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Protein

Serine/threonine-protein kinase KDX1

Gene

KDX1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Serine/threonine-protein kinase involved in the SLT2 mitogen-activated (MAP) kinase signaling pathway that regulates cell wall integrity. May also be involved in the mating pheromone and the CWI MAPK pathways.3 Publications

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei55 – 551ATPPROSITE-ProRule annotation
Active sitei153 – 1531Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi29 – 379ATPPROSITE-ProRule annotation

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • protein kinase activity Source: SGD
  • protein serine/threonine kinase activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-31929-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase KDX1 (EC:2.7.11.1)
Alternative name(s):
Kinase dead X-talker protein 1
MPK1-like protein kinase 1
Gene namesi
Name:KDX1
Synonyms:MLP1
Ordered Locus Names:YKL161C
ORF Names:YKL615
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XI

Organism-specific databases

EuPathDBiFungiDB:YKL161C.
SGDiS000001644. KDX1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 433433Serine/threonine-protein kinase KDX1PRO_0000086150Add
BLAST

PTM databases

iPTMnetiP36005.

Expressioni

Inductioni

Accumulates in large amounts when cell wall integrity is compromised.1 Publication

Interactioni

Subunit structurei

Interacts with RLM1.1 Publication

Protein-protein interaction databases

BioGridi33977. 65 interactions.
DIPiDIP-6316N.
IntActiP36005. 20 interactions.
MINTiMINT-698763.

Structurei

3D structure databases

ProteinModelPortaliP36005.
SMRiP36005. Positions 14-366.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini23 – 318296Protein kinasePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.PROSITE-ProRule annotation
Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

GeneTreeiENSGT00840000129971.
InParanoidiP36005.
KOiK19847.
OMAiTERCIFR.
OrthoDBiEOG7K3TWD.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P36005-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATDTERCIF RAFGQDFILN KHFHLTGKIG RGSHSLICSS TYTESNEETH
60 70 80 90 100
VAIRKIPNAF GNKLSCKRTL RELKLLRHLR GHPNIVWLFD TDIVFYPNGA
110 120 130 140 150
LNGVYLYEEL MECDLSQIIR SEQRLEDAHF QSFIYQILCA LKYIHSANVL
160 170 180 190 200
HCDLKPKNLL VNSDCQLKIC NFGLSCSYSE NHKVNDGFIK GYITSIWYKA
210 220 230 240 250
PEILLNYQEC TKAVDIWSTG CILAELLGRK PMFEGKDYVD HLNHILQILG
260 270 280 290 300
TPPEETLQEI ASQKVYNYIF QFGNIPGRSF ESILPGANPE ALELLKKMLE
310 320 330 340 350
FDPKKRITVE DALEHPYLSM WHDIDEEFSC QKTFRFEFEH IESMAELGNE
360 370 380 390 400
VIKEVFDFRK VVRKHPISGD SPSSSLSLED AIPQEVVQVH PSRKVLPSYS
410 420 430
PEFSYVSQLP SLTTTQPYQN LMGISSNSFQ GVN
Length:433
Mass (Da):49,633
Last modified:June 1, 1994 - v1
Checksum:iBC27B76B7DB95822
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z26877 Genomic DNA. Translation: CAA81493.1.
Z28161 Genomic DNA. Translation: CAA82003.1.
BK006944 Genomic DNA. Translation: DAA09004.1.
PIRiS37790.
RefSeqiNP_012761.1. NM_001179727.1.

Genome annotation databases

EnsemblFungiiYKL161C; YKL161C; YKL161C.
GeneIDi853696.
KEGGisce:YKL161C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z26877 Genomic DNA. Translation: CAA81493.1.
Z28161 Genomic DNA. Translation: CAA82003.1.
BK006944 Genomic DNA. Translation: DAA09004.1.
PIRiS37790.
RefSeqiNP_012761.1. NM_001179727.1.

3D structure databases

ProteinModelPortaliP36005.
SMRiP36005. Positions 14-366.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi33977. 65 interactions.
DIPiDIP-6316N.
IntActiP36005. 20 interactions.
MINTiMINT-698763.

PTM databases

iPTMnetiP36005.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYKL161C; YKL161C; YKL161C.
GeneIDi853696.
KEGGisce:YKL161C.

Organism-specific databases

EuPathDBiFungiDB:YKL161C.
SGDiS000001644. KDX1.

Phylogenomic databases

GeneTreeiENSGT00840000129971.
InParanoidiP36005.
KOiK19847.
OMAiTERCIFR.
OrthoDBiEOG7K3TWD.

Enzyme and pathway databases

BioCyciYEAST:G3O-31929-MONOMER.

Miscellaneous databases

PROiP36005.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "DNA sequencing of a 36.2 kb fragment located between the FAS1 and LAP loci of chromosome XI of Saccharomyces cerevisiae."
    Vandenbol M., Bolle P.-A., Dion C., Portetelle D., Hilger F.
    Yeast 10:S35-S40(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. "Complete DNA sequence of yeast chromosome XI."
    Dujon B., Alexandraki D., Andre B., Ansorge W., Baladron V., Ballesta J.P.G., Banrevi A., Bolle P.-A., Bolotin-Fukuhara M., Bossier P., Bou G., Boyer J., Buitrago M.J., Cheret G., Colleaux L., Daignan-Fornier B., del Rey F., Dion C.
    , Domdey H., Duesterhoeft A., Duesterhus S., Entian K.-D., Erfle H., Esteban P.F., Feldmann H., Fernandes L., Fobo G.M., Fritz C., Fukuhara H., Gabel C., Gaillon L., Garcia-Cantalejo J.M., Garcia-Ramirez J.J., Gent M.E., Ghazvini M., Goffeau A., Gonzalez A., Grothues D., Guerreiro P., Hegemann J.H., Hewitt N., Hilger F., Hollenberg C.P., Horaitis O., Indge K.J., Jacquier A., James C.M., Jauniaux J.-C., Jimenez A., Keuchel H., Kirchrath L., Kleine K., Koetter P., Legrain P., Liebl S., Louis E.J., Maia e Silva A., Marck C., Monnier A.-L., Moestl D., Mueller S., Obermaier B., Oliver S.G., Pallier C., Pascolo S., Pfeiffer F., Philippsen P., Planta R.J., Pohl F.M., Pohl T.M., Poehlmann R., Portetelle D., Purnelle B., Puzos V., Ramezani Rad M., Rasmussen S.W., Remacha M.A., Revuelta J.L., Richard G.-F., Rieger M., Rodrigues-Pousada C., Rose M., Rupp T., Santos M.A., Schwager C., Sensen C., Skala J., Soares H., Sor F., Stegemann J., Tettelin H., Thierry A., Tzermia M., Urrestarazu L.A., van Dyck L., van Vliet-Reedijk J.C., Valens M., Vandenbol M., Vilela C., Vissers S., von Wettstein D., Voss H., Wiemann S., Xu G., Zimmermann J., Haasemann M., Becker I., Mewes H.-W.
    Nature 369:371-378(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  4. "Characterization of a serum response factor-like protein in Saccharomyces cerevisiae, Rlm1, which has transcriptional activity regulated by the Mpk1 (Slt2) mitogen-activated protein kinase pathway."
    Watanabe Y., Takaesu G., Hagiwara M., Irie K., Matsumoto K.
    Mol. Cell. Biol. 17:2615-2623(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH RLM1.
  5. Cited for: FUNCTION.
  6. "A yeast strain biosensor to detect cell wall-perturbing agents."
    Rodriguez-Pena J.M., Diez-Muniz S., Nombela C., Arroyo J.
    J. Biotechnol. 133:311-317(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION.
  7. Cited for: FUNCTION.

Entry informationi

Entry nameiKDX1_YEAST
AccessioniPrimary (citable) accession number: P36005
Secondary accession number(s): D6VX38
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: July 6, 2016
This is version 137 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XI
    Yeast (Saccharomyces cerevisiae) chromosome XI: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.