P36054 (RCN1_YEAST) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Calcipressin-like protein

Alternative name(s):
Down syndrome candidate region 1-like protein
Regulator of calcineurin 1

Gene names

Name:	RCN1
Synonyms:	DSCR1L
Ordered Locus Names:	YKL159C
ORF Names:	YKL613

Organism

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)

Taxonomic identifier

559292 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces

Protein attributes

Sequence length	211 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin.
Miscellaneous	Present with 521 molecules/cell in log phase SD medium. Ref.6
Sequence similarities	Belongs to the RCAN family.

Ontologies

Keywords
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	calcium-mediated signaling Inferred from mutant phenotype. Source: SGD
Cellular component	cytoplasm Inferred by curator Ref.5. Source: SGD
Molecular function	calcium-dependent protein serine/threonine phosphatase regulator activity Inferred from genetic interaction Ref.5. Source: SGD protein phosphatase 2B binding Inferred from direct assay Ref.5. Source: SGD
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 211	211	Calcipressin-like protein		PRO_0000211424
Amino acid modifications
	Modified residue	117	1	Phosphoserine Ref.7

Sequences

	Sequence		Length	Mass (Da)
	P36054 [UniParc]. Last modified June 1, 1994. Version 1. Checksum: 668EA0C10D4E39AA	FASTA	211	24,135
	10 20 30 40 50 60 MGNIITDTII ITSDKCDIVD NDNVERIQVW LSKNILRKFQ INENEPLQLI ILKRFKRILL 70 80 90 100 110 120 ICPSHDISQH VMDASRALEM ENFNFSYSLQ DGQRNLTKQY LKVPESEKMF LISPPASPPP 130 140 150 160 170 180 EFDFSKCEDA PQRHIQSHIQ QDQQQRLEAS QLLPNNPDKN NNGTFTLLKS KVGAITIDRC 190 200 210 PTNDGNGQMQ LADHVKTAFP PKSIFDTDDD D

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A new gene family including DSCR1 (Down syndrome candidate region 1) and ZAKI-4: characterization from yeast to human and identification of DSCR1-like 2, a novel human member (DSCR1L2)." Strippoli P., Lenzi L., Petrini M., Carinci P., Zannotti M. Genomics 64:252-263(2000) [PubMed: 10756093] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: CG1945.
[2]	"DNA sequencing of a 36.2 kb fragment located between the FAS1 and LAP loci of chromosome XI of Saccharomyces cerevisiae." Vandenbol M., Bolle P.-A., Dion C., Portetelle D., Hilger F. Yeast 10:S35-S40(1994) [PubMed: 8091859] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 204508 / S288c.
[3]	"Complete DNA sequence of yeast chromosome XI." Dujon B., Alexandraki D., Andre B., Ansorge W., Baladron V., Ballesta J.P.G., Banrevi A., Bolle P.-A., Bolotin-Fukuhara M., Bossier P., Bou G., Boyer J., Buitrago M.J., Cheret G., Colleaux L., Daignan-Fornier B., del Rey F., Dion C. , Domdey H., Duesterhoeft A., Duesterhus S., Entian K.-D., Erfle H., Esteban P.F., Feldmann H., Fernandes L., Fobo G.M., Fritz C., Fukuhara H., Gabel C., Gaillon L., Garcia-Cantalejo J.M., Garcia-Ramirez J.J., Gent M.E., Ghazvini M., Goffeau A., Gonzalez A., Grothues D., Guerreiro P., Hegemann J.H., Hewitt N., Hilger F., Hollenberg C.P., Horaitis O., Indge K.J., Jacquier A., James C.M., Jauniaux J.-C., Jimenez A., Keuchel H., Kirchrath L., Kleine K., Koetter P., Legrain P., Liebl S., Louis E.J., Maia e Silva A., Marck C., Monnier A.-L., Moestl D., Mueller S., Obermaier B., Oliver S.G., Pallier C., Pascolo S., Pfeiffer F., Philippsen P., Planta R.J., Pohl F.M., Pohl T.M., Poehlmann R., Portetelle D., Purnelle B., Puzos V., Ramezani Rad M., Rasmussen S.W., Remacha M.A., Revuelta J.L., Richard G.-F., Rieger M., Rodrigues-Pousada C., Rose M., Rupp T., Santos M.A., Schwager C., Sensen C., Skala J., Soares H., Sor F., Stegemann J., Tettelin H., Thierry A., Tzermia M., Urrestarazu L.A., van Dyck L., van Vliet-Reedijk J.C., Valens M., Vandenbol M., Vilela C., Vissers S., von Wettstein D., Voss H., Wiemann S., Xu G., Zimmermann J., Haasemann M., Becker I., Mewes H.-W. Nature 369:371-378(1994) [PubMed: 8196765] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 204508 / S288c.
[4]	Saccharomyces Genome Database Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: ATCC 204508 / S288c.
[5]	"A conserved family of calcineurin regulators." Kingsbury T.J., Cunningham K.W. Genes Dev. 14:1595-1604(2000) [PubMed: 10887154] [Abstract] Cited for: CHARACTERIZATION.
[6]	"Global analysis of protein expression in yeast." Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S. Nature 425:737-741(2003) [PubMed: 14562106] [Abstract] Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
[7]	"A multidimensional chromatography technology for in-depth phosphoproteome analysis." Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H. Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed: 18407956] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-117, MASS SPECTROMETRY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF174139 mRNA. Translation: AAF01680.1. Z26877 Genomic DNA. Translation: CAA81495.1. Z28159 Genomic DNA. Translation: CAA82001.1. BK006944 Genomic DNA. Translation: DAA09006.1.
PIR	S37792.
RefSeq	NP_012763.1. NM_001179725.1.
3D structure databases
ProteinModelPortal	P36054.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-7429N.
IntAct	P36054. 5 interactions.
MINT	MINT-2785513.
STRING	P36054.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	YKL159C; YKL159C; YKL159C.
GeneID	853698.
KEGG	sce:YKL159C.
NMPDR	fig|4932.3.peg.3742.
Organism-specific databases
CYGD	YKL159c.
SGD	S000001642. RCN1.
Phylogenomic databases
eggNOG	fuNOG12755.
HOGENOM	HBG202410.
OMA	RALEMEN.
OrthoDB	EOG48H0D5.
Gene expression databases
ArrayExpress	P36054.
Genevestigator	P36054.
GermOnline	YKL159C. Saccharomyces cerevisiae.
Family and domain databases
InterPro	IPR006931. Calcipressin. IPR016523. UCP007798. [Graphical view]
PANTHER	PTHR10300. Calcipressin. 1 hit.
Pfam	PF04847. Calcipressin. 1 hit. [Graphical view]
PIRSF	PIRSF007798. UCP007798. 1 hit.
ProtoNet	Search...
Other
NextBio	974684.

Entry information

Entry name

RCN1_YEAST

Accession

Primary (citable) accession number: P36054
Secondary accession number(s): D6VX40

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 1, 1994
Last sequence update:	June 1, 1994
Last modified:	December 14, 2011
This is version 85 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program