P36002 (PTK1_YEAST) Reviewed, UniProtKB/Swiss-Prot
Last modified
January 25, 2012.
Version 103.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Serine/threonine-protein kinase PTK1/STK1 EC=2.7.11.1 | ||||||
| Gene names |
| ||||||
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | ||||||
| Taxonomic identifier | 559292 [NCBI] | ||||||
| Taxonomic lineage | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces |
Protein attributes
| Sequence length | 662 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at protein level |
General annotation (Comments)
| Function | Essential determinant for low-affinity spermidine transport. |
| Catalytic activity | ATP + a protein = ADP + a phosphoprotein. |
| Sequence similarities | Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Contains 1 protein kinase domain. |
| Sequence caution | The sequence BAA09884.1 differs from that shown. Reason: Frameshift at position 455. The sequence CAA82042.1 differs from that shown. Reason: Frameshift at position 455. The sequence CAA82043.1 differs from that shown. Reason: Frameshift at position 455. |
Ontologies
| Keywords | |
|---|---|
| Ligand | ATP-binding Nucleotide-binding |
| Molecular function | Kinase Serine/threonine-protein kinase Transferase |
| Technical term | Complete proteome Reference proteome |
| Gene Ontology (GO) | |
| Biological process | polyamine transport Inferred from mutant phenotype Ref.3. Source: SGD |
| Molecular function | ATP binding Inferred from electronic annotation. Source: UniProtKB-KW protein serine/threonine kinase activityInferred from electronic annotation. Source: UniProtKB-KW |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 662 | 662 | Serine/threonine-protein kinase PTK1/STK1 | PRO_0000086589 | |||||
Regions | |||||||||
| Domain | 196 – 503 | 308 | Protein kinase | ||||||
| Nucleotide binding | 202 – 210 | 9 | ATP By similarity | ||||||
| Compositional bias | 4 – 146 | 143 | Ser-rich | ||||||
| Compositional bias | 567 – 624 | 58 | Pro-rich | ||||||
Sites | |||||||||
| Active site | 329 | 1 | Proton acceptor By similarity | ||||||
| Binding site | 226 | 1 | ATP By similarity | ||||||
Experimental info | |||||||||
| Sequence conflict | 241 – 244 | 4 | KRCS → NAAP in CAA82043. Ref.1 | ||||||
| Sequence conflict | 300 | 1 | S → H in CAA82043. Ref.1 | ||||||
| Sequence conflict | 356 – 375 | 20 | TDPHD…MIGSP → HGSTRPVQPCQEVRRDDRLA in CAA82043. Ref.1 | ||||||
| Sequence conflict | 637 – 662 | 26 | VHHHL…VPAST → GASPSEHCQQLGP in CAA82042. Ref.1 | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Complete DNA sequence of yeast chromosome XI." Dujon B., Alexandraki D., Andre B., Ansorge W., Baladron V., Ballesta J.P.G., Banrevi A., Bolle P.-A., Bolotin-Fukuhara M., Bossier P., Bou G., Boyer J., Buitrago M.J., Cheret G., Colleaux L., Daignan-Fornier B., del Rey F., Dion C. Mewes H.-W.Nature 369:371-378(1994) [PubMed: 8196765] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 96604 / S288c / FY1679. |
| [2] | Saccharomyces Genome Database Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION, SEQUENCE REVISION TO 241-244; 300; 356-375 AND 637-662. Strain: ATCC 204508 / S288c. |
| [3] | "Cloning of the gene encoding a putative serine/threonine protein kinase which enhances spermine uptake in Saccharomyces cerevisiae." Kakinuma Y., Maruyama T., Nozaki T., Wada Y., Ohsumi Y., Igarashi K. Biochem. Biophys. Res. Commun. 216:985-992(1995) [PubMed: 7488221] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-584, CHARACTERIZATION. |
| [4] | "The STK2 gene, which encodes a putative Ser/Thr protein kinase, is required for high-affinity spermidine transport in Saccharomyces cerevisiae." Kaouass M., Audette M., Ramotar D., Verma S., de Montigny D., Gamache I., Torossian K., Poulin R. Mol. Cell. Biol. 17:2994-3004(1997) [PubMed: 9154797] [Abstract] Cited for: CHARACTERIZATION. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | Z28198 Genomic DNA. Translation: CAA82043.1. Frameshift. Z28198 Genomic DNA. Translation: CAA82042.1. Frameshift. D63815 Genomic DNA. Translation: BAA09884.1. Frameshift. BK006944 Genomic DNA. Translation: DAA08968.2. |
| PIR | S38035. S38036. |
| RefSeq | NP_012723.3. NM_001179764.2. |
3D structure databases | |
| ProteinModelPortal | P36002. |
| SMR | P36002. Positions 197-508. |
| ModBase | Search... |
Protein-protein interaction databases | |
| IntAct | P36002. 14 interactions. |
| MINT | MINT-6490143. |
| STRING | P36002. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| GeneID | 853635. |
| KEGG | sce:YKL198C. |
| NMPDR | fig|4932.3.peg.3700. |
Organism-specific databases | |
| CYGD | YKL198c. |
| SGD | S000001681. PTK1. |
Phylogenomic databases | |
| eggNOG | fuNOG04254. |
| GeneTree | EFGT00070000008718. |
| HOGENOM | HBG202364. |
| OMA | ACIRNIN. |
| OrthoDB | EOG4RJK8Z. |
Enzyme and pathway databases | |
| BRENDA | 2.7.11.1. 984. |
Gene expression databases | |
| ArrayExpress | P36002. |
| Genevestigator | P36002. |
| GermOnline | YKL198C. Saccharomyces cerevisiae. |
Family and domain databases | |
| InterPro | IPR011009. Kinase-like_dom. IPR000719. Prot_kinase_cat_dom. IPR017442. Se/Thr_kinase-like_dom. IPR008271. Ser/Thr_kinase_AS. [Graphical view] |
| KO | K08286. |
| Pfam | PF00069. Pkinase. 1 hit. [Graphical view] |
| SUPFAM | SSF56112. Kinase_like. 1 hit. |
| PROSITE | PS00107. PROTEIN_KINASE_ATP. False negative. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other | |
| NextBio | 974517. |
Entry information
| Entry name | PTK1_YEAST | ||||||||
| Accession | Primary (citable) accession number: P36002 Secondary accession number(s): D6VX02, P36045, Q06941 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Fungal Protein Annotation Program | ||||||||
Relevant documents
| Yeast Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD |
| Yeast chromosome XI Yeast (Saccharomyces cerevisiae) chromosome XI: entries and gene names |
| SIMILARITY comments Index of protein domains and families |

Clusters with