Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Polyamine transporter TPO5

Gene

TPO5

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Required for polyamine transport. Transports putrescine effectively and spermidine less effectively.1 Publication

GO - Molecular functioni

  • antiporter activity Source: GO_Central
  • L-amino acid transmembrane transporter activity Source: GO_Central
  • polyamine transmembrane transporter activity Source: SGD

GO - Biological processi

  • polyamine transport Source: SGD
Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-31941-MONOMER.

Protein family/group databases

TCDBi2.A.3.4.5. the amino acid-polyamine-organocation (apc) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Polyamine transporter TPO5
Gene namesi
Name:TPO5
Ordered Locus Names:YKL174C
ORF Names:YKL639
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XI

Organism-specific databases

EuPathDBiFungiDB:YKL174C.
SGDiS000001657. TPO5.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 60CytoplasmicSequence analysisAdd BLAST60
Transmembranei61 – 84HelicalSequence analysisAdd BLAST24
Topological domaini85 – 90ExtracellularSequence analysis6
Transmembranei91 – 110HelicalSequence analysisAdd BLAST20
Topological domaini111 – 131CytoplasmicSequence analysisAdd BLAST21
Transmembranei132 – 148HelicalSequence analysisAdd BLAST17
Topological domaini149 – 154ExtracellularSequence analysis6
Transmembranei155 – 171HelicalSequence analysisAdd BLAST17
Topological domaini172 – 179CytoplasmicSequence analysis8
Transmembranei180 – 200HelicalSequence analysisAdd BLAST21
Topological domaini201 – 211ExtracellularSequence analysisAdd BLAST11
Transmembranei212 – 231HelicalSequence analysisAdd BLAST20
Topological domaini232 – 297CytoplasmicSequence analysisAdd BLAST66
Transmembranei298 – 317HelicalSequence analysisAdd BLAST20
Topological domaini318 – 342ExtracellularSequence analysisAdd BLAST25
Transmembranei343 – 367HelicalSequence analysisAdd BLAST25
Topological domaini368 – 402CytoplasmicSequence analysisAdd BLAST35
Transmembranei403 – 419HelicalSequence analysisAdd BLAST17
Topological domaini420 – 425ExtracellularSequence analysis6
Transmembranei426 – 449HelicalSequence analysisAdd BLAST24
Topological domaini450 – 464CytoplasmicSequence analysisAdd BLAST15
Transmembranei465 – 486HelicalSequence analysisAdd BLAST22
Topological domaini487 – 498ExtracellularSequence analysisAdd BLAST12
Transmembranei499 – 516HelicalSequence analysisAdd BLAST18
Topological domaini517 – 618CytoplasmicSequence analysisAdd BLAST102

GO - Cellular componenti

  • Golgi apparatus Source: SGD
  • Golgi membrane Source: UniProtKB-SubCell
  • integral component of plasma membrane Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000541651 – 618Polyamine transporter TPO5Add BLAST618

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei569PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP36029.
PRIDEiP36029.
TopDownProteomicsiP36029.

PTM databases

iPTMnetiP36029.

Interactioni

Protein-protein interaction databases

BioGridi33964. 24 interactors.
DIPiDIP-4038N.
IntActiP36029. 3 interactors.
MINTiMINT-485381.

Structurei

3D structure databases

ProteinModelPortaliP36029.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00530000067168.
HOGENOMiHOG000162166.
InParanoidiP36029.
OMAiCAISISC.
OrthoDBiEOG092C27GF.

Family and domain databases

InterProiIPR004841. AA-permease/SLC12A_dom.
IPR002293. AA/rel_permease1.
IPR004840. Amoino_acid_permease_CS.
[Graphical view]
PANTHERiPTHR11785. PTHR11785. 1 hit.
PfamiPF00324. AA_permease. 1 hit.
[Graphical view]
PROSITEiPS00218. AMINO_ACID_PERMEASE_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P36029-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPEYTLLADN IRENIVHFDP NGLFDNLHTI VHEDDSQENE EAEHFNYDQV
60 70 80 90 100
LDKSLLSRGS IVGLGLGLMS PVLGMCTSMA IGLINGGPLT IMLGFLISGV
110 120 130 140 150
CIWFSSLSLG EIVSKFPMEL HVGSAMLAPE KLKLVCSWYT GWLMLIGNWT
160 170 180 190 200
MSTSITFAGA QLTISLILMT NSNLISEAHL IFYTVIVFYL VVTVVGLVNL
210 220 230 240 250
KFARFIETIN KVCVYWIIYA IIFIDILLLV FHKGKFRSLK YALFHFDNNL
260 270 280 290 300
SGYKSAFLSF IIGFQQSNFT LQGFSMLPAL ADEVKVPEKD IPRGMSNAVL
310 320 330 340 350
LSAFSGVIFL IPIMLILPDN DLLFTNHKVL PIVNIFTKST DSVVLSFFLV
360 370 380 390 400
LLILGNLLFS GIGSITTSSR AVYSFSRDQA IPYYDKWTYV EPDSQSKVPK
410 420 430 440 450
NSVVLSMIIS YFLGLLALIS TAAFNAFIGA AVLCLCSATF IPLVLVLFTR
460 470 480 490 500
RRAIRSAPVK IRYKFGWFIN IVSIVWLLLS MVSVCLPTQV PVTFKTMNYA
510 520 530 540 550
LMVYVFCILV ITGLYFKWGK YNFRLPLADD IKAPIPSDAE ETVFELEDSN
560 570 580 590 600
VEHTLNSGTT VKESVENNSE EGFIKVHPKS STENPFEENE ENVITDYGDE
610
HHTAEQEFDL ADDRRYDI
Length:618
Mass (Da):69,243
Last modified:June 1, 1994 - v1
Checksum:i035CB927C624CE74
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z26878 Genomic DNA. Translation: CAA81512.1.
Z28174 Genomic DNA. Translation: CAA82016.1.
BK006944 Genomic DNA. Translation: DAA08992.1.
PIRiS38004.
RefSeqiNP_012747.1. NM_001179740.1.

Genome annotation databases

EnsemblFungiiYKL174C; YKL174C; YKL174C.
GeneIDi853680.
KEGGisce:YKL174C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z26878 Genomic DNA. Translation: CAA81512.1.
Z28174 Genomic DNA. Translation: CAA82016.1.
BK006944 Genomic DNA. Translation: DAA08992.1.
PIRiS38004.
RefSeqiNP_012747.1. NM_001179740.1.

3D structure databases

ProteinModelPortaliP36029.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi33964. 24 interactors.
DIPiDIP-4038N.
IntActiP36029. 3 interactors.
MINTiMINT-485381.

Protein family/group databases

TCDBi2.A.3.4.5. the amino acid-polyamine-organocation (apc) family.

PTM databases

iPTMnetiP36029.

Proteomic databases

MaxQBiP36029.
PRIDEiP36029.
TopDownProteomicsiP36029.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYKL174C; YKL174C; YKL174C.
GeneIDi853680.
KEGGisce:YKL174C.

Organism-specific databases

EuPathDBiFungiDB:YKL174C.
SGDiS000001657. TPO5.

Phylogenomic databases

GeneTreeiENSGT00530000067168.
HOGENOMiHOG000162166.
InParanoidiP36029.
OMAiCAISISC.
OrthoDBiEOG092C27GF.

Enzyme and pathway databases

BioCyciYEAST:G3O-31941-MONOMER.

Miscellaneous databases

PROiP36029.

Family and domain databases

InterProiIPR004841. AA-permease/SLC12A_dom.
IPR002293. AA/rel_permease1.
IPR004840. Amoino_acid_permease_CS.
[Graphical view]
PANTHERiPTHR11785. PTHR11785. 1 hit.
PfamiPF00324. AA_permease. 1 hit.
[Graphical view]
PROSITEiPS00218. AMINO_ACID_PERMEASE_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTPO5_YEAST
AccessioniPrimary (citable) accession number: P36029
Secondary accession number(s): D6VX26
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: November 2, 2016
This is version 139 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XI
    Yeast (Saccharomyces cerevisiae) chromosome XI: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.