UniProtKB - P36040 (POC2_YEAST)
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Protein
Proteasome assembly chaperone 2
Gene
ADD66
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Functioni
Involved in 20S proteasome assembly. Required for maximal proteasome activity. Affects the chymotrypsin-like activity of the proteasome. Can be degraded by the proteasome. Involved in the endoplasmic reticulum-associated degradation (ERAD).3 Publications
Miscellaneous
Present with 2940 molecules/cell in log phase SD medium.1 Publication
Deletion induces the unfolded protein response (UPR).
GO - Biological processi
- proteasome assembly Source: SGD
Keywordsi
Molecular function | Chaperone |
Enzyme and pathway databases
BioCyci | YEAST:G3O-31965-MONOMER. |
Names & Taxonomyi
Protein namesi | Recommended name: Proteasome assembly chaperone 2Alternative name(s): Alpha-1-proteinase inhibitor-degradation deficient protein 66 Proteasome biogenesis-associated protein 2 |
Gene namesi | Name:ADD66 Synonyms:PBA2, POC2 Ordered Locus Names:YKL206C |
Organismi | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
Taxonomic identifieri | 559292 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › |
Proteomesi |
|
Organism-specific databases
EuPathDBi | FungiDB:YKL206C. |
SGDi | S000001689. ADD66. |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000203132 | 1 – 267 | Proteasome assembly chaperone 2Add BLAST | 267 |
Proteomic databases
MaxQBi | P36040. |
PaxDbi | P36040. |
PRIDEi | P36040. |
Interactioni
Subunit structurei
Component of the 20S proteasome chaperone. Forms a heterodimer with PBA1 that binds to proteasome precursors.2 Publications
Binary interactionsi
Protein-protein interaction databases
BioGridi | 33917. 155 interactors. |
DIPi | DIP-6515N. |
IntActi | P36040. 9 interactors. |
MINTi | P36040. |
STRINGi | 4932.YKL206C. |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more detailsFeature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Beta strandi | 3 – 7 | Combined sources | 5 | |
Helixi | 11 – 13 | Combined sources | 3 | |
Helixi | 14 – 25 | Combined sources | 12 | |
Beta strandi | 28 – 35 | Combined sources | 8 | |
Beta strandi | 51 – 54 | Combined sources | 4 | |
Beta strandi | 67 – 75 | Combined sources | 9 | |
Turni | 76 – 79 | Combined sources | 4 | |
Beta strandi | 80 – 85 | Combined sources | 6 | |
Helixi | 92 – 94 | Combined sources | 3 | |
Helixi | 95 – 108 | Combined sources | 14 | |
Helixi | 109 – 111 | Combined sources | 3 | |
Beta strandi | 113 – 118 | Combined sources | 6 | |
Helixi | 183 – 188 | Combined sources | 6 | |
Helixi | 220 – 228 | Combined sources | 9 | |
Helixi | 247 – 251 | Combined sources | 5 | |
Helixi | 258 – 266 | Combined sources | 9 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
4G4S | X-ray | 2.49 | P | 1-267 | [»] | |
ProteinModelPortali | P36040. | |||||
SMRi | P36040. | |||||
ModBasei | Search... | |||||
MobiDBi | Search... |
Family & Domainsi
Sequence similaritiesi
Belongs to the PSMG2 family.Curated
Phylogenomic databases
HOGENOMi | HOG000066091. |
InParanoidi | P36040. |
KOi | K11880. |
OMAi | SWKGVYG. |
OrthoDBi | EOG092C4LOR. |
Family and domain databases
Gene3Di | 3.40.50.10900. 2 hits. |
InterProi | View protein in InterPro IPR019151. Proteasome_assmbl_chaperone_2. IPR016562. Proteasome_assmbl_chp_2_euk. IPR038389. PSMG2_sf. |
Pfami | View protein in Pfam PF09754. PAC2. 1 hit. |
PIRSFi | PIRSF010044. UCP010044. 1 hit. |
i Sequence
Sequence statusi: Complete.
P36040-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSCLVLPLVS VGNIPQLSID WLLNSQANEW EYLEALDSKY LVEFVGPLDR
60 70 80 90 100
PEDGSDSLYK DADMKYSSAL EVFYNKKRGL FAIQQRTPLV SVNYLNNFIV
110 120 130 140 150
EIILPFLSKY NISEICIWDS LYAMEDENGV IVRPQEVYSL GEFYFDDEAE
160 170 180 190 200
LLSNLHLNDQ ESMVNNWLHF TPTSFQDKIS VDQPIFKILF QILNASQRPK
210 220 230 240 250
ALRSIKYCSC LANEGDNSLD SQQFLQWIIS QKVIKNAPPI VKFVRPISWQ
260
GAYGMADARD KFVDLYN
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z28206 Genomic DNA. Translation: CAA82051.1. AY558394 Genomic DNA. Translation: AAS56720.1. BK006944 Genomic DNA. Translation: DAA08963.1. |
PIRi | S38044. |
RefSeqi | NP_012716.1. NM_001179771.1. |
Genome annotation databases
EnsemblFungii | YKL206C; YKL206C; YKL206C. |
GeneIDi | 853629. |
KEGGi | sce:YKL206C. |
Similar proteinsi
Entry informationi
Entry namei | POC2_YEAST | |
Accessioni | P36040Primary (citable) accession number: P36040 Secondary accession number(s): D6VWZ7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 1, 1994 |
Last sequence update: | June 1, 1994 | |
Last modified: | March 28, 2018 | |
This is version 124 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |