Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Carboxylic acid transporter protein homolog

Gene

JEN1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Essential to lactate transport.

GO - Molecular functioni

  • carbohydrate transmembrane transporter activity Source: InterPro
  • secondary active monocarboxylate transmembrane transporter activity Source: SGD
  • selenite:proton symporter activity Source: SGD

GO - Biological processi

  • plasma membrane lactate transport Source: SGD
  • plasma membrane pyruvate transport Source: SGD
  • plasma membrane selenite transport Source: SGD
Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-31974-MONOMER.

Protein family/group databases

TCDBi2.A.1.12.2. the major facilitator superfamily (mfs).

Names & Taxonomyi

Protein namesi
Recommended name:
Carboxylic acid transporter protein homolog
Gene namesi
Name:JEN1
Ordered Locus Names:YKL217W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XI

Organism-specific databases

EuPathDBiFungiDB:YKL217W.
SGDiS000001700. JEN1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini2 – 140CytoplasmicSequence analysisAdd BLAST139
Transmembranei141 – 161Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini162 – 176ExtracellularSequence analysisAdd BLAST15
Transmembranei177 – 197Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini198 – 205CytoplasmicSequence analysis8
Transmembranei206 – 226Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini227 – 230ExtracellularSequence analysis4
Transmembranei231 – 251Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini252 – 263CytoplasmicSequence analysisAdd BLAST12
Transmembranei264 – 284Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini285 – 296ExtracellularSequence analysisAdd BLAST12
Transmembranei297 – 317Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini318 – 363CytoplasmicSequence analysisAdd BLAST46
Transmembranei364 – 384Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini385 – 402ExtracellularSequence analysisAdd BLAST18
Transmembranei403 – 423Helical; Name=8Sequence analysisAdd BLAST21
Topological domaini424 – 432CytoplasmicSequence analysis9
Transmembranei433 – 453Helical; Name=9Sequence analysisAdd BLAST21
Topological domaini454 – 457ExtracellularSequence analysis4
Transmembranei458 – 478Helical; Name=10Sequence analysisAdd BLAST21
Topological domaini479 – 489CytoplasmicSequence analysisAdd BLAST11
Transmembranei490 – 510Helical; Name=11Sequence analysisAdd BLAST21
Topological domaini511 – 535ExtracellularSequence analysisAdd BLAST25
Transmembranei536 – 556Helical; Name=12Sequence analysisAdd BLAST21
Topological domaini557 – 616CytoplasmicSequence analysisAdd BLAST60

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources1 Publication
ChainiPRO_00000504602 – 616Carboxylic acid transporter protein homologAdd BLAST615

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineCombined sources1 Publication1
Modified residuei4PhosphoserineCombined sources1
Cross-linki9Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication
Modified residuei11PhosphoserineCombined sources1
Modified residuei61PhosphoserineCombined sources1
Modified residuei66PhosphoserineCombined sources1
Modified residuei70PhosphothreonineCombined sources1
Cross-linki338Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication
Modified residuei584PhosphoserineCombined sources1
Modified residuei603PhosphoserineCombined sources1
Modified residuei606PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

PRIDEiP36035.

PTM databases

iPTMnetiP36035.

Interactioni

Protein-protein interaction databases

BioGridi33948. 27 interactors.
DIPiDIP-8064N.
MINTiMINT-4988115.

Structurei

3D structure databases

ProteinModelPortaliP36035.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000259757.
InParanoidiP36035.
KOiK08178.
OMAiDSMDFFC.
OrthoDBiEOG092C1A59.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR020846. MFS_dom.
IPR005828. MFS_sugar_transport-like.
IPR004742. SA_transporter.
[Graphical view]
PfamiPF00083. Sugar_tr. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.
TIGRFAMsiTIGR00891. 2A0112. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P36035-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSSITDEKI SGEQQQPAGR KLYYNTSTFA EPPLVDGEGN PINYEPEVYN
60 70 80 90 100
PDHEKLYHNP SLPAQSIQDT RDDELLERVY SQDQGVEYEE DEEDKPNLSA
110 120 130 140 150
ASIKSYALTR FTSLLHIHEF SWENVNPIPE LRKMTWQNWN YFFMGYFAWL
160 170 180 190 200
SAAWAFFCVS VSVAPLAELY DRPTKDITWG LGLVLFVRSA GAVIFGLWTD
210 220 230 240 250
KSSRKWPYIT CLFLFVIAQL CTPWCDTYEK FLGVRWITGI AMGGIYGCAS
260 270 280 290 300
ATAIEDAPVK ARSFLSGLFF SAYAMGFIFA IIFYRAFGYF RDDGWKILFW
310 320 330 340 350
FSIFLPILLI FWRLLWPETK YFTKVLKARK LILSDAVKAN GGEPLPKANF
360 370 380 390 400
KQKMVSMKRT VQKYWLLFAY LVVLLVGPNY LTHASQDLLP TMLRAQLGLS
410 420 430 440 450
KDAVTVIVVV TNIGAICGGM IFGQFMEVTG RRLGLLIACT MGGCFTYPAF
460 470 480 490 500
MLRSEKAILG AGFMLYFCVF GVWGILPIHL AELAPADARA LVAGLSYQLG
510 520 530 540 550
NLASAAASTI ETQLADRYPL ERDASGAVIK EDYAKVMAIL TGSVFIFTFA
560 570 580 590 600
CVFVGHEKFH RDLSSPVMKK YINQVEEYEA DGLSISDIVE QKTECASVKM
610
IDSNVSKTYE EHIETV
Length:616
Mass (Da):69,376
Last modified:June 1, 1994 - v1
Checksum:i47926F50842ACD5B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U24155 Genomic DNA. Translation: AAB60291.1.
X75951 Genomic DNA. Translation: CAA53556.1.
Z28217 Genomic DNA. Translation: CAA82062.1.
BK006944 Genomic DNA. Translation: DAA08952.1.
PIRiS38060.
RefSeqiNP_012705.1. NM_001179782.1.

Genome annotation databases

EnsemblFungiiYKL217W; YKL217W; YKL217W.
GeneIDi853663.
KEGGisce:YKL217W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U24155 Genomic DNA. Translation: AAB60291.1.
X75951 Genomic DNA. Translation: CAA53556.1.
Z28217 Genomic DNA. Translation: CAA82062.1.
BK006944 Genomic DNA. Translation: DAA08952.1.
PIRiS38060.
RefSeqiNP_012705.1. NM_001179782.1.

3D structure databases

ProteinModelPortaliP36035.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi33948. 27 interactors.
DIPiDIP-8064N.
MINTiMINT-4988115.

Protein family/group databases

TCDBi2.A.1.12.2. the major facilitator superfamily (mfs).

PTM databases

iPTMnetiP36035.

Proteomic databases

PRIDEiP36035.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYKL217W; YKL217W; YKL217W.
GeneIDi853663.
KEGGisce:YKL217W.

Organism-specific databases

EuPathDBiFungiDB:YKL217W.
SGDiS000001700. JEN1.

Phylogenomic databases

HOGENOMiHOG000259757.
InParanoidiP36035.
KOiK08178.
OMAiDSMDFFC.
OrthoDBiEOG092C1A59.

Enzyme and pathway databases

BioCyciYEAST:G3O-31974-MONOMER.

Miscellaneous databases

PROiP36035.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR020846. MFS_dom.
IPR005828. MFS_sugar_transport-like.
IPR004742. SA_transporter.
[Graphical view]
PfamiPF00083. Sugar_tr. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.
TIGRFAMsiTIGR00891. 2A0112. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiJEN1_YEAST
AccessioniPrimary (citable) accession number: P36035
Secondary accession number(s): D6VWY6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: November 30, 2016
This is version 140 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XI
    Yeast (Saccharomyces cerevisiae) chromosome XI: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.