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Protein

Vacuolar amino acid transporter 3

Gene

AVT3

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Involved in amino acid efflux from the vacuole to the cytoplasm. Capable of transporting large neutral amino acids including tyrosine, glutamine, asparagine, isoleucine and leucine.1 Publication

GO - Molecular functioni

  • L-glutamine transmembrane transporter activity Source: SGD
  • L-isoleucine transmembrane transporter activity Source: SGD
  • L-tyrosine transmembrane transporter activity Source: SGD

GO - Biological processi

  • amino acid transmembrane export from vacuole Source: SGD
  • proline transport Source: SGD
Complete GO annotation...

Keywords - Biological processi

Amino-acid transport, Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-31921-MONOMER.
ReactomeiR-SCE-352230. Amino acid transport across the plasma membrane.
R-SCE-428559. Proton-coupled neutral amino acid transporters.

Protein family/group databases

TCDBi2.A.18.7.1. the amino acid/auxin permease (aaap) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Vacuolar amino acid transporter 3
Gene namesi
Name:AVT3
Ordered Locus Names:YKL146W
ORF Names:YKL600
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XI

Organism-specific databases

EuPathDBiFungiDB:YKL146W.
SGDiS000001629. AVT3.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei302 – 322HelicalSequence analysisAdd BLAST21
Transmembranei329 – 349HelicalSequence analysisAdd BLAST21
Transmembranei374 – 394HelicalSequence analysisAdd BLAST21
Transmembranei412 – 432HelicalSequence analysisAdd BLAST21
Transmembranei443 – 463HelicalSequence analysisAdd BLAST21
Transmembranei483 – 503HelicalSequence analysisAdd BLAST21
Transmembranei519 – 539HelicalSequence analysisAdd BLAST21
Transmembranei561 – 581HelicalSequence analysisAdd BLAST21
Transmembranei607 – 627HelicalSequence analysisAdd BLAST21
Transmembranei630 – 650HelicalSequence analysisAdd BLAST21
Transmembranei665 – 685HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

  • fungal-type vacuole Source: SGD
  • fungal-type vacuole membrane Source: SGD
  • integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Vacuole

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000938361 – 692Vacuolar amino acid transporter 3Add BLAST692

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei59PhosphoserineCombined sources1
Modified residuei119PhosphoserineCombined sources1
Modified residuei121PhosphoserineCombined sources1
Modified residuei165PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP36062.
PRIDEiP36062.

PTM databases

iPTMnetiP36062.

Interactioni

Protein-protein interaction databases

BioGridi33990. 43 interactors.
DIPiDIP-4105N.
MINTiMINT-542142.

Structurei

3D structure databases

ProteinModelPortaliP36062.
SMRiP36062.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi261 – 276Poly-GluAdd BLAST16

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00390000011245.
HOGENOMiHOG000185918.
InParanoidiP36062.
KOiK14209.
OMAiKYNPYIK.
OrthoDBiEOG092C13D8.

Family and domain databases

InterProiIPR013057. AA_transpt_TM.
[Graphical view]
PfamiPF01490. Aa_trans. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P36062-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNGKEVSSGS GRTQSNNNKK NNNGGSTGIS HASGSPLTDG NGGNSNGNSR
60 70 80 90 100
SRSRSRKSSG TTGGLLKKPP LLVNNEAVHA SVPDASHTSC NNGTLEVSIN
110 120 130 140 150
NPEPHVVDAV ARHLIRNPSN SLQLQGGDIT RDLYKWTNDH PSSPSQYQYP
160 170 180 190 200
SQPALSTSIP SQAPSFSNRK RSMSFSAASI ASSSHLNNNS EANGNPLAAI
210 220 230 240 250
GLAPAPMTHE EIRAPGGFRR SFIIQKRRKH NVDAPIPNFF TRNFIEFLTL
260 270 280 290 300
YGHFAGEDLS EEEEEEEETE EEPEEEALET ESTQLVSREH GRHPHKSSTV
310 320 330 340 350
KAVLLLLKSF VGTGVLFLPK AFHNGGWGFS ALCLLSCALI SYGCFVSLIT
360 370 380 390 400
TKDKVGVDGY GDMGRILYGP KMKFAILSSI ALSQIGFSAA YTVFTATNLQ
410 420 430 440 450
VFSENFFHLK PGSISLATYI FAQVLIFVPL SLTRNIAKLS GTALIADLFI
460 470 480 490 500
LLGLVYVYVY SIYYIAVNGV ASDTMLMFNK ADWSLFIGTA IFTFEGIGLL
510 520 530 540 550
IPIQESMKHP KHFRPSLSAV MCIVAVIFIS CGLLCYAAFG SDVKTVVLLN
560 570 580 590 600
FPQDTSYTLT VQLLYALAIL LSTPLQLFPA IRILENWTFP SNASGKYNPK
610 620 630 640 650
VKWLKNYFRC AIVVLTSILA WVGANDLDKF VSLVGSFACI PLIYIYPPLL
660 670 680 690
HYKASILSGT SRARLLLDLI VIVFGVAVMA YTSWQTIKMW SQ
Length:692
Mass (Da):75,459
Last modified:June 1, 1994 - v1
Checksum:i379054D69094A0F5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z26877 Genomic DNA. Translation: CAA81508.1.
Z28146 Genomic DNA. Translation: CAA81988.1.
BK006944 Genomic DNA. Translation: DAA09016.1.
PIRiS37976.
RefSeqiNP_012776.1. NM_001179712.1.

Genome annotation databases

EnsemblFungiiYKL146W; YKL146W; YKL146W.
GeneIDi853710.
KEGGisce:YKL146W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z26877 Genomic DNA. Translation: CAA81508.1.
Z28146 Genomic DNA. Translation: CAA81988.1.
BK006944 Genomic DNA. Translation: DAA09016.1.
PIRiS37976.
RefSeqiNP_012776.1. NM_001179712.1.

3D structure databases

ProteinModelPortaliP36062.
SMRiP36062.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi33990. 43 interactors.
DIPiDIP-4105N.
MINTiMINT-542142.

Protein family/group databases

TCDBi2.A.18.7.1. the amino acid/auxin permease (aaap) family.

PTM databases

iPTMnetiP36062.

Proteomic databases

MaxQBiP36062.
PRIDEiP36062.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYKL146W; YKL146W; YKL146W.
GeneIDi853710.
KEGGisce:YKL146W.

Organism-specific databases

EuPathDBiFungiDB:YKL146W.
SGDiS000001629. AVT3.

Phylogenomic databases

GeneTreeiENSGT00390000011245.
HOGENOMiHOG000185918.
InParanoidiP36062.
KOiK14209.
OMAiKYNPYIK.
OrthoDBiEOG092C13D8.

Enzyme and pathway databases

BioCyciYEAST:G3O-31921-MONOMER.
ReactomeiR-SCE-352230. Amino acid transport across the plasma membrane.
R-SCE-428559. Proton-coupled neutral amino acid transporters.

Miscellaneous databases

PROiP36062.

Family and domain databases

InterProiIPR013057. AA_transpt_TM.
[Graphical view]
PfamiPF01490. Aa_trans. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiAVT3_YEAST
AccessioniPrimary (citable) accession number: P36062
Secondary accession number(s): D6VX50
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: November 2, 2016
This is version 129 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XI
    Yeast (Saccharomyces cerevisiae) chromosome XI: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.