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Protein

Protein MNN4

Gene

MNN4

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein predictedi

Functioni

May function as a positive regulator for mannosylphosphate transferase. Is required to mediate mannosylphosphate transfer in both the core and outer chain portions of N-linked oligosaccharides.

GO - Molecular functioni

  • enzyme activator activity Source: SGD

GO - Biological processi

  • cellular response to osmotic stress Source: SGD
  • protein N-linked glycosylation Source: SGD
  • protein O-linked glycosylation Source: SGD
Complete GO annotation...

Enzyme and pathway databases

BioCyciYEAST:G3O-31961-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein MNN4
Gene namesi
Name:MNN4
Ordered Locus Names:YKL201C
ORF Names:YKL200C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XI

Organism-specific databases

EuPathDBiFungiDB:YKL201C.
SGDiS000001684. MNN4.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 27CytoplasmicSequence analysisAdd BLAST27
Transmembranei28 – 48Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini49 – 1178LumenalSequence analysisAdd BLAST1130

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • membrane Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000965251 – 1178Protein MNN4Add BLAST1178

Proteomic databases

MaxQBiP36044.
PRIDEiP36044.

Interactioni

Protein-protein interaction databases

BioGridi33921. 34 interactors.
DIPiDIP-4199N.
IntActiP36044. 3 interactors.
MINTiMINT-564199.

Structurei

3D structure databases

ProteinModelPortaliP36044.
SMRiP36044.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati1042 – 104918
Repeati1050 – 105728
Repeati1058 – 106538
Repeati1066 – 107348
Repeati1074 – 108158
Repeati1082 – 108968
Repeati1090 – 10977; approximate8
Repeati1098 – 110588
Repeati1106 – 11139; approximate8
Repeati1114 – 112110; approximate8
Repeati1122 – 112911; approximate8
Repeati1130 – 1137128
Repeati1138 – 114413; approximate7
Repeati1145 – 115214; approximate8
Repeati1153 – 116015; approximate8
Repeati1161 – 116816; approximate8
Repeati1169 – 117417; truncated6

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1042 – 117417 X 8 AA tandem repeats of K-K-K-K-E-E-E-EAdd BLAST133

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi37 – 40Poly-Ile4
Compositional biasi1032 – 1174Arg/Glu/Lys-rich (highly charged)Add BLAST143
Compositional biasi1042 – 1045Poly-Lys4
Compositional biasi1046 – 1049Poly-Glu4
Compositional biasi1050 – 1053Poly-Lys4
Compositional biasi1054 – 1057Poly-Glu4
Compositional biasi1058 – 1061Poly-Lys4
Compositional biasi1062 – 1065Poly-Glu4
Compositional biasi1066 – 1069Poly-Lys4
Compositional biasi1070 – 1073Poly-Glu4
Compositional biasi1074 – 1077Poly-Lys4
Compositional biasi1078 – 1081Poly-Glu4
Compositional biasi1082 – 1085Poly-Lys4
Compositional biasi1086 – 1089Poly-Glu4
Compositional biasi1094 – 1097Poly-Glu4
Compositional biasi1098 – 1101Poly-Lys4
Compositional biasi1102 – 1105Poly-Glu4
Compositional biasi1134 – 1137Poly-Glu4
Compositional biasi1157 – 1160Poly-Glu4
Compositional biasi1165 – 1168Poly-Glu4

Sequence similaritiesi

To yeast YJR061w.Curated

Keywords - Domaini

Repeat, Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00730000113216.
HOGENOMiHOG000113617.
InParanoidiP36044.
OMAiSMIRTFQ.
OrthoDBiEOG092C0SEZ.

Family and domain databases

InterProiIPR009644. Fukutin-related.
IPR007074. LicD_fam.
[Graphical view]
PANTHERiPTHR15407. PTHR15407. 4 hits.
PfamiPF04991. LicD. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P36044-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLQRISSKLH RRFLSGLLRV KHYPLRRILL PLILLQIIII TFIWSNSPQR
60 70 80 90 100
NGLGRDADYL LPNYNELDSD DDSWYSILTS SFKNDRKIQF AKTLYENLKF
110 120 130 140 150
GTNPKWVNEY TLQNDLLSVK MGPRKGSKLE SVDELKFYDF DPRLTWSVVL
160 170 180 190 200
NHLQNNDADQ PEKLPFSWYD WTTFHELNKL ISIDKTVLPC NFLFQSAFDK
210 220 230 240 250
ESLEAIETEL GEPLFLYERP KYAQKLWYKA ARNQDRIKDS KELKKHCSKL
260 270 280 290 300
FTPDGHGSPK GLRFNTQFQI KELYDKVRPE VYQLQARNYI LTTQSHPLSI
310 320 330 340 350
SIIESDNSTY QVPLQTEKSK NLVQSGLLQE YINDNINSTN KRKKNKQDVE
360 370 380 390 400
FNHNRLFQEF VNNDQVNSLY KLEIEETDKF TFDKDLVYLS PSDFKFDASK
410 420 430 440 450
KIEELEEQKK LYPDKFSAHN ENYLNSLKNS VKTSPALQRK FFYEAGAVKQ
460 470 480 490 500
YKGMGFHRDK RFFNVDTLIN DKQEYQARLN SMIRTFQKFT KANGIISWLS
510 520 530 540 550
HGTLYGYLYN GMAFPWDNDF DLQMPIKHLQ LLSQYFNQSL ILEDPRQGNG
560 570 580 590 600
RYFLDVSDSL TVRINGNGKN NIDARFIDVD TGLYIDITGL ASTSAPSRDY
610 620 630 640 650
LNSYIEERLQ EEHLDINNIP ESNGETATLP DKVDDGLVNM ATLNITELRD
660 670 680 690 700
YITSDENKNH KRVPTDTDLK DLLKKELEEL PKSKTIENKL NPKQRYFLNE
710 720 730 740 750
KLKLYNCRNN HFNSFEELSP LINTVFHGVP ALIPHRHTYC LHNEYHVPDR
760 770 780 790 800
YAFDAYKNTA YLPEFRFWFD YDGLKKCSNI NSWYPNIPSI NSWNPNLLKE
810 820 830 840 850
ISSTKFESKL FDSNKVSEYS FKNLSMDDVR LIYKNIPKAG FIEVFTNLYN
860 870 880 890 900
SFNVTAYRQK ELEIQYCQNL TFIEKKKLLH QLRINVAPKL SSPAKDPFLF
910 920 930 940 950
GYEKAMWKDL SKSMNQTTLD QVTKIVHEEY VGKIIDLSES LKYRNFSLFN
960 970 980 990 1000
ITFDETGTTL DDNTEDYTPA NTVEVNPVDF KSNLNFSSNS FLDLNSYGLD
1010 1020 1030 1040 1050
LFAPTLSDVN RKGIQMFDKD PIIVYEDYAY AKLLEERKRR EKKKKEEEEK
1060 1070 1080 1090 1100
KKKEEEEKKK KEEEEKKKKE EEEKKKKEEE EKKKKEEEEK KKQEEEEKKK
1110 1120 1130 1140 1150
KEEEEKKKQE EGEKMKNEDE ENKKNEDEEK KKNEEEEKKK QEEKNKKNED
1160 1170
EEKKKQEEEE KKKNEEEEKK KQEEGHSN
Length:1,178
Mass (Da):139,381
Last modified:December 15, 1998 - v2
Checksum:iBC05DAE0AEFCB282
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D83006 Genomic DNA. Translation: BAA11676.1.
Z28201 Genomic DNA. Translation: CAA82046.1.
Z28200 Genomic DNA. Translation: CAA82044.1.
BK006944 Genomic DNA. Translation: DAA08967.1.
PIRiS78475.
RefSeqiNP_012721.1. NM_001179766.1.

Genome annotation databases

EnsemblFungiiYKL201C; YKL201C; YKL201C.
GeneIDi853634.
KEGGisce:YKL201C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D83006 Genomic DNA. Translation: BAA11676.1.
Z28201 Genomic DNA. Translation: CAA82046.1.
Z28200 Genomic DNA. Translation: CAA82044.1.
BK006944 Genomic DNA. Translation: DAA08967.1.
PIRiS78475.
RefSeqiNP_012721.1. NM_001179766.1.

3D structure databases

ProteinModelPortaliP36044.
SMRiP36044.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi33921. 34 interactors.
DIPiDIP-4199N.
IntActiP36044. 3 interactors.
MINTiMINT-564199.

Proteomic databases

MaxQBiP36044.
PRIDEiP36044.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYKL201C; YKL201C; YKL201C.
GeneIDi853634.
KEGGisce:YKL201C.

Organism-specific databases

EuPathDBiFungiDB:YKL201C.
SGDiS000001684. MNN4.

Phylogenomic databases

GeneTreeiENSGT00730000113216.
HOGENOMiHOG000113617.
InParanoidiP36044.
OMAiSMIRTFQ.
OrthoDBiEOG092C0SEZ.

Enzyme and pathway databases

BioCyciYEAST:G3O-31961-MONOMER.

Miscellaneous databases

PROiP36044.

Family and domain databases

InterProiIPR009644. Fukutin-related.
IPR007074. LicD_fam.
[Graphical view]
PANTHERiPTHR15407. PTHR15407. 4 hits.
PfamiPF04991. LicD. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMNN4_YEAST
AccessioniPrimary (citable) accession number: P36044
Secondary accession number(s): D6VX01, P36043, P89095
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: December 15, 1998
Last modified: November 2, 2016
This is version 133 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome XI
    Yeast (Saccharomyces cerevisiae) chromosome XI: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.