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Protein

Signal recognition particle receptor subunit beta

Gene

SRP102

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the SRP (signal recognition particle) receptor. Ensures, in conjunction with the signal recognition particle, the correct targeting of the nascent secretory proteins to the endoplasmic reticulum membrane system. Has GTPase activity. May mediate the membrane association of SRPR.

Miscellaneous

Present with 8250 molecules/cell in log phase SD medium.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei90GTP; via amide nitrogen1 Publication1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi45 – 53GTP1 Publication9
Nucleotide bindingi66 – 69GTP1 Publication4
Nucleotide bindingi154 – 157GTP1 Publication4

GO - Molecular functioni

  • GTPase activity Source: SGD
  • GTP binding Source: SGD
  • identical protein binding Source: IntAct
  • signal recognition particle binding Source: SGD

GO - Biological processi

  • protein targeting to ER Source: SGD
  • SRP-dependent cotranslational protein targeting to membrane Source: SGD

Keywordsi

Molecular functionReceptor
LigandGTP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-31924-MONOMER

Protein family/group databases

TCDBi3.A.5.8.1 the general secretory pathway (sec) family

Names & Taxonomyi

Protein namesi
Recommended name:
Signal recognition particle receptor subunit beta
Short name:
SR-beta
Gene namesi
Name:SRP102
Ordered Locus Names:YKL154W
ORF Names:YKL609
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XI

Organism-specific databases

EuPathDBiFungiDB:YKL154W
SGDiS000001637 SRP102

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei7 – 23HelicalSequence analysisAdd BLAST17

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001012301 – 244Signal recognition particle receptor subunit betaAdd BLAST244

Proteomic databases

MaxQBiP36057
PaxDbiP36057
PRIDEiP36057

Interactioni

Subunit structurei

Heterodimer of an alpha and a beta chain.1 Publication

Binary interactionsi

Show more details

GO - Molecular functioni

  • identical protein binding Source: IntAct

Protein-protein interaction databases

BioGridi33983, 424 interactors
DIPiDIP-4753N
IntActiP36057, 15 interactors
MINTiP36057
STRINGi4932.YKL154W

Structurei

Secondary structure

1244
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi40 – 44Combined sources5
Helixi51 – 60Combined sources10
Beta strandi73 – 75Combined sources3
Helixi78 – 80Combined sources3
Beta strandi84 – 87Combined sources4
Helixi92 – 95Combined sources4
Helixi96 – 105Combined sources10
Helixi106 – 108Combined sources3
Beta strandi109 – 117Combined sources9
Helixi126 – 142Combined sources17
Beta strandi149 – 154Combined sources6
Helixi164 – 187Combined sources24
Helixi214 – 216Combined sources3
Beta strandi217 – 219Combined sources3
Beta strandi221 – 225Combined sources5
Turni228 – 231Combined sources4
Helixi234 – 243Combined sources10

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1NRJX-ray1.70B31-244[»]
2GEDX-ray2.20A/B36-183[»]
ProteinModelPortaliP36057
SMRiP36057
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP36057

Family & Domainsi

Sequence similaritiesi

Belongs to the SRP receptor beta subunit family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00510000048347
HOGENOMiHOG000248720
InParanoidiP36057
KOiK12272
OMAiNKQDQTT
OrthoDBiEOG092C5BU6

Family and domain databases

CDDicd04105 SR_beta, 1 hit
InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR019009 SRP_receptor_beta_su
PANTHERiPTHR11485:SF34 PTHR11485:SF34, 1 hit
PfamiView protein in Pfam
PF09439 SRPRB, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit

Sequencei

Sequence statusi: Complete.

P36057-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLSNTLIIAC LLVIGTTIAL IAVQKASSKT GIKQKSYQPS IIIAGPQNSG
60 70 80 90 100
KTSLLTLLTT DSVRPTVVSQ EPLSAADYDG SGVTLVDFPG HVKLRYKLSD
110 120 130 140 150
YLKTRAKFVK GLIFMVDSTV DPKKLTTTAE FLVDILSITE SSCENGIDIL
160 170 180 190 200
IACNKSELFT ARPPSKIKDA LESEIQKVIE RRKKSLNEVE RKINEEDYAE
210 220 230 240
NTLDVLQSTD GFKFANLEAS VVAFEGSINK RKISQWREWI DEKL
Length:244
Mass (Da):26,974
Last modified:June 1, 1994 - v1
Checksum:iEA4AE9126B2A04B5
GO

Sequence cautioni

The sequence CAA81499 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z26877 Genomic DNA Translation: CAA81499.1 Different initiation.
Z28154 Genomic DNA Translation: CAA81995.1
BK006944 Genomic DNA Translation: DAA09010.1
PIRiS37984
RefSeqiNP_012768.1, NM_001179720.1

Genome annotation databases

EnsemblFungiiYKL154W; YKL154W; YKL154W
GeneIDi853702
KEGGisce:YKL154W

Similar proteinsi

Entry informationi

Entry nameiSRPB_YEAST
AccessioniPrimary (citable) accession number: P36057
Secondary accession number(s): D6VX44
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: May 23, 2018
This is version 163 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome XI
    Yeast (Saccharomyces cerevisiae) chromosome XI: entries and gene names

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