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P36053

- ELF1_YEAST

UniProt

P36053 - ELF1_YEAST

Protein

Transcription elongation factor 1

Gene

ELF1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 119 (01 Oct 2014)
      Sequence version 1 (01 Jun 1994)
      Previous versions | rss
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    Functioni

    Transcription elongation factor implicated in the maintenance of proper chromatin structure in actively transcribed regions.1 Publication

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi25 – 251ZincBy similarity
    Metal bindingi28 – 281ZincBy similarity
    Metal bindingi49 – 491ZincBy similarity
    Metal bindingi52 – 521ZincBy similarity

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. RNA polymerase II core binding Source: SGD

    GO - Biological processi

    1. regulation of transcription by chromatin organization Source: SGD
    2. transcription elongation from RNA polymerase II promoter Source: SGD

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    Metal-binding, Zinc

    Enzyme and pathway databases

    BioCyciYEAST:G3O-31928-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Transcription elongation factor 1
    Gene namesi
    Name:ELF1
    Ordered Locus Names:YKL160W
    ORF Names:YKL614
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome XI

    Organism-specific databases

    CYGDiYKL160w.
    SGDiS000001643. ELF1.

    Subcellular locationi

    Nucleus 1 Publication

    GO - Cellular componenti

    1. nucleus Source: SGD
    2. transcription elongation factor complex Source: SGD

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 145145Transcription elongation factor 1PRO_0000120950Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei55 – 551Phosphoserine1 Publication
    Modified residuei117 – 1171Phosphoserine3 Publications
    Modified residuei124 – 1241Phosphoserine3 Publications
    Modified residuei142 – 1421Phosphoserine2 Publications

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiP36053.
    PaxDbiP36053.
    PeptideAtlasiP36053.

    Expressioni

    Gene expression databases

    GenevestigatoriP36053.

    Interactioni

    Protein-protein interaction databases

    BioGridi33978. 164 interactions.
    DIPiDIP-2119N.
    IntActiP36053. 2 interactions.
    MINTiMINT-508271.
    STRINGi4932.YKL160W.

    Structurei

    3D structure databases

    ProteinModelPortaliP36053.
    SMRiP36053. Positions 2-78.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ELOF1 family.Curated

    Keywords - Domaini

    Zinc-finger

    Phylogenomic databases

    eggNOGiCOG4888.
    GeneTreeiENSGT00390000000053.
    HOGENOMiHOG000159293.
    OMAiSCTLDKK.
    OrthoDBiEOG76TB4Q.

    Family and domain databases

    InterProiIPR007808. Elf1.
    [Graphical view]
    PANTHERiPTHR20934. PTHR20934. 1 hit.
    PfamiPF05129. Elf1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P36053-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGKRKKSTRK PTKRLVQKLD TKFNCLFCNH EKSVSCTLDK KNSIGTLSCK    50
    ICGQSFQTRI NSLSQPVDVY SDWFDAVEEV NSGRGSDTDD GDEGSDSDYE 100
    SDSEQDAKTQ NDGEIDSDEE EVDSDEERIG QVKRGRGALV DSDDE 145
    Length:145
    Mass (Da):16,157
    Last modified:June 1, 1994 - v1
    Checksum:i0741A4F14D6CD705
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z26877 Genomic DNA. Translation: CAA81494.1.
    Z28160 Genomic DNA. Translation: CAA82002.1.
    AY558355 Genomic DNA. Translation: AAS56681.1.
    BK006944 Genomic DNA. Translation: DAA09005.1.
    PIRiS37791.
    RefSeqiNP_012762.1. NM_001179726.1.

    Genome annotation databases

    EnsemblFungiiYKL160W; YKL160W; YKL160W.
    GeneIDi853697.
    KEGGisce:YKL160W.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z26877 Genomic DNA. Translation: CAA81494.1 .
    Z28160 Genomic DNA. Translation: CAA82002.1 .
    AY558355 Genomic DNA. Translation: AAS56681.1 .
    BK006944 Genomic DNA. Translation: DAA09005.1 .
    PIRi S37791.
    RefSeqi NP_012762.1. NM_001179726.1.

    3D structure databases

    ProteinModelPortali P36053.
    SMRi P36053. Positions 2-78.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 33978. 164 interactions.
    DIPi DIP-2119N.
    IntActi P36053. 2 interactions.
    MINTi MINT-508271.
    STRINGi 4932.YKL160W.

    Proteomic databases

    MaxQBi P36053.
    PaxDbi P36053.
    PeptideAtlasi P36053.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YKL160W ; YKL160W ; YKL160W .
    GeneIDi 853697.
    KEGGi sce:YKL160W.

    Organism-specific databases

    CYGDi YKL160w.
    SGDi S000001643. ELF1.

    Phylogenomic databases

    eggNOGi COG4888.
    GeneTreei ENSGT00390000000053.
    HOGENOMi HOG000159293.
    OMAi SCTLDKK.
    OrthoDBi EOG76TB4Q.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-31928-MONOMER.

    Miscellaneous databases

    NextBioi 974681.
    PROi P36053.

    Gene expression databases

    Genevestigatori P36053.

    Family and domain databases

    InterProi IPR007808. Elf1.
    [Graphical view ]
    PANTHERi PTHR20934. PTHR20934. 1 hit.
    Pfami PF05129. Elf1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "DNA sequencing of a 36.2 kb fragment located between the FAS1 and LAP loci of chromosome XI of Saccharomyces cerevisiae."
      Vandenbol M., Bolle P.-A., Dion C., Portetelle D., Hilger F.
      Yeast 10:S35-S40(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    2. "Complete DNA sequence of yeast chromosome XI."
      Dujon B., Alexandraki D., Andre B., Ansorge W., Baladron V., Ballesta J.P.G., Banrevi A., Bolle P.-A., Bolotin-Fukuhara M., Bossier P., Bou G., Boyer J., Buitrago M.J., Cheret G., Colleaux L., Daignan-Fornier B., del Rey F., Dion C.
      , Domdey H., Duesterhoeft A., Duesterhus S., Entian K.-D., Erfle H., Esteban P.F., Feldmann H., Fernandes L., Fobo G.M., Fritz C., Fukuhara H., Gabel C., Gaillon L., Garcia-Cantalejo J.M., Garcia-Ramirez J.J., Gent M.E., Ghazvini M., Goffeau A., Gonzalez A., Grothues D., Guerreiro P., Hegemann J.H., Hewitt N., Hilger F., Hollenberg C.P., Horaitis O., Indge K.J., Jacquier A., James C.M., Jauniaux J.-C., Jimenez A., Keuchel H., Kirchrath L., Kleine K., Koetter P., Legrain P., Liebl S., Louis E.J., Maia e Silva A., Marck C., Monnier A.-L., Moestl D., Mueller S., Obermaier B., Oliver S.G., Pallier C., Pascolo S., Pfeiffer F., Philippsen P., Planta R.J., Pohl F.M., Pohl T.M., Poehlmann R., Portetelle D., Purnelle B., Puzos V., Ramezani Rad M., Rasmussen S.W., Remacha M.A., Revuelta J.L., Richard G.-F., Rieger M., Rodrigues-Pousada C., Rose M., Rupp T., Santos M.A., Schwager C., Sensen C., Skala J., Soares H., Sor F., Stegemann J., Tettelin H., Thierry A., Tzermia M., Urrestarazu L.A., van Dyck L., van Vliet-Reedijk J.C., Valens M., Vandenbol M., Vilela C., Vissers S., von Wettstein D., Voss H., Wiemann S., Xu G., Zimmermann J., Haasemann M., Becker I., Mewes H.-W.
      Nature 369:371-378(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    3. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    4. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    5. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
    6. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
    7. "Identification and characterization of Elf1, a conserved transcription elongation factor in Saccharomyces cerevisiae."
      Prather D., Krogan N.J., Emili A., Greenblatt J.F., Winston F.
      Mol. Cell. Biol. 25:10122-10135(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    8. "Large-scale phosphorylation analysis of alpha-factor-arrested Saccharomyces cerevisiae."
      Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J., Elias J.E., Gygi S.P.
      J. Proteome Res. 6:1190-1197(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-117; SER-124 AND SER-142, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Strain: ADR376.
    9. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
      Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
      Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-55; SER-117 AND SER-124, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    10. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
      Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
      Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-117; SER-124 AND SER-142, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiELF1_YEAST
    AccessioniPrimary (citable) accession number: P36053
    Secondary accession number(s): D6VX39
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 1, 1994
    Last sequence update: June 1, 1994
    Last modified: October 1, 2014
    This is version 119 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Present with 5860 molecules/cell in log phase SD medium.1 Publication

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Uncharacterized protein families (UPF)
      List of uncharacterized protein family (UPF) entries
    3. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    4. Yeast chromosome XI
      Yeast (Saccharomyces cerevisiae) chromosome XI: entries and gene names

    External Data

    Dasty 3