P35995 (YKW2_YEAST) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Uncharacterized transcriptional regulatory protein YKL222C

Gene names

Ordered Locus Names:

YKL222C

Organism

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)

Taxonomic identifier

559292 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces

Protein attributes

Sequence length	705 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Subcellular location	Nucleus Probable.
Sequence similarities	Contains 1 Zn(2)-C6 fungal-type DNA-binding domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Ligand	DNA-binding Metal-binding Zinc
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	mitotic spindle Inferred from direct assay. Source: SGD nucleus Inferred from direct assay. Source: SGD
Molecular function	sequence-specific DNA binding Inferred from direct assay. Source: SGD sequence-specific DNA binding transcription factor activity Inferred from electronic annotation. Source: InterPro zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 705	705	Uncharacterized transcriptional regulatory protein YKL222C		PRO_0000115000
Regions
	DNA binding	24 – 52	29	Zn(2)-C6 fungal-type

Sequences

	Sequence		Length	Mass (Da)
	P35995 [UniParc]. Last modified June 1, 1994. Version 1. Checksum: 31BF148717D72E1C	FASTA	705	82,248
	10 20 30 40 50 60 MKNTELSQKK KLDRQSRRKP AKSCHFCRVR KLKCDRVRPF CGSCSSRNRK QCEYKENTSA 70 80 90 100 110 120 MEDQLRKKYR RCSKLEMARR IEELESQLTK QSQPNIHEGQ NPLSNMRYLS SKHNRHILYG 130 140 150 160 170 180 PTSYRAILAT QTDTFAKYRE EIWQVLKLSR NNWKREHHYS TLSEISSIET APPHSGSPSV 190 200 210 220 230 240 IEYLCESLPN YEVLCEYLTD FFASDFYDSY QIVHKEKVLR DLQDCFVKGP RSHKTGQHTI 250 260 270 280 290 300 ISLNLDSKKN YYKVGVMTAI MCLASHPKEV PEAIEVFHKV LTSFVSAKVF YTERVQFLFL 310 320 330 340 350 360 RYLYINVAGL DGGDQSHCIF IHGLTIDTAI HMGLNEDLRR LYLSKNHPIE EIPYLERLWL 370 380 390 400 410 420 WILFTDVKIS LSTGIPVRIN DDFVNKVRLE NYSSSGDILL YKTTLRLRNI MKQIHAREKP 430 440 450 460 470 480 PDIPLIIEDL KKFTIKMFKP LDFYLNASNL NGNEFTELQL WHATLHMIGS LSNLYTLTHQ 490 500 510 520 530 540 DFDARIFNFS VLAPLNSLHL CFNVLETYFE LDNSKLSSKS LCLSKKWPHL NNALFLIYVN 550 560 570 580 590 600 AFRALIQIYT IFLQYMENKD IQLFIQRNSS ALTYSICPGD FEGPHNKCIS LKIAFKEMEN 610 620 630 640 650 660 IFDHIHQEKL KPLTQIWQNS YYFSIIISME KIGRRAFNKG MKNIDEGPET ENDATENSLT 670 680 690 700 TILNDLEGPL EDFSENFIDD ILGSPSAFFD TAISGWSNFE DFFSR

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Sequencing of a 13.2 kb segment next to the left telomere of yeast chromosome XI revealed five open reading frames and recent recombination events with the right arms of chromosomes III and V." Alexandraki D., Tzermia M. Yeast 10:S81-S91(1994) [PubMed: 8091865] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Complete DNA sequence of yeast chromosome XI." Dujon B., Alexandraki D., Andre B., Ansorge W., Baladron V., Ballesta J.P.G., Banrevi A., Bolle P.-A., Bolotin-Fukuhara M., Bossier P., Bou G., Boyer J., Buitrago M.J., Cheret G., Colleaux L., Daignan-Fornier B., del Rey F., Dion C. , Domdey H., Duesterhoeft A., Duesterhus S., Entian K.-D., Erfle H., Esteban P.F., Feldmann H., Fernandes L., Fobo G.M., Fritz C., Fukuhara H., Gabel C., Gaillon L., Garcia-Cantalejo J.M., Garcia-Ramirez J.J., Gent M.E., Ghazvini M., Goffeau A., Gonzalez A., Grothues D., Guerreiro P., Hegemann J.H., Hewitt N., Hilger F., Hollenberg C.P., Horaitis O., Indge K.J., Jacquier A., James C.M., Jauniaux J.-C., Jimenez A., Keuchel H., Kirchrath L., Kleine K., Koetter P., Legrain P., Liebl S., Louis E.J., Maia e Silva A., Marck C., Monnier A.-L., Moestl D., Mueller S., Obermaier B., Oliver S.G., Pallier C., Pascolo S., Pfeiffer F., Philippsen P., Planta R.J., Pohl F.M., Pohl T.M., Poehlmann R., Portetelle D., Purnelle B., Puzos V., Ramezani Rad M., Rasmussen S.W., Remacha M.A., Revuelta J.L., Richard G.-F., Rieger M., Rodrigues-Pousada C., Rose M., Rupp T., Santos M.A., Schwager C., Sensen C., Skala J., Soares H., Sor F., Stegemann J., Tettelin H., Thierry A., Tzermia M., Urrestarazu L.A., van Dyck L., van Vliet-Reedijk J.C., Valens M., Vandenbol M., Vilela C., Vissers S., von Wettstein D., Voss H., Wiemann S., Xu G., Zimmermann J., Haasemann M., Becker I., Mewes H.-W. Nature 369:371-378(1994) [PubMed: 8196765] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 204508 / S288c.
[3]	Saccharomyces Genome Database Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: ATCC 204508 / S288c.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X75950 Genomic DNA. Translation: CAA53551.1. Z28222 Genomic DNA. Translation: CAA82067.1. BK006944 Genomic DNA. Translation: DAA08947.1.
PIR	S38066.
RefSeq	NP_012700.1. NM_001179787.1.
3D structure databases
ProteinModelPortal	P35995.
SMR	P35995. Positions 22-92.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-5690N.
MINT	MINT-474976.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	YKL222C; YKL222C; YKL222C.
GeneID	853658.
KEGG	sce:YKL222C.
NMPDR	fig|4932.3.peg.3678.
Organism-specific databases
CYGD	YKL222c.
SGD	S000001705. YKL222C.
Phylogenomic databases
eggNOG	fuNOG12756.
GeneTree	EFGT00050000008555.
OMA	ENTSAME.
OrthoDB	EOG4C5GTT.
Gene expression databases
ArrayExpress	P35995.
Genevestigator	P35995.
GermOnline	YKL222C. Saccharomyces cerevisiae.
Family and domain databases
InterPro	IPR001611. Leu-rich_rpt. IPR007219. Transcription_factor_fun. IPR001138. Zn2-C6_fun-type_DNA-bd. [Graphical view]
Gene3D	G3DSA:4.10.240.10. Zn2-C6_fun-type_DNA-bd. 1 hit.
Pfam	PF04082. Fungal_trans. 1 hit. PF00172. Zn_clus. 1 hit. [Graphical view]
SMART	SM00906. Fungal_trans. 1 hit. SM00066. GAL4. 1 hit. [Graphical view]
SUPFAM	SSF57701. Fungi_TrN. 1 hit.
PROSITE	PS51450. LRR. 2 hits. PS00463. ZN2_CY6_FUNGAL_1. 1 hit. PS50048. ZN2_CY6_FUNGAL_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	974578.

Entry information

Entry name

YKW2_YEAST

Accession

Primary (citable) accession number: P35995
Secondary accession number(s): D6VWY1

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 1, 1994
Last sequence update:	June 1, 1994
Last modified:	December 14, 2011
This is version 87 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program