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P36044 (MNN4_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 94. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein MNN4
Gene names
Name:MNN4
Ordered Locus Names:YKL201C/YKL200C
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces

Protein attributes

Sequence length1178 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May function as a positive regulator for mannosylphosphate transferase. Is required to mediate mannosylphosphate transfer in both the core and outer chain portions of N-linked oligosaccharides.

Subcellular location

Membrane; Single-pass type II membrane protein Probable.

Sequence similarities

To yeast YJR061w.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 11781178Protein MNN4
PRO_0000096525

Regions

Topological domain1 – 2727Cytoplasmic Potential
Transmembrane28 – 4821Helical; Signal-anchor for type II membrane protein; Potential
Topological domain49 – 11781130Lumenal Potential
Repeat1042 – 104981
Repeat1050 – 105782
Repeat1058 – 106583
Repeat1066 – 107384
Repeat1074 – 108185
Repeat1082 – 108986
Repeat1090 – 109787; approximate
Repeat1098 – 110588
Repeat1106 – 111389; approximate
Repeat1114 – 1121810; approximate
Repeat1122 – 1129811; approximate
Repeat1130 – 1137812
Repeat1138 – 1144713; approximate
Repeat1145 – 1152814; approximate
Repeat1153 – 1160815; approximate
Repeat1161 – 1168816; approximate
Repeat1169 – 1174617; truncated
Region1042 – 117413317 X 8 AA tandem repeats of K-K-K-K-E-E-E-E
Compositional bias37 – 404Poly-Ile
Compositional bias1032 – 1174143Arg/Glu/Lys-rich (highly charged)
Compositional bias1042 – 10454Poly-Lys
Compositional bias1046 – 10494Poly-Glu
Compositional bias1050 – 10534Poly-Lys
Compositional bias1054 – 10574Poly-Glu
Compositional bias1058 – 10614Poly-Lys
Compositional bias1062 – 10654Poly-Glu
Compositional bias1066 – 10694Poly-Lys
Compositional bias1070 – 10734Poly-Glu
Compositional bias1074 – 10774Poly-Lys
Compositional bias1078 – 10814Poly-Glu
Compositional bias1082 – 10854Poly-Lys
Compositional bias1086 – 10894Poly-Glu
Compositional bias1094 – 10974Poly-Glu
Compositional bias1098 – 11014Poly-Lys
Compositional bias1102 – 11054Poly-Glu
Compositional bias1134 – 11374Poly-Glu
Compositional bias1157 – 11604Poly-Glu
Compositional bias1165 – 11684Poly-Glu

Sequences

Sequence LengthMass (Da)Tools
P36044 [UniParc].

Last modified December 15, 1998. Version 2.
Checksum: BC05DAE0AEFCB282

FASTA1,178139,381
        10         20         30         40         50         60 
MLQRISSKLH RRFLSGLLRV KHYPLRRILL PLILLQIIII TFIWSNSPQR NGLGRDADYL 

        70         80         90        100        110        120 
LPNYNELDSD DDSWYSILTS SFKNDRKIQF AKTLYENLKF GTNPKWVNEY TLQNDLLSVK 

       130        140        150        160        170        180 
MGPRKGSKLE SVDELKFYDF DPRLTWSVVL NHLQNNDADQ PEKLPFSWYD WTTFHELNKL 

       190        200        210        220        230        240 
ISIDKTVLPC NFLFQSAFDK ESLEAIETEL GEPLFLYERP KYAQKLWYKA ARNQDRIKDS 

       250        260        270        280        290        300 
KELKKHCSKL FTPDGHGSPK GLRFNTQFQI KELYDKVRPE VYQLQARNYI LTTQSHPLSI 

       310        320        330        340        350        360 
SIIESDNSTY QVPLQTEKSK NLVQSGLLQE YINDNINSTN KRKKNKQDVE FNHNRLFQEF 

       370        380        390        400        410        420 
VNNDQVNSLY KLEIEETDKF TFDKDLVYLS PSDFKFDASK KIEELEEQKK LYPDKFSAHN 

       430        440        450        460        470        480 
ENYLNSLKNS VKTSPALQRK FFYEAGAVKQ YKGMGFHRDK RFFNVDTLIN DKQEYQARLN 

       490        500        510        520        530        540 
SMIRTFQKFT KANGIISWLS HGTLYGYLYN GMAFPWDNDF DLQMPIKHLQ LLSQYFNQSL 

       550        560        570        580        590        600 
ILEDPRQGNG RYFLDVSDSL TVRINGNGKN NIDARFIDVD TGLYIDITGL ASTSAPSRDY 

       610        620        630        640        650        660 
LNSYIEERLQ EEHLDINNIP ESNGETATLP DKVDDGLVNM ATLNITELRD YITSDENKNH 

       670        680        690        700        710        720 
KRVPTDTDLK DLLKKELEEL PKSKTIENKL NPKQRYFLNE KLKLYNCRNN HFNSFEELSP 

       730        740        750        760        770        780 
LINTVFHGVP ALIPHRHTYC LHNEYHVPDR YAFDAYKNTA YLPEFRFWFD YDGLKKCSNI 

       790        800        810        820        830        840 
NSWYPNIPSI NSWNPNLLKE ISSTKFESKL FDSNKVSEYS FKNLSMDDVR LIYKNIPKAG 

       850        860        870        880        890        900 
FIEVFTNLYN SFNVTAYRQK ELEIQYCQNL TFIEKKKLLH QLRINVAPKL SSPAKDPFLF 

       910        920        930        940        950        960 
GYEKAMWKDL SKSMNQTTLD QVTKIVHEEY VGKIIDLSES LKYRNFSLFN ITFDETGTTL 

       970        980        990       1000       1010       1020 
DDNTEDYTPA NTVEVNPVDF KSNLNFSSNS FLDLNSYGLD LFAPTLSDVN RKGIQMFDKD 

      1030       1040       1050       1060       1070       1080 
PIIVYEDYAY AKLLEERKRR EKKKKEEEEK KKKEEEEKKK KEEEEKKKKE EEEKKKKEEE 

      1090       1100       1110       1120       1130       1140 
EKKKKEEEEK KKQEEEEKKK KEEEEKKKQE EGEKMKNEDE ENKKNEDEEK KKNEEEEKKK 

      1150       1160       1170 
QEEKNKKNED EEKKKQEEEE KKKNEEEEKK KQEEGHSN

« Hide

References

« Hide 'large scale' references
[1]"Cloning and analysis of the MNN4 gene required for phosphorylation of N-linked oligosaccharides in Saccharomyces cerevisiae."
Odani T., Shimma Y., Tanaka A., Jigami Y.
Glycobiology 6:805-810(1996) [PubMed: 9023541] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[2]"Complete DNA sequence of yeast chromosome XI."
Dujon B., Alexandraki D., Andre B., Ansorge W., Baladron V., Ballesta J.P.G., Banrevi A., Bolle P.-A., Bolotin-Fukuhara M., Bossier P., Bou G., Boyer J., Buitrago M.J., Cheret G., Colleaux L., Daignan-Fornier B., del Rey F., Dion C. expand/collapse author list , Domdey H., Duesterhoeft A., Duesterhus S., Entian K.-D., Erfle H., Esteban P.F., Feldmann H., Fernandes L., Fobo G.M., Fritz C., Fukuhara H., Gabel C., Gaillon L., Garcia-Cantalejo J.M., Garcia-Ramirez J.J., Gent M.E., Ghazvini M., Goffeau A., Gonzalez A., Grothues D., Guerreiro P., Hegemann J.H., Hewitt N., Hilger F., Hollenberg C.P., Horaitis O., Indge K.J., Jacquier A., James C.M., Jauniaux J.-C., Jimenez A., Keuchel H., Kirchrath L., Kleine K., Koetter P., Legrain P., Liebl S., Louis E.J., Maia e Silva A., Marck C., Monnier A.-L., Moestl D., Mueller S., Obermaier B., Oliver S.G., Pallier C., Pascolo S., Pfeiffer F., Philippsen P., Planta R.J., Pohl F.M., Pohl T.M., Poehlmann R., Portetelle D., Purnelle B., Puzos V., Ramezani Rad M., Rasmussen S.W., Remacha M.A., Revuelta J.L., Richard G.-F., Rieger M., Rodrigues-Pousada C., Rose M., Rupp T., Santos M.A., Schwager C., Sensen C., Skala J., Soares H., Sor F., Stegemann J., Tettelin H., Thierry A., Tzermia M., Urrestarazu L.A., van Dyck L., van Vliet-Reedijk J.C., Valens M., Vandenbol M., Vilela C., Vissers S., von Wettstein D., Voss H., Wiemann S., Xu G., Zimmermann J., Haasemann M., Becker I., Mewes H.-W.
Nature 369:371-378(1994) [PubMed: 8196765] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 96604 / S288c / FY1679.
[3]Saccharomyces Genome Database
Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		D83006 Genomic DNA. Translation: BAA11676.1.
Z28201 Genomic DNA. Translation: CAA82046.1.
Z28200 Genomic DNA. Translation: CAA82044.1.
BK006944 Genomic DNA. Translation: DAA08967.1.
PIRS78475.
RefSeqNP_012721.1. NM_001179766.1.

3D structure databases

ProteinModelPortalP36044.
ModBaseSearch...

Protein-protein interaction databases

DIPDIP-4199N.
IntActP36044. 3 interactions.
MINTMINT-564199.
STRINGP36044.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYKL201C; YKL201C; YKL201C.
GeneID853634.
KEGGsce:YKL201C.
NMPDRfig|4932.3.peg.3699.

Organism-specific databases

CYGDYKL201c.
SGDS000001684. MNN4.

Phylogenomic databases

eggNOGfuNOG09393.
GeneTreeEFGT00050000000475.
HOGENOMHBG202357.
OMAMIRTFQK.
OrthoDBEOG4HX88S.

Gene expression databases

ArrayExpressP36044.
GenevestigatorP36044.
GermOnlineYKL201C. Saccharomyces cerevisiae.

Family and domain databases

InterProIPR007074. LicD.
[Graphical view]
PfamPF04991. LicD. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio974514.

Entry information

Entry nameMNN4_YEAST
AccessionPrimary (citable) accession number: P36044
Secondary accession number(s): D6VX01, P36043, P89095
Entry history
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: December 15, 1998
Last modified: December 14, 2011
This is version 94 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

Yeast chromosome XI

Yeast (Saccharomyces cerevisiae) chromosome XI: entries and gene names

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