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P36035

- JEN1_YEAST

UniProt

P36035 - JEN1_YEAST

Protein

Carboxylic acid transporter protein homolog

Gene

JEN1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 122 (01 Oct 2014)
      Sequence version 1 (01 Jun 1994)
      Previous versions | rss
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    Functioni

    Essential to lactate transport.

    GO - Molecular functioni

    1. carbohydrate transmembrane transporter activity Source: InterPro
    2. secondary active monocarboxylate transmembrane transporter activity Source: SGD
    3. selenite:proton symporter activity Source: SGD

    GO - Biological processi

    1. plasma membrane lactate transport Source: SGD
    2. plasma membrane pyruvate transport Source: SGD
    3. plasma membrane selenite transport Source: SGD
    4. proton transport Source: GOC

    Keywords - Biological processi

    Transport

    Enzyme and pathway databases

    BioCyciYEAST:G3O-31974-MONOMER.

    Protein family/group databases

    TCDBi2.A.1.12.2. the major facilitator superfamily (mfs).

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Carboxylic acid transporter protein homolog
    Gene namesi
    Name:JEN1
    Ordered Locus Names:YKL217W
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome XI

    Organism-specific databases

    CYGDiYKL217w.
    SGDiS000001700. JEN1.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: SGD

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed2 Publications
    Chaini2 – 616615Carboxylic acid transporter protein homologPRO_0000050460Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylserine2 Publications
    Modified residuei4 – 41Phosphoserine1 Publication
    Cross-linki9 – 9Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication
    Modified residuei11 – 111Phosphoserine1 Publication
    Modified residuei61 – 611Phosphoserine1 Publication
    Modified residuei66 – 661Phosphoserine1 Publication
    Modified residuei70 – 701Phosphothreonine1 Publication
    Cross-linki338 – 338Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication
    Modified residuei584 – 5841Phosphoserine1 Publication
    Modified residuei603 – 6031Phosphoserine1 Publication
    Modified residuei606 – 6061Phosphoserine2 Publications

    Keywords - PTMi

    Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

    Proteomic databases

    PaxDbiP36035.
    PeptideAtlasiP36035.

    Expressioni

    Gene expression databases

    GenevestigatoriP36035.

    Interactioni

    Protein-protein interaction databases

    BioGridi33948. 28 interactions.
    DIPiDIP-8064N.
    MINTiMINT-4988115.
    STRINGi4932.YKL217W.

    Structurei

    3D structure databases

    ProteinModelPortaliP36035.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini2 – 140139CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini162 – 17615ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini198 – 2058CytoplasmicSequence Analysis
    Topological domaini227 – 2304ExtracellularSequence Analysis
    Topological domaini252 – 26312CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini285 – 29612ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini318 – 36346CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini385 – 40218ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini424 – 4329CytoplasmicSequence Analysis
    Topological domaini454 – 4574ExtracellularSequence Analysis
    Topological domaini479 – 48911CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini511 – 53525ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini557 – 61660CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei141 – 16121Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei177 – 19721Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei206 – 22621Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei231 – 25121Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei264 – 28421Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei297 – 31721Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei364 – 38421Helical; Name=7Sequence AnalysisAdd
    BLAST
    Transmembranei403 – 42321Helical; Name=8Sequence AnalysisAdd
    BLAST
    Transmembranei433 – 45321Helical; Name=9Sequence AnalysisAdd
    BLAST
    Transmembranei458 – 47821Helical; Name=10Sequence AnalysisAdd
    BLAST
    Transmembranei490 – 51021Helical; Name=11Sequence AnalysisAdd
    BLAST
    Transmembranei536 – 55621Helical; Name=12Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Repeat, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0477.
    HOGENOMiHOG000259757.
    KOiK08178.
    OMAiDSMDFFC.
    OrthoDBiEOG78H430.

    Family and domain databases

    InterProiIPR020846. MFS_dom.
    IPR016196. MFS_dom_general_subst_transpt.
    IPR004742. SA_transporter.
    IPR005828. Sub_transporter.
    [Graphical view]
    PfamiPF00083. Sugar_tr. 1 hit.
    [Graphical view]
    SUPFAMiSSF103473. SSF103473. 1 hit.
    TIGRFAMsiTIGR00891. 2A0112. 1 hit.
    PROSITEiPS50850. MFS. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P36035-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSSSITDEKI SGEQQQPAGR KLYYNTSTFA EPPLVDGEGN PINYEPEVYN    50
    PDHEKLYHNP SLPAQSIQDT RDDELLERVY SQDQGVEYEE DEEDKPNLSA 100
    ASIKSYALTR FTSLLHIHEF SWENVNPIPE LRKMTWQNWN YFFMGYFAWL 150
    SAAWAFFCVS VSVAPLAELY DRPTKDITWG LGLVLFVRSA GAVIFGLWTD 200
    KSSRKWPYIT CLFLFVIAQL CTPWCDTYEK FLGVRWITGI AMGGIYGCAS 250
    ATAIEDAPVK ARSFLSGLFF SAYAMGFIFA IIFYRAFGYF RDDGWKILFW 300
    FSIFLPILLI FWRLLWPETK YFTKVLKARK LILSDAVKAN GGEPLPKANF 350
    KQKMVSMKRT VQKYWLLFAY LVVLLVGPNY LTHASQDLLP TMLRAQLGLS 400
    KDAVTVIVVV TNIGAICGGM IFGQFMEVTG RRLGLLIACT MGGCFTYPAF 450
    MLRSEKAILG AGFMLYFCVF GVWGILPIHL AELAPADARA LVAGLSYQLG 500
    NLASAAASTI ETQLADRYPL ERDASGAVIK EDYAKVMAIL TGSVFIFTFA 550
    CVFVGHEKFH RDLSSPVMKK YINQVEEYEA DGLSISDIVE QKTECASVKM 600
    IDSNVSKTYE EHIETV 616
    Length:616
    Mass (Da):69,376
    Last modified:June 1, 1994 - v1
    Checksum:i47926F50842ACD5B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U24155 Genomic DNA. Translation: AAB60291.1.
    X75951 Genomic DNA. Translation: CAA53556.1.
    Z28217 Genomic DNA. Translation: CAA82062.1.
    BK006944 Genomic DNA. Translation: DAA08952.1.
    PIRiS38060.
    RefSeqiNP_012705.1. NM_001179782.1.

    Genome annotation databases

    EnsemblFungiiYKL217W; YKL217W; YKL217W.
    GeneIDi853663.
    KEGGisce:YKL217W.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U24155 Genomic DNA. Translation: AAB60291.1 .
    X75951 Genomic DNA. Translation: CAA53556.1 .
    Z28217 Genomic DNA. Translation: CAA82062.1 .
    BK006944 Genomic DNA. Translation: DAA08952.1 .
    PIRi S38060.
    RefSeqi NP_012705.1. NM_001179782.1.

    3D structure databases

    ProteinModelPortali P36035.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 33948. 28 interactions.
    DIPi DIP-8064N.
    MINTi MINT-4988115.
    STRINGi 4932.YKL217W.

    Protein family/group databases

    TCDBi 2.A.1.12.2. the major facilitator superfamily (mfs).

    Proteomic databases

    PaxDbi P36035.
    PeptideAtlasi P36035.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YKL217W ; YKL217W ; YKL217W .
    GeneIDi 853663.
    KEGGi sce:YKL217W.

    Organism-specific databases

    CYGDi YKL217w.
    SGDi S000001700. JEN1.

    Phylogenomic databases

    eggNOGi COG0477.
    HOGENOMi HOG000259757.
    KOi K08178.
    OMAi DSMDFFC.
    OrthoDBi EOG78H430.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-31974-MONOMER.

    Miscellaneous databases

    NextBioi 974593.
    PROi P36035.

    Gene expression databases

    Genevestigatori P36035.

    Family and domain databases

    InterProi IPR020846. MFS_dom.
    IPR016196. MFS_dom_general_subst_transpt.
    IPR004742. SA_transporter.
    IPR005828. Sub_transporter.
    [Graphical view ]
    Pfami PF00083. Sugar_tr. 1 hit.
    [Graphical view ]
    SUPFAMi SSF103473. SSF103473. 1 hit.
    TIGRFAMsi TIGR00891. 2A0112. 1 hit.
    PROSITEi PS50850. MFS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Davis E.S., Brennan M.B.
      Submitted (APR-1995) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 204510 / AB320.
    2. "The complete sequencing of a 24.6 kb segment of yeast chromosome XI identified the known loci URA1, SAC1 and TRP3, and revealed 6 new open reading frames including homologues to the threonine dehydratases, membrane transporters, hydantoinases and the phospholipase A2-activating protein."
      Tzermia M., Horaitis O., Alexandraki D.
      Yeast 10:663-679(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    3. "Complete DNA sequence of yeast chromosome XI."
      Dujon B., Alexandraki D., Andre B., Ansorge W., Baladron V., Ballesta J.P.G., Banrevi A., Bolle P.-A., Bolotin-Fukuhara M., Bossier P., Bou G., Boyer J., Buitrago M.J., Cheret G., Colleaux L., Daignan-Fornier B., del Rey F., Dion C.
      , Domdey H., Duesterhoeft A., Duesterhus S., Entian K.-D., Erfle H., Esteban P.F., Feldmann H., Fernandes L., Fobo G.M., Fritz C., Fukuhara H., Gabel C., Gaillon L., Garcia-Cantalejo J.M., Garcia-Ramirez J.J., Gent M.E., Ghazvini M., Goffeau A., Gonzalez A., Grothues D., Guerreiro P., Hegemann J.H., Hewitt N., Hilger F., Hollenberg C.P., Horaitis O., Indge K.J., Jacquier A., James C.M., Jauniaux J.-C., Jimenez A., Keuchel H., Kirchrath L., Kleine K., Koetter P., Legrain P., Liebl S., Louis E.J., Maia e Silva A., Marck C., Monnier A.-L., Moestl D., Mueller S., Obermaier B., Oliver S.G., Pallier C., Pascolo S., Pfeiffer F., Philippsen P., Planta R.J., Pohl F.M., Pohl T.M., Poehlmann R., Portetelle D., Purnelle B., Puzos V., Ramezani Rad M., Rasmussen S.W., Remacha M.A., Revuelta J.L., Richard G.-F., Rieger M., Rodrigues-Pousada C., Rose M., Rupp T., Santos M.A., Schwager C., Sensen C., Skala J., Soares H., Sor F., Stegemann J., Tettelin H., Thierry A., Tzermia M., Urrestarazu L.A., van Dyck L., van Vliet-Reedijk J.C., Valens M., Vandenbol M., Vilela C., Vissers S., von Wettstein D., Voss H., Wiemann S., Xu G., Zimmermann J., Haasemann M., Becker I., Mewes H.-W.
      Nature 369:371-378(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    4. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    5. Cited for: UBIQUITINATION [LARGE SCALE ANALYSIS] AT LYS-9 AND LYS-338.
      Strain: SUB592.
    6. "A global topology map of the Saccharomyces cerevisiae membrane proteome."
      Kim H., Melen K., Oesterberg M., von Heijne G.
      Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
      Strain: ATCC 208353 / W303-1A.
    7. "Profiling phosphoproteins of yeast mitochondria reveals a role of phosphorylation in assembly of the ATP synthase."
      Reinders J., Wagner K., Zahedi R.P., Stojanovski D., Eyrich B., van der Laan M., Rehling P., Sickmann A., Pfanner N., Meisinger C.
      Mol. Cell. Proteomics 6:1896-1906(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-4; SER-11; SER-584 AND SER-606, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].
      Strain: ATCC 76625 / YPH499.
    8. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
      Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
      Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-61; SER-66; THR-70; SER-603 AND SER-606, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    9. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiJEN1_YEAST
    AccessioniPrimary (citable) accession number: P36035
    Secondary accession number(s): D6VWY6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 1, 1994
    Last sequence update: June 1, 1994
    Last modified: October 1, 2014
    This is version 122 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    3. Yeast chromosome XI
      Yeast (Saccharomyces cerevisiae) chromosome XI: entries and gene names

    External Data

    Dasty 3