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P36053

- ELF1_YEAST

UniProt

P36053 - ELF1_YEAST

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Protein

Transcription elongation factor 1

Gene
ELF1, YKL160W, YKL614
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Transcription elongation factor implicated in the maintenance of proper chromatin structure in actively transcribed regions.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi25 – 251Zinc By similarity
Metal bindingi28 – 281Zinc By similarity
Metal bindingi49 – 491Zinc By similarity
Metal bindingi52 – 521Zinc By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. RNA polymerase II core binding Source: SGD

GO - Biological processi

  1. regulation of transcription by chromatin organization Source: SGD
  2. transcription elongation from RNA polymerase II promoter Source: SGD
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BioCyciYEAST:G3O-31928-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription elongation factor 1
Gene namesi
Name:ELF1
Ordered Locus Names:YKL160W
ORF Names:YKL614
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome XI

Organism-specific databases

CYGDiYKL160w.
SGDiS000001643. ELF1.

Subcellular locationi

Nucleus 1 Publication

GO - Cellular componenti

  1. nucleus Source: SGD
  2. transcription elongation factor complex Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 145145Transcription elongation factor 1PRO_0000120950Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei55 – 551Phosphoserine1 Publication
Modified residuei117 – 1171Phosphoserine3 Publications
Modified residuei124 – 1241Phosphoserine3 Publications
Modified residuei142 – 1421Phosphoserine2 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP36053.
PaxDbiP36053.
PeptideAtlasiP36053.

Expressioni

Gene expression databases

GenevestigatoriP36053.

Interactioni

Protein-protein interaction databases

BioGridi33978. 164 interactions.
DIPiDIP-2119N.
IntActiP36053. 2 interactions.
MINTiMINT-508271.
STRINGi4932.YKL160W.

Structurei

3D structure databases

ProteinModelPortaliP36053.
SMRiP36053. Positions 2-78.

Family & Domainsi

Sequence similaritiesi

Belongs to the ELOF1 family.

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiCOG4888.
GeneTreeiENSGT00390000000053.
HOGENOMiHOG000159293.
OMAiSCTLDKK.
OrthoDBiEOG76TB4Q.

Family and domain databases

InterProiIPR007808. Elf1.
[Graphical view]
PANTHERiPTHR20934. PTHR20934. 1 hit.
PfamiPF05129. Elf1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P36053-1 [UniParc]FASTAAdd to Basket

« Hide

MGKRKKSTRK PTKRLVQKLD TKFNCLFCNH EKSVSCTLDK KNSIGTLSCK    50
ICGQSFQTRI NSLSQPVDVY SDWFDAVEEV NSGRGSDTDD GDEGSDSDYE 100
SDSEQDAKTQ NDGEIDSDEE EVDSDEERIG QVKRGRGALV DSDDE 145
Length:145
Mass (Da):16,157
Last modified:June 1, 1994 - v1
Checksum:i0741A4F14D6CD705
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z26877 Genomic DNA. Translation: CAA81494.1.
Z28160 Genomic DNA. Translation: CAA82002.1.
AY558355 Genomic DNA. Translation: AAS56681.1.
BK006944 Genomic DNA. Translation: DAA09005.1.
PIRiS37791.
RefSeqiNP_012762.1. NM_001179726.1.

Genome annotation databases

EnsemblFungiiYKL160W; YKL160W; YKL160W.
GeneIDi853697.
KEGGisce:YKL160W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z26877 Genomic DNA. Translation: CAA81494.1 .
Z28160 Genomic DNA. Translation: CAA82002.1 .
AY558355 Genomic DNA. Translation: AAS56681.1 .
BK006944 Genomic DNA. Translation: DAA09005.1 .
PIRi S37791.
RefSeqi NP_012762.1. NM_001179726.1.

3D structure databases

ProteinModelPortali P36053.
SMRi P36053. Positions 2-78.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 33978. 164 interactions.
DIPi DIP-2119N.
IntActi P36053. 2 interactions.
MINTi MINT-508271.
STRINGi 4932.YKL160W.

Proteomic databases

MaxQBi P36053.
PaxDbi P36053.
PeptideAtlasi P36053.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YKL160W ; YKL160W ; YKL160W .
GeneIDi 853697.
KEGGi sce:YKL160W.

Organism-specific databases

CYGDi YKL160w.
SGDi S000001643. ELF1.

Phylogenomic databases

eggNOGi COG4888.
GeneTreei ENSGT00390000000053.
HOGENOMi HOG000159293.
OMAi SCTLDKK.
OrthoDBi EOG76TB4Q.

Enzyme and pathway databases

BioCyci YEAST:G3O-31928-MONOMER.

Miscellaneous databases

NextBioi 974681.
PROi P36053.

Gene expression databases

Genevestigatori P36053.

Family and domain databases

InterProi IPR007808. Elf1.
[Graphical view ]
PANTHERi PTHR20934. PTHR20934. 1 hit.
Pfami PF05129. Elf1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "DNA sequencing of a 36.2 kb fragment located between the FAS1 and LAP loci of chromosome XI of Saccharomyces cerevisiae."
    Vandenbol M., Bolle P.-A., Dion C., Portetelle D., Hilger F.
    Yeast 10:S35-S40(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. "Complete DNA sequence of yeast chromosome XI."
    Dujon B., Alexandraki D., Andre B., Ansorge W., Baladron V., Ballesta J.P.G., Banrevi A., Bolle P.-A., Bolotin-Fukuhara M., Bossier P., Bou G., Boyer J., Buitrago M.J., Cheret G., Colleaux L., Daignan-Fornier B., del Rey F., Dion C.
    , Domdey H., Duesterhoeft A., Duesterhus S., Entian K.-D., Erfle H., Esteban P.F., Feldmann H., Fernandes L., Fobo G.M., Fritz C., Fukuhara H., Gabel C., Gaillon L., Garcia-Cantalejo J.M., Garcia-Ramirez J.J., Gent M.E., Ghazvini M., Goffeau A., Gonzalez A., Grothues D., Guerreiro P., Hegemann J.H., Hewitt N., Hilger F., Hollenberg C.P., Horaitis O., Indge K.J., Jacquier A., James C.M., Jauniaux J.-C., Jimenez A., Keuchel H., Kirchrath L., Kleine K., Koetter P., Legrain P., Liebl S., Louis E.J., Maia e Silva A., Marck C., Monnier A.-L., Moestl D., Mueller S., Obermaier B., Oliver S.G., Pallier C., Pascolo S., Pfeiffer F., Philippsen P., Planta R.J., Pohl F.M., Pohl T.M., Poehlmann R., Portetelle D., Purnelle B., Puzos V., Ramezani Rad M., Rasmussen S.W., Remacha M.A., Revuelta J.L., Richard G.-F., Rieger M., Rodrigues-Pousada C., Rose M., Rupp T., Santos M.A., Schwager C., Sensen C., Skala J., Soares H., Sor F., Stegemann J., Tettelin H., Thierry A., Tzermia M., Urrestarazu L.A., van Dyck L., van Vliet-Reedijk J.C., Valens M., Vandenbol M., Vilela C., Vissers S., von Wettstein D., Voss H., Wiemann S., Xu G., Zimmermann J., Haasemann M., Becker I., Mewes H.-W.
    Nature 369:371-378(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  4. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  5. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
  6. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  7. "Identification and characterization of Elf1, a conserved transcription elongation factor in Saccharomyces cerevisiae."
    Prather D., Krogan N.J., Emili A., Greenblatt J.F., Winston F.
    Mol. Cell. Biol. 25:10122-10135(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  8. "Large-scale phosphorylation analysis of alpha-factor-arrested Saccharomyces cerevisiae."
    Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J., Elias J.E., Gygi S.P.
    J. Proteome Res. 6:1190-1197(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-117; SER-124 AND SER-142, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Strain: ADR376.
  9. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
    Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
    Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-55; SER-117 AND SER-124, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  10. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
    Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
    Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-117; SER-124 AND SER-142, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiELF1_YEAST
AccessioniPrimary (citable) accession number: P36053
Secondary accession number(s): D6VX39
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: May 14, 2014
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 5860 molecules/cell in log phase SD medium.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome XI
    Yeast (Saccharomyces cerevisiae) chromosome XI: entries and gene names

External Data

Dasty 3

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