P36056 (RT22_YEAST) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
37S ribosomal protein S22, mitochondrial
EC=2.1.1.-

Gene names

Name:	RSM22
Ordered Locus Names:	YKL155C
ORF Names:	YKL610

Organism

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]

Taxonomic identifier

559292 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › Saccharomyces cerevisiae

Protein attributes

Sequence length	628 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Subunit structure	Component of the mitochondrial small ribosomal subunit. Mature mitochondrial ribosomes consist of a small (37S) and a large (54S) subunit. The 37S subunit contains at least 33 different proteins and 1 molecule of RNA (15S). The 54S subunit contains at least 45 different proteins and 1 molecule of RNA (21S). Ref.4 Ref.5
Subcellular location	Mitochondrion Ref.4 Ref.6 Ref.8.
Miscellaneous	Present with 1900 molecules/cell in log phase SD medium.
Sequence similarities	Belongs to the methyltransferase superfamily. Rsm22 family.

Ontologies

Keywords
Cellular component	Mitochondrion
Domain	Transit peptide
Molecular function	Methyltransferase Ribonucleoprotein Ribosomal protein Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	mitochondrial translation Inferred by curator Ref.4. Source: SGD
Cellular_component	mitochondrial small ribosomal subunit Inferred from physical interaction Ref.4. Source: SGD
Molecular_function	S-adenosylmethionine-dependent methyltransferase activity Inferred from sequence model PubMed 19351663. Source: SGD structural constituent of ribosome Inferred from physical interaction Ref.4. Source: SGD
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Transit peptide	1 – 15	15	Mitochondrion Potential
	Chain	16 – 628	613	37S ribosomal protein S22, mitochondrial		PRO_0000203144

Sequences

	Sequence		Length	Mass (Da)
	P36056 [UniParc]. Last modified June 1, 1994. Version 1. Checksum: 9612A09DA01CD969	FASTA	628	72,190
	10 20 30 40 50 60 MMKRCFSILP QNVRFSSKFT SLNLPKLDLA DFIDSNKRGI NVLPSYRDET ASTTQATNSK 70 80 90 100 110 120 ELRLLSKTLQ GQSYRDQLEL NPDVSKAINN NIMAVHIPNN LRRVATNYYK EIQEPNSLHR 130 140 150 160 170 180 PCRTKMEVDA HIASIFLQNY GSIFQSLKEL QKRVGPDNFK PQRILDVGYG PATGIVALND 190 200 210 220 230 240 ILGPNYRPDL KDAVILGNAE MQERAKIILS RQLNEVVDTV EENVSTEKEQ ETDRRNKNFQ 250 260 270 280 290 300 EDEHIGEVMT KKINIMTNLR SSIPASKEYD LIILTHQLLH DGNQFPIQVD ENIEHYLNIL 310 320 330 340 350 360 APGGHIVIIE RGNPMGFEII ARARQITLRP ENFPDEFGKI PRPWSRGVTV RGKKDAELGN 370 380 390 400 410 420 ISSNYFLKVI APCPHQRKCP LQVGNPNFYT HKEGKDLKFC NFQKSIKRPK FSIELKKGKL 430 440 450 460 470 480 LATSWDGSQG NASRLKGTGR RNGRDYEILN YSYLIFERSH KDENTLKEIK KLRNENVNGK 490 500 510 520 530 540 YDIGSLGDDT QNSWPRIIND PVKRKGHVMM DLCAPSGELE KWTVSRSFSK QIYHDARKSK 550 560 570 580 590 600 KGDLWASAAK TQIKGLGDLN VKKFHKLEKE RIKQLKKEER QKARKAMESY NELEDSLQFD 610 620 DHQFSNFEVM KKLSTFHGND FLQHVNRK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"DNA sequencing of a 36.2 kb fragment located between the FAS1 and LAP loci of chromosome XI of Saccharomyces cerevisiae." Vandenbol M., Bolle P.-A., Dion C., Portetelle D., Hilger F. Yeast 10:S35-S40(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 204508 / S288c.
[2]	"Complete DNA sequence of yeast chromosome XI." Dujon B., Alexandraki D., Andre B., Ansorge W., Baladron V., Ballesta J.P.G., Banrevi A., Bolle P.-A., Bolotin-Fukuhara M., Bossier P., Bou G., Boyer J., Buitrago M.J., Cheret G., Colleaux L., Daignan-Fornier B., del Rey F., Dion C. , Domdey H., Duesterhoeft A., Duesterhus S., Entian K.-D., Erfle H., Esteban P.F., Feldmann H., Fernandes L., Fobo G.M., Fritz C., Fukuhara H., Gabel C., Gaillon L., Garcia-Cantalejo J.M., Garcia-Ramirez J.J., Gent M.E., Ghazvini M., Goffeau A., Gonzalez A., Grothues D., Guerreiro P., Hegemann J.H., Hewitt N., Hilger F., Hollenberg C.P., Horaitis O., Indge K.J., Jacquier A., James C.M., Jauniaux J.-C., Jimenez A., Keuchel H., Kirchrath L., Kleine K., Koetter P., Legrain P., Liebl S., Louis E.J., Maia e Silva A., Marck C., Monnier A.-L., Moestl D., Mueller S., Obermaier B., Oliver S.G., Pallier C., Pascolo S., Pfeiffer F., Philippsen P., Planta R.J., Pohl F.M., Pohl T.M., Poehlmann R., Portetelle D., Purnelle B., Puzos V., Ramezani Rad M., Rasmussen S.W., Remacha M.A., Revuelta J.L., Richard G.-F., Rieger M., Rodrigues-Pousada C., Rose M., Rupp T., Santos M.A., Schwager C., Sensen C., Skala J., Soares H., Sor F., Stegemann J., Tettelin H., Thierry A., Tzermia M., Urrestarazu L.A., van Dyck L., van Vliet-Reedijk J.C., Valens M., Vandenbol M., Vilela C., Vissers S., von Wettstein D., Voss H., Wiemann S., Xu G., Zimmermann J., Haasemann M., Becker I., Mewes H.-W. Nature 369:371-378(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 96604 / S288c / FY1679.
[3]	Saccharomyces Genome Database Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: ATCC 204508 / S288c.
[4]	"Identification of 12 new yeast mitochondrial ribosomal proteins including 6 that have no prokaryotic homologues." Saveanu C., Fromont-Racine M., Harington A., Ricard F., Namane A., Jacquier A. J. Biol. Chem. 276:15861-15867(2001) [PubMed] [Europe PMC] [Abstract] Cited for: SUBCELLULAR LOCATION, IDENTIFICATION IN THE MITOCHONDRIAL RIBOSOMAL SMALL COMPLEX, MASS SPECTROMETRY.
[5]	"Tag-mediated isolation of yeast mitochondrial ribosome and mass spectrometric identification of its new components." Gan X., Kitakawa M., Yoshino K., Oshiro N., Yonezawa K., Isono K. Eur. J. Biochem. 269:5203-5214(2002) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION IN THE MITOCHONDRIAL RIBOSOMAL SMALL COMPLEX, MASS SPECTROMETRY.
[6]	"Global analysis of protein localization in budding yeast." Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W., Weissman J.S., O'Shea E.K. Nature 425:686-691(2003) [PubMed] [Europe PMC] [Abstract] Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
[7]	"Global analysis of protein expression in yeast." Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S. Nature 425:737-741(2003) [PubMed] [Europe PMC] [Abstract] Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
[8]	"Toward the complete yeast mitochondrial proteome: multidimensional separation techniques for mitochondrial proteomics." Reinders J., Zahedi R.P., Pfanner N., Meisinger C., Sickmann A. J. Proteome Res. 5:1543-1554(2006) [PubMed] [Europe PMC] [Abstract] Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	Z26877 Genomic DNA. Translation: CAA81498.1. Z28155 Genomic DNA. Translation: CAA81996.1. BK006944 Genomic DNA. Translation: DAA09009.1.
PIR	S37795.
RefSeq	NP_012767.1. NM_001179721.1.
3D structure databases
ProteinModelPortal	P36056.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-756N.
IntAct	P36056. 7 interactions.
MINT	MINT-638530.
STRING	4932.YKL155C.
Proteomic databases
PaxDb	P36056.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	YKL155C; YKL155C; YKL155C.
GeneID	853701.
KEGG	sce:YKL155C.
Organism-specific databases
CYGD	YKL155c.
SGD	S000001638. RSM22.
Phylogenomic databases
eggNOG	COG5459.
HOGENOM	HOG000246590.
OMA	GKIPRPW.
OrthoDB	EOG4BS0TW.
Gene expression databases
Genevestigator	P36056.
GermOnline	YKL155C. Saccharomyces cerevisiae.
Family and domain databases
InterPro	IPR015324. Ribosomal_Rsm22_bac-type. IPR016522. Ribosome_S22_mit_fun. [Graphical view]
Pfam	PF09243. Rsm22. 2 hits. [Graphical view]
PIRSF	PIRSF007797. RSM22. 1 hit.
ProtoNet	Search...
Other
NextBio	974693.

Entry information

Entry name

RT22_YEAST

Accession

Primary (citable) accession number: P36056
Secondary accession number(s): D6VX43

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 1, 1994
Last sequence update:	June 1, 1994
Last modified:	May 1, 2013
This is version 95 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program