Reviewed,
UniProtKB/Swiss-Prot P35998 (PRS7_HUMAN)
Last modified
June 16, 2009.
Version 95.
History...
Clusters with 100%,
90%,
50% identity |
Documents (3) |
Third-party data |
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Names and origin
| Protein names | Recommended name: 26S protease regulatory subunit 7 Alternative name(s): Proteasome 26S subunit ATPase 2 Protein MSS1 | ||||
| Gene names |
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| Organism | Homo sapiens (Human) | ||||
| Taxonomic identifier | 9606 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 433 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | The 26S protease is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex. In case of HIV-1 infection, positive modulator of Tat-mediated transactivation. Ref.5 |
| Subunit structure | Interacts with NDC80 and SQSTM1. Interacts with PAAF1. Interacts with HIV-1 Tat. Ref.5 Ref.6 Ref.7 Ref.8 |
| Subcellular location | |
| Sequence similarities | Belongs to the AAA ATPase family. |
Ontologies
Binary interactions
With | Entry | #Exp. | IntAct | Notes |
|---|---|---|---|---|
| NDRG1 | Q92597 | 1 | EBI-359710,EBI-716486 | |
| PAAF1 | Q9BRP4 | 1 | EBI-359710,EBI-1056358 | |
| PSMC4 | P43686 | 1 | EBI-359710,EBI-743997 | |
| PSMD10 | O75832 | 1 | EBI-359710,EBI-752185 | |
| PSMD6 | Q15008 | 1 | EBI-359710,EBI-359701 |
Sequence annotation (Features)
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "New human gene encoding a positive modulator of HIV Tat-mediated transactivation." Shibuya H., Irie K., Ninomiya-Tsuji J., Goebl M., Taniguchi T., Matsumoto K. Nature 357:700-702(1992) [PubMed: 1377363] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. |
| [2] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain. |
| [3] | "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides." Gevaert K., Goethals M., Martens L., Van Damme J., Staes A., Thomas G.R., Vandekerckhove J. Nat. Biotechnol. 21:566-569(2003) [PubMed: 12665801] [Abstract] Cited for: PROTEIN SEQUENCE OF 2-10. Tissue: Platelet. |
| [4] | Lubec G., Vishwanath V., Chen W.-Q., Sun Y. Submitted (DEC-2008) to UniProtKB Cited for: PROTEIN SEQUENCE OF 85-97; 101-110; 201-210; 269-284 AND 298-312, MASS SPECTROMETRY. Tissue: Brain, Cajal-Retzius cell and Fetal brain cortex. |
| [5] | "HEC binds to the seventh regulatory subunit of the 26 S proteasome and modulates the proteolysis of mitotic cyclins." Chen Y., Sharp Z.D., Lee W.-H. J. Biol. Chem. 272:24081-24087(1997) [PubMed: 9295362] [Abstract] Cited for: FUNCTION, INTERACTION WITH NDC80. |
| [6] | "Hec1p, an evolutionarily conserved coiled-coil protein, modulates chromosome segregation through interaction with SMC proteins." Zheng L., Chen Y., Lee W.-H. Mol. Cell. Biol. 19:5417-5428(1999) [PubMed: 10409732] [Abstract] Cited for: INTERACTION WITH NDC80. |
| [7] | "Sequestosome 1/p62 is a polyubiquitin chain binding protein involved in ubiquitin proteasome degradation." Seibenhener M.L., Babu J.R., Geetha T., Wong H.C., Krishna N.R., Wooten M.W. Mol. Cell. Biol. 24:8055-8068(2004) [PubMed: 15340068] [Abstract] Cited for: INTERACTION WITH SQSTM1. |
| [8] | "Proteasomal ATPase-associated factor 1 negatively regulates proteasome activity by interacting with proteasomal ATPases." Park Y., Hwang Y.-P., Lee J.-S., Seo S.-H., Yoon S.K., Yoon J.-B. Mol. Cell. Biol. 25:3842-3853(2005) [PubMed: 15831487] [Abstract] Cited for: INTERACTION WITH PAAF1. |
| [9] | "Mass spectrometric characterization of the affinity-purified human 26S proteasome complex." Wang X., Chen C.-F., Baker P.R., Chen P.-L., Kaiser P., Huang L. Biochemistry 46:3553-3565(2007) [PubMed: 17323924] [Abstract] Cited for: CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS], MASS SPECTROMETRY. |
| [10] | Colinge J., Superti-Furga G., Bennett K.L. Submitted (OCT-2008) to UniProtKB Cited for: IDENTIFICATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY. |
Cross-references
Sequence databases | |
|---|---|
| D11094 mRNA. Translation: BAA01868.1. BC002589 mRNA. Translation: AAH02589.1. | |
| IPI | IPI00021435. |
| PIR | S24353. |
| RefSeq | NP_002794.1. |
| UniGene | Hs.437366 |
3D structure databases | |
| HSSP | HSSP built from PDB template 1IXZ based on UniProtKB Q9LCZ4. |
| ModBase | Search... |
Protein-protein interaction databases | |
| DIP | DIP:27554N. |
| IntAct | P35998. 13 interactions. |
PTM databases | |
| PhosphoSite | P35998. |
2-D gel databases | |
| OGP | P35998. |
| REPRODUCTION-2DPAGE | IPI00021435. P35998. |
Proteomic databases | |
| PeptideAtlas | P35998. |
| PRIDE | P35998. |
Genome annotation databases | |
| Ensembl | ENSG00000161057. Homo sapiens. [Contig view] |
| GeneID | 5701. |
| KEGG | hsa:5701. |
Organism-specific databases | |
| GeneCards | GC07P102775. |
| H-InvDB | HIX0006971. |
| HGNC | HGNC:9548. PSMC2. |
| MIM | 154365. gene. |
| PharmGKB | PA33893. |
| GenAtlas | Search... |
Phylogenomic databases | |
| HOGENOM | P35998. |
| HOVERGEN | P35998. |
| OMA | P35998. KACIIFF. |
Enzyme and pathway databases | |
| Reactome | REACT_11045. Signaling by Wnt. REACT_13. Metabolism of amino acids. REACT_13635. Regulation of activated PAK-2p34 by proteasome mediated degradation. REACT_152. Cell Cycle, Mitotic. REACT_1538. Cell Cycle Checkpoints. REACT_383. DNA Replication. REACT_578. Apoptosis. REACT_6185. HIV Infection. REACT_6850. Cdc20:Phospho-APC/C mediated degradation of Cyclin A. REACT_9035. APC/C:Cdh1-mediated degradation of Skp2. |
Gene expression databases | |
| ArrayExpress | P35998. |
| Bgee | P35998. |
| CleanEx | HS_PSMC2. |
| GermOnline | ENSG00000161057. Homo sapiens. |
Family and domain databases | |
| InterPro | IPR005937. 26S_Psome_P45. IPR003593. ATPase_AAA+_core. IPR003959. ATPase_AAA_core. IPR003960. ATPase_AAA_CS. [Graphical view] |
| Pfam | PF00004. AAA. 1 hit. [Graphical view] |
| SMART | SM00382. AAA. 1 hit. [Graphical view] |
| TIGRFAMs | TIGR01242. 26Sp45. 1 hit. |
| PROSITE | PS00674. AAA. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 22150. |
| SOURCE | Search... |
Entry information
| Entry name | PRS7_HUMAN | ||||||||
| Accession | Primary (citable) accession number: P35998 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| Human chromosome 7 Human chromosome 7: entries, gene names and cross-references to MIM |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

Clusters with


