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P36044

- MNN4_YEAST

UniProt

P36044 - MNN4_YEAST

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Protein

Protein MNN4

Gene

MNN4

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5- Protein predictedi

Functioni

May function as a positive regulator for mannosylphosphate transferase. Is required to mediate mannosylphosphate transfer in both the core and outer chain portions of N-linked oligosaccharides.

GO - Molecular functioni

  1. enzyme activator activity Source: SGD

GO - Biological processi

  1. cellular response to osmotic stress Source: SGD
  2. positive regulation of catalytic activity Source: GOC
  3. protein N-linked glycosylation Source: SGD
  4. protein O-linked glycosylation Source: SGD
Complete GO annotation...

Enzyme and pathway databases

BioCyciYEAST:G3O-31961-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein MNN4
Gene namesi
Name:MNN4
Ordered Locus Names:YKL201C
ORF Names:YKL200C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome XI

Organism-specific databases

CYGDiYKL201c.
SGDiS000001684. MNN4.

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. membrane Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 11781178Protein MNN4PRO_0000096525Add
BLAST

Proteomic databases

MaxQBiP36044.
PaxDbiP36044.
PRIDEiP36044.

Expressioni

Gene expression databases

GenevestigatoriP36044.

Interactioni

Protein-protein interaction databases

BioGridi33921. 34 interactions.
DIPiDIP-4199N.
IntActiP36044. 3 interactions.
MINTiMINT-564199.

Structurei

3D structure databases

ProteinModelPortaliP36044.
SMRiP36044. Positions 1037-1174.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2727CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini49 – 11781130LumenalSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei28 – 4821Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati1042 – 104981
Repeati1050 – 105782
Repeati1058 – 106583
Repeati1066 – 107384
Repeati1074 – 108185
Repeati1082 – 108986
Repeati1090 – 109787; approximate
Repeati1098 – 110588
Repeati1106 – 111389; approximate
Repeati1114 – 1121810; approximate
Repeati1122 – 1129811; approximate
Repeati1130 – 1137812
Repeati1138 – 1144713; approximate
Repeati1145 – 1152814; approximate
Repeati1153 – 1160815; approximate
Repeati1161 – 1168816; approximate
Repeati1169 – 1174617; truncated

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1042 – 117413317 X 8 AA tandem repeats of K-K-K-K-E-E-E-EAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi37 – 404Poly-Ile
Compositional biasi1032 – 1174143Arg/Glu/Lys-rich (highly charged)Add
BLAST
Compositional biasi1042 – 10454Poly-Lys
Compositional biasi1046 – 10494Poly-Glu
Compositional biasi1050 – 10534Poly-Lys
Compositional biasi1054 – 10574Poly-Glu
Compositional biasi1058 – 10614Poly-Lys
Compositional biasi1062 – 10654Poly-Glu
Compositional biasi1066 – 10694Poly-Lys
Compositional biasi1070 – 10734Poly-Glu
Compositional biasi1074 – 10774Poly-Lys
Compositional biasi1078 – 10814Poly-Glu
Compositional biasi1082 – 10854Poly-Lys
Compositional biasi1086 – 10894Poly-Glu
Compositional biasi1094 – 10974Poly-Glu
Compositional biasi1098 – 11014Poly-Lys
Compositional biasi1102 – 11054Poly-Glu
Compositional biasi1134 – 11374Poly-Glu
Compositional biasi1157 – 11604Poly-Glu
Compositional biasi1165 – 11684Poly-Glu

Sequence similaritiesi

To yeast YJR061w.Curated

Keywords - Domaini

Repeat, Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG85218.
GeneTreeiENSGT00730000113216.
HOGENOMiHOG000113617.
InParanoidiP36044.
OMAiMIRTFQK.
OrthoDBiEOG7HQNHH.

Family and domain databases

InterProiIPR009644. Fukutin-related.
IPR007074. LicD.
[Graphical view]
PANTHERiPTHR15407. PTHR15407. 1 hit.
PfamiPF04991. LicD. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P36044-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLQRISSKLH RRFLSGLLRV KHYPLRRILL PLILLQIIII TFIWSNSPQR
60 70 80 90 100
NGLGRDADYL LPNYNELDSD DDSWYSILTS SFKNDRKIQF AKTLYENLKF
110 120 130 140 150
GTNPKWVNEY TLQNDLLSVK MGPRKGSKLE SVDELKFYDF DPRLTWSVVL
160 170 180 190 200
NHLQNNDADQ PEKLPFSWYD WTTFHELNKL ISIDKTVLPC NFLFQSAFDK
210 220 230 240 250
ESLEAIETEL GEPLFLYERP KYAQKLWYKA ARNQDRIKDS KELKKHCSKL
260 270 280 290 300
FTPDGHGSPK GLRFNTQFQI KELYDKVRPE VYQLQARNYI LTTQSHPLSI
310 320 330 340 350
SIIESDNSTY QVPLQTEKSK NLVQSGLLQE YINDNINSTN KRKKNKQDVE
360 370 380 390 400
FNHNRLFQEF VNNDQVNSLY KLEIEETDKF TFDKDLVYLS PSDFKFDASK
410 420 430 440 450
KIEELEEQKK LYPDKFSAHN ENYLNSLKNS VKTSPALQRK FFYEAGAVKQ
460 470 480 490 500
YKGMGFHRDK RFFNVDTLIN DKQEYQARLN SMIRTFQKFT KANGIISWLS
510 520 530 540 550
HGTLYGYLYN GMAFPWDNDF DLQMPIKHLQ LLSQYFNQSL ILEDPRQGNG
560 570 580 590 600
RYFLDVSDSL TVRINGNGKN NIDARFIDVD TGLYIDITGL ASTSAPSRDY
610 620 630 640 650
LNSYIEERLQ EEHLDINNIP ESNGETATLP DKVDDGLVNM ATLNITELRD
660 670 680 690 700
YITSDENKNH KRVPTDTDLK DLLKKELEEL PKSKTIENKL NPKQRYFLNE
710 720 730 740 750
KLKLYNCRNN HFNSFEELSP LINTVFHGVP ALIPHRHTYC LHNEYHVPDR
760 770 780 790 800
YAFDAYKNTA YLPEFRFWFD YDGLKKCSNI NSWYPNIPSI NSWNPNLLKE
810 820 830 840 850
ISSTKFESKL FDSNKVSEYS FKNLSMDDVR LIYKNIPKAG FIEVFTNLYN
860 870 880 890 900
SFNVTAYRQK ELEIQYCQNL TFIEKKKLLH QLRINVAPKL SSPAKDPFLF
910 920 930 940 950
GYEKAMWKDL SKSMNQTTLD QVTKIVHEEY VGKIIDLSES LKYRNFSLFN
960 970 980 990 1000
ITFDETGTTL DDNTEDYTPA NTVEVNPVDF KSNLNFSSNS FLDLNSYGLD
1010 1020 1030 1040 1050
LFAPTLSDVN RKGIQMFDKD PIIVYEDYAY AKLLEERKRR EKKKKEEEEK
1060 1070 1080 1090 1100
KKKEEEEKKK KEEEEKKKKE EEEKKKKEEE EKKKKEEEEK KKQEEEEKKK
1110 1120 1130 1140 1150
KEEEEKKKQE EGEKMKNEDE ENKKNEDEEK KKNEEEEKKK QEEKNKKNED
1160 1170
EEKKKQEEEE KKKNEEEEKK KQEEGHSN
Length:1,178
Mass (Da):139,381
Last modified:December 15, 1998 - v2
Checksum:iBC05DAE0AEFCB282
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D83006 Genomic DNA. Translation: BAA11676.1.
Z28201 Genomic DNA. Translation: CAA82046.1.
Z28200 Genomic DNA. Translation: CAA82044.1.
BK006944 Genomic DNA. Translation: DAA08967.1.
PIRiS78475.
RefSeqiNP_012721.1. NM_001179766.1.

Genome annotation databases

EnsemblFungiiYKL201C; YKL201C; YKL201C.
GeneIDi853634.
KEGGisce:YKL201C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D83006 Genomic DNA. Translation: BAA11676.1 .
Z28201 Genomic DNA. Translation: CAA82046.1 .
Z28200 Genomic DNA. Translation: CAA82044.1 .
BK006944 Genomic DNA. Translation: DAA08967.1 .
PIRi S78475.
RefSeqi NP_012721.1. NM_001179766.1.

3D structure databases

ProteinModelPortali P36044.
SMRi P36044. Positions 1037-1174.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 33921. 34 interactions.
DIPi DIP-4199N.
IntActi P36044. 3 interactions.
MINTi MINT-564199.

Proteomic databases

MaxQBi P36044.
PaxDbi P36044.
PRIDEi P36044.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YKL201C ; YKL201C ; YKL201C .
GeneIDi 853634.
KEGGi sce:YKL201C.

Organism-specific databases

CYGDi YKL201c.
SGDi S000001684. MNN4.

Phylogenomic databases

eggNOGi NOG85218.
GeneTreei ENSGT00730000113216.
HOGENOMi HOG000113617.
InParanoidi P36044.
OMAi MIRTFQK.
OrthoDBi EOG7HQNHH.

Enzyme and pathway databases

BioCyci YEAST:G3O-31961-MONOMER.

Miscellaneous databases

NextBioi 974514.

Gene expression databases

Genevestigatori P36044.

Family and domain databases

InterProi IPR009644. Fukutin-related.
IPR007074. LicD.
[Graphical view ]
PANTHERi PTHR15407. PTHR15407. 1 hit.
Pfami PF04991. LicD. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and analysis of the MNN4 gene required for phosphorylation of N-linked oligosaccharides in Saccharomyces cerevisiae."
    Odani T., Shimma Y., Tanaka A., Jigami Y.
    Glycobiology 6:805-810(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. "Complete DNA sequence of yeast chromosome XI."
    Dujon B., Alexandraki D., Andre B., Ansorge W., Baladron V., Ballesta J.P.G., Banrevi A., Bolle P.-A., Bolotin-Fukuhara M., Bossier P., Bou G., Boyer J., Buitrago M.J., Cheret G., Colleaux L., Daignan-Fornier B., del Rey F., Dion C.
    , Domdey H., Duesterhoeft A., Duesterhus S., Entian K.-D., Erfle H., Esteban P.F., Feldmann H., Fernandes L., Fobo G.M., Fritz C., Fukuhara H., Gabel C., Gaillon L., Garcia-Cantalejo J.M., Garcia-Ramirez J.J., Gent M.E., Ghazvini M., Goffeau A., Gonzalez A., Grothues D., Guerreiro P., Hegemann J.H., Hewitt N., Hilger F., Hollenberg C.P., Horaitis O., Indge K.J., Jacquier A., James C.M., Jauniaux J.-C., Jimenez A., Keuchel H., Kirchrath L., Kleine K., Koetter P., Legrain P., Liebl S., Louis E.J., Maia e Silva A., Marck C., Monnier A.-L., Moestl D., Mueller S., Obermaier B., Oliver S.G., Pallier C., Pascolo S., Pfeiffer F., Philippsen P., Planta R.J., Pohl F.M., Pohl T.M., Poehlmann R., Portetelle D., Purnelle B., Puzos V., Ramezani Rad M., Rasmussen S.W., Remacha M.A., Revuelta J.L., Richard G.-F., Rieger M., Rodrigues-Pousada C., Rose M., Rupp T., Santos M.A., Schwager C., Sensen C., Skala J., Soares H., Sor F., Stegemann J., Tettelin H., Thierry A., Tzermia M., Urrestarazu L.A., van Dyck L., van Vliet-Reedijk J.C., Valens M., Vandenbol M., Vilela C., Vissers S., von Wettstein D., Voss H., Wiemann S., Xu G., Zimmermann J., Haasemann M., Becker I., Mewes H.-W.
    Nature 369:371-378(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.

Entry informationi

Entry nameiMNN4_YEAST
AccessioniPrimary (citable) accession number: P36044
Secondary accession number(s): D6VX01, P36043, P89095
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: December 15, 1998
Last modified: October 29, 2014
This is version 118 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome XI
    Yeast (Saccharomyces cerevisiae) chromosome XI: entries and gene names

External Data

Dasty 3