P35992 (PTP10_DROME) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Tyrosine-protein phosphatase 10D
EC=3.1.3.48

Alternative name(s):
Receptor-linked protein-tyrosine phosphatase 10D
Short name=DPTP10D

Gene names

Name:	Ptp10D
ORF Names:	CG1817

Organism

Drosophila melanogaster (Fruit fly) [Reference proteome]

Taxonomic identifier

7227 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Protostomia › Ecdysozoa › Panarthropoda › Arthropoda › Mandibulata › Pancrustacea › Hexapoda › Insecta › Dicondylia › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Eremoneura › Cyclorrhapha › Schizophora › Acalyptratae › Ephydroidea › Drosophilidae › Drosophilinae › Drosophilini › Drosophilina › Drosophiliti › Drosophila › Sophophora › melanogaster group › melanogaster subgroup

Protein attributes

Sequence length	1631 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May have a role in axon outgrowth and guidance. Ref.1
Catalytic activity	Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.
Subcellular location	Membrane; Single-pass type I membrane protein.
Tissue specificity	In 9-12 hour embryos, expression is specifically seen in the anterior commissure and its junctions with the longitudinal tracts. Ref.1 Ref.2
Developmental stage	Expressed both maternally and zygotically. Expressed throughout development to adulthood, lowest expression is during second and third larval instars. Ref.1
Sequence similarities	Belongs to the protein-tyrosine phosphatase family. Receptor class subfamily. Contains 12 fibronectin type-III domains. Contains 1 tyrosine-protein phosphatase domain.

Ontologies

Keywords
Biological process	Differentiation Neurogenesis
Cellular component	Membrane
Coding sequence diversity	Alternative splicing
Domain	Repeat Signal Transmembrane Transmembrane helix
Molecular function	Developmental protein Hydrolase Protein phosphatase
PTM	Glycoprotein
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	central nervous system development Inferred from genetic interaction PubMed 18237413. Source: FlyBase long-term memory Inferred from mutant phenotype PubMed 17442824. Source: FlyBase motor neuron axon guidance Inferred from genetic interaction PubMed 11178866PubMed 18237413. Source: FlyBase open tracheal system development Inferred from genetic interaction PubMed 18237413. Source: FlyBase
Cellular_component	apical part of cell Inferred from direct assay PubMed 19675131. Source: FlyBase axon Inferred from direct assay PubMed 18237413. Source: FlyBase integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from sequence or structural similarity Ref.1Ref.2. Source: FlyBase
Molecular_function	transmembrane receptor protein tyrosine phosphatase activity Inferred from sequence or structural similarity Ref.1. Source: FlyBase
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform B (identifier: P35992-1)

Also known as: Long;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform A (identifier: P35992-3)

Also known as: D;

The sequence of this isoform differs from the canonical sequence as follows:
     1626-1631: VDAPDR → PSSMICKDSK...DDEGIAESGM

Note: No experimental confirmation available.

Isoform E (identifier: P35992-2)

Also known as: Short;

The sequence of this isoform differs from the canonical sequence as follows:
     1549-1558: GQQVQLDENG → DDEGIAESGM
     1559-1631: Missing.

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

1 – 42

42

Potential

Chain

43 – 1631

1589

Tyrosine-protein phosphatase 10D

PRO_0000025427

Regions

Topological domain

43 – 1197

1155

Extracellular Potential

Transmembrane

1198 – 1218

21

Helical; Potential

Topological domain

1219 – 1631

413

Cytoplasmic Potential

Domain

43 – 119

77

Fibronectin type-III 1

Domain

120 – 214

95

Fibronectin type-III 2

Domain

215 – 308

94

Fibronectin type-III 3

Domain

309 – 402

94

Fibronectin type-III 4

Domain

403 – 493

91

Fibronectin type-III 5

Domain

494 – 580

87

Fibronectin type-III 6

Domain

581 – 669

89

Fibronectin type-III 7

Domain

670 – 766

97

Fibronectin type-III 8

Domain

767 – 861

95

Fibronectin type-III 9

Domain

862 – 955

94

Fibronectin type-III 10

Domain

956 – 1048

93

Fibronectin type-III 11

Domain

1049 – 1190

142

Fibronectin type-III 12

Domain

1272 – 1527

256

Tyrosine-protein phosphatase

Region

1468 – 1474

7

Substrate binding By similarity

Sites

Active site

1468

1

Phosphocysteine intermediate By similarity

Binding site

1436

1

Substrate By similarity

Binding site

1512

1

Substrate By similarity

Amino acid modifications

Glycosylation

75

1

N-linked (GlcNAc...) Potential

Glycosylation

106

1

N-linked (GlcNAc...) Potential

Glycosylation

128

1

N-linked (GlcNAc...) Potential

Glycosylation

169

1

N-linked (GlcNAc...) Potential

Glycosylation

212

1

N-linked (GlcNAc...) Potential

Glycosylation

229

1

N-linked (GlcNAc...) Potential

Glycosylation

259

1

N-linked (GlcNAc...) Potential

Glycosylation

289

1

N-linked (GlcNAc...) Potential

Glycosylation

317

1

N-linked (GlcNAc...) Potential

Glycosylation

471

1

N-linked (GlcNAc...) Potential

Glycosylation

486

1

N-linked (GlcNAc...) Potential

Glycosylation

512

1

N-linked (GlcNAc...) Potential

Glycosylation

533

1

N-linked (GlcNAc...) Potential

Glycosylation

588

1

N-linked (GlcNAc...) Potential

Glycosylation

668

1

N-linked (GlcNAc...) Potential

Glycosylation

687

1

N-linked (GlcNAc...) Potential

Glycosylation

719

1

N-linked (GlcNAc...) Potential

Glycosylation

723

1

N-linked (GlcNAc...) Potential

Glycosylation

823

1

N-linked (GlcNAc...) Potential

Glycosylation

841

1

N-linked (GlcNAc...) Potential

Glycosylation

874

1

N-linked (GlcNAc...) Potential

Glycosylation

908

1

N-linked (GlcNAc...) Potential

Glycosylation

925

1

N-linked (GlcNAc...) Potential

Glycosylation

1001

1

N-linked (GlcNAc...) Potential

Glycosylation

1104

1

N-linked (GlcNAc...) Potential

Glycosylation

1136

1

N-linked (GlcNAc...) Potential

Glycosylation

1195

1

N-linked (GlcNAc...) Potential

Natural variations

Alternative sequence

1549 – 1558

10

GQQVQLDENG → DDEGIAESGM in isoform E.

VSP_005143

Alternative sequence

1559 – 1631

73

Missing in isoform E.

VSP_005144

Alternative sequence

1626 – 1631

6

VDAPDR → PSSMICKDSKGGNIDVLESQ QQQQQQQQQQPNQGGHNITT ISAINGYNTLQHRRKSQLIT FSSSSCDIKNSLSHEYINGS NGSAANGPPSSGSGSGSGPG SNRASRANVRLSFAEEDVMI LPQNHSQQSNHQDDEVFTRR RSLLEVEIGVEVGEDGELAP HEMEEDLEEEDEDEELYMHD EFETHIDTKSNNANDDSGGG SYEDSHALHSSLGGSNRNSL EKDDDDIEVDVISTDVSCYD QLLGSSCNTRNGDDDDIATL VGDGDYSTTKLSKASRLSGA GVGGLVVSGGGGGTAIGGGI AVNGGGVLGNGVGSEAGGGI IYANPFMDDEGIAESGM in isoform A.

VSP_015266

Experimental info

Sequence conflict

124

1

D → I in AAA28484. Ref.1

Sequence conflict

127

1

S → L in AAA28484. Ref.1

Sequence conflict

188

1

P → L in AAO42638. Ref.5

Sequence conflict

369

1

F → S in AAA28484. Ref.1

Sequence conflict

369

1

F → S in AAA28952. Ref.2

Sequence conflict

558

1

G → A in AAA28484. Ref.1

Sequence conflict

558

1

G → A in AAA28952. Ref.2

Sequence conflict

810

1

L → S in AAA28484. Ref.1

Sequence conflict

810

1

L → S in AAA28952. Ref.2

Sequence conflict

1403

1

N → S in AAO42638. Ref.5

Secondary structure

1

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

1631

Helix Strand Turn

Details...

Helix

1254 – 1256

3

Helix

1257 – 1277

21

Turn

1278 – 1285

8

Helix

1290 – 1292

3

Turn

1294 – 1296

3

Helix

1297 – 1299

3

Helix

1309 – 1311

3

Beta strand

1312 – 1314

3

Turn

1319 – 1321

3

Turn

1322 – 1325

4

Beta strand

1326 – 1332

7

Beta strand

1340 – 1344

5

Helix

1349 – 1351

3

Helix

1352 – 1361

10

Beta strand

1366 – 1369

4

Beta strand

1373 – 1375

3

Beta strand

1387 – 1390

4

Beta strand

1392 – 1394

3

Beta strand

1397 – 1406

10

Beta strand

1408 – 1419

12

Beta strand

1422 – 1431

10

Beta strand

1436 – 1438

3

Helix

1444 – 1457

14

Beta strand

1464 – 1467

4

Beta strand

1469 – 1472

4

Helix

1473 – 1487

15

Turn

1488 – 1490

3

Beta strand

1492 – 1494

3

Helix

1496 – 1506

11

Helix

1514 – 1528

15

Sequences

	Sequence		Length	Mass (Da)
	Isoform B (Long) [UniParc]. Last modified August 30, 2005. Version 3. Checksum: 22A59AB61665875D	FASTA	1,631	185,081
	10 20 30 40 50 60 MLYQLSKATT RIRLKRQKAV PQHRWLWSLA FLAAFTLKDV RCADLAISIP NNPGLDDGAS 70 80 90 100 110 120 YRLDYSPPFG YPEPNTTIAS REIGDEIQFS RALPGTKYNF WLYYTNFTHH DWLTWTVTIT 130 140 150 160 170 180 TAPDPPSNLS VQVRSGKNAI ILWSPPTQGS YTAFKIKVLG LSEASSSYNR TFQVNDNTFQ 190 200 210 220 230 240 HSVKELTPGA TYQVQAYTIY DGKESVAYTS RNFTTKPNTP GKFIVWFRNE TTLLVLWQPP 250 260 270 280 290 300 YPAGIYTHYK VSIEPPDAND SVLYVEKEGE PPGPAQAAFK GLVPGRAYNI SVQTMSEDEI 310 320 330 340 350 360 SLPTTAQYRT VPLRPLNVTF DRDFITSNSF RVLWEAPKGI SEFDKYQVSV ATTRRQSTVP 370 380 390 400 410 420 RSNEPVAFFD FRDIAEPGKT FNVIVKTVSG KVTSWPATGD VTLRPLPVRN LRSINDDKTN 430 440 450 460 470 480 TMIITWEADP ASTQDEYRIV YHELETFNGD TSTLTTDRTR FTLESLLPGR NYSLSVQAVS 490 500 510 520 530 540 KKMESNETSI FVVTRPSSPI IEDLKSIRMG LNISWKSDVN SKQEQYEVLY SRNGTSDLRT 550 560 570 580 590 600 QKTKESRLVI KNLQPGAGYE LKVFAVSHDL RSEPHAYFQA VYPNPPRNMT IETVRSNSVL 610 620 630 640 650 660 VHWSPPESGE FTEYSIRYRT DSEQQWVRLP SVRSTEADIT DMTKGEKYTI QVNTVSFGVE 670 680 690 700 710 720 SPVPQEVNTT VPPNPVSNII QLVDSRNITL EWPKPEGRVE SYILKWWPSD NPGRVQTKNV 730 740 750 760 770 780 SENKSADDLS TVRVLIGELM PGVQYKFDIQ TTSYGILSGI TSLYPRTMPL IQSDVVVANG 790 800 810 820 830 840 EKEDERDTIT LSYTPTPQSS SKFDIYRFSL GDAEIRDKEK LANDTDRKVT FTGLVPGRLY 850 860 870 880 890 900 NITVWTVSGG VASLPIQRQD RLYPEPITQL HATNITDTEI SLRWDLPKGE YNDFDIAYLT 910 920 930 940 950 960 ADNLLAQNMT TRNEITISDL RPHRNYTFTV VVRSGTESSV LRSSSPLSAS FTTNEAVPGR 970 980 990 1000 1010 1020 VERFHPTDVQ PSEINFEWSL PSSEANGVIR QFSIAYTNIN NLTDAGMQDF ESEEAFGVIK 1030 1040 1050 1060 1070 1080 NLKPGETYVF KIQAKTAIGF GPEREYRQTM PILAPPRPAT QVVPTEVYRS SSTIQIRFRK 1090 1100 1110 1120 1130 1140 NYFSDQNGQV RMYTIIVAED DAKNASGLEM PSWLDVQSYS VWLPYQAIDP YYPFENRSVE 1150 1160 1170 1180 1190 1200 DFTIGTENCD NHKIGYCNGP LKSGTTYRVK VRAFTGADKF TDTAYSFPIQ TDQDNTSLIV 1210 1220 1230 1240 1250 1260 AITVPLTIIL VLLVTLLFYK RRRNNCRKTT KDSRANDNMS LPDSVIEQNR PILIKNFAEH 1270 1280 1290 1300 1310 1320 YRLMSADSDF RFSEEFEELK HVGRDQPCTF ADLPCNRPKN RFTNILPYDH SRFKLQPVDD 1330 1340 1350 1360 1370 1380 DEGSDYINAN YVPGHNSPRE FIVTQGPLHS TRDDFWRMCW ESNSRAIVML TRCFEKGREK 1390 1400 1410 1420 1430 1440 CDQYWPNDTV PVFYGDIKVQ ILNDSHYADW VMTEFMLCRG SEQRILRHFH FTTWPDFGVP 1450 1460 1470 1480 1490 1500 NPPQTLVRFV RAFRDRIGAE QRPIVVHCSA GVGRSGTFIT LDRILQQINT SDYVDIFGIV 1510 1520 1530 1540 1550 1560 YAMRKERVWM VQTEQQYICI HQCLLAVLEG KENIVGPARE MHDNEGYEGQ QVQLDENGDV 1570 1580 1590 1600 1610 1620 VATIEGHLSH HDLQQAEAEA IDDENAAILH DDQQPLTSSF TGHHTHMPPT TSMSSFGGGG 1630 GGHTNVDAPD R
	Isoform A (D) [UniParc]. Checksum: CC270682A42A60ED	FASTA	1,962	219,699
	10 20 30 40 50 60 MLYQLSKATT RIRLKRQKAV PQHRWLWSLA FLAAFTLKDV RCADLAISIP NNPGLDDGAS 70 80 90 100 110 120 YRLDYSPPFG YPEPNTTIAS REIGDEIQFS RALPGTKYNF WLYYTNFTHH DWLTWTVTIT 130 140 150 160 170 180 TAPDPPSNLS VQVRSGKNAI ILWSPPTQGS YTAFKIKVLG LSEASSSYNR TFQVNDNTFQ 190 200 210 220 230 240 HSVKELTPGA TYQVQAYTIY DGKESVAYTS RNFTTKPNTP GKFIVWFRNE TTLLVLWQPP 250 260 270 280 290 300 YPAGIYTHYK VSIEPPDAND SVLYVEKEGE PPGPAQAAFK GLVPGRAYNI SVQTMSEDEI 310 320 330 340 350 360 SLPTTAQYRT VPLRPLNVTF DRDFITSNSF RVLWEAPKGI SEFDKYQVSV ATTRRQSTVP 370 380 390 400 410 420 RSNEPVAFFD FRDIAEPGKT FNVIVKTVSG KVTSWPATGD VTLRPLPVRN LRSINDDKTN 430 440 450 460 470 480 TMIITWEADP ASTQDEYRIV YHELETFNGD TSTLTTDRTR FTLESLLPGR NYSLSVQAVS 490 500 510 520 530 540 KKMESNETSI FVVTRPSSPI IEDLKSIRMG LNISWKSDVN SKQEQYEVLY SRNGTSDLRT 550 560 570 580 590 600 QKTKESRLVI KNLQPGAGYE LKVFAVSHDL RSEPHAYFQA VYPNPPRNMT IETVRSNSVL 610 620 630 640 650 660 VHWSPPESGE FTEYSIRYRT DSEQQWVRLP SVRSTEADIT DMTKGEKYTI QVNTVSFGVE 670 680 690 700 710 720 SPVPQEVNTT VPPNPVSNII QLVDSRNITL EWPKPEGRVE SYILKWWPSD NPGRVQTKNV 730 740 750 760 770 780 SENKSADDLS TVRVLIGELM PGVQYKFDIQ TTSYGILSGI TSLYPRTMPL IQSDVVVANG 790 800 810 820 830 840 EKEDERDTIT LSYTPTPQSS SKFDIYRFSL GDAEIRDKEK LANDTDRKVT FTGLVPGRLY 850 860 870 880 890 900 NITVWTVSGG VASLPIQRQD RLYPEPITQL HATNITDTEI SLRWDLPKGE YNDFDIAYLT 910 920 930 940 950 960 ADNLLAQNMT TRNEITISDL RPHRNYTFTV VVRSGTESSV LRSSSPLSAS FTTNEAVPGR 970 980 990 1000 1010 1020 VERFHPTDVQ PSEINFEWSL PSSEANGVIR QFSIAYTNIN NLTDAGMQDF ESEEAFGVIK 1030 1040 1050 1060 1070 1080 NLKPGETYVF KIQAKTAIGF GPEREYRQTM PILAPPRPAT QVVPTEVYRS SSTIQIRFRK 1090 1100 1110 1120 1130 1140 NYFSDQNGQV RMYTIIVAED DAKNASGLEM PSWLDVQSYS VWLPYQAIDP YYPFENRSVE 1150 1160 1170 1180 1190 1200 DFTIGTENCD NHKIGYCNGP LKSGTTYRVK VRAFTGADKF TDTAYSFPIQ TDQDNTSLIV 1210 1220 1230 1240 1250 1260 AITVPLTIIL VLLVTLLFYK RRRNNCRKTT KDSRANDNMS LPDSVIEQNR PILIKNFAEH 1270 1280 1290 1300 1310 1320 YRLMSADSDF RFSEEFEELK HVGRDQPCTF ADLPCNRPKN RFTNILPYDH SRFKLQPVDD 1330 1340 1350 1360 1370 1380 DEGSDYINAN YVPGHNSPRE FIVTQGPLHS TRDDFWRMCW ESNSRAIVML TRCFEKGREK 1390 1400 1410 1420 1430 1440 CDQYWPNDTV PVFYGDIKVQ ILNDSHYADW VMTEFMLCRG SEQRILRHFH FTTWPDFGVP 1450 1460 1470 1480 1490 1500 NPPQTLVRFV RAFRDRIGAE QRPIVVHCSA GVGRSGTFIT LDRILQQINT SDYVDIFGIV 1510 1520 1530 1540 1550 1560 YAMRKERVWM VQTEQQYICI HQCLLAVLEG KENIVGPARE MHDNEGYEGQ QVQLDENGDV 1570 1580 1590 1600 1610 1620 VATIEGHLSH HDLQQAEAEA IDDENAAILH DDQQPLTSSF TGHHTHMPPT TSMSSFGGGG 1630 1640 1650 1660 1670 1680 GGHTNPSSMI CKDSKGGNID VLESQQQQQQ QQQQQPNQGG HNITTISAIN GYNTLQHRRK 1690 1700 1710 1720 1730 1740 SQLITFSSSS CDIKNSLSHE YINGSNGSAA NGPPSSGSGS GSGPGSNRAS RANVRLSFAE 1750 1760 1770 1780 1790 1800 EDVMILPQNH SQQSNHQDDE VFTRRRSLLE VEIGVEVGED GELAPHEMEE DLEEEDEDEE 1810 1820 1830 1840 1850 1860 LYMHDEFETH IDTKSNNAND DSGGGSYEDS HALHSSLGGS NRNSLEKDDD DIEVDVISTD 1870 1880 1890 1900 1910 1920 VSCYDQLLGS SCNTRNGDDD DIATLVGDGD YSTTKLSKAS RLSGAGVGGL VVSGGGGGTA 1930 1940 1950 1960 IGGGIAVNGG GVLGNGVGSE AGGGIIYANP FMDDEGIAES GM
	Isoform E (Short) [UniParc]. Checksum: 716C60806FDAC9DD	FASTA	1,558	177,366
	10 20 30 40 50 60 MLYQLSKATT RIRLKRQKAV PQHRWLWSLA FLAAFTLKDV RCADLAISIP NNPGLDDGAS 70 80 90 100 110 120 YRLDYSPPFG YPEPNTTIAS REIGDEIQFS RALPGTKYNF WLYYTNFTHH DWLTWTVTIT 130 140 150 160 170 180 TAPDPPSNLS VQVRSGKNAI ILWSPPTQGS YTAFKIKVLG LSEASSSYNR TFQVNDNTFQ 190 200 210 220 230 240 HSVKELTPGA TYQVQAYTIY DGKESVAYTS RNFTTKPNTP GKFIVWFRNE TTLLVLWQPP 250 260 270 280 290 300 YPAGIYTHYK VSIEPPDAND SVLYVEKEGE PPGPAQAAFK GLVPGRAYNI SVQTMSEDEI 310 320 330 340 350 360 SLPTTAQYRT VPLRPLNVTF DRDFITSNSF RVLWEAPKGI SEFDKYQVSV ATTRRQSTVP 370 380 390 400 410 420 RSNEPVAFFD FRDIAEPGKT FNVIVKTVSG KVTSWPATGD VTLRPLPVRN LRSINDDKTN 430 440 450 460 470 480 TMIITWEADP ASTQDEYRIV YHELETFNGD TSTLTTDRTR FTLESLLPGR NYSLSVQAVS 490 500 510 520 530 540 KKMESNETSI FVVTRPSSPI IEDLKSIRMG LNISWKSDVN SKQEQYEVLY SRNGTSDLRT 550 560 570 580 590 600 QKTKESRLVI KNLQPGAGYE LKVFAVSHDL RSEPHAYFQA VYPNPPRNMT IETVRSNSVL 610 620 630 640 650 660 VHWSPPESGE FTEYSIRYRT DSEQQWVRLP SVRSTEADIT DMTKGEKYTI QVNTVSFGVE 670 680 690 700 710 720 SPVPQEVNTT VPPNPVSNII QLVDSRNITL EWPKPEGRVE SYILKWWPSD NPGRVQTKNV 730 740 750 760 770 780 SENKSADDLS TVRVLIGELM PGVQYKFDIQ TTSYGILSGI TSLYPRTMPL IQSDVVVANG 790 800 810 820 830 840 EKEDERDTIT LSYTPTPQSS SKFDIYRFSL GDAEIRDKEK LANDTDRKVT FTGLVPGRLY 850 860 870 880 890 900 NITVWTVSGG VASLPIQRQD RLYPEPITQL HATNITDTEI SLRWDLPKGE YNDFDIAYLT 910 920 930 940 950 960 ADNLLAQNMT TRNEITISDL RPHRNYTFTV VVRSGTESSV LRSSSPLSAS FTTNEAVPGR 970 980 990 1000 1010 1020 VERFHPTDVQ PSEINFEWSL PSSEANGVIR QFSIAYTNIN NLTDAGMQDF ESEEAFGVIK 1030 1040 1050 1060 1070 1080 NLKPGETYVF KIQAKTAIGF GPEREYRQTM PILAPPRPAT QVVPTEVYRS SSTIQIRFRK 1090 1100 1110 1120 1130 1140 NYFSDQNGQV RMYTIIVAED DAKNASGLEM PSWLDVQSYS VWLPYQAIDP YYPFENRSVE 1150 1160 1170 1180 1190 1200 DFTIGTENCD NHKIGYCNGP LKSGTTYRVK VRAFTGADKF TDTAYSFPIQ TDQDNTSLIV 1210 1220 1230 1240 1250 1260 AITVPLTIIL VLLVTLLFYK RRRNNCRKTT KDSRANDNMS LPDSVIEQNR PILIKNFAEH 1270 1280 1290 1300 1310 1320 YRLMSADSDF RFSEEFEELK HVGRDQPCTF ADLPCNRPKN RFTNILPYDH SRFKLQPVDD 1330 1340 1350 1360 1370 1380 DEGSDYINAN YVPGHNSPRE FIVTQGPLHS TRDDFWRMCW ESNSRAIVML TRCFEKGREK 1390 1400 1410 1420 1430 1440 CDQYWPNDTV PVFYGDIKVQ ILNDSHYADW VMTEFMLCRG SEQRILRHFH FTTWPDFGVP 1450 1460 1470 1480 1490 1500 NPPQTLVRFV RAFRDRIGAE QRPIVVHCSA GVGRSGTFIT LDRILQQINT SDYVDIFGIV 1510 1520 1530 1540 1550 YAMRKERVWM VQTEQQYICI HQCLLAVLEG KENIVGPARE MHDNEGYEDD EGIAESGM

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Two Drosophila receptor-like tyrosine phosphatase genes are expressed in a subset of developing axons and pioneer neurons in the embryonic CNS." Yang X., Seow K.T., Bahri S.M., Oon S.H., Chia W. Cell 67:661-673(1991) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS B AND E), FUNCTION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE. Tissue: Embryo.
[2]	"Three receptor-linked protein-tyrosine phosphatases are selectively expressed on central nervous system axons in the Drosophila embryo." Tian S.-S., Tsoulfas P., Zinn K. Cell 67:675-685(1991) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM E), TISSUE SPECIFICITY. Tissue: Embryo.
[3]	"The genome sequence of Drosophila melanogaster." Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C. Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Berkeley.
[4]	"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review." Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E. Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed] [Europe PMC] [Abstract] Cited for: GENOME REANNOTATION, ALTERNATIVE SPLICING. Strain: Berkeley.
[5]	Stapleton M., Brokstein P., Hong L., Agbayani A., Carlson J.W., Champe M., Chavez C., Dorsett V., Dresnek D., Farfan D., Frise E., George R.A., Gonzalez M., Guarin H., Kronmiller B., Li P.W., Liao G., Miranda A. , Mungall C.J., Nunoo J., Pacleb J.M., Paragas V., Park S., Patel S., Phouanenavong S., Wan K.H., Yu C., Lewis S.E., Rubin G.M., Celniker S.E. Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM B). Strain: Berkeley. Tissue: Embryo.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

M80465 mRNA. Translation: AAA28484.1.
M80538 mRNA. Translation: AAA28952.1.
AE014298 Genomic DNA. Translation: AAF48072.3.
AE014298 Genomic DNA. Translation: AAS65319.1.
AE014298 Genomic DNA. Translation: AAS65320.1.
AE014298 Genomic DNA. Translation: ACL82919.1.
BT004474 mRNA. Translation: AAO42638.1.

PIR

C41214.
D41214.

RefSeq

NP_001138187.1. NM_001144715.2.
NP_001259454.1. NM_001272525.1.
NP_727544.2. NM_167292.3.
NP_996413.2. NM_206690.2.
NP_996414.2. NM_206691.3.

UniGene

Dm.7386.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
3S3E	X-ray	2.40	A/B	1250-1533	[»]
3S3F	X-ray	2.70	A/B	1250-1533	[»]
3S3H	X-ray	2.80	A/B	1250-1533	[»]
3S3K	X-ray	3.20	A/B	1250-1533	[»]

ProteinModelPortal

P35992.

SMR

P35992. Positions 121-1050, 1249-1531.

ModBase

Search...

Protein-protein interaction databases

IntAct

P35992. 2 interactions.

Proteomic databases

PaxDb

P35992.

PRIDE

P35992.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

EnsemblMetazoa

FBtr0073522; FBpp0073369; FBgn0004370.

GeneID

32115.

KEGG

dme:Dmel_CG1817.

Organism-specific databases

CTD

32115.

FlyBase

FBgn0004370. Ptp10D.

Phylogenomic databases

eggNOG

COG5599.

GeneTree

ENSGT00700000104166.

InParanoid

P35992.

KO

K01104.

OMA

LHSTRDD.

OrthoDB

EOG483BKC.

Gene expression databases

Bgee

P35992.

GermOnline

CG1817. Drosophila melanogaster.

Family and domain databases

Gene3D

2.60.40.10. 9 hits.

InterPro

IPR003961. Fibronectin_type3.
IPR013783. Ig-like_fold.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
IPR000242. Tyr_Pase_rcpt/non-rcpt.
[Graphical view]

Pfam

PF00041. fn3. 10 hits.
PF00102. Y_phosphatase. 1 hit.
[Graphical view]

PRINTS

PR00700. PRTYPHPHTASE.

SMART

SM00060. FN3. 11 hits.
SM00194. PTPc. 1 hit.
[Graphical view]

SUPFAM

SSF49265. FN_III-like. 10 hits.

PROSITE

PS50853. FN3. 11 hits.
PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

ChiTaRS

Ptp10D. drosophila.

GenomeRNAi

32115.

NextBio

776913.

Entry information

Entry name

PTP10_DROME

Accession

Primary (citable) accession number: P35992
Secondary accession number(s): A4V4B4 , B7Z142, Q0KHT5, Q86NN9, Q8IR87, Q9VYW1

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 1, 1994
Last sequence update:	August 30, 2005
Last modified:	May 1, 2013
This is version 121 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Drosophila annotation project