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P35992

- PTP10_DROME

UniProt

P35992 - PTP10_DROME

Protein

Tyrosine-protein phosphatase 10D

Gene

Ptp10D

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 132 (01 Oct 2014)
      Sequence version 3 (30 Aug 2005)
      Previous versions | rss
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    Functioni

    May have a role in axon outgrowth and guidance.1 Publication

    Catalytic activityi

    Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei1436 – 14361SubstrateBy similarity
    Active sitei1468 – 14681Phosphocysteine intermediatePROSITE-ProRule annotation
    Binding sitei1512 – 15121SubstrateBy similarity

    GO - Molecular functioni

    1. phosphoprotein phosphatase activity Source: FlyBase
    2. protein tyrosine phosphatase activity Source: FlyBase
    3. transmembrane receptor protein tyrosine phosphatase activity Source: FlyBase

    GO - Biological processi

    1. axon guidance Source: FlyBase
    2. central nervous system development Source: FlyBase
    3. long-term memory Source: FlyBase
    4. motor neuron axon guidance Source: FlyBase
    5. open tracheal system development Source: FlyBase
    6. peptidyl-tyrosine dephosphorylation Source: GOC
    7. protein dephosphorylation Source: FlyBase

    Keywords - Molecular functioni

    Developmental protein, Hydrolase, Protein phosphatase

    Keywords - Biological processi

    Differentiation, Neurogenesis

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Tyrosine-protein phosphatase 10D (EC:3.1.3.48)
    Alternative name(s):
    Receptor-linked protein-tyrosine phosphatase 10D
    Short name:
    DPTP10D
    Gene namesi
    Name:Ptp10D
    ORF Names:CG1817
    OrganismiDrosophila melanogaster (Fruit fly)
    Taxonomic identifieri7227 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
    ProteomesiUP000000803: Chromosome X

    Organism-specific databases

    FlyBaseiFBgn0004370. Ptp10D.

    Subcellular locationi

    GO - Cellular componenti

    1. apical part of cell Source: FlyBase
    2. axon Source: FlyBase
    3. integral component of membrane Source: UniProtKB-KW
    4. plasma membrane Source: FlyBase

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 4242Sequence AnalysisAdd
    BLAST
    Chaini43 – 16311589Tyrosine-protein phosphatase 10DPRO_0000025427Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi75 – 751N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi106 – 1061N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi128 – 1281N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi169 – 1691N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi212 – 2121N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi229 – 2291N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi259 – 2591N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi289 – 2891N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi317 – 3171N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi471 – 4711N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi486 – 4861N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi512 – 5121N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi533 – 5331N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi588 – 5881N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi668 – 6681N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi687 – 6871N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi719 – 7191N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi723 – 7231N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi823 – 8231N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi841 – 8411N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi874 – 8741N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi908 – 9081N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi925 – 9251N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1001 – 10011N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1104 – 11041N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1136 – 11361N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1195 – 11951N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiP35992.
    PRIDEiP35992.

    Expressioni

    Tissue specificityi

    In 9-12 hour embryos, expression is specifically seen in the anterior commissure and its junctions with the longitudinal tracts.2 Publications

    Developmental stagei

    Expressed both maternally and zygotically. Expressed throughout development to adulthood, lowest expression is during second and third larval instars.1 Publication

    Gene expression databases

    BgeeiP35992.

    Interactioni

    Protein-protein interaction databases

    BioGridi58524. 4 interactions.
    IntActiP35992. 2 interactions.

    Structurei

    Secondary structure

    1
    1631
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi1254 – 12563
    Helixi1257 – 127721
    Turni1278 – 12858
    Helixi1290 – 12923
    Turni1294 – 12963
    Helixi1297 – 12993
    Helixi1309 – 13113
    Beta strandi1312 – 13143
    Turni1319 – 13213
    Turni1322 – 13254
    Beta strandi1326 – 13327
    Beta strandi1340 – 13445
    Helixi1349 – 13513
    Helixi1352 – 136110
    Beta strandi1366 – 13694
    Beta strandi1373 – 13753
    Beta strandi1387 – 13904
    Beta strandi1392 – 13943
    Beta strandi1397 – 140610
    Beta strandi1408 – 141912
    Beta strandi1422 – 143110
    Beta strandi1436 – 14383
    Helixi1444 – 145714
    Beta strandi1464 – 14674
    Beta strandi1469 – 14724
    Helixi1473 – 148715
    Turni1488 – 14903
    Beta strandi1492 – 14943
    Helixi1496 – 150611
    Helixi1514 – 152815

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3S3EX-ray2.40A/B1250-1533[»]
    3S3FX-ray2.70A/B1250-1533[»]
    3S3HX-ray2.80A/B1250-1533[»]
    3S3KX-ray3.20A/B1250-1533[»]
    ProteinModelPortaliP35992.
    SMRiP35992. Positions 1249-1531.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini43 – 11971155ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini1219 – 1631413CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei1198 – 121821HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini43 – 11977Fibronectin type-III 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini125 – 21894Fibronectin type-III 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini219 – 31496Fibronectin type-III 3PROSITE-ProRule annotationAdd
    BLAST
    Domaini309 – 40294Fibronectin type-III 4PROSITE-ProRule annotationAdd
    BLAST
    Domaini407 – 49892Fibronectin type-III 5PROSITE-ProRule annotationAdd
    BLAST
    Domaini499 – 58486Fibronectin type-III 6PROSITE-ProRule annotationAdd
    BLAST
    Domaini585 – 67490Fibronectin type-III 7PROSITE-ProRule annotationAdd
    BLAST
    Domaini675 – 77197Fibronectin type-III 8PROSITE-ProRule annotationAdd
    BLAST
    Domaini775 – 86591Fibronectin type-III 9PROSITE-ProRule annotationAdd
    BLAST
    Domaini866 – 95691Fibronectin type-III 10PROSITE-ProRule annotationAdd
    BLAST
    Domaini957 – 1057101Fibronectin type-III 11PROSITE-ProRule annotationAdd
    BLAST
    Domaini1049 – 1190142Fibronectin type-III 12PROSITE-ProRule annotationAdd
    BLAST
    Domaini1272 – 1527256Tyrosine-protein phosphatasePROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1468 – 14747Substrate bindingBy similarity

    Sequence similaritiesi

    Contains 12 fibronectin type-III domains.PROSITE-ProRule annotation
    Contains 1 tyrosine-protein phosphatase domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG5599.
    GeneTreeiENSGT00750000117631.
    InParanoidiP35992.
    KOiK05694.
    OrthoDBiEOG7PCJFZ.
    PhylomeDBiP35992.

    Family and domain databases

    Gene3Di2.60.40.10. 9 hits.
    3.90.190.10. 1 hit.
    InterProiIPR003961. Fibronectin_type3.
    IPR013783. Ig-like_fold.
    IPR029021. Prot-tyrosine_phosphatase-like.
    IPR000387. Tyr/Dual-sp_Pase.
    IPR016130. Tyr_Pase_AS.
    IPR000242. Tyr_Pase_rcpt/non-rcpt.
    [Graphical view]
    PfamiPF00041. fn3. 10 hits.
    PF00102. Y_phosphatase. 1 hit.
    [Graphical view]
    PRINTSiPR00700. PRTYPHPHTASE.
    SMARTiSM00060. FN3. 11 hits.
    SM00194. PTPc. 1 hit.
    [Graphical view]
    SUPFAMiSSF49265. SSF49265. 6 hits.
    SSF52799. SSF52799. 1 hit.
    PROSITEiPS50853. FN3. 9 hits.
    PS00383. TYR_PHOSPHATASE_1. 1 hit.
    PS50056. TYR_PHOSPHATASE_2. 1 hit.
    PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform B (identifier: P35992-1) [UniParc]FASTAAdd to Basket

    Also known as: Long

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MLYQLSKATT RIRLKRQKAV PQHRWLWSLA FLAAFTLKDV RCADLAISIP     50
    NNPGLDDGAS YRLDYSPPFG YPEPNTTIAS REIGDEIQFS RALPGTKYNF 100
    WLYYTNFTHH DWLTWTVTIT TAPDPPSNLS VQVRSGKNAI ILWSPPTQGS 150
    YTAFKIKVLG LSEASSSYNR TFQVNDNTFQ HSVKELTPGA TYQVQAYTIY 200
    DGKESVAYTS RNFTTKPNTP GKFIVWFRNE TTLLVLWQPP YPAGIYTHYK 250
    VSIEPPDAND SVLYVEKEGE PPGPAQAAFK GLVPGRAYNI SVQTMSEDEI 300
    SLPTTAQYRT VPLRPLNVTF DRDFITSNSF RVLWEAPKGI SEFDKYQVSV 350
    ATTRRQSTVP RSNEPVAFFD FRDIAEPGKT FNVIVKTVSG KVTSWPATGD 400
    VTLRPLPVRN LRSINDDKTN TMIITWEADP ASTQDEYRIV YHELETFNGD 450
    TSTLTTDRTR FTLESLLPGR NYSLSVQAVS KKMESNETSI FVVTRPSSPI 500
    IEDLKSIRMG LNISWKSDVN SKQEQYEVLY SRNGTSDLRT QKTKESRLVI 550
    KNLQPGAGYE LKVFAVSHDL RSEPHAYFQA VYPNPPRNMT IETVRSNSVL 600
    VHWSPPESGE FTEYSIRYRT DSEQQWVRLP SVRSTEADIT DMTKGEKYTI 650
    QVNTVSFGVE SPVPQEVNTT VPPNPVSNII QLVDSRNITL EWPKPEGRVE 700
    SYILKWWPSD NPGRVQTKNV SENKSADDLS TVRVLIGELM PGVQYKFDIQ 750
    TTSYGILSGI TSLYPRTMPL IQSDVVVANG EKEDERDTIT LSYTPTPQSS 800
    SKFDIYRFSL GDAEIRDKEK LANDTDRKVT FTGLVPGRLY NITVWTVSGG 850
    VASLPIQRQD RLYPEPITQL HATNITDTEI SLRWDLPKGE YNDFDIAYLT 900
    ADNLLAQNMT TRNEITISDL RPHRNYTFTV VVRSGTESSV LRSSSPLSAS 950
    FTTNEAVPGR VERFHPTDVQ PSEINFEWSL PSSEANGVIR QFSIAYTNIN 1000
    NLTDAGMQDF ESEEAFGVIK NLKPGETYVF KIQAKTAIGF GPEREYRQTM 1050
    PILAPPRPAT QVVPTEVYRS SSTIQIRFRK NYFSDQNGQV RMYTIIVAED 1100
    DAKNASGLEM PSWLDVQSYS VWLPYQAIDP YYPFENRSVE DFTIGTENCD 1150
    NHKIGYCNGP LKSGTTYRVK VRAFTGADKF TDTAYSFPIQ TDQDNTSLIV 1200
    AITVPLTIIL VLLVTLLFYK RRRNNCRKTT KDSRANDNMS LPDSVIEQNR 1250
    PILIKNFAEH YRLMSADSDF RFSEEFEELK HVGRDQPCTF ADLPCNRPKN 1300
    RFTNILPYDH SRFKLQPVDD DEGSDYINAN YVPGHNSPRE FIVTQGPLHS 1350
    TRDDFWRMCW ESNSRAIVML TRCFEKGREK CDQYWPNDTV PVFYGDIKVQ 1400
    ILNDSHYADW VMTEFMLCRG SEQRILRHFH FTTWPDFGVP NPPQTLVRFV 1450
    RAFRDRIGAE QRPIVVHCSA GVGRSGTFIT LDRILQQINT SDYVDIFGIV 1500
    YAMRKERVWM VQTEQQYICI HQCLLAVLEG KENIVGPARE MHDNEGYEGQ 1550
    QVQLDENGDV VATIEGHLSH HDLQQAEAEA IDDENAAILH DDQQPLTSSF 1600
    TGHHTHMPPT TSMSSFGGGG GGHTNVDAPD R 1631
    Length:1,631
    Mass (Da):185,081
    Last modified:August 30, 2005 - v3
    Checksum:i22A59AB61665875D
    GO
    Isoform A (identifier: P35992-3) [UniParc]FASTAAdd to Basket

    Also known as: D

    The sequence of this isoform differs from the canonical sequence as follows:
         1626-1631: VDAPDR → PSSMICKDSK...DDEGIAESGM

    Note: No experimental confirmation available.

    Show »
    Length:1,962
    Mass (Da):219,699
    Checksum:iCC270682A42A60ED
    GO
    Isoform E (identifier: P35992-2) [UniParc]FASTAAdd to Basket

    Also known as: Short

    The sequence of this isoform differs from the canonical sequence as follows:
         1549-1558: GQQVQLDENG → DDEGIAESGM
         1559-1631: Missing.

    Show »
    Length:1,558
    Mass (Da):177,366
    Checksum:i716C60806FDAC9DD
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti124 – 1241D → I in AAA28484. (PubMed:1657401)Curated
    Sequence conflicti127 – 1271S → L in AAA28484. (PubMed:1657401)Curated
    Sequence conflicti188 – 1881P → L in AAO42638. 1 PublicationCurated
    Sequence conflicti369 – 3691F → S in AAA28484. (PubMed:1657401)Curated
    Sequence conflicti369 – 3691F → S in AAA28952. (PubMed:1657402)Curated
    Sequence conflicti558 – 5581G → A in AAA28484. (PubMed:1657401)Curated
    Sequence conflicti558 – 5581G → A in AAA28952. (PubMed:1657402)Curated
    Sequence conflicti810 – 8101L → S in AAA28484. (PubMed:1657401)Curated
    Sequence conflicti810 – 8101L → S in AAA28952. (PubMed:1657402)Curated
    Sequence conflicti1403 – 14031N → S in AAO42638. 1 PublicationCurated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1549 – 155810GQQVQLDENG → DDEGIAESGM in isoform E. 2 PublicationsVSP_005143
    Alternative sequencei1559 – 163173Missing in isoform E. 2 PublicationsVSP_005144Add
    BLAST
    Alternative sequencei1626 – 16316VDAPDR → PSSMICKDSKGGNIDVLESQ QQQQQQQQQQPNQGGHNITT ISAINGYNTLQHRRKSQLIT FSSSSCDIKNSLSHEYINGS NGSAANGPPSSGSGSGSGPG SNRASRANVRLSFAEEDVMI LPQNHSQQSNHQDDEVFTRR RSLLEVEIGVEVGEDGELAP HEMEEDLEEEDEDEELYMHD EFETHIDTKSNNANDDSGGG SYEDSHALHSSLGGSNRNSL EKDDDDIEVDVISTDVSCYD QLLGSSCNTRNGDDDDIATL VGDGDYSTTKLSKASRLSGA GVGGLVVSGGGGGTAIGGGI AVNGGGVLGNGVGSEAGGGI IYANPFMDDEGIAESGM in isoform A. CuratedVSP_015266

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M80465 mRNA. Translation: AAA28484.1.
    M80538 mRNA. Translation: AAA28952.1.
    AE014298 Genomic DNA. Translation: AAF48072.3.
    AE014298 Genomic DNA. Translation: AAS65319.1.
    AE014298 Genomic DNA. Translation: AAS65320.1.
    AE014298 Genomic DNA. Translation: ACL82919.1.
    BT004474 mRNA. Translation: AAO42638.1.
    PIRiC41214.
    D41214.
    RefSeqiNP_001138187.1. NM_001144715.2. [P35992-2]
    NP_001259454.1. NM_001272525.1. [P35992-2]
    NP_727544.2. NM_167292.3. [P35992-1]
    NP_996413.2. NM_206690.2.
    NP_996414.2. NM_206691.3.
    UniGeneiDm.7386.

    Genome annotation databases

    EnsemblMetazoaiFBtr0073522; FBpp0073369; FBgn0004370. [P35992-1]
    GeneIDi32115.
    KEGGidme:Dmel_CG1817.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M80465 mRNA. Translation: AAA28484.1 .
    M80538 mRNA. Translation: AAA28952.1 .
    AE014298 Genomic DNA. Translation: AAF48072.3 .
    AE014298 Genomic DNA. Translation: AAS65319.1 .
    AE014298 Genomic DNA. Translation: AAS65320.1 .
    AE014298 Genomic DNA. Translation: ACL82919.1 .
    BT004474 mRNA. Translation: AAO42638.1 .
    PIRi C41214.
    D41214.
    RefSeqi NP_001138187.1. NM_001144715.2. [P35992-2 ]
    NP_001259454.1. NM_001272525.1. [P35992-2 ]
    NP_727544.2. NM_167292.3. [P35992-1 ]
    NP_996413.2. NM_206690.2.
    NP_996414.2. NM_206691.3.
    UniGenei Dm.7386.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3S3E X-ray 2.40 A/B 1250-1533 [» ]
    3S3F X-ray 2.70 A/B 1250-1533 [» ]
    3S3H X-ray 2.80 A/B 1250-1533 [» ]
    3S3K X-ray 3.20 A/B 1250-1533 [» ]
    ProteinModelPortali P35992.
    SMRi P35992. Positions 1249-1531.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 58524. 4 interactions.
    IntActi P35992. 2 interactions.

    Proteomic databases

    PaxDbi P35992.
    PRIDEi P35992.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai FBtr0073522 ; FBpp0073369 ; FBgn0004370 . [P35992-1 ]
    GeneIDi 32115.
    KEGGi dme:Dmel_CG1817.

    Organism-specific databases

    CTDi 32115.
    FlyBasei FBgn0004370. Ptp10D.

    Phylogenomic databases

    eggNOGi COG5599.
    GeneTreei ENSGT00750000117631.
    InParanoidi P35992.
    KOi K05694.
    OrthoDBi EOG7PCJFZ.
    PhylomeDBi P35992.

    Miscellaneous databases

    ChiTaRSi Ptp10D. drosophila.
    GenomeRNAii 32115.
    NextBioi 776913.
    PROi P35992.

    Gene expression databases

    Bgeei P35992.

    Family and domain databases

    Gene3Di 2.60.40.10. 9 hits.
    3.90.190.10. 1 hit.
    InterProi IPR003961. Fibronectin_type3.
    IPR013783. Ig-like_fold.
    IPR029021. Prot-tyrosine_phosphatase-like.
    IPR000387. Tyr/Dual-sp_Pase.
    IPR016130. Tyr_Pase_AS.
    IPR000242. Tyr_Pase_rcpt/non-rcpt.
    [Graphical view ]
    Pfami PF00041. fn3. 10 hits.
    PF00102. Y_phosphatase. 1 hit.
    [Graphical view ]
    PRINTSi PR00700. PRTYPHPHTASE.
    SMARTi SM00060. FN3. 11 hits.
    SM00194. PTPc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49265. SSF49265. 6 hits.
    SSF52799. SSF52799. 1 hit.
    PROSITEi PS50853. FN3. 9 hits.
    PS00383. TYR_PHOSPHATASE_1. 1 hit.
    PS50056. TYR_PHOSPHATASE_2. 1 hit.
    PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Two Drosophila receptor-like tyrosine phosphatase genes are expressed in a subset of developing axons and pioneer neurons in the embryonic CNS."
      Yang X., Seow K.T., Bahri S.M., Oon S.H., Chia W.
      Cell 67:661-673(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS B AND E), FUNCTION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
      Tissue: Embryo.
    2. "Three receptor-linked protein-tyrosine phosphatases are selectively expressed on central nervous system axons in the Drosophila embryo."
      Tian S.-S., Tsoulfas P., Zinn K.
      Cell 67:675-685(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM E), TISSUE SPECIFICITY.
      Tissue: Embryo.
    3. "The genome sequence of Drosophila melanogaster."
      Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
      , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
      Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Berkeley.
    4. Cited for: GENOME REANNOTATION, ALTERNATIVE SPLICING.
      Strain: Berkeley.
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM B).
      Strain: Berkeley.
      Tissue: Embryo.

    Entry informationi

    Entry nameiPTP10_DROME
    AccessioniPrimary (citable) accession number: P35992
    Secondary accession number(s): A4V4B4
    , B7Z142, Q0KHT5, Q86NN9, Q8IR87, Q9VYW1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 1, 1994
    Last sequence update: August 30, 2005
    Last modified: October 1, 2014
    This is version 132 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programDrosophila annotation project

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Drosophila
      Drosophila: entries, gene names and cross-references to FlyBase
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3