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P36075 (CUE2_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 111. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ubiquitin-binding protein CUE2
Alternative name(s):
Coupling of ubiquitin conjugation to ER degradation protein 2
Gene names
Name:CUE2
Ordered Locus Names:YKL090W
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length443 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Subunit structure

Binds to ubiquitin.

Sequence similarities

Contains 2 CUE domains.

Contains 1 Smr domain.

Ontologies

Keywords
   Biological processUbl conjugation pathway
   DomainRepeat
   Technical term3D-structure
Complete proteome
Reference proteome
Gene Ontology (GO)
   Molecular_functionubiquitin binding

Inferred from direct assay PubMed 12628920Ref.3. Source: SGD

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 443443Ubiquitin-binding protein CUE2
PRO_0000079558

Regions

Domain8 – 5144CUE 1
Domain55 – 9844CUE 2
Domain347 – 44397Smr

Secondary structure

.......... 443
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P36075 [UniParc].

Last modified June 1, 1994. Version 1.
Checksum: 8B7BB872C2BDC734

FASTA44350,874
        10         20         30         40         50         60 
MSMDNNDDHE SKLSILMDMF PAISKSKLQV HLLENNNDLD LTIGLLLKEN DDKSTVDNEL 

        70         80         90        100        110        120 
HQLYDMFPQL DCSVIKDQFV INEKSVESTI SDLLNYETLQ KLKDNQANSP DSVKRNEKKN 

       130        140        150        160        170        180 
NWESTNDHIE SIIKFTDAPK NIAQEYLAEN GFDTVKAIIK IILDYYDKRD FKKDVDTFKV 

       190        200        210        220        230        240 
KRSPNTTVRG GRVQSSTGLA HVLKKGKESA NVAQESLKRP RSYKHSLDSP QMVELNELVA 

       250        260        270        280        290        300 
DNRDLKAINH EFLQKCLQFY DGDVVKVLNI SSLLIEDDKN ITKTWNFDEG FTLTSRDNCK 

       310        320        330        340        350        360 
QHLPKFSTPQ ISRRNEVGNT YKLPLHDKET PEGAVPVINN LFQTYRLDFH GFLPSEAVST 

       370        380        390        400        410        420 
LKLALNKWWS KEVAERELNS HNINSYGSKV QFVSPLIVVT GRGIHSIGGI SKVRLQVKSF 

       430        440 
LEKNHYIFWE ESSYFRIEGK KKK 

« Hide

References

« Hide 'large scale' references
[1]"Complete DNA sequence of yeast chromosome XI."
Dujon B., Alexandraki D., Andre B., Ansorge W., Baladron V., Ballesta J.P.G., Banrevi A., Bolle P.-A., Bolotin-Fukuhara M., Bossier P., Bou G., Boyer J., Buitrago M.J., Cheret G., Colleaux L., Daignan-Fornier B., del Rey F., Dion C. expand/collapse author list , Domdey H., Duesterhoeft A., Duesterhus S., Entian K.-D., Erfle H., Esteban P.F., Feldmann H., Fernandes L., Fobo G.M., Fritz C., Fukuhara H., Gabel C., Gaillon L., Garcia-Cantalejo J.M., Garcia-Ramirez J.J., Gent M.E., Ghazvini M., Goffeau A., Gonzalez A., Grothues D., Guerreiro P., Hegemann J.H., Hewitt N., Hilger F., Hollenberg C.P., Horaitis O., Indge K.J., Jacquier A., James C.M., Jauniaux J.-C., Jimenez A., Keuchel H., Kirchrath L., Kleine K., Koetter P., Legrain P., Liebl S., Louis E.J., Maia e Silva A., Marck C., Monnier A.-L., Moestl D., Mueller S., Obermaier B., Oliver S.G., Pallier C., Pascolo S., Pfeiffer F., Philippsen P., Planta R.J., Pohl F.M., Pohl T.M., Poehlmann R., Portetelle D., Purnelle B., Puzos V., Ramezani Rad M., Rasmussen S.W., Remacha M.A., Revuelta J.L., Richard G.-F., Rieger M., Rodrigues-Pousada C., Rose M., Rupp T., Santos M.A., Schwager C., Sensen C., Skala J., Soares H., Sor F., Stegemann J., Tettelin H., Thierry A., Tzermia M., Urrestarazu L.A., van Dyck L., van Vliet-Reedijk J.C., Valens M., Vandenbol M., Vilela C., Vissers S., von Wettstein D., Voss H., Wiemann S., Xu G., Zimmermann J., Haasemann M., Becker I., Mewes H.-W.
Nature 369:371-378(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[2]"The reference genome sequence of Saccharomyces cerevisiae: Then and now."
Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R., Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S., Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.
G3 (Bethesda) 4:389-398(2014) [PubMed] [Europe PMC] [Abstract]
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[3]"Solution structure of a CUE-ubiquitin complex reveals a conserved mode of ubiquitin binding."
Kang R.S., Daniels C.M., Francis S.A., Shih S.C., Salerno W.J., Hicke L., Radhakrishnan I.
Cell 113:621-630(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: STRUCTURE BY NMR OF 1-54 IN COMPLEX WITH UBIQUITIN.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Z28090 Genomic DNA. Translation: CAA81928.1.
BK006944 Genomic DNA. Translation: DAA09068.1.
PIRS37915.
RefSeqNP_012833.1. NM_001179656.1.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1OTRNMR-A6-54[»]
ProteinModelPortalP36075.
SMRP36075. Positions 6-54.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid34043. 11 interactions.
DIPDIP-1917N.
IntActP36075. 4 interactions.
MINTMINT-394365.
STRING4932.YKL090W.

Proteomic databases

MaxQBP36075.
PaxDbP36075.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYKL090W; YKL090W; YKL090W.
GeneID853772.
KEGGsce:YKL090W.

Organism-specific databases

CYGDYKL090w.
SGDS000001573. CUE2.

Phylogenomic databases

eggNOGNOG262951.
OMANDINLAC.
OrthoDBEOG7M98RQ.

Enzyme and pathway databases

BioCycYEAST:G3O-31881-MONOMER.

Gene expression databases

GenevestigatorP36075.

Family and domain databases

InterProIPR003892. CUE.
IPR002625. Smr/MutS2_C.
IPR009060. UBA-like.
[Graphical view]
PfamPF02845. CUE. 2 hits.
PF01713. Smr. 1 hit.
[Graphical view]
SMARTSM00546. CUE. 2 hits.
SM00463. SMR. 1 hit.
[Graphical view]
SUPFAMSSF46934. SSF46934. 2 hits.
PROSITEPS51140. CUE. 2 hits.
PS50828. SMR. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceP36075.
NextBio974873.

Entry information

Entry nameCUE2_YEAST
AccessionPrimary (citable) accession number: P36075
Secondary accession number(s): D6VXJ8
Entry history
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: June 11, 2014
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast chromosome XI

Yeast (Saccharomyces cerevisiae) chromosome XI: entries and gene names

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references