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Protein

Transcription elongation factor 1

Gene

ELF1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Transcription elongation factor implicated in the maintenance of proper chromatin structure in actively transcribed regions.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi25 – 251ZincBy similarity
Metal bindingi28 – 281ZincBy similarity
Metal bindingi49 – 491ZincBy similarity
Metal bindingi52 – 521ZincBy similarity

GO - Molecular functioni

  • metal ion binding Source: UniProtKB-KW
  • RNA polymerase II core binding Source: SGD

GO - Biological processi

  • chromatin-mediated maintenance of transcription Source: SGD
  • transcription elongation from RNA polymerase II promoter Source: SGD
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BioCyciYEAST:G3O-31928-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription elongation factor 1
Gene namesi
Name:ELF1
Ordered Locus Names:YKL160W
ORF Names:YKL614
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311 Componenti: Chromosome XI

Organism-specific databases

CYGDiYKL160w.
EuPathDBiFungiDB:YKL160W.
SGDiS000001643. ELF1.

Subcellular locationi

GO - Cellular componenti

  • nucleus Source: SGD
  • transcription elongation factor complex Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 145145Transcription elongation factor 1PRO_0000120950Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei55 – 551Phosphoserine1 Publication
Modified residuei117 – 1171Phosphoserine3 Publications
Modified residuei124 – 1241Phosphoserine3 Publications
Modified residuei142 – 1421Phosphoserine2 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP36053.
PaxDbiP36053.
PeptideAtlasiP36053.

Interactioni

Protein-protein interaction databases

BioGridi33978. 163 interactions.
DIPiDIP-2119N.
IntActiP36053. 2 interactions.
MINTiMINT-508271.

Structurei

3D structure databases

ProteinModelPortaliP36053.
SMRiP36053. Positions 2-78.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ELOF1 family.Curated

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiCOG4888.
GeneTreeiENSGT00390000000053.
HOGENOMiHOG000159293.
InParanoidiP36053.
OMAiSCTLDKK.
OrthoDBiEOG76TB4Q.

Family and domain databases

InterProiIPR007808. Elf1.
[Graphical view]
PANTHERiPTHR20934. PTHR20934. 1 hit.
PfamiPF05129. Elf1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P36053-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGKRKKSTRK PTKRLVQKLD TKFNCLFCNH EKSVSCTLDK KNSIGTLSCK
60 70 80 90 100
ICGQSFQTRI NSLSQPVDVY SDWFDAVEEV NSGRGSDTDD GDEGSDSDYE
110 120 130 140
SDSEQDAKTQ NDGEIDSDEE EVDSDEERIG QVKRGRGALV DSDDE
Length:145
Mass (Da):16,157
Last modified:June 1, 1994 - v1
Checksum:i0741A4F14D6CD705
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z26877 Genomic DNA. Translation: CAA81494.1.
Z28160 Genomic DNA. Translation: CAA82002.1.
AY558355 Genomic DNA. Translation: AAS56681.1.
BK006944 Genomic DNA. Translation: DAA09005.1.
PIRiS37791.
RefSeqiNP_012762.1. NM_001179726.1.

Genome annotation databases

EnsemblFungiiYKL160W; YKL160W; YKL160W.
GeneIDi853697.
KEGGisce:YKL160W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z26877 Genomic DNA. Translation: CAA81494.1.
Z28160 Genomic DNA. Translation: CAA82002.1.
AY558355 Genomic DNA. Translation: AAS56681.1.
BK006944 Genomic DNA. Translation: DAA09005.1.
PIRiS37791.
RefSeqiNP_012762.1. NM_001179726.1.

3D structure databases

ProteinModelPortaliP36053.
SMRiP36053. Positions 2-78.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi33978. 163 interactions.
DIPiDIP-2119N.
IntActiP36053. 2 interactions.
MINTiMINT-508271.

Proteomic databases

MaxQBiP36053.
PaxDbiP36053.
PeptideAtlasiP36053.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYKL160W; YKL160W; YKL160W.
GeneIDi853697.
KEGGisce:YKL160W.

Organism-specific databases

CYGDiYKL160w.
EuPathDBiFungiDB:YKL160W.
SGDiS000001643. ELF1.

Phylogenomic databases

eggNOGiCOG4888.
GeneTreeiENSGT00390000000053.
HOGENOMiHOG000159293.
InParanoidiP36053.
OMAiSCTLDKK.
OrthoDBiEOG76TB4Q.

Enzyme and pathway databases

BioCyciYEAST:G3O-31928-MONOMER.

Miscellaneous databases

NextBioi974681.
PROiP36053.

Family and domain databases

InterProiIPR007808. Elf1.
[Graphical view]
PANTHERiPTHR20934. PTHR20934. 1 hit.
PfamiPF05129. Elf1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "DNA sequencing of a 36.2 kb fragment located between the FAS1 and LAP loci of chromosome XI of Saccharomyces cerevisiae."
    Vandenbol M., Bolle P.-A., Dion C., Portetelle D., Hilger F.
    Yeast 10:S35-S40(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. "Complete DNA sequence of yeast chromosome XI."
    Dujon B., Alexandraki D., Andre B., Ansorge W., Baladron V., Ballesta J.P.G., Banrevi A., Bolle P.-A., Bolotin-Fukuhara M., Bossier P., Bou G., Boyer J., Buitrago M.J., Cheret G., Colleaux L., Daignan-Fornier B., del Rey F., Dion C.
    , Domdey H., Duesterhoeft A., Duesterhus S., Entian K.-D., Erfle H., Esteban P.F., Feldmann H., Fernandes L., Fobo G.M., Fritz C., Fukuhara H., Gabel C., Gaillon L., Garcia-Cantalejo J.M., Garcia-Ramirez J.J., Gent M.E., Ghazvini M., Goffeau A., Gonzalez A., Grothues D., Guerreiro P., Hegemann J.H., Hewitt N., Hilger F., Hollenberg C.P., Horaitis O., Indge K.J., Jacquier A., James C.M., Jauniaux J.-C., Jimenez A., Keuchel H., Kirchrath L., Kleine K., Koetter P., Legrain P., Liebl S., Louis E.J., Maia e Silva A., Marck C., Monnier A.-L., Moestl D., Mueller S., Obermaier B., Oliver S.G., Pallier C., Pascolo S., Pfeiffer F., Philippsen P., Planta R.J., Pohl F.M., Pohl T.M., Poehlmann R., Portetelle D., Purnelle B., Puzos V., Ramezani Rad M., Rasmussen S.W., Remacha M.A., Revuelta J.L., Richard G.-F., Rieger M., Rodrigues-Pousada C., Rose M., Rupp T., Santos M.A., Schwager C., Sensen C., Skala J., Soares H., Sor F., Stegemann J., Tettelin H., Thierry A., Tzermia M., Urrestarazu L.A., van Dyck L., van Vliet-Reedijk J.C., Valens M., Vandenbol M., Vilela C., Vissers S., von Wettstein D., Voss H., Wiemann S., Xu G., Zimmermann J., Haasemann M., Becker I., Mewes H.-W.
    Nature 369:371-378(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  4. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  5. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
  6. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  7. "Identification and characterization of Elf1, a conserved transcription elongation factor in Saccharomyces cerevisiae."
    Prather D., Krogan N.J., Emili A., Greenblatt J.F., Winston F.
    Mol. Cell. Biol. 25:10122-10135(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  8. "Large-scale phosphorylation analysis of alpha-factor-arrested Saccharomyces cerevisiae."
    Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J., Elias J.E., Gygi S.P.
    J. Proteome Res. 6:1190-1197(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-117; SER-124 AND SER-142, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Strain: ADR376.
  9. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
    Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
    Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-55; SER-117 AND SER-124, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  10. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
    Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
    Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-117; SER-124 AND SER-142, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiELF1_YEAST
AccessioniPrimary (citable) accession number: P36053
Secondary accession number(s): D6VX39
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: July 22, 2015
This is version 126 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 5860 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome XI
    Yeast (Saccharomyces cerevisiae) chromosome XI: entries and gene names

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.