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P36044

- MNN4_YEAST

UniProt

P36044 - MNN4_YEAST

Protein

Protein MNN4

Gene

MNN4

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5- Protein predictedi
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    • History
      Entry version 117 (01 Oct 2014)
      Sequence version 2 (15 Dec 1998)
      Previous versions | rss
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    Functioni

    May function as a positive regulator for mannosylphosphate transferase. Is required to mediate mannosylphosphate transfer in both the core and outer chain portions of N-linked oligosaccharides.

    GO - Molecular functioni

    1. enzyme activator activity Source: SGD

    GO - Biological processi

    1. cellular response to osmotic stress Source: SGD
    2. positive regulation of catalytic activity Source: GOC
    3. protein N-linked glycosylation Source: SGD
    4. protein O-linked glycosylation Source: SGD

    Enzyme and pathway databases

    BioCyciYEAST:G3O-31961-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein MNN4
    Gene namesi
    Name:MNN4
    Ordered Locus Names:YKL201C
    ORF Names:YKL200C
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome XI

    Organism-specific databases

    CYGDiYKL201c.
    SGDiS000001684. MNN4.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. membrane Source: SGD

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 11781178Protein MNN4PRO_0000096525Add
    BLAST

    Proteomic databases

    MaxQBiP36044.
    PaxDbiP36044.
    PRIDEiP36044.

    Expressioni

    Gene expression databases

    GenevestigatoriP36044.

    Interactioni

    Protein-protein interaction databases

    BioGridi33921. 34 interactions.
    DIPiDIP-4199N.
    IntActiP36044. 3 interactions.
    MINTiMINT-564199.

    Structurei

    3D structure databases

    ProteinModelPortaliP36044.
    SMRiP36044. Positions 1037-1174.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2727CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini49 – 11781130LumenalSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei28 – 4821Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati1042 – 104981
    Repeati1050 – 105782
    Repeati1058 – 106583
    Repeati1066 – 107384
    Repeati1074 – 108185
    Repeati1082 – 108986
    Repeati1090 – 109787; approximate
    Repeati1098 – 110588
    Repeati1106 – 111389; approximate
    Repeati1114 – 1121810; approximate
    Repeati1122 – 1129811; approximate
    Repeati1130 – 1137812
    Repeati1138 – 1144713; approximate
    Repeati1145 – 1152814; approximate
    Repeati1153 – 1160815; approximate
    Repeati1161 – 1168816; approximate
    Repeati1169 – 1174617; truncated

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1042 – 117413317 X 8 AA tandem repeats of K-K-K-K-E-E-E-EAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi37 – 404Poly-Ile
    Compositional biasi1032 – 1174143Arg/Glu/Lys-rich (highly charged)Add
    BLAST
    Compositional biasi1042 – 10454Poly-Lys
    Compositional biasi1046 – 10494Poly-Glu
    Compositional biasi1050 – 10534Poly-Lys
    Compositional biasi1054 – 10574Poly-Glu
    Compositional biasi1058 – 10614Poly-Lys
    Compositional biasi1062 – 10654Poly-Glu
    Compositional biasi1066 – 10694Poly-Lys
    Compositional biasi1070 – 10734Poly-Glu
    Compositional biasi1074 – 10774Poly-Lys
    Compositional biasi1078 – 10814Poly-Glu
    Compositional biasi1082 – 10854Poly-Lys
    Compositional biasi1086 – 10894Poly-Glu
    Compositional biasi1094 – 10974Poly-Glu
    Compositional biasi1098 – 11014Poly-Lys
    Compositional biasi1102 – 11054Poly-Glu
    Compositional biasi1134 – 11374Poly-Glu
    Compositional biasi1157 – 11604Poly-Glu
    Compositional biasi1165 – 11684Poly-Glu

    Sequence similaritiesi

    To yeast YJR061w.Curated

    Keywords - Domaini

    Repeat, Signal-anchor, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG85218.
    GeneTreeiENSGT00730000113216.
    HOGENOMiHOG000113617.
    OMAiMIRTFQK.
    OrthoDBiEOG7HQNHH.

    Family and domain databases

    InterProiIPR009644. Fukutin-related.
    IPR007074. LicD.
    [Graphical view]
    PANTHERiPTHR15407. PTHR15407. 1 hit.
    PfamiPF04991. LicD. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P36044-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLQRISSKLH RRFLSGLLRV KHYPLRRILL PLILLQIIII TFIWSNSPQR     50
    NGLGRDADYL LPNYNELDSD DDSWYSILTS SFKNDRKIQF AKTLYENLKF 100
    GTNPKWVNEY TLQNDLLSVK MGPRKGSKLE SVDELKFYDF DPRLTWSVVL 150
    NHLQNNDADQ PEKLPFSWYD WTTFHELNKL ISIDKTVLPC NFLFQSAFDK 200
    ESLEAIETEL GEPLFLYERP KYAQKLWYKA ARNQDRIKDS KELKKHCSKL 250
    FTPDGHGSPK GLRFNTQFQI KELYDKVRPE VYQLQARNYI LTTQSHPLSI 300
    SIIESDNSTY QVPLQTEKSK NLVQSGLLQE YINDNINSTN KRKKNKQDVE 350
    FNHNRLFQEF VNNDQVNSLY KLEIEETDKF TFDKDLVYLS PSDFKFDASK 400
    KIEELEEQKK LYPDKFSAHN ENYLNSLKNS VKTSPALQRK FFYEAGAVKQ 450
    YKGMGFHRDK RFFNVDTLIN DKQEYQARLN SMIRTFQKFT KANGIISWLS 500
    HGTLYGYLYN GMAFPWDNDF DLQMPIKHLQ LLSQYFNQSL ILEDPRQGNG 550
    RYFLDVSDSL TVRINGNGKN NIDARFIDVD TGLYIDITGL ASTSAPSRDY 600
    LNSYIEERLQ EEHLDINNIP ESNGETATLP DKVDDGLVNM ATLNITELRD 650
    YITSDENKNH KRVPTDTDLK DLLKKELEEL PKSKTIENKL NPKQRYFLNE 700
    KLKLYNCRNN HFNSFEELSP LINTVFHGVP ALIPHRHTYC LHNEYHVPDR 750
    YAFDAYKNTA YLPEFRFWFD YDGLKKCSNI NSWYPNIPSI NSWNPNLLKE 800
    ISSTKFESKL FDSNKVSEYS FKNLSMDDVR LIYKNIPKAG FIEVFTNLYN 850
    SFNVTAYRQK ELEIQYCQNL TFIEKKKLLH QLRINVAPKL SSPAKDPFLF 900
    GYEKAMWKDL SKSMNQTTLD QVTKIVHEEY VGKIIDLSES LKYRNFSLFN 950
    ITFDETGTTL DDNTEDYTPA NTVEVNPVDF KSNLNFSSNS FLDLNSYGLD 1000
    LFAPTLSDVN RKGIQMFDKD PIIVYEDYAY AKLLEERKRR EKKKKEEEEK 1050
    KKKEEEEKKK KEEEEKKKKE EEEKKKKEEE EKKKKEEEEK KKQEEEEKKK 1100
    KEEEEKKKQE EGEKMKNEDE ENKKNEDEEK KKNEEEEKKK QEEKNKKNED 1150
    EEKKKQEEEE KKKNEEEEKK KQEEGHSN 1178
    Length:1,178
    Mass (Da):139,381
    Last modified:December 15, 1998 - v2
    Checksum:iBC05DAE0AEFCB282
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D83006 Genomic DNA. Translation: BAA11676.1.
    Z28201 Genomic DNA. Translation: CAA82046.1.
    Z28200 Genomic DNA. Translation: CAA82044.1.
    BK006944 Genomic DNA. Translation: DAA08967.1.
    PIRiS78475.
    RefSeqiNP_012721.1. NM_001179766.1.

    Genome annotation databases

    EnsemblFungiiYKL201C; YKL201C; YKL201C.
    GeneIDi853634.
    KEGGisce:YKL201C.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D83006 Genomic DNA. Translation: BAA11676.1 .
    Z28201 Genomic DNA. Translation: CAA82046.1 .
    Z28200 Genomic DNA. Translation: CAA82044.1 .
    BK006944 Genomic DNA. Translation: DAA08967.1 .
    PIRi S78475.
    RefSeqi NP_012721.1. NM_001179766.1.

    3D structure databases

    ProteinModelPortali P36044.
    SMRi P36044. Positions 1037-1174.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 33921. 34 interactions.
    DIPi DIP-4199N.
    IntActi P36044. 3 interactions.
    MINTi MINT-564199.

    Proteomic databases

    MaxQBi P36044.
    PaxDbi P36044.
    PRIDEi P36044.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YKL201C ; YKL201C ; YKL201C .
    GeneIDi 853634.
    KEGGi sce:YKL201C.

    Organism-specific databases

    CYGDi YKL201c.
    SGDi S000001684. MNN4.

    Phylogenomic databases

    eggNOGi NOG85218.
    GeneTreei ENSGT00730000113216.
    HOGENOMi HOG000113617.
    OMAi MIRTFQK.
    OrthoDBi EOG7HQNHH.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-31961-MONOMER.

    Miscellaneous databases

    NextBioi 974514.

    Gene expression databases

    Genevestigatori P36044.

    Family and domain databases

    InterProi IPR009644. Fukutin-related.
    IPR007074. LicD.
    [Graphical view ]
    PANTHERi PTHR15407. PTHR15407. 1 hit.
    Pfami PF04991. LicD. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and analysis of the MNN4 gene required for phosphorylation of N-linked oligosaccharides in Saccharomyces cerevisiae."
      Odani T., Shimma Y., Tanaka A., Jigami Y.
      Glycobiology 6:805-810(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    2. "Complete DNA sequence of yeast chromosome XI."
      Dujon B., Alexandraki D., Andre B., Ansorge W., Baladron V., Ballesta J.P.G., Banrevi A., Bolle P.-A., Bolotin-Fukuhara M., Bossier P., Bou G., Boyer J., Buitrago M.J., Cheret G., Colleaux L., Daignan-Fornier B., del Rey F., Dion C.
      , Domdey H., Duesterhoeft A., Duesterhus S., Entian K.-D., Erfle H., Esteban P.F., Feldmann H., Fernandes L., Fobo G.M., Fritz C., Fukuhara H., Gabel C., Gaillon L., Garcia-Cantalejo J.M., Garcia-Ramirez J.J., Gent M.E., Ghazvini M., Goffeau A., Gonzalez A., Grothues D., Guerreiro P., Hegemann J.H., Hewitt N., Hilger F., Hollenberg C.P., Horaitis O., Indge K.J., Jacquier A., James C.M., Jauniaux J.-C., Jimenez A., Keuchel H., Kirchrath L., Kleine K., Koetter P., Legrain P., Liebl S., Louis E.J., Maia e Silva A., Marck C., Monnier A.-L., Moestl D., Mueller S., Obermaier B., Oliver S.G., Pallier C., Pascolo S., Pfeiffer F., Philippsen P., Planta R.J., Pohl F.M., Pohl T.M., Poehlmann R., Portetelle D., Purnelle B., Puzos V., Ramezani Rad M., Rasmussen S.W., Remacha M.A., Revuelta J.L., Richard G.-F., Rieger M., Rodrigues-Pousada C., Rose M., Rupp T., Santos M.A., Schwager C., Sensen C., Skala J., Soares H., Sor F., Stegemann J., Tettelin H., Thierry A., Tzermia M., Urrestarazu L.A., van Dyck L., van Vliet-Reedijk J.C., Valens M., Vandenbol M., Vilela C., Vissers S., von Wettstein D., Voss H., Wiemann S., Xu G., Zimmermann J., Haasemann M., Becker I., Mewes H.-W.
      Nature 369:371-378(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    3. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.

    Entry informationi

    Entry nameiMNN4_YEAST
    AccessioniPrimary (citable) accession number: P36044
    Secondary accession number(s): D6VX01, P36043, P89095
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 1, 1994
    Last sequence update: December 15, 1998
    Last modified: October 1, 2014
    This is version 117 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    2. Yeast chromosome XI
      Yeast (Saccharomyces cerevisiae) chromosome XI: entries and gene names

    External Data

    Dasty 3