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Protein

Probable S-adenosyl-L-methionine-dependent RNA methyltransferase RSM22, mitochondrial

Gene

RSM22

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Probable S-adenosyl-L-methionine-dependent RNA methyltransferase (PubMed:19351663, PubMed:24651469). May provide the activity for methylation of the rRNA of the small mitochondrial subunit, which is required for the assembly and stability of the mitochondrial ribosome (PubMed:22689777). Has no protein methyltransferase activity (PubMed:24651469).2 Publications1 Publication

Miscellaneous

Present with 1900 molecules/cell in log phase SD medium.1 Publication
Although reported constituent of the mitochondrial small ribosomal subunit (PubMed:11278769), it has not been identified in the structure of the yeast mitoribosome (PubMed:28154081), indicating that RSM22 only transiently interacts with the mitoribosome.2 Publications

GO - Molecular functioni

  • methyltransferase activity Source: UniProtKB-KW
  • structural constituent of ribosome Source: SGD

GO - Biological processi

  • mitochondrial translation Source: SGD

Keywordsi

Molecular functionMethyltransferase, Ribonucleoprotein, Ribosomal protein, Transferase

Enzyme and pathway databases

BioCyciYEAST:G3O-31925-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Probable S-adenosyl-L-methionine-dependent RNA methyltransferase RSM22, mitochondrial (EC:2.1.1.-)
Gene namesi
Name:RSM22
Ordered Locus Names:YKL155C
ORF Names:YKL610
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XI

Organism-specific databases

EuPathDBiFungiDB:YKL155C
SGDiS000001638 RSM22

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 15MitochondrionSequence analysisAdd BLAST15
ChainiPRO_000020314416 – 628Probable S-adenosyl-L-methionine-dependent RNA methyltransferase RSM22, mitochondrialAdd BLAST613

Proteomic databases

MaxQBiP36056
PaxDbiP36056
PRIDEiP36056

PTM databases

iPTMnetiP36056

Interactioni

Subunit structurei

Associates with mitochondrial ribosomes.2 Publications

Protein-protein interaction databases

BioGridi33982, 89 interactors
DIPiDIP-756N
IntActiP36056, 7 interactors
MINTiP36056
STRINGi4932.YKL155C

Structurei

3D structure databases

ProteinModelPortaliP36056
SMRiP36056
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

HOGENOMiHOG000246590
InParanoidiP36056
OMAiGKIPRPY
OrthoDBiEOG092C4AE3

Family and domain databases

InterProiView protein in InterPro
IPR015324 Ribosomal_Rsm22-like
IPR016522 Ribosome_S22_mit_bud
IPR029063 SAM-dependent_MTases
PfamiView protein in Pfam
PF09243 Rsm22, 2 hits
PIRSFiPIRSF007797 RSM22, 1 hit
SUPFAMiSSF53335 SSF53335, 2 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P36056-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMKRCFSILP QNVRFSSKFT SLNLPKLDLA DFIDSNKRGI NVLPSYRDET
60 70 80 90 100
ASTTQATNSK ELRLLSKTLQ GQSYRDQLEL NPDVSKAINN NIMAVHIPNN
110 120 130 140 150
LRRVATNYYK EIQEPNSLHR PCRTKMEVDA HIASIFLQNY GSIFQSLKEL
160 170 180 190 200
QKRVGPDNFK PQRILDVGYG PATGIVALND ILGPNYRPDL KDAVILGNAE
210 220 230 240 250
MQERAKIILS RQLNEVVDTV EENVSTEKEQ ETDRRNKNFQ EDEHIGEVMT
260 270 280 290 300
KKINIMTNLR SSIPASKEYD LIILTHQLLH DGNQFPIQVD ENIEHYLNIL
310 320 330 340 350
APGGHIVIIE RGNPMGFEII ARARQITLRP ENFPDEFGKI PRPWSRGVTV
360 370 380 390 400
RGKKDAELGN ISSNYFLKVI APCPHQRKCP LQVGNPNFYT HKEGKDLKFC
410 420 430 440 450
NFQKSIKRPK FSIELKKGKL LATSWDGSQG NASRLKGTGR RNGRDYEILN
460 470 480 490 500
YSYLIFERSH KDENTLKEIK KLRNENVNGK YDIGSLGDDT QNSWPRIIND
510 520 530 540 550
PVKRKGHVMM DLCAPSGELE KWTVSRSFSK QIYHDARKSK KGDLWASAAK
560 570 580 590 600
TQIKGLGDLN VKKFHKLEKE RIKQLKKEER QKARKAMESY NELEDSLQFD
610 620
DHQFSNFEVM KKLSTFHGND FLQHVNRK
Length:628
Mass (Da):72,190
Last modified:June 1, 1994 - v1
Checksum:i9612A09DA01CD969
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z26877 Genomic DNA Translation: CAA81498.1
Z28155 Genomic DNA Translation: CAA81996.1
BK006944 Genomic DNA Translation: DAA09009.1
PIRiS37795
RefSeqiNP_012767.1, NM_001179721.1

Genome annotation databases

EnsemblFungiiYKL155C; YKL155C; YKL155C
GeneIDi853701
KEGGisce:YKL155C

Similar proteinsi

Entry informationi

Entry nameiRT22_YEAST
AccessioniPrimary (citable) accession number: P36056
Secondary accession number(s): D6VX43
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: May 23, 2018
This is version 138 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XI
    Yeast (Saccharomyces cerevisiae) chromosome XI: entries and gene names

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