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Protein

Probable serine/threonine-protein kinase KKQ8

Gene

KKQ8

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei455ATPPROSITE-ProRule annotation1
Active sitei563Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi418 – 426ATPPROSITE-ProRule annotation9

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • protein kinase activity Source: SGD
  • protein serine/threonine kinase activity Source: GO_Central

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-31936-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable serine/threonine-protein kinase KKQ8 (EC:2.7.11.1)
Gene namesi
Name:KKQ8
Ordered Locus Names:YKL168C
ORF Names:YKL632
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XI

Organism-specific databases

EuPathDBiFungiDB:YKL168C.
SGDiS000001651. KKQ8.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000861511 – 724Probable serine/threonine-protein kinase KKQ8Add BLAST724

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei19PhosphoserineCombined sources1
Modified residuei232PhosphoserineCombined sources1
Modified residuei238PhosphoserineCombined sources1
Modified residuei241PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP36004.
PRIDEiP36004.

PTM databases

iPTMnetiP36004.

Interactioni

Protein-protein interaction databases

BioGridi33969. 92 interactors.
DIPiDIP-4838N.
IntActiP36004. 6 interactors.
MINTiMINT-473137.

Structurei

3D structure databases

ProteinModelPortaliP36004.
SMRiP36004.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini412 – 712Protein kinasePROSITE-ProRule annotationAdd BLAST301

Sequence similaritiesi

Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

GeneTreeiENSGT00550000075309.
HOGENOMiHOG000112846.
InParanoidiP36004.
KOiK08286.
OrthoDBiEOG092C2CDU.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P36004-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVMQEEKKRQ QPVTRRVRSF SESFKNLFRP PRSRDSSPIN VTRIPYRSSS
60 70 80 90 100
TSPKRSSEPP RRSTVSAQIL DPKNSPIRQR SYTLKCCTPG LSHPFRQTGS
110 120 130 140 150
GASNSPTRHR SISGEEQEIV NSLPEYKRSA SHTFHGIRRP RSRSSSVSSC
160 170 180 190 200
DSSNGTTSSS DSQWAMDSLL DDSDNDLTPY RGSNKDILKS KDRAPYNYID
210 220 230 240 250
DYNKKALRRA TSYPNPLPSK QFYNERLYTR RSHPDEESLE SLPRFAGADV
260 270 280 290 300
QCIIEQNGFK VYEDGSHEHN IKLSGVIAKL EKGNSLPAHR QGSLSRPRLG
310 320 330 340 350
ITLSGLFKHH KNECDIENAL SLLPNVEKSQ TNHEKRTGQS PNDSNRSSPT
360 370 380 390 400
QGREDYLKIV NPDASLGSDE LKLINSLSSR IHKSLQNYLQ EKNLKPAECI
410 420 430 440 450
GEQAPTFQDN YGHPVGLVGA GAYGEVKLCA RLRNEKDSPP FETYHDSKYI
460 470 480 490 500
YYAVKELKPK PDSDLEKFCT KITSEFIIGH SLSHYHKNGK KPAPNILNVF
510 520 530 540 550
DILEDSSSFI EVMEFCPAGD LYGMLVGKSK LKGRLHPLEA DCFMKQLLHG
560 570 580 590 600
VKFMHDHGIA HCDLKPENIL FYPHGLLKIC DFGTSSVFQT AWERRVHAQK
610 620 630 640 650
GIIGSEPYVA PEEFVDGEYY DPRLIDCWSC GVVYITMILG HYLWKVASRE
660 670 680 690 700
KDMSYDEFYK EMQRKNQFRV FEELKHVNSE LATNRKIALY RIFQWEPRKR
710 720
ISVGKLLDMQ WMKSTNCCLI YDST
Length:724
Mass (Da):82,590
Last modified:May 20, 2008 - v2
Checksum:i7EAC570CE6E5154F
GO

Sequence cautioni

The sequence CAA81519 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAA82010 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z26878 Genomic DNA. Translation: CAA81519.1. Different initiation.
Z28168 Genomic DNA. Translation: CAA82010.1. Different initiation.
BK006944 Genomic DNA. Translation: DAA08997.1.
PIRiS37998.
RefSeqiNP_012753.2. NM_001179734.1.

Genome annotation databases

EnsemblFungiiYKL168C; YKL168C; YKL168C.
GeneIDi853686.
KEGGisce:YKL168C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z26878 Genomic DNA. Translation: CAA81519.1. Different initiation.
Z28168 Genomic DNA. Translation: CAA82010.1. Different initiation.
BK006944 Genomic DNA. Translation: DAA08997.1.
PIRiS37998.
RefSeqiNP_012753.2. NM_001179734.1.

3D structure databases

ProteinModelPortaliP36004.
SMRiP36004.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi33969. 92 interactors.
DIPiDIP-4838N.
IntActiP36004. 6 interactors.
MINTiMINT-473137.

PTM databases

iPTMnetiP36004.

Proteomic databases

MaxQBiP36004.
PRIDEiP36004.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYKL168C; YKL168C; YKL168C.
GeneIDi853686.
KEGGisce:YKL168C.

Organism-specific databases

EuPathDBiFungiDB:YKL168C.
SGDiS000001651. KKQ8.

Phylogenomic databases

GeneTreeiENSGT00550000075309.
HOGENOMiHOG000112846.
InParanoidiP36004.
KOiK08286.
OrthoDBiEOG092C2CDU.

Enzyme and pathway databases

BioCyciYEAST:G3O-31936-MONOMER.

Miscellaneous databases

PROiP36004.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKKQ8_YEAST
AccessioniPrimary (citable) accession number: P36004
Secondary accession number(s): D6VX31
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: May 20, 2008
Last modified: November 2, 2016
This is version 144 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 981 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XI
    Yeast (Saccharomyces cerevisiae) chromosome XI: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.