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P35992 (PTP10_DROME) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 127. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Tyrosine-protein phosphatase 10D

EC=3.1.3.48
Alternative name(s):
Receptor-linked protein-tyrosine phosphatase 10D
Short name=DPTP10D
Gene names
Name:Ptp10D
ORF Names:CG1817
OrganismDrosophila melanogaster (Fruit fly) [Reference proteome]
Taxonomic identifier7227 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora

Protein attributes

Sequence length1631 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May have a role in axon outgrowth and guidance. Ref.1

Catalytic activity

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

Subcellular location

Membrane; Single-pass type I membrane protein.

Tissue specificity

In 9-12 hour embryos, expression is specifically seen in the anterior commissure and its junctions with the longitudinal tracts. Ref.1 Ref.2

Developmental stage

Expressed both maternally and zygotically. Expressed throughout development to adulthood, lowest expression is during second and third larval instars. Ref.1

Sequence similarities

Belongs to the protein-tyrosine phosphatase family. Receptor class subfamily.

Contains 12 fibronectin type-III domains.

Contains 1 tyrosine-protein phosphatase domain.

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform B (identifier: P35992-1)

Also known as: Long;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform A (identifier: P35992-3)

Also known as: D;

The sequence of this isoform differs from the canonical sequence as follows:
     1626-1631: VDAPDR → PSSMICKDSK...DDEGIAESGM
Note: No experimental confirmation available.
Isoform E (identifier: P35992-2)

Also known as: Short;

The sequence of this isoform differs from the canonical sequence as follows:
     1549-1558: GQQVQLDENG → DDEGIAESGM
     1559-1631: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 4242 Potential
Chain43 – 16311589Tyrosine-protein phosphatase 10D
PRO_0000025427

Regions

Topological domain43 – 11971155Extracellular Potential
Transmembrane1198 – 121821Helical; Potential
Topological domain1219 – 1631413Cytoplasmic Potential
Domain43 – 11977Fibronectin type-III 1
Domain125 – 21894Fibronectin type-III 2
Domain219 – 31496Fibronectin type-III 3
Domain309 – 40294Fibronectin type-III 4
Domain407 – 49892Fibronectin type-III 5
Domain499 – 58486Fibronectin type-III 6
Domain585 – 67490Fibronectin type-III 7
Domain675 – 77197Fibronectin type-III 8
Domain775 – 86591Fibronectin type-III 9
Domain866 – 95691Fibronectin type-III 10
Domain957 – 1057101Fibronectin type-III 11
Domain1049 – 1190142Fibronectin type-III 12
Domain1272 – 1527256Tyrosine-protein phosphatase
Region1468 – 14747Substrate binding By similarity

Sites

Active site14681Phosphocysteine intermediate By similarity
Binding site14361Substrate By similarity
Binding site15121Substrate By similarity

Amino acid modifications

Glycosylation751N-linked (GlcNAc...) Potential
Glycosylation1061N-linked (GlcNAc...) Potential
Glycosylation1281N-linked (GlcNAc...) Potential
Glycosylation1691N-linked (GlcNAc...) Potential
Glycosylation2121N-linked (GlcNAc...) Potential
Glycosylation2291N-linked (GlcNAc...) Potential
Glycosylation2591N-linked (GlcNAc...) Potential
Glycosylation2891N-linked (GlcNAc...) Potential
Glycosylation3171N-linked (GlcNAc...) Potential
Glycosylation4711N-linked (GlcNAc...) Potential
Glycosylation4861N-linked (GlcNAc...) Potential
Glycosylation5121N-linked (GlcNAc...) Potential
Glycosylation5331N-linked (GlcNAc...) Potential
Glycosylation5881N-linked (GlcNAc...) Potential
Glycosylation6681N-linked (GlcNAc...) Potential
Glycosylation6871N-linked (GlcNAc...) Potential
Glycosylation7191N-linked (GlcNAc...) Potential
Glycosylation7231N-linked (GlcNAc...) Potential
Glycosylation8231N-linked (GlcNAc...) Potential
Glycosylation8411N-linked (GlcNAc...) Potential
Glycosylation8741N-linked (GlcNAc...) Potential
Glycosylation9081N-linked (GlcNAc...) Potential
Glycosylation9251N-linked (GlcNAc...) Potential
Glycosylation10011N-linked (GlcNAc...) Potential
Glycosylation11041N-linked (GlcNAc...) Potential
Glycosylation11361N-linked (GlcNAc...) Potential
Glycosylation11951N-linked (GlcNAc...) Potential

Natural variations

Alternative sequence1549 – 155810GQQVQLDENG → DDEGIAESGM in isoform E.
VSP_005143
Alternative sequence1559 – 163173Missing in isoform E.
VSP_005144
Alternative sequence1626 – 16316VDAPDR → PSSMICKDSKGGNIDVLESQ QQQQQQQQQQPNQGGHNITT ISAINGYNTLQHRRKSQLIT FSSSSCDIKNSLSHEYINGS NGSAANGPPSSGSGSGSGPG SNRASRANVRLSFAEEDVMI LPQNHSQQSNHQDDEVFTRR RSLLEVEIGVEVGEDGELAP HEMEEDLEEEDEDEELYMHD EFETHIDTKSNNANDDSGGG SYEDSHALHSSLGGSNRNSL EKDDDDIEVDVISTDVSCYD QLLGSSCNTRNGDDDDIATL VGDGDYSTTKLSKASRLSGA GVGGLVVSGGGGGTAIGGGI AVNGGGVLGNGVGSEAGGGI IYANPFMDDEGIAESGM in isoform A.
VSP_015266

Experimental info

Sequence conflict1241D → I in AAA28484. Ref.1
Sequence conflict1271S → L in AAA28484. Ref.1
Sequence conflict1881P → L in AAO42638. Ref.5
Sequence conflict3691F → S in AAA28484. Ref.1
Sequence conflict3691F → S in AAA28952. Ref.2
Sequence conflict5581G → A in AAA28484. Ref.1
Sequence conflict5581G → A in AAA28952. Ref.2
Sequence conflict8101L → S in AAA28484. Ref.1
Sequence conflict8101L → S in AAA28952. Ref.2
Sequence conflict14031N → S in AAO42638. Ref.5

Secondary structure

.................................................... 1631
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Isoform B (Long) [UniParc].

Last modified August 30, 2005. Version 3.
Checksum: 22A59AB61665875D

FASTA1,631185,081
        10         20         30         40         50         60 
MLYQLSKATT RIRLKRQKAV PQHRWLWSLA FLAAFTLKDV RCADLAISIP NNPGLDDGAS 

        70         80         90        100        110        120 
YRLDYSPPFG YPEPNTTIAS REIGDEIQFS RALPGTKYNF WLYYTNFTHH DWLTWTVTIT 

       130        140        150        160        170        180 
TAPDPPSNLS VQVRSGKNAI ILWSPPTQGS YTAFKIKVLG LSEASSSYNR TFQVNDNTFQ 

       190        200        210        220        230        240 
HSVKELTPGA TYQVQAYTIY DGKESVAYTS RNFTTKPNTP GKFIVWFRNE TTLLVLWQPP 

       250        260        270        280        290        300 
YPAGIYTHYK VSIEPPDAND SVLYVEKEGE PPGPAQAAFK GLVPGRAYNI SVQTMSEDEI 

       310        320        330        340        350        360 
SLPTTAQYRT VPLRPLNVTF DRDFITSNSF RVLWEAPKGI SEFDKYQVSV ATTRRQSTVP 

       370        380        390        400        410        420 
RSNEPVAFFD FRDIAEPGKT FNVIVKTVSG KVTSWPATGD VTLRPLPVRN LRSINDDKTN 

       430        440        450        460        470        480 
TMIITWEADP ASTQDEYRIV YHELETFNGD TSTLTTDRTR FTLESLLPGR NYSLSVQAVS 

       490        500        510        520        530        540 
KKMESNETSI FVVTRPSSPI IEDLKSIRMG LNISWKSDVN SKQEQYEVLY SRNGTSDLRT 

       550        560        570        580        590        600 
QKTKESRLVI KNLQPGAGYE LKVFAVSHDL RSEPHAYFQA VYPNPPRNMT IETVRSNSVL 

       610        620        630        640        650        660 
VHWSPPESGE FTEYSIRYRT DSEQQWVRLP SVRSTEADIT DMTKGEKYTI QVNTVSFGVE 

       670        680        690        700        710        720 
SPVPQEVNTT VPPNPVSNII QLVDSRNITL EWPKPEGRVE SYILKWWPSD NPGRVQTKNV 

       730        740        750        760        770        780 
SENKSADDLS TVRVLIGELM PGVQYKFDIQ TTSYGILSGI TSLYPRTMPL IQSDVVVANG 

       790        800        810        820        830        840 
EKEDERDTIT LSYTPTPQSS SKFDIYRFSL GDAEIRDKEK LANDTDRKVT FTGLVPGRLY 

       850        860        870        880        890        900 
NITVWTVSGG VASLPIQRQD RLYPEPITQL HATNITDTEI SLRWDLPKGE YNDFDIAYLT 

       910        920        930        940        950        960 
ADNLLAQNMT TRNEITISDL RPHRNYTFTV VVRSGTESSV LRSSSPLSAS FTTNEAVPGR 

       970        980        990       1000       1010       1020 
VERFHPTDVQ PSEINFEWSL PSSEANGVIR QFSIAYTNIN NLTDAGMQDF ESEEAFGVIK 

      1030       1040       1050       1060       1070       1080 
NLKPGETYVF KIQAKTAIGF GPEREYRQTM PILAPPRPAT QVVPTEVYRS SSTIQIRFRK 

      1090       1100       1110       1120       1130       1140 
NYFSDQNGQV RMYTIIVAED DAKNASGLEM PSWLDVQSYS VWLPYQAIDP YYPFENRSVE 

      1150       1160       1170       1180       1190       1200 
DFTIGTENCD NHKIGYCNGP LKSGTTYRVK VRAFTGADKF TDTAYSFPIQ TDQDNTSLIV 

      1210       1220       1230       1240       1250       1260 
AITVPLTIIL VLLVTLLFYK RRRNNCRKTT KDSRANDNMS LPDSVIEQNR PILIKNFAEH 

      1270       1280       1290       1300       1310       1320 
YRLMSADSDF RFSEEFEELK HVGRDQPCTF ADLPCNRPKN RFTNILPYDH SRFKLQPVDD 

      1330       1340       1350       1360       1370       1380 
DEGSDYINAN YVPGHNSPRE FIVTQGPLHS TRDDFWRMCW ESNSRAIVML TRCFEKGREK 

      1390       1400       1410       1420       1430       1440 
CDQYWPNDTV PVFYGDIKVQ ILNDSHYADW VMTEFMLCRG SEQRILRHFH FTTWPDFGVP 

      1450       1460       1470       1480       1490       1500 
NPPQTLVRFV RAFRDRIGAE QRPIVVHCSA GVGRSGTFIT LDRILQQINT SDYVDIFGIV 

      1510       1520       1530       1540       1550       1560 
YAMRKERVWM VQTEQQYICI HQCLLAVLEG KENIVGPARE MHDNEGYEGQ QVQLDENGDV 

      1570       1580       1590       1600       1610       1620 
VATIEGHLSH HDLQQAEAEA IDDENAAILH DDQQPLTSSF TGHHTHMPPT TSMSSFGGGG 

      1630 
GGHTNVDAPD R 

« Hide

Isoform A (D) [UniParc].

Checksum: CC270682A42A60ED
Show »

FASTA1,962219,699
Isoform E (Short) [UniParc].

Checksum: 716C60806FDAC9DD
Show »

FASTA1,558177,366

References

« Hide 'large scale' references
[1]"Two Drosophila receptor-like tyrosine phosphatase genes are expressed in a subset of developing axons and pioneer neurons in the embryonic CNS."
Yang X., Seow K.T., Bahri S.M., Oon S.H., Chia W.
Cell 67:661-673(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS B AND E), FUNCTION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
Tissue: Embryo.
[2]"Three receptor-linked protein-tyrosine phosphatases are selectively expressed on central nervous system axons in the Drosophila embryo."
Tian S.-S., Tsoulfas P., Zinn K.
Cell 67:675-685(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM E), TISSUE SPECIFICITY.
Tissue: Embryo.
[3]"The genome sequence of Drosophila melanogaster."
Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. expand/collapse author list , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Berkeley.
[4]"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review."
Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. expand/collapse author list , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.
Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: GENOME REANNOTATION, ALTERNATIVE SPLICING.
Strain: Berkeley.
[5]Stapleton M., Brokstein P., Hong L., Agbayani A., Carlson J.W., Champe M., Chavez C., Dorsett V., Dresnek D., Farfan D., Frise E., George R.A., Gonzalez M., Guarin H., Kronmiller B., Li P.W., Liao G., Miranda A. expand/collapse author list , Mungall C.J., Nunoo J., Pacleb J.M., Paragas V., Park S., Patel S., Phouanenavong S., Wan K.H., Yu C., Lewis S.E., Rubin G.M., Celniker S.E.
Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM B).
Strain: Berkeley.
Tissue: Embryo.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M80465 mRNA. Translation: AAA28484.1.
M80538 mRNA. Translation: AAA28952.1.
AE014298 Genomic DNA. Translation: AAF48072.3.
AE014298 Genomic DNA. Translation: AAS65319.1.
AE014298 Genomic DNA. Translation: AAS65320.1.
AE014298 Genomic DNA. Translation: ACL82919.1.
BT004474 mRNA. Translation: AAO42638.1.
PIRC41214.
D41214.
RefSeqNP_001138187.1. NM_001144715.2.
NP_001259454.1. NM_001272525.1.
NP_727544.2. NM_167292.3.
NP_996413.2. NM_206690.2.
NP_996414.2. NM_206691.3.
UniGeneDm.7386.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
3S3EX-ray2.40A/B1250-1533[»]
3S3FX-ray2.70A/B1250-1533[»]
3S3HX-ray2.80A/B1250-1533[»]
3S3KX-ray3.20A/B1250-1533[»]
ProteinModelPortalP35992.
SMRP35992. Positions 1249-1531.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid58524. 4 interactions.
IntActP35992. 2 interactions.

Proteomic databases

PaxDbP35992.
PRIDEP35992.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaFBtr0073522; FBpp0073369; FBgn0004370.
GeneID32115.
KEGGdme:Dmel_CG1817.

Organism-specific databases

CTD32115.
FlyBaseFBgn0004370. Ptp10D.

Phylogenomic databases

eggNOGCOG5599.
GeneTreeENSGT00740000115043.
InParanoidP35992.
KOK01104.
OrthoDBEOG7PCJFZ.

Gene expression databases

BgeeP35992.

Family and domain databases

Gene3D2.60.40.10. 9 hits.
InterProIPR003961. Fibronectin_type3.
IPR013783. Ig-like_fold.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
IPR000242. Tyr_Pase_rcpt/non-rcpt.
[Graphical view]
PfamPF00041. fn3. 10 hits.
PF00102. Y_phosphatase. 1 hit.
[Graphical view]
PRINTSPR00700. PRTYPHPHTASE.
SMARTSM00060. FN3. 11 hits.
SM00194. PTPc. 1 hit.
[Graphical view]
SUPFAMSSF49265. SSF49265. 6 hits.
PROSITEPS50853. FN3. 9 hits.
PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSPtp10D. drosophila.
GenomeRNAi32115.
NextBio776913.
PROP35992.

Entry information

Entry namePTP10_DROME
AccessionPrimary (citable) accession number: P35992
Secondary accession number(s): A4V4B4 expand/collapse secondary AC list , B7Z142, Q0KHT5, Q86NN9, Q8IR87, Q9VYW1
Entry history
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: August 30, 2005
Last modified: February 19, 2014
This is version 127 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

Drosophila

Drosophila: entries, gene names and cross-references to FlyBase