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Protein

Ubiquitin carboxyl-terminal hydrolase 11

Gene

UBP11

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei307NucleophilePROSITE-ProRule annotation1
Active sitei649Proton acceptorPROSITE-ProRule annotation1

GO - Molecular functioni

  • thiol-dependent ubiquitin-specific protease activity Source: SGD

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Keywords - Biological processi

Ubl conjugation pathway

Enzyme and pathway databases

BioCyciYEAST:G3O-32060-MONOMER.

Protein family/group databases

MEROPSiC19.102.

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin carboxyl-terminal hydrolase 11 (EC:3.4.19.12)
Alternative name(s):
Deubiquitinating enzyme 11
Ubiquitin thioesterase 11
Ubiquitin-specific-processing protease 11
Gene namesi
Name:UBP11
Ordered Locus Names:YKR098C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XI

Organism-specific databases

EuPathDBiFungiDB:YKR098C.
SGDiS000001806. UBP11.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000805961 – 717Ubiquitin carboxyl-terminal hydrolase 11Add BLAST717

Proteomic databases

MaxQBiP36026.
PRIDEiP36026.

Interactioni

Protein-protein interaction databases

BioGridi34229. 24 interactors.
IntActiP36026. 1 interactor.
MINTiMINT-2785419.

Structurei

3D structure databases

ProteinModelPortaliP36026.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini298 – 707USPAdd BLAST410

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi557 – 564Poly-His8

Sequence similaritiesi

Belongs to the peptidase C19 family.Curated
Contains 1 USP domain.Curated

Phylogenomic databases

GeneTreeiENSGT00670000099202.
HOGENOMiHOG000142359.
InParanoidiP36026.
KOiK11871.
OrthoDBiEOG092C5R71.

Family and domain databases

InterProiIPR001394. Peptidase_C19_UCH.
IPR018200. USP_CS.
IPR028889. USP_dom.
[Graphical view]
PfamiPF00443. UCH. 1 hit.
[Graphical view]
PROSITEiPS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P36026-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLLNPDQILN LVRKVYEVDI KQFYSQLRLK NLRGLLDHAA HLFNVYLRDL
60 70 80 90 100
EINQEMEALT AFIIGCYYLY LIIPQSLQFQ TRNNLYSSYA KLKNDYQDEH
110 120 130 140 150
VMGYVLKVVR DESTVIVDRY LAESNGICRT IKRKRAYSLP LRPLPVHMAS
160 170 180 190 200
LSIHNKFDGS LHEIPNELTK PTNDNSKEDI VRESNQIASS NKLEAGSEVA
210 220 230 240 250
YYTSKEALSK PSYLKLSTGK DALFKTLSSP ATAPPVHSLE VSSQIRDSSQ
260 270 280 290 300
DSSSSLSKVE KPKEEEGKIE AIESSAPKAY NLPVIEDSND LLSELSITGL
310 320 330 340 350
QNPCNTCYIN SIIQCLFGTT LFRDLFLTKK YRLFLNTNKY PKEVQLSRSI
360 370 380 390 400
YVLFKKMYLN GGRAIIPNRF LKMCKKLRPD LNIPDDQQDT QEFLLIVLAR
410 420 430 440 450
IHEELSNENV VKYYPDLVSY DANALQVNPS KYEKWYERNV ITDGLSPIDH
460 470 480 490 500
IYRGQLENIL KCQRCGNSSY SYSTFYVLSL AIPKLSLYSF TSKSRKIKLE
510 520 530 540 550
DCINLFTGDE ELSGDNAWDC PNCRITDSKS KKEEITSQKK KSTIFGFHSR
560 570 580 590 600
SRSKSPHHHH HHHHSSDDST KNAKKRNSKK LTTIKSLDFI VLPPILVIHL
610 620 630 640 650
SRFYYDLTKK NSTVITYPLI LNIILKNGKV IRYKLYGTVN HSGNLINGHY
660 670 680 690 700
TSVVNKEKSH EIGLNRQVWV TFDDDYIQQH RKDRNNFEAG KTEMSSDEVY
710
VLFYERMDEE NYEEEFC
Length:717
Mass (Da):82,703
Last modified:June 1, 1994 - v1
Checksum:i9BAA1EEEB5DD9A65
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z28323 Genomic DNA. Translation: CAA82178.1.
BK006944 Genomic DNA. Translation: DAA09249.1.
PIRiS38177.
RefSeqiNP_013024.1. NM_001179888.1.

Genome annotation databases

EnsemblFungiiYKR098C; YKR098C; YKR098C.
GeneIDi853973.
KEGGisce:YKR098C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z28323 Genomic DNA. Translation: CAA82178.1.
BK006944 Genomic DNA. Translation: DAA09249.1.
PIRiS38177.
RefSeqiNP_013024.1. NM_001179888.1.

3D structure databases

ProteinModelPortaliP36026.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi34229. 24 interactors.
IntActiP36026. 1 interactor.
MINTiMINT-2785419.

Protein family/group databases

MEROPSiC19.102.

Proteomic databases

MaxQBiP36026.
PRIDEiP36026.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYKR098C; YKR098C; YKR098C.
GeneIDi853973.
KEGGisce:YKR098C.

Organism-specific databases

EuPathDBiFungiDB:YKR098C.
SGDiS000001806. UBP11.

Phylogenomic databases

GeneTreeiENSGT00670000099202.
HOGENOMiHOG000142359.
InParanoidiP36026.
KOiK11871.
OrthoDBiEOG092C5R71.

Enzyme and pathway databases

BioCyciYEAST:G3O-32060-MONOMER.

Miscellaneous databases

PROiP36026.

Family and domain databases

InterProiIPR001394. Peptidase_C19_UCH.
IPR018200. USP_CS.
IPR028889. USP_dom.
[Graphical view]
PfamiPF00443. UCH. 1 hit.
[Graphical view]
PROSITEiPS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiUBP11_YEAST
AccessioniPrimary (citable) accession number: P36026
Secondary accession number(s): D6VXF9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: November 2, 2016
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome XI
    Yeast (Saccharomyces cerevisiae) chromosome XI: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.