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P36035

- JEN1_YEAST

UniProt

P36035 - JEN1_YEAST

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Protein

Carboxylic acid transporter protein homolog

Gene

JEN1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Essential to lactate transport.

GO - Molecular functioni

  1. carbohydrate transmembrane transporter activity Source: InterPro
  2. secondary active monocarboxylate transmembrane transporter activity Source: SGD
  3. selenite:proton symporter activity Source: SGD

GO - Biological processi

  1. plasma membrane lactate transport Source: SGD
  2. plasma membrane pyruvate transport Source: SGD
  3. plasma membrane selenite transport Source: SGD
  4. proton transport Source: GOC
Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-31974-MONOMER.

Protein family/group databases

TCDBi2.A.1.12.2. the major facilitator superfamily (mfs).

Names & Taxonomyi

Protein namesi
Recommended name:
Carboxylic acid transporter protein homolog
Gene namesi
Name:JEN1
Ordered Locus Names:YKL217W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome XI

Organism-specific databases

CYGDiYKL217w.
SGDiS000001700. JEN1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini2 – 140139CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei141 – 16121Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini162 – 17615ExtracellularSequence AnalysisAdd
BLAST
Transmembranei177 – 19721Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini198 – 2058CytoplasmicSequence Analysis
Transmembranei206 – 22621Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini227 – 2304ExtracellularSequence Analysis
Transmembranei231 – 25121Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini252 – 26312CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei264 – 28421Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini285 – 29612ExtracellularSequence AnalysisAdd
BLAST
Transmembranei297 – 31721Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini318 – 36346CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei364 – 38421Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini385 – 40218ExtracellularSequence AnalysisAdd
BLAST
Transmembranei403 – 42321Helical; Name=8Sequence AnalysisAdd
BLAST
Topological domaini424 – 4329CytoplasmicSequence Analysis
Transmembranei433 – 45321Helical; Name=9Sequence AnalysisAdd
BLAST
Topological domaini454 – 4574ExtracellularSequence Analysis
Transmembranei458 – 47821Helical; Name=10Sequence AnalysisAdd
BLAST
Topological domaini479 – 48911CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei490 – 51021Helical; Name=11Sequence AnalysisAdd
BLAST
Topological domaini511 – 53525ExtracellularSequence AnalysisAdd
BLAST
Transmembranei536 – 55621Helical; Name=12Sequence AnalysisAdd
BLAST
Topological domaini557 – 61660CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed2 Publications
Chaini2 – 616615Carboxylic acid transporter protein homologPRO_0000050460Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserine2 Publications
Modified residuei4 – 41Phosphoserine1 Publication
Cross-linki9 – 9Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication
Modified residuei11 – 111Phosphoserine1 Publication
Modified residuei61 – 611Phosphoserine1 Publication
Modified residuei66 – 661Phosphoserine1 Publication
Modified residuei70 – 701Phosphothreonine1 Publication
Cross-linki338 – 338Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication
Modified residuei584 – 5841Phosphoserine1 Publication
Modified residuei603 – 6031Phosphoserine1 Publication
Modified residuei606 – 6061Phosphoserine2 Publications

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiP36035.
PeptideAtlasiP36035.

Expressioni

Gene expression databases

GenevestigatoriP36035.

Interactioni

Protein-protein interaction databases

BioGridi33948. 28 interactions.
DIPiDIP-8064N.
MINTiMINT-4988115.
STRINGi4932.YKL217W.

Structurei

3D structure databases

ProteinModelPortaliP36035.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0477.
HOGENOMiHOG000259757.
InParanoidiP36035.
KOiK08178.
OMAiDSMDFFC.
OrthoDBiEOG78H430.

Family and domain databases

InterProiIPR020846. MFS_dom.
IPR016196. MFS_dom_general_subst_transpt.
IPR004742. SA_transporter.
IPR005828. Sub_transporter.
[Graphical view]
PfamiPF00083. Sugar_tr. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.
TIGRFAMsiTIGR00891. 2A0112. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P36035-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSSSITDEKI SGEQQQPAGR KLYYNTSTFA EPPLVDGEGN PINYEPEVYN
60 70 80 90 100
PDHEKLYHNP SLPAQSIQDT RDDELLERVY SQDQGVEYEE DEEDKPNLSA
110 120 130 140 150
ASIKSYALTR FTSLLHIHEF SWENVNPIPE LRKMTWQNWN YFFMGYFAWL
160 170 180 190 200
SAAWAFFCVS VSVAPLAELY DRPTKDITWG LGLVLFVRSA GAVIFGLWTD
210 220 230 240 250
KSSRKWPYIT CLFLFVIAQL CTPWCDTYEK FLGVRWITGI AMGGIYGCAS
260 270 280 290 300
ATAIEDAPVK ARSFLSGLFF SAYAMGFIFA IIFYRAFGYF RDDGWKILFW
310 320 330 340 350
FSIFLPILLI FWRLLWPETK YFTKVLKARK LILSDAVKAN GGEPLPKANF
360 370 380 390 400
KQKMVSMKRT VQKYWLLFAY LVVLLVGPNY LTHASQDLLP TMLRAQLGLS
410 420 430 440 450
KDAVTVIVVV TNIGAICGGM IFGQFMEVTG RRLGLLIACT MGGCFTYPAF
460 470 480 490 500
MLRSEKAILG AGFMLYFCVF GVWGILPIHL AELAPADARA LVAGLSYQLG
510 520 530 540 550
NLASAAASTI ETQLADRYPL ERDASGAVIK EDYAKVMAIL TGSVFIFTFA
560 570 580 590 600
CVFVGHEKFH RDLSSPVMKK YINQVEEYEA DGLSISDIVE QKTECASVKM
610
IDSNVSKTYE EHIETV
Length:616
Mass (Da):69,376
Last modified:June 1, 1994 - v1
Checksum:i47926F50842ACD5B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U24155 Genomic DNA. Translation: AAB60291.1.
X75951 Genomic DNA. Translation: CAA53556.1.
Z28217 Genomic DNA. Translation: CAA82062.1.
BK006944 Genomic DNA. Translation: DAA08952.1.
PIRiS38060.
RefSeqiNP_012705.1. NM_001179782.1.

Genome annotation databases

EnsemblFungiiYKL217W; YKL217W; YKL217W.
GeneIDi853663.
KEGGisce:YKL217W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U24155 Genomic DNA. Translation: AAB60291.1 .
X75951 Genomic DNA. Translation: CAA53556.1 .
Z28217 Genomic DNA. Translation: CAA82062.1 .
BK006944 Genomic DNA. Translation: DAA08952.1 .
PIRi S38060.
RefSeqi NP_012705.1. NM_001179782.1.

3D structure databases

ProteinModelPortali P36035.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 33948. 28 interactions.
DIPi DIP-8064N.
MINTi MINT-4988115.
STRINGi 4932.YKL217W.

Protein family/group databases

TCDBi 2.A.1.12.2. the major facilitator superfamily (mfs).

Proteomic databases

PaxDbi P36035.
PeptideAtlasi P36035.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YKL217W ; YKL217W ; YKL217W .
GeneIDi 853663.
KEGGi sce:YKL217W.

Organism-specific databases

CYGDi YKL217w.
SGDi S000001700. JEN1.

Phylogenomic databases

eggNOGi COG0477.
HOGENOMi HOG000259757.
InParanoidi P36035.
KOi K08178.
OMAi DSMDFFC.
OrthoDBi EOG78H430.

Enzyme and pathway databases

BioCyci YEAST:G3O-31974-MONOMER.

Miscellaneous databases

NextBioi 974593.
PROi P36035.

Gene expression databases

Genevestigatori P36035.

Family and domain databases

InterProi IPR020846. MFS_dom.
IPR016196. MFS_dom_general_subst_transpt.
IPR004742. SA_transporter.
IPR005828. Sub_transporter.
[Graphical view ]
Pfami PF00083. Sugar_tr. 1 hit.
[Graphical view ]
SUPFAMi SSF103473. SSF103473. 1 hit.
TIGRFAMsi TIGR00891. 2A0112. 1 hit.
PROSITEi PS50850. MFS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Davis E.S., Brennan M.B.
    Submitted (APR-1995) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204510 / AB320.
  2. "The complete sequencing of a 24.6 kb segment of yeast chromosome XI identified the known loci URA1, SAC1 and TRP3, and revealed 6 new open reading frames including homologues to the threonine dehydratases, membrane transporters, hydantoinases and the phospholipase A2-activating protein."
    Tzermia M., Horaitis O., Alexandraki D.
    Yeast 10:663-679(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. "Complete DNA sequence of yeast chromosome XI."
    Dujon B., Alexandraki D., Andre B., Ansorge W., Baladron V., Ballesta J.P.G., Banrevi A., Bolle P.-A., Bolotin-Fukuhara M., Bossier P., Bou G., Boyer J., Buitrago M.J., Cheret G., Colleaux L., Daignan-Fornier B., del Rey F., Dion C.
    , Domdey H., Duesterhoeft A., Duesterhus S., Entian K.-D., Erfle H., Esteban P.F., Feldmann H., Fernandes L., Fobo G.M., Fritz C., Fukuhara H., Gabel C., Gaillon L., Garcia-Cantalejo J.M., Garcia-Ramirez J.J., Gent M.E., Ghazvini M., Goffeau A., Gonzalez A., Grothues D., Guerreiro P., Hegemann J.H., Hewitt N., Hilger F., Hollenberg C.P., Horaitis O., Indge K.J., Jacquier A., James C.M., Jauniaux J.-C., Jimenez A., Keuchel H., Kirchrath L., Kleine K., Koetter P., Legrain P., Liebl S., Louis E.J., Maia e Silva A., Marck C., Monnier A.-L., Moestl D., Mueller S., Obermaier B., Oliver S.G., Pallier C., Pascolo S., Pfeiffer F., Philippsen P., Planta R.J., Pohl F.M., Pohl T.M., Poehlmann R., Portetelle D., Purnelle B., Puzos V., Ramezani Rad M., Rasmussen S.W., Remacha M.A., Revuelta J.L., Richard G.-F., Rieger M., Rodrigues-Pousada C., Rose M., Rupp T., Santos M.A., Schwager C., Sensen C., Skala J., Soares H., Sor F., Stegemann J., Tettelin H., Thierry A., Tzermia M., Urrestarazu L.A., van Dyck L., van Vliet-Reedijk J.C., Valens M., Vandenbol M., Vilela C., Vissers S., von Wettstein D., Voss H., Wiemann S., Xu G., Zimmermann J., Haasemann M., Becker I., Mewes H.-W.
    Nature 369:371-378(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  4. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  5. Cited for: UBIQUITINATION [LARGE SCALE ANALYSIS] AT LYS-9 AND LYS-338.
    Strain: SUB592.
  6. "A global topology map of the Saccharomyces cerevisiae membrane proteome."
    Kim H., Melen K., Oesterberg M., von Heijne G.
    Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
    Strain: ATCC 208353 / W303-1A.
  7. "Profiling phosphoproteins of yeast mitochondria reveals a role of phosphorylation in assembly of the ATP synthase."
    Reinders J., Wagner K., Zahedi R.P., Stojanovski D., Eyrich B., van der Laan M., Rehling P., Sickmann A., Pfanner N., Meisinger C.
    Mol. Cell. Proteomics 6:1896-1906(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-4; SER-11; SER-584 AND SER-606, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].
    Strain: ATCC 76625 / YPH499.
  8. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
    Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
    Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-61; SER-66; THR-70; SER-603 AND SER-606, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  9. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiJEN1_YEAST
AccessioniPrimary (citable) accession number: P36035
Secondary accession number(s): D6VWY6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: October 29, 2014
This is version 123 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XI
    Yeast (Saccharomyces cerevisiae) chromosome XI: entries and gene names

External Data

Dasty 3