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Protein

Ubiquitin-binding protein CUE2

Gene

CUE2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • ubiquitin binding Source: SGD
Complete GO annotation...

Keywords - Biological processi

Ubl conjugation pathway

Enzyme and pathway databases

BioCyciYEAST:G3O-31881-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin-binding protein CUE2
Alternative name(s):
Coupling of ubiquitin conjugation to ER degradation protein 2
Gene namesi
Name:CUE2
Ordered Locus Names:YKL090W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XI

Organism-specific databases

EuPathDBiFungiDB:YKL090W.
SGDiS000001573. CUE2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000795581 – 443Ubiquitin-binding protein CUE2Add BLAST443

Proteomic databases

MaxQBiP36075.
PRIDEiP36075.

PTM databases

iPTMnetiP36075.

Interactioni

Subunit structurei

Binds to ubiquitin.1 Publication

GO - Molecular functioni

  • ubiquitin binding Source: SGD

Protein-protein interaction databases

BioGridi34043. 11 interactors.
DIPiDIP-1917N.
IntActiP36075. 4 interactors.
MINTiMINT-394365.

Structurei

Secondary structure

1443
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi9 – 19Combined sources11
Beta strandi21 – 23Combined sources3
Helixi25 – 34Combined sources10
Turni35 – 37Combined sources3
Helixi40 – 49Combined sources10

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1OTRNMR-A6-54[»]
ProteinModelPortaliP36075.
SMRiP36075.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP36075.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini8 – 51CUE 1PROSITE-ProRule annotationAdd BLAST44
Domaini55 – 98CUE 2PROSITE-ProRule annotationAdd BLAST44
Domaini347 – 443SmrPROSITE-ProRule annotationAdd BLAST97

Sequence similaritiesi

Contains 2 CUE domains.PROSITE-ProRule annotation
Contains 1 Smr domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

InParanoidiP36075.
OMAiNDINLAC.
OrthoDBiEOG092C2JH1.

Family and domain databases

InterProiIPR003892. CUE.
IPR002625. Smr_dom.
IPR009060. UBA-like.
[Graphical view]
PfamiPF02845. CUE. 2 hits.
[Graphical view]
SMARTiSM00546. CUE. 2 hits.
SM00463. SMR. 1 hit.
[Graphical view]
SUPFAMiSSF160443. SSF160443. 1 hit.
SSF46934. SSF46934. 2 hits.
PROSITEiPS51140. CUE. 2 hits.
PS50828. SMR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P36075-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSMDNNDDHE SKLSILMDMF PAISKSKLQV HLLENNNDLD LTIGLLLKEN
60 70 80 90 100
DDKSTVDNEL HQLYDMFPQL DCSVIKDQFV INEKSVESTI SDLLNYETLQ
110 120 130 140 150
KLKDNQANSP DSVKRNEKKN NWESTNDHIE SIIKFTDAPK NIAQEYLAEN
160 170 180 190 200
GFDTVKAIIK IILDYYDKRD FKKDVDTFKV KRSPNTTVRG GRVQSSTGLA
210 220 230 240 250
HVLKKGKESA NVAQESLKRP RSYKHSLDSP QMVELNELVA DNRDLKAINH
260 270 280 290 300
EFLQKCLQFY DGDVVKVLNI SSLLIEDDKN ITKTWNFDEG FTLTSRDNCK
310 320 330 340 350
QHLPKFSTPQ ISRRNEVGNT YKLPLHDKET PEGAVPVINN LFQTYRLDFH
360 370 380 390 400
GFLPSEAVST LKLALNKWWS KEVAERELNS HNINSYGSKV QFVSPLIVVT
410 420 430 440
GRGIHSIGGI SKVRLQVKSF LEKNHYIFWE ESSYFRIEGK KKK
Length:443
Mass (Da):50,874
Last modified:June 1, 1994 - v1
Checksum:i8B7BB872C2BDC734
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z28090 Genomic DNA. Translation: CAA81928.1.
BK006944 Genomic DNA. Translation: DAA09068.1.
PIRiS37915.
RefSeqiNP_012833.1. NM_001179656.1.

Genome annotation databases

EnsemblFungiiYKL090W; YKL090W; YKL090W.
GeneIDi853772.
KEGGisce:YKL090W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z28090 Genomic DNA. Translation: CAA81928.1.
BK006944 Genomic DNA. Translation: DAA09068.1.
PIRiS37915.
RefSeqiNP_012833.1. NM_001179656.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1OTRNMR-A6-54[»]
ProteinModelPortaliP36075.
SMRiP36075.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi34043. 11 interactors.
DIPiDIP-1917N.
IntActiP36075. 4 interactors.
MINTiMINT-394365.

PTM databases

iPTMnetiP36075.

Proteomic databases

MaxQBiP36075.
PRIDEiP36075.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYKL090W; YKL090W; YKL090W.
GeneIDi853772.
KEGGisce:YKL090W.

Organism-specific databases

EuPathDBiFungiDB:YKL090W.
SGDiS000001573. CUE2.

Phylogenomic databases

InParanoidiP36075.
OMAiNDINLAC.
OrthoDBiEOG092C2JH1.

Enzyme and pathway databases

BioCyciYEAST:G3O-31881-MONOMER.

Miscellaneous databases

EvolutionaryTraceiP36075.
PROiP36075.

Family and domain databases

InterProiIPR003892. CUE.
IPR002625. Smr_dom.
IPR009060. UBA-like.
[Graphical view]
PfamiPF02845. CUE. 2 hits.
[Graphical view]
SMARTiSM00546. CUE. 2 hits.
SM00463. SMR. 1 hit.
[Graphical view]
SUPFAMiSSF160443. SSF160443. 1 hit.
SSF46934. SSF46934. 2 hits.
PROSITEiPS51140. CUE. 2 hits.
PS50828. SMR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCUE2_YEAST
AccessioniPrimary (citable) accession number: P36075
Secondary accession number(s): D6VXJ8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: November 2, 2016
This is version 128 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome XI
    Yeast (Saccharomyces cerevisiae) chromosome XI: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.