Reviewed, UniProtKB/Swiss-Prot P36038 (CBT1_YEAST)

Names and origin

Protein names

Recommended name:
    Cytochrome b termination protein 1

Gene names

Name:	CBT1
Synonyms:	SOC1
Ordered Locus Names:	YKL208W

Organism

Saccharomyces cerevisiae (Baker's yeast) [Complete proteome]

Taxonomic identifier

4932 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces

Protein attributes

Sequence length	271 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Involved in 5'-end processing of mitochondrial COB, 15S rRNA, and RPM1 transcript. May also have a role in 3'-end processing of the COB pre-mRNA. Ref.3 Ref.4 Ref.5 Ref.7
Subcellular location	Mitochondrion.

Ontologies

Keywords
Biological process	Ribosome biogenesis mRNA processing rRNA processing
Cellular component	Mitochondrion
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	cytochrome complex assembly Ref.4 Inferred from direct assay. Source: SGD mRNA processing Ref.4 Ref.7 Inferred from direct assay. Source: SGD mRNA stabilization Ref.7 Inferred from mutant phenotype. Source: SGD rRNA processing Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	mitochondrion Ref.6 Inferred from direct assay. Source: SGD
Molecular function	protein binding Inferred from physical interaction. Source: IntAct
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
ECM4	P36156	1	EBI-27009,EBI-2042717

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 271	271	Cytochrome b termination protein 1		PRO_0000203131
Experimental info
	Sequence conflict	270	1	R → Q in AAS56721. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	P36038-1 [UniParc]. Last modified June 1, 1994. Version 1. Checksum: 6022348CA619123C	FASTA	271	31,157
	10 20 30 40 50 60 MVSYGSHSSE VSKVLKTPKF VLRYGNVSSK QRFALKRKIN YKLRESKYQE YLNEYNTFVL 70 80 90 100 110 120 YDWENSGAGS LVDSSYNLPS LWKEFITEGI SKGAINDKLP TVFMKRKLTN SALGHCLGLD 130 140 150 160 170 180 FLTDPSESEH EYRCMFQTVQ DIPSLSQLIL FNSMPNVPVR LKLHTIGINI NFGCKRSLIS 190 200 210 220 230 240 NGGDQDTEMS EAVSYIQPLL EESSRMYRNL NYWKLLKIAR NNKKDEPLDQ STRIKSQVKL 250 260 270 LLSQLATNRI TSPSVTDHGG HNWLIFTRRR L

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Complete DNA sequence of yeast chromosome XI." Dujon B., Alexandraki D., Andre B., Ansorge W., Baladron V., Ballesta J.P.G., Banrevi A., Bolle P.-A., Bolotin-Fukuhara M., Bossier P., Bou G., Boyer J., Buitrago M.J., Cheret G., Colleaux L., Daignan-Fornier B., del Rey F., Dion C. , Domdey H., Duesterhoeft A., Duesterhus S., Entian K.-D., Erfle H., Esteban P.F., Feldmann H., Fernandes L., Fobo G.M., Fritz C., Fukuhara H., Gabel C., Gaillon L., Garcia-Cantalejo J.M., Garcia-Ramirez J.J., Gent M.E., Ghazvini M., Goffeau A., Gonzalez A., Grothues D., Guerreiro P., Hegemann J.H., Hewitt N., Hilger F., Hollenberg C.P., Horaitis O., Indge K.J., Jacquier A., James C.M., Jauniaux J.-C., Jimenez A., Keuchel H., Kirchrath L., Kleine K., Koetter P., Legrain P., Liebl S., Louis E.J., Maia e Silva A., Marck C., Monnier A.-L., Moestl D., Mueller S., Obermaier B., Oliver S.G., Pallier C., Pascolo S., Pfeiffer F., Philippsen P., Planta R.J., Pohl F.M., Pohl T.M., Poehlmann R., Portetelle D., Purnelle B., Puzos V., Ramezani Rad M., Rasmussen S.W., Remacha M.A., Revuelta J.L., Richard G.-F., Rieger M., Rodrigues-Pousada C., Rose M., Rupp T., Santos M.A., Schwager C., Sensen C., Skala J., Soares H., Sor F., Stegemann J., Tettelin H., Thierry A., Tzermia M., Urrestarazu L.A., van Dyck L., van Vliet-Reedijk J.C., Valens M., Vandenbol M., Vilela C., Vissers S., von Wettstein D., Voss H., Wiemann S., Xu G., Zimmermann J., Haasemann M., Becker I., Mewes H.-W. Nature 369:371-378(1994) [PubMed: 8196765] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 96604 / S288c / FY1679.
[2]	"Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae." Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F., Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J., Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J. , Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D., LaBaer J. Genome Res. 17:536-543(2007) [PubMed: 17322287] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 204508 / S288c.
[3]	"Suppressor analyses of temperature-sensitive cbp1 strains of Saccharomyces cerevisiae: the product of the nuclear gene SOC1 affects mitochondrial cytochrome b mRNA post-transcriptionally." Staples R.R., Dieckmann C.L. Genetics 138:565-575(1994) [PubMed: 7851755] [Abstract] Cited for: FUNCTION.
[4]	"A novel nuclear gene, CBT1, essential for mitochondrial cytochrome b formation: terminal processing of mRNA and intron dependence." Rieger K.-J., Aljinovic G., Lazowska J., Pohl T.M., Slonimski P.P., Aljinovic G. Curr. Genet. 32:163-174(1997) [PubMed: 9339340] [Abstract] Cited for: FUNCTION.
[5]	"Suppressor analysis of mutations in the 5'-untranslated region of COB mRNA identifies components of general pathways for mitochondrial mRNA processing and decay in Saccharomyces cerevisiae." Chen W., Islas-Osuna M.A., Dieckmann C.L. Genetics 151:1315-1325(1999) [PubMed: 10101159] [Abstract] Cited for: FUNCTION.
[6]	"Global analysis of protein localization in budding yeast." Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W., Weissman J.S., O'Shea E.K. Nature 425:686-691(2003) [PubMed: 14562095] [Abstract] Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
[7]	"CBT1 interacts genetically with CBP1 and the mitochondrially encoded cytochrome b gene and is required to stabilize the mature cytochrome b mRNA of Saccharomyces cerevisiae." Ellis T.P., Schonauer M.S., Dieckmann C.L. Genetics 171:949-957(2005) [PubMed: 16118200] [Abstract] Cited for: FUNCTION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	Z28208 Genomic DNA. Translation: CAA82053.1. AY558395 Genomic DNA. Translation: AAS56721.1.
PIR	S38046.
RefSeq	NP_012714.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
DIP	DIP:3855N.
IntAct	P36038. 2 interactions.
STRING	P36038.
Proteomic databases
PRIDE	P36038.
Genome annotation databases
Ensembl	YKL208W; YKL208W; YKL208W; Saccharomyces cerevisiae. [Genome view]
GeneID	853673.
KEGG	sce:YKL208W.
NMPDR	fig|4932.3.peg.3692.
Organism-specific databases
CYGD	YKL208w.
SGD	S000001691. CBT1.
Phylogenomic databases
OMA	SESEHEY
OrthoDB	EOG9KM0KW
Gene expression databases
ArrayExpress	P36038.
Genevestigator	P36038.
GermOnline	YKL208W. Saccharomyces cerevisiae.
Family and domain databases
ProtoNet	Search...
Other Resources
NextBio	974622.

Entry information

Entry name

CBT1_YEAST

Accession

Primary (citable) accession number: P36038
Secondary accession number(s): Q6Q574

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 1, 1994
Last sequence update:	June 1, 1994
Last modified:	November 24, 2009
This is version 58 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)