Reviewed, UniProtKB/Swiss-Prot P36054 (RCN1_YEAST)

Names and origin

Protein names

Recommended name:
    Calcipressin-like protein
Alternative name(s):
    Regulator of calcineurin 1
    Down syndrome candidate region 1-like protein

Gene names

Name:	RCN1
Synonyms:	DSCR1L
Ordered Locus Names:	YKL159C
ORF Names:	YKL613

Organism

Saccharomyces cerevisiae (Baker's yeast) [Complete proteome]

Taxonomic identifier

4932 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces

Protein attributes

Sequence length	211 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin.
Miscellaneous	Present with 521 molecules/cell in log phase SD medium. Ref.5
Sequence similarities	Belongs to the RCAN family.

Ontologies

Keywords
PTM	Phosphoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	calcium-mediated signaling Ref.4 Inferred from mutant phenotype. Source: SGD
Cellular component	cytoplasm Ref.4 Inferred by curator. Source: SGD
Molecular function	calcium-dependent protein serine/threonine phosphatase regulator activity Ref.4 Inferred from genetic interaction. Source: SGD protein phosphatase 2B binding Ref.4 Inferred from direct assay. Source: SGD
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
CNB1	P25296	1	EBI-14898,EBI-3968

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 211	211	Calcipressin-like protein		PRO_0000211424
Amino acid modifications
	Modified residue	117	1	Phosphoserine Ref.6

Sequences

	Sequence		Length	Mass (Da)
	P36054-1 [UniParc]. Last modified June 1, 1994. Version 1. Checksum: 668EA0C10D4E39AA	FASTA	211	24,135
	10 20 30 40 50 60 MGNIITDTII ITSDKCDIVD NDNVERIQVW LSKNILRKFQ INENEPLQLI ILKRFKRILL 70 80 90 100 110 120 ICPSHDISQH VMDASRALEM ENFNFSYSLQ DGQRNLTKQY LKVPESEKMF LISPPASPPP 130 140 150 160 170 180 EFDFSKCEDA PQRHIQSHIQ QDQQQRLEAS QLLPNNPDKN NNGTFTLLKS KVGAITIDRC 190 200 210 PTNDGNGQMQ LADHVKTAFP PKSIFDTDDD D

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A new gene family including DSCR1 (Down syndrome candidate region 1) and ZAKI-4: characterization from yeast to human and identification of DSCR1-like 2, a novel human member (DSCR1L2)." Strippoli P., Lenzi L., Petrini M., Carinci P., Zannotti M. Genomics 64:252-263(2000) [PubMed: 10756093] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: CG1945.
[2]	"DNA sequencing of a 36.2 kb fragment located between the FAS1 and LAP loci of chromosome XI of Saccharomyces cerevisiae." Vandenbol M., Bolle P.-A., Dion C., Portetelle D., Hilger F. Yeast 10:S35-S40(1994) [PubMed: 8091859] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 204508 / S288c.
[3]	"Complete DNA sequence of yeast chromosome XI." Dujon B., Alexandraki D., Andre B., Ansorge W., Baladron V., Ballesta J.P.G., Banrevi A., Bolle P.-A., Bolotin-Fukuhara M., Bossier P., Bou G., Boyer J., Buitrago M.J., Cheret G., Colleaux L., Daignan-Fornier B., del Rey F., Dion C. , Domdey H., Duesterhoeft A., Duesterhus S., Entian K.-D., Erfle H., Esteban P.F., Feldmann H., Fernandes L., Fobo G.M., Fritz C., Fukuhara H., Gabel C., Gaillon L., Garcia-Cantalejo J.M., Garcia-Ramirez J.J., Gent M.E., Ghazvini M., Goffeau A., Gonzalez A., Grothues D., Guerreiro P., Hegemann J.H., Hewitt N., Hilger F., Hollenberg C.P., Horaitis O., Indge K.J., Jacquier A., James C.M., Jauniaux J.-C., Jimenez A., Keuchel H., Kirchrath L., Kleine K., Koetter P., Legrain P., Liebl S., Louis E.J., Maia e Silva A., Marck C., Monnier A.-L., Moestl D., Mueller S., Obermaier B., Oliver S.G., Pallier C., Pascolo S., Pfeiffer F., Philippsen P., Planta R.J., Pohl F.M., Pohl T.M., Poehlmann R., Portetelle D., Purnelle B., Puzos V., Ramezani Rad M., Rasmussen S.W., Remacha M.A., Revuelta J.L., Richard G.-F., Rieger M., Rodrigues-Pousada C., Rose M., Rupp T., Santos M.A., Schwager C., Sensen C., Skala J., Soares H., Sor F., Stegemann J., Tettelin H., Thierry A., Tzermia M., Urrestarazu L.A., van Dyck L., van Vliet-Reedijk J.C., Valens M., Vandenbol M., Vilela C., Vissers S., von Wettstein D., Voss H., Wiemann S., Xu G., Zimmermann J., Haasemann M., Becker I., Mewes H.-W. Nature 369:371-378(1994) [PubMed: 8196765] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 204508 / S288c.
[4]	"A conserved family of calcineurin regulators." Kingsbury T.J., Cunningham K.W. Genes Dev. 14:1595-1604(2000) [PubMed: 10887154] [Abstract] Cited for: CHARACTERIZATION.
[5]	"Global analysis of protein expression in yeast." Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S. Nature 425:737-741(2003) [PubMed: 14562106] [Abstract] Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
[6]	"A multidimensional chromatography technology for in-depth phosphoproteome analysis." Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H. Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed: 18407956] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-117, MASS SPECTROMETRY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF174139 mRNA. Translation: AAF01680.1. Z26877 Genomic DNA. Translation: CAA81495.1. Z28159 Genomic DNA. Translation: CAA82001.1.
PIR	S37792.
RefSeq	NP_012763.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
IntAct	P36054. 5 interactions.
STRING	P36054.
Proteomic databases
PRIDE	P36054.
Genome annotation databases
Ensembl	YKL159C; YKL159C; YKL159C; Saccharomyces cerevisiae. [Genome view]
GeneID	853698.
GenomeReviews	Gene locus YKL159C in contig Y13137_GR.
KEGG	sce:YKL159C.
NMPDR	fig|4932.3.peg.3742.
Organism-specific databases
CYGD	YKL159c.
SGD	S000001642. RCN1.
Phylogenomic databases
HOGENOM	P36054.
OMA	PPPEFDF.
Gene expression databases
ArrayExpress	P36054.
Genevestigator	P36054.
GermOnline	YKL159C. Saccharomyces cerevisiae.
Family and domain databases
InterPro	IPR006931. Calcipressin. IPR016523. UCP007798. [Graphical view]
Pfam	PF04847. Calcipressin. 1 hit. [Graphical view]
PIRSF	PIRSF007798. UCP007798. 1 hit.
ProtoNet	Search...
Other Resources
NextBio	974684.

Entry information

Entry name

RCN1_YEAST

Accession

Primary (citable) accession number: P36054

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 1, 1994
Last sequence update:	June 1, 1994
Last modified:	November 3, 2009
This is version 67 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)