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P36054 (RCN1_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 85. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Calcipressin-like protein
Alternative name(s):
Down syndrome candidate region 1-like protein
Regulator of calcineurin 1
Gene names
Name:RCN1
Synonyms:DSCR1L
Ordered Locus Names:YKL159C
ORF Names:YKL613
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length211 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin.

Miscellaneous

Present with 521 molecules/cell in log phase SD medium. Ref.6

Sequence similarities

Belongs to the RCAN family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 211211Calcipressin-like protein
PRO_0000211424

Amino acid modifications

Modified residue1171Phosphoserine Ref.7

Sequences

Sequence LengthMass (Da)Tools
P36054 [UniParc].

Last modified June 1, 1994. Version 1.
Checksum: 668EA0C10D4E39AA

FASTA21124,135
        10         20         30         40         50         60 
MGNIITDTII ITSDKCDIVD NDNVERIQVW LSKNILRKFQ INENEPLQLI ILKRFKRILL 

        70         80         90        100        110        120 
ICPSHDISQH VMDASRALEM ENFNFSYSLQ DGQRNLTKQY LKVPESEKMF LISPPASPPP 

       130        140        150        160        170        180 
EFDFSKCEDA PQRHIQSHIQ QDQQQRLEAS QLLPNNPDKN NNGTFTLLKS KVGAITIDRC 

       190        200        210 
PTNDGNGQMQ LADHVKTAFP PKSIFDTDDD D 

« Hide

References

« Hide 'large scale' references
[1]"A new gene family including DSCR1 (Down syndrome candidate region 1) and ZAKI-4: characterization from yeast to human and identification of DSCR1-like 2, a novel human member (DSCR1L2)."
Strippoli P., Lenzi L., Petrini M., Carinci P., Zannotti M.
Genomics 64:252-263(2000) [PubMed: 10756093] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: CG1945.
[2]"DNA sequencing of a 36.2 kb fragment located between the FAS1 and LAP loci of chromosome XI of Saccharomyces cerevisiae."
Vandenbol M., Bolle P.-A., Dion C., Portetelle D., Hilger F.
Yeast 10:S35-S40(1994) [PubMed: 8091859] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[3]"Complete DNA sequence of yeast chromosome XI."
Dujon B., Alexandraki D., Andre B., Ansorge W., Baladron V., Ballesta J.P.G., Banrevi A., Bolle P.-A., Bolotin-Fukuhara M., Bossier P., Bou G., Boyer J., Buitrago M.J., Cheret G., Colleaux L., Daignan-Fornier B., del Rey F., Dion C. expand/collapse author list , Domdey H., Duesterhoeft A., Duesterhus S., Entian K.-D., Erfle H., Esteban P.F., Feldmann H., Fernandes L., Fobo G.M., Fritz C., Fukuhara H., Gabel C., Gaillon L., Garcia-Cantalejo J.M., Garcia-Ramirez J.J., Gent M.E., Ghazvini M., Goffeau A., Gonzalez A., Grothues D., Guerreiro P., Hegemann J.H., Hewitt N., Hilger F., Hollenberg C.P., Horaitis O., Indge K.J., Jacquier A., James C.M., Jauniaux J.-C., Jimenez A., Keuchel H., Kirchrath L., Kleine K., Koetter P., Legrain P., Liebl S., Louis E.J., Maia e Silva A., Marck C., Monnier A.-L., Moestl D., Mueller S., Obermaier B., Oliver S.G., Pallier C., Pascolo S., Pfeiffer F., Philippsen P., Planta R.J., Pohl F.M., Pohl T.M., Poehlmann R., Portetelle D., Purnelle B., Puzos V., Ramezani Rad M., Rasmussen S.W., Remacha M.A., Revuelta J.L., Richard G.-F., Rieger M., Rodrigues-Pousada C., Rose M., Rupp T., Santos M.A., Schwager C., Sensen C., Skala J., Soares H., Sor F., Stegemann J., Tettelin H., Thierry A., Tzermia M., Urrestarazu L.A., van Dyck L., van Vliet-Reedijk J.C., Valens M., Vandenbol M., Vilela C., Vissers S., von Wettstein D., Voss H., Wiemann S., Xu G., Zimmermann J., Haasemann M., Becker I., Mewes H.-W.
Nature 369:371-378(1994) [PubMed: 8196765] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[4]Saccharomyces Genome Database
Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[5]"A conserved family of calcineurin regulators."
Kingsbury T.J., Cunningham K.W.
Genes Dev. 14:1595-1604(2000) [PubMed: 10887154] [Abstract]
Cited for: CHARACTERIZATION.
[6]"Global analysis of protein expression in yeast."
Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S.
Nature 425:737-741(2003) [PubMed: 14562106] [Abstract]
Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
[7]"A multidimensional chromatography technology for in-depth phosphoproteome analysis."
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed: 18407956] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-117, MASS SPECTROMETRY.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF174139 mRNA. Translation: AAF01680.1.
Z26877 Genomic DNA. Translation: CAA81495.1.
Z28159 Genomic DNA. Translation: CAA82001.1.
BK006944 Genomic DNA. Translation: DAA09006.1.
PIRS37792.
RefSeqNP_012763.1. NM_001179725.1.

3D structure databases

ProteinModelPortalP36054.
ModBaseSearch...

Protein-protein interaction databases

DIPDIP-7429N.
IntActP36054. 5 interactions.
MINTMINT-2785513.
STRINGP36054.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYKL159C; YKL159C; YKL159C.
GeneID853698.
KEGGsce:YKL159C.
NMPDRfig|4932.3.peg.3742.

Organism-specific databases

CYGDYKL159c.
SGDS000001642. RCN1.

Phylogenomic databases

eggNOGfuNOG12755.
HOGENOMHBG202410.
OMARALEMEN.
OrthoDBEOG48H0D5.

Gene expression databases

ArrayExpressP36054.
GenevestigatorP36054.
GermOnlineYKL159C. Saccharomyces cerevisiae.

Family and domain databases

InterProIPR006931. Calcipressin.
IPR016523. UCP007798.
[Graphical view]
PANTHERPTHR10300. Calcipressin. 1 hit.
PfamPF04847. Calcipressin. 1 hit.
[Graphical view]
PIRSFPIRSF007798. UCP007798. 1 hit.
ProtoNetSearch...

Other

NextBio974684.

Entry information

Entry nameRCN1_YEAST
AccessionPrimary (citable) accession number: P36054
Secondary accession number(s): D6VX40
Entry history
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: December 14, 2011
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

Yeast chromosome XI

Yeast (Saccharomyces cerevisiae) chromosome XI: entries and gene names

SIMILARITY comments

Index of protein domains and families