P36026 (UBP11_YEAST) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Ubiquitin carboxyl-terminal hydrolase 11
EC=3.4.19.12

Alternative name(s):
Deubiquitinating enzyme 11
Ubiquitin thioesterase 11
Ubiquitin-specific-processing protease 11

Gene names

Name:	UBP11
Ordered Locus Names:	YKR098C

Organism

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]

Taxonomic identifier

559292 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › Saccharomyces cerevisiae

Protein attributes

Sequence length	717 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).
Sequence similarities	Belongs to the peptidase C19 family.

Ontologies

Keywords
Biological process	Ubl conjugation pathway
Molecular function	Hydrolase Protease Thiol protease
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	ubiquitin-dependent protein catabolic process Inferred from electronic annotation. Source: InterPro
Molecular_function	ubiquitin thiolesterase activity Inferred from electronic annotation. Source: InterPro ubiquitin-specific protease activity Inferred from direct assay PubMed 10527495. Source: SGD
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 717	717	Ubiquitin carboxyl-terminal hydrolase 11		PRO_0000080596
Regions
	Compositional bias	557 – 564	8	Poly-His
Sites
	Active site	307	1	Nucleophile By similarity
	Active site	649	1	Proton acceptor By similarity

Sequences

	Sequence		Length	Mass (Da)
	P36026 [UniParc]. Last modified June 1, 1994. Version 1. Checksum: 9BAA1EEEB5DD9A65	FASTA	717	82,703
	10 20 30 40 50 60 MLLNPDQILN LVRKVYEVDI KQFYSQLRLK NLRGLLDHAA HLFNVYLRDL EINQEMEALT 70 80 90 100 110 120 AFIIGCYYLY LIIPQSLQFQ TRNNLYSSYA KLKNDYQDEH VMGYVLKVVR DESTVIVDRY 130 140 150 160 170 180 LAESNGICRT IKRKRAYSLP LRPLPVHMAS LSIHNKFDGS LHEIPNELTK PTNDNSKEDI 190 200 210 220 230 240 VRESNQIASS NKLEAGSEVA YYTSKEALSK PSYLKLSTGK DALFKTLSSP ATAPPVHSLE 250 260 270 280 290 300 VSSQIRDSSQ DSSSSLSKVE KPKEEEGKIE AIESSAPKAY NLPVIEDSND LLSELSITGL 310 320 330 340 350 360 QNPCNTCYIN SIIQCLFGTT LFRDLFLTKK YRLFLNTNKY PKEVQLSRSI YVLFKKMYLN 370 380 390 400 410 420 GGRAIIPNRF LKMCKKLRPD LNIPDDQQDT QEFLLIVLAR IHEELSNENV VKYYPDLVSY 430 440 450 460 470 480 DANALQVNPS KYEKWYERNV ITDGLSPIDH IYRGQLENIL KCQRCGNSSY SYSTFYVLSL 490 500 510 520 530 540 AIPKLSLYSF TSKSRKIKLE DCINLFTGDE ELSGDNAWDC PNCRITDSKS KKEEITSQKK 550 560 570 580 590 600 KSTIFGFHSR SRSKSPHHHH HHHHSSDDST KNAKKRNSKK LTTIKSLDFI VLPPILVIHL 610 620 630 640 650 660 SRFYYDLTKK NSTVITYPLI LNIILKNGKV IRYKLYGTVN HSGNLINGHY TSVVNKEKSH 670 680 690 700 710 EIGLNRQVWV TFDDDYIQQH RKDRNNFEAG KTEMSSDEVY VLFYERMDEE NYEEEFC

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Complete DNA sequence of yeast chromosome XI." Dujon B., Alexandraki D., Andre B., Ansorge W., Baladron V., Ballesta J.P.G., Banrevi A., Bolle P.-A., Bolotin-Fukuhara M., Bossier P., Bou G., Boyer J., Buitrago M.J., Cheret G., Colleaux L., Daignan-Fornier B., del Rey F., Dion C. , Domdey H., Duesterhoeft A., Duesterhus S., Entian K.-D., Erfle H., Esteban P.F., Feldmann H., Fernandes L., Fobo G.M., Fritz C., Fukuhara H., Gabel C., Gaillon L., Garcia-Cantalejo J.M., Garcia-Ramirez J.J., Gent M.E., Ghazvini M., Goffeau A., Gonzalez A., Grothues D., Guerreiro P., Hegemann J.H., Hewitt N., Hilger F., Hollenberg C.P., Horaitis O., Indge K.J., Jacquier A., James C.M., Jauniaux J.-C., Jimenez A., Keuchel H., Kirchrath L., Kleine K., Koetter P., Legrain P., Liebl S., Louis E.J., Maia e Silva A., Marck C., Monnier A.-L., Moestl D., Mueller S., Obermaier B., Oliver S.G., Pallier C., Pascolo S., Pfeiffer F., Philippsen P., Planta R.J., Pohl F.M., Pohl T.M., Poehlmann R., Portetelle D., Purnelle B., Puzos V., Ramezani Rad M., Rasmussen S.W., Remacha M.A., Revuelta J.L., Richard G.-F., Rieger M., Rodrigues-Pousada C., Rose M., Rupp T., Santos M.A., Schwager C., Sensen C., Skala J., Soares H., Sor F., Stegemann J., Tettelin H., Thierry A., Tzermia M., Urrestarazu L.A., van Dyck L., van Vliet-Reedijk J.C., Valens M., Vandenbol M., Vilela C., Vissers S., von Wettstein D., Voss H., Wiemann S., Xu G., Zimmermann J., Haasemann M., Becker I., Mewes H.-W. Nature 369:371-378(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 96604 / S288c / FY1679.
[2]	Saccharomyces Genome Database Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: ATCC 204508 / S288c.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	Z28323 Genomic DNA. Translation: CAA82178.1. BK006944 Genomic DNA. Translation: DAA09249.1.
PIR	S38177.
RefSeq	NP_013024.1. NM_001179888.1.
3D structure databases
ProteinModelPortal	P36026.
SMR	P36026. Positions 298-707.
ModBase	Search...
Protein-protein interaction databases
IntAct	P36026. 1 interaction.
MINT	MINT-2785419.
STRING	4932.YKR098C.
Protein family/group databases
MEROPS	C19.102.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	YKR098C; YKR098C; YKR098C.
GeneID	853973.
KEGG	sce:YKR098C.
Organism-specific databases
CYGD	YKR098c.
SGD	S000001806. UBP11.
Phylogenomic databases
eggNOG	COG5533.
GeneTree	ENSGT00670000099202.
HOGENOM	HOG000142359.
KO	K11871.
OrthoDB	EOG4QC4DV.
Gene expression databases
Genevestigator	P36026.
GermOnline	YKR098C. Saccharomyces cerevisiae.
Family and domain databases
InterPro	IPR018200. Pept_C19ubi-hydrolase_C_CS. IPR001394. Peptidase_C19. [Graphical view]
Pfam	PF00443. UCH. 1 hit. [Graphical view]
PROSITE	PS00972. UCH_2_1. 1 hit. PS00973. UCH_2_2. 1 hit. PS50235. UCH_2_3. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	975422.

Entry information

Entry name

UBP11_YEAST

Accession

Primary (citable) accession number: P36026
Secondary accession number(s): D6VXF9

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 1, 1994
Last sequence update:	June 1, 1994
Last modified:	May 1, 2013
This is version 90 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program