Reviewed, UniProtKB/Swiss-Prot P35996 (RM38_YEAST)

Names and origin

Protein names

Recommended name:
    54S ribosomal protein L38, mitochondrial
Alternative name(s):
    YmL38
Cleaved into the following chain:
    1- Recommended name:
            54S ribosomal protein L34, mitochondrial
        Alternative name(s):
            YmL34

Gene names

Name:	MRPL38
Synonyms:	MRPL34
Ordered Locus Names:	YKL170W
ORF Names:	YKL634

Organism

Saccharomyces cerevisiae (Baker's yeast) [Complete proteome]

Taxonomic identifier

4932 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces

Protein attributes

Sequence length	138 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Subunit structure	Component of the mitochondrial large ribosomal subunit. Mature mitochondrial ribosomes consist of a small (37S) and a large (54S) subunit. The 37S subunit contains at least 33 different proteins and 1 molecule of RNA (15S). The 54S subunit contains at least 45 different proteins and 1 molecule of RNA (21S). Ref.4
Subcellular location	Mitochondrion.
Miscellaneous	Present with 2500 molecules/cell in log phase SD medium. Ref.8
Sequence similarities	Belongs to the ribosomal protein L14P family.

Ontologies

Keywords
Cellular component	Mitochondrion
Molecular function	Ribonucleoprotein Ribosomal protein
Technical term	Complete proteome Direct protein sequencing
Gene Ontology (GO)
Biological process	mitochondrial translation Ref.5 Ref.6 Inferred by curator. Source: SGD
Cellular component	mitochondrial large ribosomal subunit Ref.5 Ref.6 Inferred from direct assay. Source: SGD
Molecular function	structural constituent of ribosome Ref.5 Ref.6 Inferred from direct assay. Source: SGD
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 138	138	54S ribosomal protein L38, mitochondrial		PRO_0000030464
	Chain	58 – 138	81	54S ribosomal protein L34, mitochondrial		PRO_0000030465
Experimental info
	Sequence conflict	60	1	T → A AA sequence Ref.4
	Sequence conflict	69 – 70	2	CH → DI AA sequence Ref.4

Sequences

	Sequence		Length	Mass (Da)
	P35996-1 [UniParc]. Last modified June 1, 1994. Version 1. Checksum: CD327E00B218D83B	FASTA	138	14,905
	10 20 30 40 50 60 MIFLKSVIKV IDNSGAQLAE CIKVIRKGSP KSPAMVGDRI VCVIQKAKPL TQNITGTANT 70 80 90 100 110 120 NRVKKGDICH AIVVRSKQRN MCRKDGSTVA FGDTACVLIN KNTGEPLGTR IMANDGCVDR 130 TLKDKGYNKI CSLASRVI

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Sequencing and analysis of a 20.5 kb DNA segment located on the left arm of yeast chromosome XI." Vandenbol M., Bolle P.-A., Dion C., Portetelle D., Hilger F. Yeast 10:S25-S33(1994) [PubMed: 8091858] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 204508 / S288c.
[2]	"Complete DNA sequence of yeast chromosome XI." Dujon B., Alexandraki D., Andre B., Ansorge W., Baladron V., Ballesta J.P.G., Banrevi A., Bolle P.-A., Bolotin-Fukuhara M., Bossier P., Bou G., Boyer J., Buitrago M.J., Cheret G., Colleaux L., Daignan-Fornier B., del Rey F., Dion C. , Domdey H., Duesterhoeft A., Duesterhus S., Entian K.-D., Erfle H., Esteban P.F., Feldmann H., Fernandes L., Fobo G.M., Fritz C., Fukuhara H., Gabel C., Gaillon L., Garcia-Cantalejo J.M., Garcia-Ramirez J.J., Gent M.E., Ghazvini M., Goffeau A., Gonzalez A., Grothues D., Guerreiro P., Hegemann J.H., Hewitt N., Hilger F., Hollenberg C.P., Horaitis O., Indge K.J., Jacquier A., James C.M., Jauniaux J.-C., Jimenez A., Keuchel H., Kirchrath L., Kleine K., Koetter P., Legrain P., Liebl S., Louis E.J., Maia e Silva A., Marck C., Monnier A.-L., Moestl D., Mueller S., Obermaier B., Oliver S.G., Pallier C., Pascolo S., Pfeiffer F., Philippsen P., Planta R.J., Pohl F.M., Pohl T.M., Poehlmann R., Portetelle D., Purnelle B., Puzos V., Ramezani Rad M., Rasmussen S.W., Remacha M.A., Revuelta J.L., Richard G.-F., Rieger M., Rodrigues-Pousada C., Rose M., Rupp T., Santos M.A., Schwager C., Sensen C., Skala J., Soares H., Sor F., Stegemann J., Tettelin H., Thierry A., Tzermia M., Urrestarazu L.A., van Dyck L., van Vliet-Reedijk J.C., Valens M., Vandenbol M., Vilela C., Vissers S., von Wettstein D., Voss H., Wiemann S., Xu G., Zimmermann J., Haasemann M., Becker I., Mewes H.-W. Nature 369:371-378(1994) [PubMed: 8196765] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 96604 / S288c / FY1679.
[3]	"Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae." Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F., Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J., Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J. , Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D., LaBaer J. Genome Res. 17:536-543(2007) [PubMed: 17322287] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 204508 / S288c.
[4]	"Extended N-terminal sequencing of proteins of the large ribosomal subunit from yeast mitochondria." Grohmann L., Graack H.-R., Kruft V., Choli T., Goldschmidt-Reisin S., Kitakawa M. FEBS Lett. 284:51-56(1991) [PubMed: 2060626] [Abstract] Cited for: PROTEIN SEQUENCE OF 1-28 AND 58-85, SUBUNIT. Strain: 07173.
[5]	"Identification and characterization of the genes for mitochondrial ribosomal proteins of Saccharomyces cerevisiae." Kitakawa M., Graack H.-R., Grohmann L., Goldschmidt-Reisin S., Herfurth E., Wittmann-Liebold B., Nishimura T., Isono K. Eur. J. Biochem. 245:449-456(1997) [PubMed: 9151978] [Abstract] Cited for: IDENTIFICATION OF L34 AS A FRAGMENT OF L38.
[6]	"Tag-mediated isolation of yeast mitochondrial ribosome and mass spectrometric identification of its new components." Gan X., Kitakawa M., Yoshino K., Oshiro N., Yonezawa K., Isono K. Eur. J. Biochem. 269:5203-5214(2002) [PubMed: 12392552] [Abstract] Cited for: IDENTIFICATION IN THE MITOCHONDRIAL RIBOSOMAL LARGE COMPLEX, MASS SPECTROMETRY.
[7]	"Global analysis of protein localization in budding yeast." Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W., Weissman J.S., O'Shea E.K. Nature 425:686-691(2003) [PubMed: 14562095] [Abstract] Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
[8]	"Global analysis of protein expression in yeast." Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S. Nature 425:737-741(2003) [PubMed: 14562106] [Abstract] Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
[9]	"Toward the complete yeast mitochondrial proteome: multidimensional separation techniques for mitochondrial proteomics." Reinders J., Zahedi R.P., Pfanner N., Meisinger C., Sickmann A. J. Proteome Res. 5:1543-1554(2006) [PubMed: 16823961] [Abstract] Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	Z26878 Genomic DNA. Translation: CAA81517.1. Z28169 Genomic DNA. Translation: CAA82011.1. AY693037 Genomic DNA. Translation: AAT93056.1.
PIR	S38000.
RefSeq	NP_012751.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
DIP	DIP:6834N.
STRING	P35996.
Proteomic databases
PeptideAtlas	P35996.
Genome annotation databases
Ensembl	YKL170W; YKL170W; YKL170W; Saccharomyces cerevisiae. [Genome view]
GeneID	853684.
KEGG	sce:YKL170W.
NMPDR	fig|4932.3.peg.3729.
Organism-specific databases
CYGD	YKL170w.
SGD	S000001653. MRPL38.
Phylogenomic databases
HOGENOM	P35996.
OMA	PHELRKK
OrthoDB	EOG9NKDCB
Gene expression databases
ArrayExpress	P35996.
Genevestigator	P35996.
GermOnline	YKL170W. Saccharomyces cerevisiae.
Family and domain databases
InterPro	IPR005745. Ribosomal_L14_bac-type. IPR019972. Ribosomal_L14_CS. IPR000218. Ribosomal_L14b/L23e. [Graphical view]
Gene3D	G3DSA:2.40.150.20. Ribosomal_L14. 1 hit.
PANTHER	PTHR11761:SF3. Ribosom_L14_bac. 1 hit. PTHR11761. Ribosomal_L14. 1 hit.
Pfam	PF00238. Ribosomal_L14. 1 hit. [Graphical view]
TIGRFAMs	TIGR01067. rplN_bact. 1 hit.
PROSITE	PS00049. RIBOSOMAL_L14. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	974652.

Entry information

Entry name

RM38_YEAST

Accession

Primary (citable) accession number: P35996
Secondary accession number(s): P36529

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 1, 1994
Last sequence update:	June 1, 1994
Last modified:	November 24, 2009
This is version 93 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)