P36034 (COS9_YEAST) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protein COS9

Gene names

Name:	COS9
Ordered Locus Names:	YKL219W

Organism

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)

Taxonomic identifier

559292 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces

Protein attributes

Sequence length	407 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Subcellular location	Membrane; Multi-pass membrane protein Potential.
Sequence similarities	Belongs to the DUP/COS family.

Ontologies

Keywords
Cellular component	Membrane
Domain	Transmembrane Transmembrane helix
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 407	407	Protein COS9		PRO_0000207520
Regions
	Transmembrane	75 – 95	21	Helical; Potential
	Transmembrane	98 – 118	21	Helical; Potential
	Transmembrane	261 – 281	21	Helical; Potential

Sequences

	Sequence		Length	Mass (Da)
	P36034 [UniParc]. Last modified June 1, 1994. Version 1. Checksum: 01142E58AAE0E758	FASTA	407	48,545
	10 20 30 40 50 60 MQIVRSCNSN NKPLIPSSNW HIAIRMRGDG VKDRSIDVLS LKHFESQKVV LPQDLFMDNF 70 80 90 100 110 120 TWMFYEFFKC FTFRTWLLLL LLMWLPGFLS QIKSINRIFP FKLCILVSCL VGIFLPNIYS 130 140 150 160 170 180 FSHKSVLTNQ LTQFSKEIVE HAPGTDTHDW ETVAANLNSY FYENKAWNTE YFFFNAAECQ 190 200 210 220 230 240 KAFRKVLLEP FSVKKDESSK IKSFGDSVPY IEEALQVYST EFDKKWKLFN TEKVWSPDNL 250 260 270 280 290 300 EHVQLPKKTY RYKFTWVLKR IFNLWLFPAF ILFLACIYVS WDKGHLFRIL CCGGGFLLMV 310 320 330 340 350 360 RVFQNMRPFS MHMEDKMQFL STIINEQESG ANGWDEIAKK MNRYLFEKKV WTSEEFFFDG 370 380 390 400 IDCEWFFNHF FYRLLSTKKP MFDRPLNVEL WPYIKEAQLT RKQAPPV

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The complete sequencing of a 24.6 kb segment of yeast chromosome XI identified the known loci URA1, SAC1 and TRP3, and revealed 6 new open reading frames including homologues to the threonine dehydratases, membrane transporters, hydantoinases and the phospholipase A2-activating protein." Tzermia M., Horaitis O., Alexandraki D. Yeast 10:663-679(1994) [PubMed: 7941750] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 204508 / S288c.
[2]	"Complete DNA sequence of yeast chromosome XI." Dujon B., Alexandraki D., Andre B., Ansorge W., Baladron V., Ballesta J.P.G., Banrevi A., Bolle P.-A., Bolotin-Fukuhara M., Bossier P., Bou G., Boyer J., Buitrago M.J., Cheret G., Colleaux L., Daignan-Fornier B., del Rey F., Dion C. , Domdey H., Duesterhoeft A., Duesterhus S., Entian K.-D., Erfle H., Esteban P.F., Feldmann H., Fernandes L., Fobo G.M., Fritz C., Fukuhara H., Gabel C., Gaillon L., Garcia-Cantalejo J.M., Garcia-Ramirez J.J., Gent M.E., Ghazvini M., Goffeau A., Gonzalez A., Grothues D., Guerreiro P., Hegemann J.H., Hewitt N., Hilger F., Hollenberg C.P., Horaitis O., Indge K.J., Jacquier A., James C.M., Jauniaux J.-C., Jimenez A., Keuchel H., Kirchrath L., Kleine K., Koetter P., Legrain P., Liebl S., Louis E.J., Maia e Silva A., Marck C., Monnier A.-L., Moestl D., Mueller S., Obermaier B., Oliver S.G., Pallier C., Pascolo S., Pfeiffer F., Philippsen P., Planta R.J., Pohl F.M., Pohl T.M., Poehlmann R., Portetelle D., Purnelle B., Puzos V., Ramezani Rad M., Rasmussen S.W., Remacha M.A., Revuelta J.L., Richard G.-F., Rieger M., Rodrigues-Pousada C., Rose M., Rupp T., Santos M.A., Schwager C., Sensen C., Skala J., Soares H., Sor F., Stegemann J., Tettelin H., Thierry A., Tzermia M., Urrestarazu L.A., van Dyck L., van Vliet-Reedijk J.C., Valens M., Vandenbol M., Vilela C., Vissers S., von Wettstein D., Voss H., Wiemann S., Xu G., Zimmermann J., Haasemann M., Becker I., Mewes H.-W. Nature 369:371-378(1994) [PubMed: 8196765] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 96604 / S288c / FY1679.
[3]	Saccharomyces Genome Database Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: ATCC 204508 / S288c.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X75951 Genomic DNA. Translation: CAA53554.1. Z28219 Genomic DNA. Translation: CAA82064.1. BK006944 Genomic DNA. Translation: DAA08950.1.
PIR	S38062.
RefSeq	NP_012703.1. NM_001179784.1.
3D structure databases
ProteinModelPortal	P36034.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-7808N.
IntAct	P36034. 1 interaction.
STRING	P36034.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	YKL219W; YKL219W; YKL219W.
GeneID	853661.
KEGG	sce:YKL219W.
NMPDR	fig|4932.3.peg.3681.
Organism-specific databases
CYGD	YKL219w.
SGD	S000001702. COS9.
Phylogenomic databases
GeneTree	EFGT00050000008557.
HOGENOM	HBG204451.
OrthoDB	EOG4578J4.
Gene expression databases
ArrayExpress	P36034.
Genevestigator	P36034.
GermOnline	YKL219W. Saccharomyces cerevisiae.
Family and domain databases
InterPro	IPR001142. DUP. [Graphical view]
Pfam	PF00674. DUP. 2 hits. [Graphical view]
ProtoNet	Search...
Other
NextBio	974587.

Entry information

Entry name

COS9_YEAST

Accession

Primary (citable) accession number: P36034
Secondary accession number(s): D6VWY4

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 1, 1994
Last sequence update:	June 1, 1994
Last modified:	December 14, 2011
This is version 68 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program