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P36026

- UBP11_YEAST

UniProt

P36026 - UBP11_YEAST

Protein

Ubiquitin carboxyl-terminal hydrolase 11

Gene

UBP11

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 99 (01 Oct 2014)
      Sequence version 1 (01 Jun 1994)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei307 – 3071NucleophilePROSITE-ProRule annotation
    Active sitei649 – 6491Proton acceptorPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ubiquitin-specific protease activity Source: SGD

    GO - Biological processi

    1. ubiquitin-dependent protein catabolic process Source: InterPro

    Keywords - Molecular functioni

    Hydrolase, Protease, Thiol protease

    Keywords - Biological processi

    Ubl conjugation pathway

    Enzyme and pathway databases

    BioCyciYEAST:G3O-32060-MONOMER.

    Protein family/group databases

    MEROPSiC19.102.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ubiquitin carboxyl-terminal hydrolase 11 (EC:3.4.19.12)
    Alternative name(s):
    Deubiquitinating enzyme 11
    Ubiquitin thioesterase 11
    Ubiquitin-specific-processing protease 11
    Gene namesi
    Name:UBP11
    Ordered Locus Names:YKR098C
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome XI

    Organism-specific databases

    CYGDiYKR098c.
    SGDiS000001806. UBP11.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 717717Ubiquitin carboxyl-terminal hydrolase 11PRO_0000080596Add
    BLAST

    Proteomic databases

    MaxQBiP36026.

    Expressioni

    Gene expression databases

    GenevestigatoriP36026.

    Interactioni

    Protein-protein interaction databases

    BioGridi34229. 24 interactions.
    IntActiP36026. 1 interaction.
    MINTiMINT-2785419.
    STRINGi4932.YKR098C.

    Structurei

    3D structure databases

    ProteinModelPortaliP36026.
    SMRiP36026. Positions 298-707.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini298 – 707410USPAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi557 – 5648Poly-His

    Sequence similaritiesi

    Belongs to the peptidase C19 family.Curated
    Contains 1 USP domain.Curated

    Phylogenomic databases

    eggNOGiCOG5533.
    GeneTreeiENSGT00670000099202.
    HOGENOMiHOG000142359.
    KOiK11871.
    OrthoDBiEOG7R2BSX.

    Family and domain databases

    InterProiIPR018200. Pept_C19ubi-hydrolase_C_CS.
    IPR001394. Peptidase_C19_UCH.
    IPR028889. UCH/PAN2.
    [Graphical view]
    PfamiPF00443. UCH. 1 hit.
    [Graphical view]
    PROSITEiPS00972. USP_1. 1 hit.
    PS00973. USP_2. 1 hit.
    PS50235. USP_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P36026-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLLNPDQILN LVRKVYEVDI KQFYSQLRLK NLRGLLDHAA HLFNVYLRDL    50
    EINQEMEALT AFIIGCYYLY LIIPQSLQFQ TRNNLYSSYA KLKNDYQDEH 100
    VMGYVLKVVR DESTVIVDRY LAESNGICRT IKRKRAYSLP LRPLPVHMAS 150
    LSIHNKFDGS LHEIPNELTK PTNDNSKEDI VRESNQIASS NKLEAGSEVA 200
    YYTSKEALSK PSYLKLSTGK DALFKTLSSP ATAPPVHSLE VSSQIRDSSQ 250
    DSSSSLSKVE KPKEEEGKIE AIESSAPKAY NLPVIEDSND LLSELSITGL 300
    QNPCNTCYIN SIIQCLFGTT LFRDLFLTKK YRLFLNTNKY PKEVQLSRSI 350
    YVLFKKMYLN GGRAIIPNRF LKMCKKLRPD LNIPDDQQDT QEFLLIVLAR 400
    IHEELSNENV VKYYPDLVSY DANALQVNPS KYEKWYERNV ITDGLSPIDH 450
    IYRGQLENIL KCQRCGNSSY SYSTFYVLSL AIPKLSLYSF TSKSRKIKLE 500
    DCINLFTGDE ELSGDNAWDC PNCRITDSKS KKEEITSQKK KSTIFGFHSR 550
    SRSKSPHHHH HHHHSSDDST KNAKKRNSKK LTTIKSLDFI VLPPILVIHL 600
    SRFYYDLTKK NSTVITYPLI LNIILKNGKV IRYKLYGTVN HSGNLINGHY 650
    TSVVNKEKSH EIGLNRQVWV TFDDDYIQQH RKDRNNFEAG KTEMSSDEVY 700
    VLFYERMDEE NYEEEFC 717
    Length:717
    Mass (Da):82,703
    Last modified:June 1, 1994 - v1
    Checksum:i9BAA1EEEB5DD9A65
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z28323 Genomic DNA. Translation: CAA82178.1.
    BK006944 Genomic DNA. Translation: DAA09249.1.
    PIRiS38177.
    RefSeqiNP_013024.1. NM_001179888.1.

    Genome annotation databases

    EnsemblFungiiYKR098C; YKR098C; YKR098C.
    GeneIDi853973.
    KEGGisce:YKR098C.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z28323 Genomic DNA. Translation: CAA82178.1 .
    BK006944 Genomic DNA. Translation: DAA09249.1 .
    PIRi S38177.
    RefSeqi NP_013024.1. NM_001179888.1.

    3D structure databases

    ProteinModelPortali P36026.
    SMRi P36026. Positions 298-707.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 34229. 24 interactions.
    IntActi P36026. 1 interaction.
    MINTi MINT-2785419.
    STRINGi 4932.YKR098C.

    Protein family/group databases

    MEROPSi C19.102.

    Proteomic databases

    MaxQBi P36026.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YKR098C ; YKR098C ; YKR098C .
    GeneIDi 853973.
    KEGGi sce:YKR098C.

    Organism-specific databases

    CYGDi YKR098c.
    SGDi S000001806. UBP11.

    Phylogenomic databases

    eggNOGi COG5533.
    GeneTreei ENSGT00670000099202.
    HOGENOMi HOG000142359.
    KOi K11871.
    OrthoDBi EOG7R2BSX.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-32060-MONOMER.

    Miscellaneous databases

    NextBioi 975422.

    Gene expression databases

    Genevestigatori P36026.

    Family and domain databases

    InterProi IPR018200. Pept_C19ubi-hydrolase_C_CS.
    IPR001394. Peptidase_C19_UCH.
    IPR028889. UCH/PAN2.
    [Graphical view ]
    Pfami PF00443. UCH. 1 hit.
    [Graphical view ]
    PROSITEi PS00972. USP_1. 1 hit.
    PS00973. USP_2. 1 hit.
    PS50235. USP_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete DNA sequence of yeast chromosome XI."
      Dujon B., Alexandraki D., Andre B., Ansorge W., Baladron V., Ballesta J.P.G., Banrevi A., Bolle P.-A., Bolotin-Fukuhara M., Bossier P., Bou G., Boyer J., Buitrago M.J., Cheret G., Colleaux L., Daignan-Fornier B., del Rey F., Dion C.
      , Domdey H., Duesterhoeft A., Duesterhus S., Entian K.-D., Erfle H., Esteban P.F., Feldmann H., Fernandes L., Fobo G.M., Fritz C., Fukuhara H., Gabel C., Gaillon L., Garcia-Cantalejo J.M., Garcia-Ramirez J.J., Gent M.E., Ghazvini M., Goffeau A., Gonzalez A., Grothues D., Guerreiro P., Hegemann J.H., Hewitt N., Hilger F., Hollenberg C.P., Horaitis O., Indge K.J., Jacquier A., James C.M., Jauniaux J.-C., Jimenez A., Keuchel H., Kirchrath L., Kleine K., Koetter P., Legrain P., Liebl S., Louis E.J., Maia e Silva A., Marck C., Monnier A.-L., Moestl D., Mueller S., Obermaier B., Oliver S.G., Pallier C., Pascolo S., Pfeiffer F., Philippsen P., Planta R.J., Pohl F.M., Pohl T.M., Poehlmann R., Portetelle D., Purnelle B., Puzos V., Ramezani Rad M., Rasmussen S.W., Remacha M.A., Revuelta J.L., Richard G.-F., Rieger M., Rodrigues-Pousada C., Rose M., Rupp T., Santos M.A., Schwager C., Sensen C., Skala J., Soares H., Sor F., Stegemann J., Tettelin H., Thierry A., Tzermia M., Urrestarazu L.A., van Dyck L., van Vliet-Reedijk J.C., Valens M., Vandenbol M., Vilela C., Vissers S., von Wettstein D., Voss H., Wiemann S., Xu G., Zimmermann J., Haasemann M., Becker I., Mewes H.-W.
      Nature 369:371-378(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    2. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.

    Entry informationi

    Entry nameiUBP11_YEAST
    AccessioniPrimary (citable) accession number: P36026
    Secondary accession number(s): D6VXF9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 1, 1994
    Last sequence update: June 1, 1994
    Last modified: October 1, 2014
    This is version 99 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families
    3. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    4. Yeast chromosome XI
      Yeast (Saccharomyces cerevisiae) chromosome XI: entries and gene names

    External Data

    Dasty 3