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Protein

Protein phosphatase 1 regulatory subunit SDS22

Gene

SDS22

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Regulator of the mitotic function of yeast type 1 protein phosphatase.Curated

GO - Molecular functioni

  • protein phosphatase type 1 activator activity Source: SGD
  • protein serine/threonine phosphatase inhibitor activity Source: SGD

GO - Biological processi

  • cell division Source: UniProtKB-KW
  • chromosome segregation Source: SGD
  • maintenance of protein location in nucleus Source: SGD
  • mitotic nuclear division Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division, Mitosis

Enzyme and pathway databases

BioCyciYEAST:G3O-31955-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein phosphatase 1 regulatory subunit SDS22
Gene namesi
Name:SDS22
Synonyms:EGP1
Ordered Locus Names:YKL193C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XI

Organism-specific databases

EuPathDBiFungiDB:YKL193C.
SGDiS000001676. SDS22.

Subcellular locationi

GO - Cellular componenti

  • nucleus Source: SGD
  • protein phosphatase type 1 complex Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 338338Protein phosphatase 1 regulatory subunit SDS22PRO_0000071447Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei56 – 561PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP36047.
TopDownProteomicsiP36047.

PTM databases

iPTMnetiP36047.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
GLC7P325986EBI-16783,EBI-13715
YPI1P435874EBI-16783,EBI-22913

Protein-protein interaction databases

BioGridi33928. 112 interactions.
DIPiDIP-2378N.
IntActiP36047. 12 interactions.
MINTiMINT-641828.

Structurei

3D structure databases

ProteinModelPortaliP36047.
SMRiP36047. Positions 3-336.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati43 – 6422LRR 1Add
BLAST
Repeati67 – 8822LRR 2Add
BLAST
Repeati91 – 11323LRR 3Add
BLAST
Repeati114 – 13522LRR 4Add
BLAST
Repeati136 – 15722LRR 5Add
BLAST
Repeati158 – 17922LRR 6Add
BLAST
Repeati182 – 20322LRR 7Add
BLAST
Repeati204 – 22522LRR 8Add
BLAST
Repeati226 – 24722LRR 9Add
BLAST
Repeati248 – 26922LRR 10Add
BLAST
Repeati270 – 29223LRR 11Add
BLAST
Domaini306 – 33833LRRCTAdd
BLAST

Sequence similaritiesi

Belongs to the SDS22 family.Curated
Contains 11 LRR (leucine-rich) repeats.Curated
Contains 1 LRRCT domain.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

GeneTreeiENSGT00730000110223.
HOGENOMiHOG000211189.
InParanoidiP36047.
KOiK17550.
OMAiNKIKHVG.
OrthoDBiEOG7FBRTR.

Family and domain databases

Gene3Di3.80.10.10. 2 hits.
InterProiIPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
[Graphical view]
PfamiPF00560. LRR_1. 1 hit.
PF13516. LRR_6. 1 hit.
[Graphical view]
SMARTiSM00369. LRR_TYP. 4 hits.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 1 hit.
PROSITEiPS51450. LRR. 12 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P36047-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDKNSVNKDS EEKDERHKIE VVDDTNPDFI TADSELTQDL PDDVEVIDLV
60 70 80 90 100
HLKIKSLEDL NLYRFKNLKQ LCLRQNLIES ISEVEVLPHD KIVDLDFYDN
110 120 130 140 150
KIKHISSNVN KLTKLTSLDL SFNKIKHIKN LENLTDLENL YFVQNSISKI
160 170 180 190 200
ENLSTLKSLK NLELGGNKVH SIEPDSFEGL SNLEEIWLGK NSIPRLINLH
210 220 230 240 250
PLKNLKILSI QSNKLKKIEN LEELTNLEEL YLSHNFITKI EGLEKNLKLT
260 270 280 290 300
TLDVTSNKIT SLENLNHLSN LTDIWASFNK IDQSFESLGE NLSALSRLET
310 320 330
IYLEGNPIQL ENKTSYRRKL TMNLPPSLQK IDATYIRG
Length:338
Mass (Da):38,887
Last modified:June 1, 1994 - v1
Checksum:i1EF434C7276ABAEA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X83609 Genomic DNA. Translation: CAA58588.1.
Z28193 Genomic DNA. Translation: CAA82037.1.
AY558314 Genomic DNA. Translation: AAS56640.1.
X69765 Genomic DNA. No translation available.
BK006944 Genomic DNA. Translation: DAA08973.1.
PIRiS38030.
RefSeqiNP_012728.1. NM_001179759.1.

Genome annotation databases

EnsemblFungiiYKL193C; YKL193C; YKL193C.
GeneIDi853641.
KEGGisce:YKL193C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X83609 Genomic DNA. Translation: CAA58588.1.
Z28193 Genomic DNA. Translation: CAA82037.1.
AY558314 Genomic DNA. Translation: AAS56640.1.
X69765 Genomic DNA. No translation available.
BK006944 Genomic DNA. Translation: DAA08973.1.
PIRiS38030.
RefSeqiNP_012728.1. NM_001179759.1.

3D structure databases

ProteinModelPortaliP36047.
SMRiP36047. Positions 3-336.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi33928. 112 interactions.
DIPiDIP-2378N.
IntActiP36047. 12 interactions.
MINTiMINT-641828.

PTM databases

iPTMnetiP36047.

Proteomic databases

MaxQBiP36047.
TopDownProteomicsiP36047.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYKL193C; YKL193C; YKL193C.
GeneIDi853641.
KEGGisce:YKL193C.

Organism-specific databases

EuPathDBiFungiDB:YKL193C.
SGDiS000001676. SDS22.

Phylogenomic databases

GeneTreeiENSGT00730000110223.
HOGENOMiHOG000211189.
InParanoidiP36047.
KOiK17550.
OMAiNKIKHVG.
OrthoDBiEOG7FBRTR.

Enzyme and pathway databases

BioCyciYEAST:G3O-31955-MONOMER.

Miscellaneous databases

PROiP36047.

Family and domain databases

Gene3Di3.80.10.10. 2 hits.
InterProiIPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
[Graphical view]
PfamiPF00560. LRR_1. 1 hit.
PF13516. LRR_6. 1 hit.
[Graphical view]
SMARTiSM00369. LRR_TYP. 4 hits.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 1 hit.
PROSITEiPS51450. LRR. 12 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The Saccharomyces cerevisiae gene SDS22 encodes a potential regulator of the mitotic function of yeast type 1 protein phosphatase."
    Mackelvie S.H., Andrews P.D., Stark M.J.R.
    Mol. Cell. Biol. 15:3777-3785(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 200358 / YNN 295.
  2. "Complete DNA sequence of yeast chromosome XI."
    Dujon B., Alexandraki D., Andre B., Ansorge W., Baladron V., Ballesta J.P.G., Banrevi A., Bolle P.-A., Bolotin-Fukuhara M., Bossier P., Bou G., Boyer J., Buitrago M.J., Cheret G., Colleaux L., Daignan-Fornier B., del Rey F., Dion C.
    , Domdey H., Duesterhoeft A., Duesterhus S., Entian K.-D., Erfle H., Esteban P.F., Feldmann H., Fernandes L., Fobo G.M., Fritz C., Fukuhara H., Gabel C., Gaillon L., Garcia-Cantalejo J.M., Garcia-Ramirez J.J., Gent M.E., Ghazvini M., Goffeau A., Gonzalez A., Grothues D., Guerreiro P., Hegemann J.H., Hewitt N., Hilger F., Hollenberg C.P., Horaitis O., Indge K.J., Jacquier A., James C.M., Jauniaux J.-C., Jimenez A., Keuchel H., Kirchrath L., Kleine K., Koetter P., Legrain P., Liebl S., Louis E.J., Maia e Silva A., Marck C., Monnier A.-L., Moestl D., Mueller S., Obermaier B., Oliver S.G., Pallier C., Pascolo S., Pfeiffer F., Philippsen P., Planta R.J., Pohl F.M., Pohl T.M., Poehlmann R., Portetelle D., Purnelle B., Puzos V., Ramezani Rad M., Rasmussen S.W., Remacha M.A., Revuelta J.L., Richard G.-F., Rieger M., Rodrigues-Pousada C., Rose M., Rupp T., Santos M.A., Schwager C., Sensen C., Skala J., Soares H., Sor F., Stegemann J., Tettelin H., Thierry A., Tzermia M., Urrestarazu L.A., van Dyck L., van Vliet-Reedijk J.C., Valens M., Vandenbol M., Vilela C., Vissers S., von Wettstein D., Voss H., Wiemann S., Xu G., Zimmermann J., Haasemann M., Becker I., Mewes H.-W.
    Nature 369:371-378(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  4. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  5. "DNA sequence analysis of the YCN2 region of chromosome XI in Saccharomyces cerevisiae."
    Cheret G., Mattheakis L.C., Sor F.
    Yeast 9:661-667(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-136.
    Strain: S288c / GRF88.
  6. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  7. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
    Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
    Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-56, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  8. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
    Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
    Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-56, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiSDS22_YEAST
AccessioniPrimary (citable) accession number: P36047
Secondary accession number(s): D6VX07
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: July 6, 2016
This is version 155 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 3870 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XI
    Yeast (Saccharomyces cerevisiae) chromosome XI: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.