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Protein

GTP-binding protein YPT52

Gene

YPT52

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Required for transport in the endocytic pathway and for correct sorting of the vacuolar hydrolases suggesting a possible intersection of the endocytic with the vacuolar sorting pathway.1 Publication

Miscellaneous

Present with 9380 molecules/cell in log phase SD medium.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi10 – 17GTPBy similarity8
Nucleotide bindingi66 – 70GTPBy similarity5
Nucleotide bindingi111 – 114GTPBy similarity4

GO - Molecular functioni

  • GTPase activity Source: SGD
  • GTP binding Source: UniProtKB-KW

GO - Biological processi

  • endocytosis Source: SGD
  • Golgi to endosome transport Source: SGD
  • late endosome to vacuole transport via multivesicular body sorting pathway Source: SGD
  • multivesicular body assembly Source: SGD
  • protein localization to endosome Source: SGD
  • protein targeting to vacuole Source: SGD

Keywordsi

Biological processProtein transport, Transport
LigandGTP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-31990-MONOMER
ReactomeiR-SCE-6798695 Neutrophil degranulation
R-SCE-8854214 TBC/RABGAPs
R-SCE-8873719 RAB geranylgeranylation
R-SCE-8876198 RAB GEFs exchange GTP for GDP on RABs

Names & Taxonomyi

Protein namesi
Recommended name:
GTP-binding protein YPT52
Gene namesi
Name:YPT52
Ordered Locus Names:YKR014C
ORF Names:YK112
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XI

Organism-specific databases

EuPathDBiFungiDB:YKR014C
SGDiS000001722 YPT52

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001213261 – 234GTP-binding protein YPT52Add BLAST234

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei139PhosphoserineCombined sources1
Modified residuei142PhosphoserineCombined sources1
Cross-linki151Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)Combined sources
Lipidationi232S-geranylgeranyl cysteineBy similarity1
Lipidationi233S-geranylgeranyl cysteineBy similarity1

Keywords - PTMi

Isopeptide bond, Lipoprotein, Phosphoprotein, Prenylation, Ubl conjugation

Proteomic databases

MaxQBiP36018
PaxDbiP36018
PRIDEiP36018

PTM databases

iPTMnetiP36018

Interactioni

Subunit structurei

Interacts with ROY1, YIF1, YIP3, YIP4 and YIP5.3 Publications

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi34146, 114 interactors
DIPiDIP-2121N
IntActiP36018, 18 interactors
MINTiP36018
STRINGi4932.YKR014C

Structurei

3D structure databases

ProteinModelPortaliP36018
SMRiP36018
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rab family.Curated

Phylogenomic databases

GeneTreeiENSGT00760000119101
HOGENOMiHOG000233968
InParanoidiP36018
KOiK07889
OMAiQTTVKFE
OrthoDBiEOG092C5MDH

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR005225 Small_GTP-bd_dom
IPR001806 Small_GTPase
PfamiView protein in Pfam
PF00071 Ras, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51419 RAB, 1 hit

Sequencei

Sequence statusi: Complete.

P36018-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLQFKLVLLG DSSVGKSSIV HRFVKDTFDE LRESTIGAAF LSQSITIHPN
60 70 80 90 100
DGNETKDVVI KFEIWDTAGQ ERYKSLAPMY YRNANAALVV YDITQEDSLQ
110 120 130 140 150
KARNWVDELK NKVGDDDLVI YLLGNKVDLC QETPSTETSP DSNEGGDEEQ
160 170 180 190 200
KVRAISTEEA KQYAQEQGLL FREVSAKTGE GVKEIFQDIG EKLYDLKKDE
210 220 230
ILSKQNRQIG GGNNGQVDIN LQRPSTNDPT SCCS
Length:234
Mass (Da):26,132
Last modified:June 1, 1994 - v1
Checksum:i34AB2FFE38697261
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X76174 Genomic DNA Translation: CAA53770.1
Z28239 Genomic DNA Translation: CAA82086.1
BK006944 Genomic DNA Translation: DAA09169.1
PIRiS38083
RefSeqiNP_012939.1, NM_001179804.1

Genome annotation databases

EnsemblFungiiYKR014C; YKR014C; YKR014C
GeneIDi853884
KEGGisce:YKR014C

Similar proteinsi

Entry informationi

Entry nameiYPT52_YEAST
AccessioniPrimary (citable) accession number: P36018
Secondary accession number(s): D6VX79
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: June 20, 2018
This is version 170 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

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