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Protein

Synaptobrevin homolog YKT6

Gene

YKT6

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • palmitoyltransferase activity Source: SGD
  • SNAP receptor activity Source: SGD
  • SNARE binding Source: GO_Central

GO - Biological processi

  • ER to Golgi vesicle-mediated transport Source: SGD
  • exocytosis Source: GO_Central
  • intra-Golgi vesicle-mediated transport Source: SGD
  • vacuole fusion, non-autophagic Source: SGD
  • vesicle fusion Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Enzyme and pathway databases

BioCyciYEAST:G3O-31958-MONOMER.
ReactomeiR-SCE-6807878. COPI-mediated anterograde transport.
R-SCE-6811438. Intra-Golgi traffic.

Names & Taxonomyi

Protein namesi
Recommended name:
Synaptobrevin homolog YKT6 (EC:2.3.1.-)
Gene namesi
Name:YKT6
Ordered Locus Names:YKL196C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XI

Organism-specific databases

EuPathDBiFungiDB:YKL196C.
SGDiS000001679. YKT6.

Subcellular locationi

GO - Cellular componenti

  • endosome Source: SGD
  • fungal-type vacuole Source: SGD
  • Golgi apparatus Source: SGD
  • integral component of membrane Source: InterPro
  • membrane Source: SGD
  • plasma membrane Source: UniProtKB-SubCell
  • SNARE complex Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 197197Synaptobrevin homolog YKT6PRO_0000206781Add
BLAST
Propeptidei198 – 2003Removed in mature formBy similarityPRO_0000396675

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei158 – 1581PhosphothreonineCombined sources
Lipidationi196 – 1961S-palmitoyl cysteineBy similarity
Modified residuei197 – 1971Cysteine methyl esterBy similarity
Lipidationi197 – 1971S-farnesyl cysteineBy similarity

Keywords - PTMi

Lipoprotein, Methylation, Palmitate, Phosphoprotein, Prenylation

Proteomic databases

MaxQBiP36015.

PTM databases

iPTMnetiP36015.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
PEP12P328542EBI-26982,EBI-13098
VTI1Q043386EBI-26982,EBI-20519

GO - Molecular functioni

  • SNAP receptor activity Source: SGD
  • SNARE binding Source: GO_Central

Protein-protein interaction databases

BioGridi33925. 83 interactions.
DIPiDIP-2247N.
IntActiP36015. 27 interactions.
MINTiMINT-646403.

Structurei

Secondary structure

1
200
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi3 – 108Combined sources
Beta strandi13 – 153Combined sources
Beta strandi17 – 237Combined sources
Beta strandi26 – 283Combined sources
Turni30 – 345Combined sources
Helixi35 – 5016Combined sources
Beta strandi55 – 617Combined sources
Beta strandi64 – 707Combined sources
Beta strandi74 – 829Combined sources
Helixi87 – 10418Combined sources
Helixi107 – 1093Combined sources
Turni110 – 1123Combined sources
Helixi118 – 1203Combined sources
Helixi124 – 1318Combined sources
Helixi137 – 1393Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1H8MNMR-A1-140[»]
1IOUNMR-A1-140[»]
3BW6X-ray2.50A1-140[»]
ProteinModelPortaliP36015.
SMRiP36015. Positions 1-135, 139-192.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP36015.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini7 – 129123LonginPROSITE-ProRule annotationAdd
BLAST
Domaini140 – 20061v-SNARE coiled-coil homologyPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the synaptobrevin family.Curated
Contains 1 longin domain.PROSITE-ProRule annotation
Contains 1 v-SNARE coiled-coil homology domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

GeneTreeiENSGT00390000015164.
HOGENOMiHOG000189970.
InParanoidiP36015.
KOiK08516.
OMAiNDSQPAH.
OrthoDBiEOG092C4MCV.

Family and domain databases

Gene3Di3.30.450.50. 1 hit.
InterProiIPR011012. Longin-like_dom.
IPR010908. Longin_dom.
IPR001388. Synaptobrevin.
[Graphical view]
PfamiPF13774. Longin. 1 hit.
PF00957. Synaptobrevin. 1 hit.
[Graphical view]
PRINTSiPR00219. SYNAPTOBREVN.
SMARTiSM01270. Longin. 1 hit.
[Graphical view]
SUPFAMiSSF64356. SSF64356. 1 hit.
PROSITEiPS50859. LONGIN. 1 hit.
PS00417. SYNAPTOBREVIN. 1 hit.
PS50892. V_SNARE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P36015-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRIYYIGVFR SGGEKALELS EVKDLSQFGF FERSSVGQFM TFFAETVASR
60 70 80 90 100
TGAGQRQSIE EGNYIGHVYA RSEGICGVLI TDKEYPVRPA YTLLNKILDE
110 120 130 140 150
YLVAHPKEEW ADVTETNDAL KMKQLDTYIS KYQDPSQADA IMKVQQELDE
160 170 180 190 200
TKIVLHKTIE NVLQRGEKLD NLVDKSESLT ASSKMFYKQA KKSNSCCIIM
Length:200
Mass (Da):22,707
Last modified:June 1, 1994 - v1
Checksum:i9BA0E47ED87B096D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z28196 Genomic DNA. Translation: CAA82040.1.
AY558393 Genomic DNA. Translation: AAS56719.1.
BK006944 Genomic DNA. Translation: DAA08970.1.
PIRiS38033.
RefSeqiNP_012725.1. NM_001179762.1.

Genome annotation databases

EnsemblFungiiYKL196C; YKL196C; YKL196C.
GeneIDi853638.
KEGGisce:YKL196C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z28196 Genomic DNA. Translation: CAA82040.1.
AY558393 Genomic DNA. Translation: AAS56719.1.
BK006944 Genomic DNA. Translation: DAA08970.1.
PIRiS38033.
RefSeqiNP_012725.1. NM_001179762.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1H8MNMR-A1-140[»]
1IOUNMR-A1-140[»]
3BW6X-ray2.50A1-140[»]
ProteinModelPortaliP36015.
SMRiP36015. Positions 1-135, 139-192.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi33925. 83 interactions.
DIPiDIP-2247N.
IntActiP36015. 27 interactions.
MINTiMINT-646403.

PTM databases

iPTMnetiP36015.

Proteomic databases

MaxQBiP36015.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYKL196C; YKL196C; YKL196C.
GeneIDi853638.
KEGGisce:YKL196C.

Organism-specific databases

EuPathDBiFungiDB:YKL196C.
SGDiS000001679. YKT6.

Phylogenomic databases

GeneTreeiENSGT00390000015164.
HOGENOMiHOG000189970.
InParanoidiP36015.
KOiK08516.
OMAiNDSQPAH.
OrthoDBiEOG092C4MCV.

Enzyme and pathway databases

BioCyciYEAST:G3O-31958-MONOMER.
ReactomeiR-SCE-6807878. COPI-mediated anterograde transport.
R-SCE-6811438. Intra-Golgi traffic.

Miscellaneous databases

EvolutionaryTraceiP36015.
PROiP36015.

Family and domain databases

Gene3Di3.30.450.50. 1 hit.
InterProiIPR011012. Longin-like_dom.
IPR010908. Longin_dom.
IPR001388. Synaptobrevin.
[Graphical view]
PfamiPF13774. Longin. 1 hit.
PF00957. Synaptobrevin. 1 hit.
[Graphical view]
PRINTSiPR00219. SYNAPTOBREVN.
SMARTiSM01270. Longin. 1 hit.
[Graphical view]
SUPFAMiSSF64356. SSF64356. 1 hit.
PROSITEiPS50859. LONGIN. 1 hit.
PS00417. SYNAPTOBREVIN. 1 hit.
PS50892. V_SNARE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiYKT6_YEAST
AccessioniPrimary (citable) accession number: P36015
Secondary accession number(s): D6VX04
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: September 7, 2016
This is version 160 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome XI
    Yeast (Saccharomyces cerevisiae) chromosome XI: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.