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Protein

Ubiquitin-binding protein CUE2

Gene

CUE2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • ubiquitin binding Source: SGD
Complete GO annotation...

Keywords - Biological processi

Ubl conjugation pathway

Enzyme and pathway databases

BioCyciYEAST:G3O-31881-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin-binding protein CUE2
Alternative name(s):
Coupling of ubiquitin conjugation to ER degradation protein 2
Gene namesi
Name:CUE2
Ordered Locus Names:YKL090W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311 Componenti: Chromosome XI

Organism-specific databases

CYGDiYKL090w.
EuPathDBiFungiDB:YKL090W.
SGDiS000001573. CUE2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 443443Ubiquitin-binding protein CUE2PRO_0000079558Add
BLAST

Proteomic databases

MaxQBiP36075.
PaxDbiP36075.

Interactioni

Subunit structurei

Binds to ubiquitin.1 Publication

Protein-protein interaction databases

BioGridi34043. 11 interactions.
DIPiDIP-1917N.
IntActiP36075. 4 interactions.
MINTiMINT-394365.

Structurei

Secondary structure

1
443
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi9 – 1911Combined sources
Beta strandi21 – 233Combined sources
Helixi25 – 3410Combined sources
Turni35 – 373Combined sources
Helixi40 – 4910Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1OTRNMR-A6-54[»]
ProteinModelPortaliP36075.
SMRiP36075. Positions 6-54.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP36075.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini8 – 5144CUE 1PROSITE-ProRule annotationAdd
BLAST
Domaini55 – 9844CUE 2PROSITE-ProRule annotationAdd
BLAST
Domaini347 – 44397SmrPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 2 CUE domains.PROSITE-ProRule annotation
Contains 1 Smr domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiNOG262951.
InParanoidiP36075.
OMAiNDINLAC.
OrthoDBiEOG7M98RQ.

Family and domain databases

InterProiIPR003892. CUE.
IPR002625. Smr/MutS2_C.
IPR009060. UBA-like.
[Graphical view]
PfamiPF02845. CUE. 2 hits.
PF01713. Smr. 1 hit.
[Graphical view]
SMARTiSM00546. CUE. 2 hits.
SM00463. SMR. 1 hit.
[Graphical view]
SUPFAMiSSF46934. SSF46934. 2 hits.
PROSITEiPS51140. CUE. 2 hits.
PS50828. SMR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P36075-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSMDNNDDHE SKLSILMDMF PAISKSKLQV HLLENNNDLD LTIGLLLKEN
60 70 80 90 100
DDKSTVDNEL HQLYDMFPQL DCSVIKDQFV INEKSVESTI SDLLNYETLQ
110 120 130 140 150
KLKDNQANSP DSVKRNEKKN NWESTNDHIE SIIKFTDAPK NIAQEYLAEN
160 170 180 190 200
GFDTVKAIIK IILDYYDKRD FKKDVDTFKV KRSPNTTVRG GRVQSSTGLA
210 220 230 240 250
HVLKKGKESA NVAQESLKRP RSYKHSLDSP QMVELNELVA DNRDLKAINH
260 270 280 290 300
EFLQKCLQFY DGDVVKVLNI SSLLIEDDKN ITKTWNFDEG FTLTSRDNCK
310 320 330 340 350
QHLPKFSTPQ ISRRNEVGNT YKLPLHDKET PEGAVPVINN LFQTYRLDFH
360 370 380 390 400
GFLPSEAVST LKLALNKWWS KEVAERELNS HNINSYGSKV QFVSPLIVVT
410 420 430 440
GRGIHSIGGI SKVRLQVKSF LEKNHYIFWE ESSYFRIEGK KKK
Length:443
Mass (Da):50,874
Last modified:June 1, 1994 - v1
Checksum:i8B7BB872C2BDC734
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z28090 Genomic DNA. Translation: CAA81928.1.
BK006944 Genomic DNA. Translation: DAA09068.1.
PIRiS37915.
RefSeqiNP_012833.1. NM_001179656.1.

Genome annotation databases

EnsemblFungiiYKL090W; YKL090W; YKL090W.
GeneIDi853772.
KEGGisce:YKL090W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z28090 Genomic DNA. Translation: CAA81928.1.
BK006944 Genomic DNA. Translation: DAA09068.1.
PIRiS37915.
RefSeqiNP_012833.1. NM_001179656.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1OTRNMR-A6-54[»]
ProteinModelPortaliP36075.
SMRiP36075. Positions 6-54.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi34043. 11 interactions.
DIPiDIP-1917N.
IntActiP36075. 4 interactions.
MINTiMINT-394365.

Proteomic databases

MaxQBiP36075.
PaxDbiP36075.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYKL090W; YKL090W; YKL090W.
GeneIDi853772.
KEGGisce:YKL090W.

Organism-specific databases

CYGDiYKL090w.
EuPathDBiFungiDB:YKL090W.
SGDiS000001573. CUE2.

Phylogenomic databases

eggNOGiNOG262951.
InParanoidiP36075.
OMAiNDINLAC.
OrthoDBiEOG7M98RQ.

Enzyme and pathway databases

BioCyciYEAST:G3O-31881-MONOMER.

Miscellaneous databases

EvolutionaryTraceiP36075.
NextBioi974873.
PROiP36075.

Family and domain databases

InterProiIPR003892. CUE.
IPR002625. Smr/MutS2_C.
IPR009060. UBA-like.
[Graphical view]
PfamiPF02845. CUE. 2 hits.
PF01713. Smr. 1 hit.
[Graphical view]
SMARTiSM00546. CUE. 2 hits.
SM00463. SMR. 1 hit.
[Graphical view]
SUPFAMiSSF46934. SSF46934. 2 hits.
PROSITEiPS51140. CUE. 2 hits.
PS50828. SMR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Complete DNA sequence of yeast chromosome XI."
    Dujon B., Alexandraki D., Andre B., Ansorge W., Baladron V., Ballesta J.P.G., Banrevi A., Bolle P.-A., Bolotin-Fukuhara M., Bossier P., Bou G., Boyer J., Buitrago M.J., Cheret G., Colleaux L., Daignan-Fornier B., del Rey F., Dion C.
    , Domdey H., Duesterhoeft A., Duesterhus S., Entian K.-D., Erfle H., Esteban P.F., Feldmann H., Fernandes L., Fobo G.M., Fritz C., Fukuhara H., Gabel C., Gaillon L., Garcia-Cantalejo J.M., Garcia-Ramirez J.J., Gent M.E., Ghazvini M., Goffeau A., Gonzalez A., Grothues D., Guerreiro P., Hegemann J.H., Hewitt N., Hilger F., Hollenberg C.P., Horaitis O., Indge K.J., Jacquier A., James C.M., Jauniaux J.-C., Jimenez A., Keuchel H., Kirchrath L., Kleine K., Koetter P., Legrain P., Liebl S., Louis E.J., Maia e Silva A., Marck C., Monnier A.-L., Moestl D., Mueller S., Obermaier B., Oliver S.G., Pallier C., Pascolo S., Pfeiffer F., Philippsen P., Planta R.J., Pohl F.M., Pohl T.M., Poehlmann R., Portetelle D., Purnelle B., Puzos V., Ramezani Rad M., Rasmussen S.W., Remacha M.A., Revuelta J.L., Richard G.-F., Rieger M., Rodrigues-Pousada C., Rose M., Rupp T., Santos M.A., Schwager C., Sensen C., Skala J., Soares H., Sor F., Stegemann J., Tettelin H., Thierry A., Tzermia M., Urrestarazu L.A., van Dyck L., van Vliet-Reedijk J.C., Valens M., Vandenbol M., Vilela C., Vissers S., von Wettstein D., Voss H., Wiemann S., Xu G., Zimmermann J., Haasemann M., Becker I., Mewes H.-W.
    Nature 369:371-378(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. "Solution structure of a CUE-ubiquitin complex reveals a conserved mode of ubiquitin binding."
    Kang R.S., Daniels C.M., Francis S.A., Shih S.C., Salerno W.J., Hicke L., Radhakrishnan I.
    Cell 113:621-630(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY NMR OF 1-54 IN COMPLEX WITH UBIQUITIN.

Entry informationi

Entry nameiCUE2_YEAST
AccessioniPrimary (citable) accession number: P36075
Secondary accession number(s): D6VXJ8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: July 22, 2015
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome XI
    Yeast (Saccharomyces cerevisiae) chromosome XI: entries and gene names

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.