSF46934. 2 hits.
    PROSITEi PS51140. CUE. 2 hits.
    PS50828. SMR. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete DNA sequence of yeast chromosome XI."
      Dujon B., Alexandraki D., Andre B., Ansorge W., Baladron V., Ballesta J.P.G., Banrevi A., Bolle P.-A., Bolotin-Fukuhara M., Bossier P., Bou G., Boyer J., Buitrago M.J., Cheret G., Colleaux L., Daignan-Fornier B., del Rey F., Dion C.
      , Domdey H., Duesterhoeft A., Duesterhus S., Entian K.-D., Erfle H., Esteban P.F., Feldmann H., Fernandes L., Fobo G.M., Fritz C., Fukuhara H., Gabel C., Gaillon L., Garcia-Cantalejo J.M., Garcia-Ramirez J.J., Gent M.E., Ghazvini M., Goffeau A., Gonzalez A., Grothues D., Guerreiro P., Hegemann J.H., Hewitt N., Hilger F., Hollenberg C.P., Horaitis O., Indge K.J., Jacquier A., James C.M., Jauniaux J.-C., Jimenez A., Keuchel H., Kirchrath L., Kleine K., Koetter P., Legrain P., Liebl S., Louis E.J., Maia e Silva A., Marck C., Monnier A.-L., Moestl D., Mueller S., Obermaier B., Oliver S.G., Pallier C., Pascolo S., Pfeiffer F., Philippsen P., Planta R.J., Pohl F.M., Pohl T.M., Poehlmann R., Portetelle D., Purnelle B., Puzos V., Ramezani Rad M., Rasmussen S.W., Remacha M.A., Revuelta J.L., Richard G.-F., Rieger M., Rodrigues-Pousada C., Rose M., Rupp T., Santos M.A., Schwager C., Sensen C., Skala J., Soares H., Sor F., Stegemann J., Tettelin H., Thierry A., Tzermia M., Urrestarazu L.A., van Dyck L., van Vliet-Reedijk J.C., Valens M., Vandenbol M., Vilela C., Vissers S., von Wettstein D., Voss H., Wiemann S., Xu G., Zimmermann J., Haasemann M., Becker I., Mewes H.-W.
      Nature 369:371-378(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    2. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    3. "Solution structure of a CUE-ubiquitin complex reveals a conserved mode of ubiquitin binding."
      Kang R.S., Daniels C.M., Francis S.A., Shih S.C., Salerno W.J., Hicke L., Radhakrishnan I.
      Cell 113:621-630(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: STRUCTURE BY NMR OF 1-54 IN COMPLEX WITH UBIQUITIN.

    Entry informationi

    Entry nameiCUE2_YEAST
    AccessioniPrimary (citable) accession number: P36075
    Secondary accession number(s): D6VXJ8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 1, 1994
    Last sequence update: June 1, 1994
    Last modified: October 1, 2014
    This is version 112 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families
    3. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    4. Yeast chromosome XI
      Yeast (Saccharomyces cerevisiae) chromosome XI: entries and gene names

    External Data

    Dasty 3