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Protein

Probable transporter MCH2

Gene

MCH2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Probable transporter. Does not act in the transport of monocarboxylic acids across the plasma membrane.

GO - Molecular functioni

  • symporter activity Source: UniProtKB-KW
  • transporter activity Source: SGD

GO - Biological processi

  • ion transmembrane transport Source: GO_Central
  • transport Source: SGD
Complete GO annotation...

Keywords - Biological processi

Symport, Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-31976-MONOMER.

Protein family/group databases

TCDBi2.A.1.13.18. the major facilitator superfamily (mfs).

Names & Taxonomyi

Protein namesi
Recommended name:
Probable transporter MCH2
Gene namesi
Name:MCH2
Ordered Locus Names:YKL221W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XI

Organism-specific databases

EuPathDBiFungiDB:YKL221W.
SGDiS000001704. MCH2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 37CytoplasmicSequence analysisAdd BLAST37
Transmembranei38 – 58HelicalSequence analysisAdd BLAST21
Topological domaini59 – 83ExtracellularSequence analysisAdd BLAST25
Transmembranei84 – 105HelicalSequence analysisAdd BLAST22
Topological domaini106 – 111CytoplasmicSequence analysis6
Transmembranei112 – 135HelicalSequence analysisAdd BLAST24
Topological domaini136 – 141ExtracellularSequence analysis6
Transmembranei142 – 163HelicalSequence analysisAdd BLAST22
Topological domaini164 – 169CytoplasmicSequence analysis6
Transmembranei170 – 186HelicalSequence analysisAdd BLAST17
Topological domaini187 – 200ExtracellularSequence analysisAdd BLAST14
Transmembranei201 – 220HelicalSequence analysisAdd BLAST20
Topological domaini221 – 243CytoplasmicSequence analysisAdd BLAST23
Transmembranei244 – 268HelicalSequence analysisAdd BLAST25
Topological domaini269 – 286ExtracellularSequence analysisAdd BLAST18
Transmembranei287 – 304HelicalSequence analysisAdd BLAST18
Topological domaini305 – 312CytoplasmicSequence analysis8
Transmembranei313 – 332HelicalSequence analysisAdd BLAST20
Topological domaini333 – 342ExtracellularSequence analysis10
Transmembranei343 – 362HelicalSequence analysisAdd BLAST20
Topological domaini363 – 370CytoplasmicSequence analysis8
Transmembranei371 – 394HelicalSequence analysisAdd BLAST24
Topological domaini395 – 408ExtracellularSequence analysisAdd BLAST14
Transmembranei409 – 433HelicalSequence analysisAdd BLAST25
Topological domaini434 – 473CytoplasmicSequence analysisAdd BLAST40

GO - Cellular componenti

  • integral component of fungal-type vacuolar membrane Source: GO_Central
  • membrane Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002114031 – 473Probable transporter MCH2Add BLAST473

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi72N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Interactioni

Protein-protein interaction databases

BioGridi33944. 8 interactors.
DIPiDIP-4126N.
IntActiP36032. 1 interactor.
MINTiMINT-564557.

Structurei

3D structure databases

ProteinModelPortaliP36032.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00730000112463.
HOGENOMiHOG000248493.
InParanoidiP36032.
OrthoDBiEOG092C11AV.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR011701. MFS.
IPR020846. MFS_dom.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.

Sequencei

Sequence statusi: Complete.

P36032-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSEERHEDHH RDVENKLNLN GKDDINGNTS ISIEVPDGGY GWFILLAFIL
60 70 80 90 100
YNFSTWGANS GYAIYLAHYL ENNTFAGGSK LDYASIGGLA FSCGLFFAPV
110 120 130 140 150
ITWLYHIFSI QFIIGLGILF QGAALLLAAF SVTLWEIYLT QGVLIGFGLA
160 170 180 190 200
FIFIPSVTLI PLWFRNKRSL ASGIGTAGSG LGGIVFNLGM QSILQKRGVK
210 220 230 240 250
WALIAQCIIC TSLSTIALML TRTTHQGLRQ HKRSYKFELL DYDVLSNFAV
260 270 280 290 300
WLLFGFVSFA MLGYVVLLYS LSDFTVSLGY TSKQGSYVSC MVSVGSLLGR
310 320 330 340 350
PIVGHIADKY GSLTVGMILH LVMAILCWAM WIPCKNLATA IAFGLLVGSI
360 370 380 390 400
MGTIWPTIAS IVTRIVGLQK LPGTFGSTWI FMAAFALVAP IIGLELRSTD
410 420 430 440 450
TNGNDYYRTA IFVGFAYFGV SLCQWLLRGF IIARDEIAVR EAYSADQNEL
460 470
HLNVKLSHMS KCLFRYKQLP RRV
Length:473
Mass (Da):52,257
Last modified:September 21, 2011 - v2
Checksum:i6C58D5DB3BAB5510
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti342A → R in CAA53552 (PubMed:8091865).Curated1
Sequence conflicti342A → R in CAA82066 (PubMed:8196765).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X75950 Genomic DNA. Translation: CAA53552.1.
Z28221 Genomic DNA. Translation: CAA82066.1.
BK006944 Genomic DNA. Translation: DAA08948.2.
PIRiS38065.
RefSeqiNP_012701.2. NM_001179786.2.

Genome annotation databases

EnsemblFungiiYKL221W; YKL221W; YKL221W.
GeneIDi853659.
KEGGisce:YKL221W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X75950 Genomic DNA. Translation: CAA53552.1.
Z28221 Genomic DNA. Translation: CAA82066.1.
BK006944 Genomic DNA. Translation: DAA08948.2.
PIRiS38065.
RefSeqiNP_012701.2. NM_001179786.2.

3D structure databases

ProteinModelPortaliP36032.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi33944. 8 interactors.
DIPiDIP-4126N.
IntActiP36032. 1 interactor.
MINTiMINT-564557.

Protein family/group databases

TCDBi2.A.1.13.18. the major facilitator superfamily (mfs).

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYKL221W; YKL221W; YKL221W.
GeneIDi853659.
KEGGisce:YKL221W.

Organism-specific databases

EuPathDBiFungiDB:YKL221W.
SGDiS000001704. MCH2.

Phylogenomic databases

GeneTreeiENSGT00730000112463.
HOGENOMiHOG000248493.
InParanoidiP36032.
OrthoDBiEOG092C11AV.

Enzyme and pathway databases

BioCyciYEAST:G3O-31976-MONOMER.

Miscellaneous databases

PROiP36032.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR011701. MFS.
IPR020846. MFS_dom.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiMCH2_YEAST
AccessioniPrimary (citable) accession number: P36032
Secondary accession number(s): D6VWY2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: September 21, 2011
Last modified: November 2, 2016
This is version 121 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XI
    Yeast (Saccharomyces cerevisiae) chromosome XI: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.