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Protein

Ubiquitin carboxyl-terminal hydrolase 11

Gene

UBP11

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei307NucleophilePROSITE-ProRule annotation1
Active sitei649Proton acceptorPROSITE-ProRule annotation1

GO - Molecular functioni

  • thiol-dependent ubiquitin-specific protease activity Source: SGD

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protease, Thiol protease
Biological processUbl conjugation pathway

Enzyme and pathway databases

BioCyciYEAST:G3O-32060-MONOMER

Protein family/group databases

MEROPSiC19.102

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin carboxyl-terminal hydrolase 11 (EC:3.4.19.12)
Alternative name(s):
Deubiquitinating enzyme 11
Ubiquitin thioesterase 11
Ubiquitin-specific-processing protease 11
Gene namesi
Name:UBP11
Ordered Locus Names:YKR098C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XI

Organism-specific databases

EuPathDBiFungiDB:YKR098C
SGDiS000001806 UBP11

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000805961 – 717Ubiquitin carboxyl-terminal hydrolase 11Add BLAST717

Proteomic databases

MaxQBiP36026
PaxDbiP36026
PRIDEiP36026

Interactioni

Protein-protein interaction databases

BioGridi34229, 74 interactors
IntActiP36026, 1 interactor
MINTiP36026
STRINGi4932.YKR098C

Structurei

3D structure databases

ProteinModelPortaliP36026
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini298 – 707USPAdd BLAST410

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi557 – 564Poly-His8

Sequence similaritiesi

Belongs to the peptidase C19 family.Curated

Phylogenomic databases

GeneTreeiENSGT00670000099202
HOGENOMiHOG000142359
InParanoidiP36026
KOiK11871
OrthoDBiEOG092C5R71

Family and domain databases

InterProiView protein in InterPro
IPR001394 Peptidase_C19_UCH
IPR018200 USP_CS
IPR028889 USP_dom
PfamiView protein in Pfam
PF00443 UCH, 1 hit
PROSITEiView protein in PROSITE
PS00972 USP_1, 1 hit
PS00973 USP_2, 1 hit
PS50235 USP_3, 1 hit

Sequencei

Sequence statusi: Complete.

P36026-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLLNPDQILN LVRKVYEVDI KQFYSQLRLK NLRGLLDHAA HLFNVYLRDL
60 70 80 90 100
EINQEMEALT AFIIGCYYLY LIIPQSLQFQ TRNNLYSSYA KLKNDYQDEH
110 120 130 140 150
VMGYVLKVVR DESTVIVDRY LAESNGICRT IKRKRAYSLP LRPLPVHMAS
160 170 180 190 200
LSIHNKFDGS LHEIPNELTK PTNDNSKEDI VRESNQIASS NKLEAGSEVA
210 220 230 240 250
YYTSKEALSK PSYLKLSTGK DALFKTLSSP ATAPPVHSLE VSSQIRDSSQ
260 270 280 290 300
DSSSSLSKVE KPKEEEGKIE AIESSAPKAY NLPVIEDSND LLSELSITGL
310 320 330 340 350
QNPCNTCYIN SIIQCLFGTT LFRDLFLTKK YRLFLNTNKY PKEVQLSRSI
360 370 380 390 400
YVLFKKMYLN GGRAIIPNRF LKMCKKLRPD LNIPDDQQDT QEFLLIVLAR
410 420 430 440 450
IHEELSNENV VKYYPDLVSY DANALQVNPS KYEKWYERNV ITDGLSPIDH
460 470 480 490 500
IYRGQLENIL KCQRCGNSSY SYSTFYVLSL AIPKLSLYSF TSKSRKIKLE
510 520 530 540 550
DCINLFTGDE ELSGDNAWDC PNCRITDSKS KKEEITSQKK KSTIFGFHSR
560 570 580 590 600
SRSKSPHHHH HHHHSSDDST KNAKKRNSKK LTTIKSLDFI VLPPILVIHL
610 620 630 640 650
SRFYYDLTKK NSTVITYPLI LNIILKNGKV IRYKLYGTVN HSGNLINGHY
660 670 680 690 700
TSVVNKEKSH EIGLNRQVWV TFDDDYIQQH RKDRNNFEAG KTEMSSDEVY
710
VLFYERMDEE NYEEEFC
Length:717
Mass (Da):82,703
Last modified:June 1, 1994 - v1
Checksum:i9BAA1EEEB5DD9A65
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z28323 Genomic DNA Translation: CAA82178.1
BK006944 Genomic DNA Translation: DAA09249.1
PIRiS38177
RefSeqiNP_013024.1, NM_001179888.1

Genome annotation databases

EnsemblFungiiYKR098C; YKR098C; YKR098C
GeneIDi853973
KEGGisce:YKR098C

Similar proteinsi

Entry informationi

Entry nameiUBP11_YEAST
AccessioniPrimary (citable) accession number: P36026
Secondary accession number(s): D6VXF9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: May 23, 2018
This is version 125 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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