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Protein

Transcription elongation factor 1

Gene

ELF1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Transcription elongation factor implicated in the maintenance of proper chromatin structure in actively transcribed regions.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi25ZincBy similarity1
Metal bindingi28ZincBy similarity1
Metal bindingi49ZincBy similarity1
Metal bindingi52ZincBy similarity1

GO - Molecular functioni

  • metal ion binding Source: UniProtKB-KW
  • RNA polymerase II core binding Source: SGD

GO - Biological processi

  • chromatin-mediated maintenance of transcription Source: SGD
  • transcription elongation from RNA polymerase II promoter Source: SGD
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BioCyciYEAST:G3O-31928-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription elongation factor 1
Gene namesi
Name:ELF1
Ordered Locus Names:YKL160W
ORF Names:YKL614
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XI

Organism-specific databases

EuPathDBiFungiDB:YKL160W.
SGDiS000001643. ELF1.

Subcellular locationi

GO - Cellular componenti

  • nucleus Source: SGD
  • transcription elongation factor complex Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001209501 – 145Transcription elongation factor 1Add BLAST145

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei55PhosphoserineCombined sources1
Modified residuei117PhosphoserineCombined sources1
Modified residuei124PhosphoserineCombined sources1
Modified residuei142PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP36053.
PRIDEiP36053.

PTM databases

iPTMnetiP36053.

Interactioni

GO - Molecular functioni

  • RNA polymerase II core binding Source: SGD

Protein-protein interaction databases

BioGridi33978. 168 interactors.
DIPiDIP-2119N.
IntActiP36053. 3 interactors.
MINTiMINT-508271.

Structurei

3D structure databases

ProteinModelPortaliP36053.
SMRiP36053.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ELOF1 family.Curated

Keywords - Domaini

Zinc-finger

Phylogenomic databases

GeneTreeiENSGT00390000000053.
HOGENOMiHOG000159293.
InParanoidiP36053.
OMAiHEKSITC.
OrthoDBiEOG092C5T13.

Family and domain databases

InterProiIPR007808. Elf1.
[Graphical view]
PANTHERiPTHR20934. PTHR20934. 1 hit.
PfamiPF05129. Elf1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P36053-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGKRKKSTRK PTKRLVQKLD TKFNCLFCNH EKSVSCTLDK KNSIGTLSCK
60 70 80 90 100
ICGQSFQTRI NSLSQPVDVY SDWFDAVEEV NSGRGSDTDD GDEGSDSDYE
110 120 130 140
SDSEQDAKTQ NDGEIDSDEE EVDSDEERIG QVKRGRGALV DSDDE
Length:145
Mass (Da):16,157
Last modified:June 1, 1994 - v1
Checksum:i0741A4F14D6CD705
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z26877 Genomic DNA. Translation: CAA81494.1.
Z28160 Genomic DNA. Translation: CAA82002.1.
AY558355 Genomic DNA. Translation: AAS56681.1.
BK006944 Genomic DNA. Translation: DAA09005.1.
PIRiS37791.
RefSeqiNP_012762.1. NM_001179726.1.

Genome annotation databases

EnsemblFungiiYKL160W; YKL160W; YKL160W.
GeneIDi853697.
KEGGisce:YKL160W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z26877 Genomic DNA. Translation: CAA81494.1.
Z28160 Genomic DNA. Translation: CAA82002.1.
AY558355 Genomic DNA. Translation: AAS56681.1.
BK006944 Genomic DNA. Translation: DAA09005.1.
PIRiS37791.
RefSeqiNP_012762.1. NM_001179726.1.

3D structure databases

ProteinModelPortaliP36053.
SMRiP36053.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi33978. 168 interactors.
DIPiDIP-2119N.
IntActiP36053. 3 interactors.
MINTiMINT-508271.

PTM databases

iPTMnetiP36053.

Proteomic databases

MaxQBiP36053.
PRIDEiP36053.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYKL160W; YKL160W; YKL160W.
GeneIDi853697.
KEGGisce:YKL160W.

Organism-specific databases

EuPathDBiFungiDB:YKL160W.
SGDiS000001643. ELF1.

Phylogenomic databases

GeneTreeiENSGT00390000000053.
HOGENOMiHOG000159293.
InParanoidiP36053.
OMAiHEKSITC.
OrthoDBiEOG092C5T13.

Enzyme and pathway databases

BioCyciYEAST:G3O-31928-MONOMER.

Miscellaneous databases

PROiP36053.

Family and domain databases

InterProiIPR007808. Elf1.
[Graphical view]
PANTHERiPTHR20934. PTHR20934. 1 hit.
PfamiPF05129. Elf1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiELF1_YEAST
AccessioniPrimary (citable) accession number: P36053
Secondary accession number(s): D6VX39
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: November 2, 2016
This is version 137 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 5860 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome XI
    Yeast (Saccharomyces cerevisiae) chromosome XI: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.