P36038 (CBT1_YEAST) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Cytochrome b termination protein 1

Gene names

Name:	CBT1
Synonyms:	SOC1
Ordered Locus Names:	YKL208W

Organism

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]

Taxonomic identifier

559292 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › Saccharomyces cerevisiae

Protein attributes

Sequence length	271 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Involved in 5'-end processing of mitochondrial COB, 15S rRNA, and RPM1 transcript. May also have a role in 3'-end processing of the COB pre-mRNA. Ref.4 Ref.5 Ref.6 Ref.8
Subcellular location	Mitochondrion Ref.7.

Ontologies

Keywords
Biological process	Ribosome biogenesis mRNA processing rRNA processing
Cellular component	Mitochondrion
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cytochrome complex assembly Inferred from direct assay Ref.5. Source: SGD mRNA processing Inferred from direct assay Ref.5. Source: SGD mRNA stabilization Inferred from mutant phenotype Ref.8. Source: SGD rRNA processing Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	mitochondrion Inferred from direct assay Ref.7. Source: SGD
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 271	271	Cytochrome b termination protein 1		PRO_0000203131
Experimental info
	Sequence conflict	270	1	R → Q in AAS56721. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	P36038 [UniParc]. Last modified June 1, 1994. Version 1. Checksum: 6022348CA619123C	FASTA	271	31,157
	10 20 30 40 50 60 MVSYGSHSSE VSKVLKTPKF VLRYGNVSSK QRFALKRKIN YKLRESKYQE YLNEYNTFVL 70 80 90 100 110 120 YDWENSGAGS LVDSSYNLPS LWKEFITEGI SKGAINDKLP TVFMKRKLTN SALGHCLGLD 130 140 150 160 170 180 FLTDPSESEH EYRCMFQTVQ DIPSLSQLIL FNSMPNVPVR LKLHTIGINI NFGCKRSLIS 190 200 210 220 230 240 NGGDQDTEMS EAVSYIQPLL EESSRMYRNL NYWKLLKIAR NNKKDEPLDQ STRIKSQVKL 250 260 270 LLSQLATNRI TSPSVTDHGG HNWLIFTRRR L

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Complete DNA sequence of yeast chromosome XI." Dujon B., Alexandraki D., Andre B., Ansorge W., Baladron V., Ballesta J.P.G., Banrevi A., Bolle P.-A., Bolotin-Fukuhara M., Bossier P., Bou G., Boyer J., Buitrago M.J., Cheret G., Colleaux L., Daignan-Fornier B., del Rey F., Dion C. , Domdey H., Duesterhoeft A., Duesterhus S., Entian K.-D., Erfle H., Esteban P.F., Feldmann H., Fernandes L., Fobo G.M., Fritz C., Fukuhara H., Gabel C., Gaillon L., Garcia-Cantalejo J.M., Garcia-Ramirez J.J., Gent M.E., Ghazvini M., Goffeau A., Gonzalez A., Grothues D., Guerreiro P., Hegemann J.H., Hewitt N., Hilger F., Hollenberg C.P., Horaitis O., Indge K.J., Jacquier A., James C.M., Jauniaux J.-C., Jimenez A., Keuchel H., Kirchrath L., Kleine K., Koetter P., Legrain P., Liebl S., Louis E.J., Maia e Silva A., Marck C., Monnier A.-L., Moestl D., Mueller S., Obermaier B., Oliver S.G., Pallier C., Pascolo S., Pfeiffer F., Philippsen P., Planta R.J., Pohl F.M., Pohl T.M., Poehlmann R., Portetelle D., Purnelle B., Puzos V., Ramezani Rad M., Rasmussen S.W., Remacha M.A., Revuelta J.L., Richard G.-F., Rieger M., Rodrigues-Pousada C., Rose M., Rupp T., Santos M.A., Schwager C., Sensen C., Skala J., Soares H., Sor F., Stegemann J., Tettelin H., Thierry A., Tzermia M., Urrestarazu L.A., van Dyck L., van Vliet-Reedijk J.C., Valens M., Vandenbol M., Vilela C., Vissers S., von Wettstein D., Voss H., Wiemann S., Xu G., Zimmermann J., Haasemann M., Becker I., Mewes H.-W. Nature 369:371-378(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 96604 / S288c / FY1679.
[2]	Saccharomyces Genome Database Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: ATCC 204508 / S288c.
[3]	"Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae." Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F., Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J., Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J. , Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D., LaBaer J. Genome Res. 17:536-543(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 204508 / S288c.
[4]	"Suppressor analyses of temperature-sensitive cbp1 strains of Saccharomyces cerevisiae: the product of the nuclear gene SOC1 affects mitochondrial cytochrome b mRNA post-transcriptionally." Staples R.R., Dieckmann C.L. Genetics 138:565-575(1994) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION.
[5]	"A novel nuclear gene, CBT1, essential for mitochondrial cytochrome b formation: terminal processing of mRNA and intron dependence." Rieger K.-J., Aljinovic G., Lazowska J., Pohl T.M., Slonimski P.P., Aljinovic G. Curr. Genet. 32:163-174(1997) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION.
[6]	"Suppressor analysis of mutations in the 5'-untranslated region of COB mRNA identifies components of general pathways for mitochondrial mRNA processing and decay in Saccharomyces cerevisiae." Chen W., Islas-Osuna M.A., Dieckmann C.L. Genetics 151:1315-1325(1999) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION.
[7]	"Global analysis of protein localization in budding yeast." Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W., Weissman J.S., O'Shea E.K. Nature 425:686-691(2003) [PubMed] [Europe PMC] [Abstract] Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
[8]	"CBT1 interacts genetically with CBP1 and the mitochondrially encoded cytochrome b gene and is required to stabilize the mature cytochrome b mRNA of Saccharomyces cerevisiae." Ellis T.P., Schonauer M.S., Dieckmann C.L. Genetics 171:949-957(2005) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	Z28208 Genomic DNA. Translation: CAA82053.1. AY558395 Genomic DNA. Translation: AAS56721.1. BK006944 Genomic DNA. Translation: DAA08961.1.
PIR	S38046.
RefSeq	NP_012714.1. NM_001179773.1.
3D structure databases
ProteinModelPortal	P36038.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-3855N.
MINT	MINT-490655.
STRING	4932.YKL208W.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	YKL208W; YKL208W; YKL208W.
GeneID	853673.
KEGG	sce:YKL208W.
Organism-specific databases
CYGD	YKL208w.
SGD	S000001691. CBT1.
Phylogenomic databases
eggNOG	NOG131984.
OMA	SESEHEY.
OrthoDB	EOG422DVJ.
Gene expression databases
Genevestigator	P36038.
GermOnline	YKL208W. Saccharomyces cerevisiae.
Family and domain databases
ProtoNet	Search...
Other
NextBio	974622.

Entry information

Entry name

CBT1_YEAST

Accession

Primary (citable) accession number: P36038
Secondary accession number(s): D6VWZ5, Q6Q574

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 1, 1994
Last sequence update:	June 1, 1994
Last modified:	April 3, 2013
This is version 88 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program