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Protein

Tyrosine-protein phosphatase 10D

Gene

Ptp10D

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May have a role in axon outgrowth and guidance.1 Publication

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei1436SubstrateBy similarity1
Active sitei1468Phosphocysteine intermediatePROSITE-ProRule annotation1
Binding sitei1512SubstrateBy similarity1

GO - Molecular functioni

  • phosphoprotein phosphatase activity Source: FlyBase
  • protein tyrosine phosphatase activity Source: FlyBase
  • transmembrane receptor protein tyrosine phosphatase activity Source: FlyBase

GO - Biological processi

  • axon guidance Source: FlyBase
  • central nervous system development Source: FlyBase
  • long-term memory Source: FlyBase
  • motor neuron axon guidance Source: FlyBase
  • open tracheal system development Source: FlyBase
  • protein dephosphorylation Source: FlyBase
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Hydrolase, Protein phosphatase

Keywords - Biological processi

Differentiation, Neurogenesis

Enzyme and pathway databases

ReactomeiR-DME-6798695. Neutrophil degranulation.

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine-protein phosphatase 10D (EC:3.1.3.48)
Alternative name(s):
Receptor-linked protein-tyrosine phosphatase 10D
Short name:
DPTP10D
Gene namesi
Name:Ptp10D
ORF Names:CG1817
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome X

Organism-specific databases

FlyBaseiFBgn0004370. Ptp10D.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini43 – 1197ExtracellularSequence analysisAdd BLAST1155
Transmembranei1198 – 1218HelicalSequence analysisAdd BLAST21
Topological domaini1219 – 1990CytoplasmicSequence analysisAdd BLAST772

GO - Cellular componenti

  • apical part of cell Source: FlyBase
  • axon Source: FlyBase
  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: FlyBase
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 42Sequence analysisAdd BLAST42
ChainiPRO_000002542743 – 1990Tyrosine-protein phosphatase 10DAdd BLAST1948

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi75N-linked (GlcNAc...)Sequence analysis1
Glycosylationi106N-linked (GlcNAc...)Sequence analysis1
Glycosylationi128N-linked (GlcNAc...)Sequence analysis1
Glycosylationi169N-linked (GlcNAc...)Sequence analysis1
Glycosylationi212N-linked (GlcNAc...)Sequence analysis1
Glycosylationi229N-linked (GlcNAc...)Sequence analysis1
Glycosylationi259N-linked (GlcNAc...)Sequence analysis1
Glycosylationi289N-linked (GlcNAc...)Sequence analysis1
Glycosylationi317N-linked (GlcNAc...)Sequence analysis1
Glycosylationi471N-linked (GlcNAc...)Sequence analysis1
Glycosylationi486N-linked (GlcNAc...)Sequence analysis1
Glycosylationi512N-linked (GlcNAc...)Sequence analysis1
Glycosylationi533N-linked (GlcNAc...)Sequence analysis1
Glycosylationi588N-linked (GlcNAc...)Sequence analysis1
Glycosylationi668N-linked (GlcNAc...)Sequence analysis1
Glycosylationi687N-linked (GlcNAc...)Sequence analysis1
Glycosylationi719N-linked (GlcNAc...)Sequence analysis1
Glycosylationi723N-linked (GlcNAc...)Sequence analysis1
Glycosylationi823N-linked (GlcNAc...)Sequence analysis1
Glycosylationi841N-linked (GlcNAc...)Sequence analysis1
Glycosylationi874N-linked (GlcNAc...)Sequence analysis1
Glycosylationi908N-linked (GlcNAc...)Sequence analysis1
Glycosylationi925N-linked (GlcNAc...)Sequence analysis1
Glycosylationi1001N-linked (GlcNAc...)Sequence analysis1
Glycosylationi1104N-linked (GlcNAc...)Sequence analysis1
Glycosylationi1136N-linked (GlcNAc...)Sequence analysis1
Glycosylationi1195N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiP35992.
PRIDEiP35992.

Expressioni

Tissue specificityi

In 9-12 hour embryos, expression is specifically seen in the anterior commissure and its junctions with the longitudinal tracts.2 Publications

Developmental stagei

Expressed both maternally and zygotically. Expressed throughout development to adulthood, lowest expression is during second and third larval instars.1 Publication

Gene expression databases

BgeeiFBgn0004370.
ExpressionAtlasiP35992. baseline.
GenevisibleiP35992. DM.

Interactioni

Protein-protein interaction databases

BioGridi58524. 5 interactors.
IntActiP35992. 5 interactors.
STRINGi7227.FBpp0303419.

Structurei

Secondary structure

11990
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi1254 – 1256Combined sources3
Helixi1257 – 1277Combined sources21
Turni1278 – 1285Combined sources8
Helixi1290 – 1292Combined sources3
Turni1294 – 1296Combined sources3
Helixi1297 – 1299Combined sources3
Helixi1309 – 1311Combined sources3
Beta strandi1312 – 1314Combined sources3
Turni1319 – 1321Combined sources3
Turni1322 – 1325Combined sources4
Beta strandi1326 – 1332Combined sources7
Beta strandi1340 – 1344Combined sources5
Helixi1349 – 1351Combined sources3
Helixi1352 – 1361Combined sources10
Beta strandi1366 – 1369Combined sources4
Beta strandi1373 – 1375Combined sources3
Beta strandi1387 – 1390Combined sources4
Beta strandi1392 – 1394Combined sources3
Beta strandi1397 – 1406Combined sources10
Beta strandi1408 – 1419Combined sources12
Beta strandi1422 – 1431Combined sources10
Beta strandi1436 – 1438Combined sources3
Helixi1444 – 1457Combined sources14
Beta strandi1464 – 1467Combined sources4
Beta strandi1469 – 1472Combined sources4
Helixi1473 – 1487Combined sources15
Turni1488 – 1490Combined sources3
Beta strandi1492 – 1494Combined sources3
Helixi1496 – 1506Combined sources11
Helixi1514 – 1528Combined sources15

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3S3EX-ray2.40A/B1250-1533[»]
3S3FX-ray2.70A/B1250-1533[»]
3S3HX-ray2.80A/B1250-1533[»]
3S3KX-ray3.20A/B1250-1533[»]
ProteinModelPortaliP35992.
SMRiP35992.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini125 – 218Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST94
Domaini219 – 314Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST96
Domaini407 – 498Fibronectin type-III 3PROSITE-ProRule annotationAdd BLAST92
Domaini499 – 584Fibronectin type-III 4PROSITE-ProRule annotationAdd BLAST86
Domaini585 – 674Fibronectin type-III 5PROSITE-ProRule annotationAdd BLAST90
Domaini675 – 771Fibronectin type-III 6PROSITE-ProRule annotationAdd BLAST97
Domaini775 – 865Fibronectin type-III 7PROSITE-ProRule annotationAdd BLAST91
Domaini866 – 956Fibronectin type-III 8PROSITE-ProRule annotationAdd BLAST91
Domaini957 – 1057Fibronectin type-III 9PROSITE-ProRule annotationAdd BLAST101
Domaini1272 – 1527Tyrosine-protein phosphatasePROSITE-ProRule annotationAdd BLAST256

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1468 – 1474Substrate bindingBy similarity7

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi1673 – 1686Gln-richPROSITE-ProRule annotationAdd BLAST14
Compositional biasi1932 – 1972Gly-richPROSITE-ProRule annotationAdd BLAST41

Sequence similaritiesi

Contains 9 fibronectin type-III domains.PROSITE-ProRule annotation
Contains 1 tyrosine-protein phosphatase domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0791. Eukaryota.
COG5599. LUCA.
GeneTreeiENSGT00770000120452.
InParanoidiP35992.
KOiK05694.
OMAiPSSMICK.
OrthoDBiEOG091G00JF.

Family and domain databases

CDDicd00063. FN3. 9 hits.
Gene3Di2.60.40.10. 12 hits.
3.90.190.10. 1 hit.
InterProiIPR003961. FN3_dom.
IPR013783. Ig-like_fold.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000242. PTPase_domain.
IPR016130. Tyr_Pase_AS.
IPR003595. Tyr_Pase_cat.
IPR000387. TYR_PHOSPHATASE_dom.
[Graphical view]
PfamiPF00041. fn3. 9 hits.
PF00102. Y_phosphatase. 1 hit.
[Graphical view]
PRINTSiPR00700. PRTYPHPHTASE.
SMARTiSM00060. FN3. 11 hits.
SM00194. PTPc. 1 hit.
SM00404. PTPc_motif. 1 hit.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 6 hits.
SSF52799. SSF52799. 1 hit.
PROSITEiPS50853. FN3. 9 hits.
PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Note: Isoform G is produced by readthrough of a stop codon between the codons for Arg-1631 and His-1633. This is likely to be a rare event with most transcripts using the stop codon following Arg-1631.Curated
Isoform GImported (identifier: P35992-5) [UniParc]FASTAAdd to basket
Also known as: FImported

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLYQLSKATT RIRLKRQKAV PQHRWLWSLA FLAAFTLKDV RCADLAISIP
60 70 80 90 100
NNPGLDDGAS YRLDYSPPFG YPEPNTTIAS REIGDEIQFS RALPGTKYNF
110 120 130 140 150
WLYYTNFTHH DWLTWTVTIT TAPDPPSNLS VQVRSGKNAI ILWSPPTQGS
160 170 180 190 200
YTAFKIKVLG LSEASSSYNR TFQVNDNTFQ HSVKELTPGA TYQVQAYTIY
210 220 230 240 250
DGKESVAYTS RNFTTKPNTP GKFIVWFRNE TTLLVLWQPP YPAGIYTHYK
260 270 280 290 300
VSIEPPDAND SVLYVEKEGE PPGPAQAAFK GLVPGRAYNI SVQTMSEDEI
310 320 330 340 350
SLPTTAQYRT VPLRPLNVTF DRDFITSNSF RVLWEAPKGI SEFDKYQVSV
360 370 380 390 400
ATTRRQSTVP RSNEPVAFFD FRDIAEPGKT FNVIVKTVSG KVTSWPATGD
410 420 430 440 450
VTLRPLPVRN LRSINDDKTN TMIITWEADP ASTQDEYRIV YHELETFNGD
460 470 480 490 500
TSTLTTDRTR FTLESLLPGR NYSLSVQAVS KKMESNETSI FVVTRPSSPI
510 520 530 540 550
IEDLKSIRMG LNISWKSDVN SKQEQYEVLY SRNGTSDLRT QKTKESRLVI
560 570 580 590 600
KNLQPGAGYE LKVFAVSHDL RSEPHAYFQA VYPNPPRNMT IETVRSNSVL
610 620 630 640 650
VHWSPPESGE FTEYSIRYRT DSEQQWVRLP SVRSTEADIT DMTKGEKYTI
660 670 680 690 700
QVNTVSFGVE SPVPQEVNTT VPPNPVSNII QLVDSRNITL EWPKPEGRVE
710 720 730 740 750
SYILKWWPSD NPGRVQTKNV SENKSADDLS TVRVLIGELM PGVQYKFDIQ
760 770 780 790 800
TTSYGILSGI TSLYPRTMPL IQSDVVVANG EKEDERDTIT LSYTPTPQSS
810 820 830 840 850
SKFDIYRFSL GDAEIRDKEK LANDTDRKVT FTGLVPGRLY NITVWTVSGG
860 870 880 890 900
VASLPIQRQD RLYPEPITQL HATNITDTEI SLRWDLPKGE YNDFDIAYLT
910 920 930 940 950
ADNLLAQNMT TRNEITISDL RPHRNYTFTV VVRSGTESSV LRSSSPLSAS
960 970 980 990 1000
FTTNEAVPGR VERFHPTDVQ PSEINFEWSL PSSEANGVIR QFSIAYTNIN
1010 1020 1030 1040 1050
NLTDAGMQDF ESEEAFGVIK NLKPGETYVF KIQAKTAIGF GPEREYRQTM
1060 1070 1080 1090 1100
PILAPPRPAT QVVPTEVYRS SSTIQIRFRK NYFSDQNGQV RMYTIIVAED
1110 1120 1130 1140 1150
DAKNASGLEM PSWLDVQSYS VWLPYQAIDP YYPFENRSVE DFTIGTENCD
1160 1170 1180 1190 1200
NHKIGYCNGP LKSGTTYRVK VRAFTGADKF TDTAYSFPIQ TDQDNTSLIV
1210 1220 1230 1240 1250
AITVPLTIIL VLLVTLLFYK RRRNNCRKTT KDSRANDNMS LPDSVIEQNR
1260 1270 1280 1290 1300
PILIKNFAEH YRLMSADSDF RFSEEFEELK HVGRDQPCTF ADLPCNRPKN
1310 1320 1330 1340 1350
RFTNILPYDH SRFKLQPVDD DEGSDYINAN YVPGHNSPRE FIVTQGPLHS
1360 1370 1380 1390 1400
TRDDFWRMCW ESNSRAIVML TRCFEKGREK CDQYWPNDTV PVFYGDIKVQ
1410 1420 1430 1440 1450
ILNDSHYADW VMTEFMLCRG SEQRILRHFH FTTWPDFGVP NPPQTLVRFV
1460 1470 1480 1490 1500
RAFRDRIGAE QRPIVVHCSA GVGRSGTFIT LDRILQQINT SDYVDIFGIV
1510 1520 1530 1540 1550
YAMRKERVWM VQTEQQYICI HQCLLAVLEG KENIVGPARE MHDNEGYEGQ
1560 1570 1580 1590 1600
QVQLDENGDV VATIEGHLSH HDLQQAEAEA IDDENAAILH DDQQPLTSSF
1610 1620 1630 1640 1650
TGHHTHMPPT TSMSSFGGGG GGHTNVDAPD RXHSVVNQSD NNNSVVIVLV
1660 1670 1680 1690 1700
DNKPSSMICK DSKGGNIDVL ESQQQQQQQQ QQQPNQGGHN ITTISAINGY
1710 1720 1730 1740 1750
NTLQHRRKSQ LITFSSSSCD IKNSLSHEYI NGSNGSAANG PPSSGSGSGS
1760 1770 1780 1790 1800
GPGSNRASRA NVRLSFAEED VMILPQNHSQ QSNHQDDEVF TRRRSLLEVE
1810 1820 1830 1840 1850
IGVEVGEDGE LAPHEMEEDL EEEDEDEELY MHDEFETHID TKSNNANDDS
1860 1870 1880 1890 1900
GGGSYEDSHA LHSSLGGSNR NSLEKDDDDI EVDVISTDVS CYDQLLGSSC
1910 1920 1930 1940 1950
NTRNGDDDDI ATLVGDGDYS TTKLSKASRL SGAGVGGLVV SGGGGGTAIG
1960 1970 1980 1990
GGIAVNGGGV LGNGVGSEAG GGIIYANPFM DDEGIAESGM
Note: No experimental confirmation available.Curated
Length:1,990
Mass (Da):222,740
Last modified:January 7, 2015 - v4
Checksum:i76FAAA08565AE8DA
GO
Isoform BImported (identifier: P35992-1) [UniParc]FASTAAdd to basket
Also known as: Long

The sequence of this isoform differs from the canonical sequence as follows:
     1632-1990: Missing.

Show »
Length:1,631
Mass (Da):185,081
Checksum:i22A59AB61665875D
GO
Isoform EImported (identifier: P35992-2) [UniParc]FASTAAdd to basket
Also known as: Short, IImported

The sequence of this isoform differs from the canonical sequence as follows:
     1549-1980: Missing.

Show »
Length:1,558
Mass (Da):177,366
Checksum:i716C60806FDAC9DD
GO
Isoform HImported (identifier: P35992-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     216-216: K → SRRTRHKELLDIKILRE
     1191-1191: T → TEMLSSP
     1632-1990: Missing.

Note: No experimental confirmation available.Curated
Show »
Length:1,653
Mass (Da):187,743
Checksum:i2E58394F82C827DB
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti124D → I in AAA28484 (PubMed:1657401).Curated1
Sequence conflicti127S → L in AAA28484 (PubMed:1657401).Curated1
Sequence conflicti188P → L in AAO42638 (Ref. 5) Curated1
Sequence conflicti369F → S in AAA28484 (PubMed:1657401).Curated1
Sequence conflicti369F → S in AAA28952 (PubMed:1657402).Curated1
Sequence conflicti558G → A in AAA28484 (PubMed:1657401).Curated1
Sequence conflicti558G → A in AAA28952 (PubMed:1657402).Curated1
Sequence conflicti810L → S in AAA28484 (PubMed:1657401).Curated1
Sequence conflicti810L → S in AAA28952 (PubMed:1657402).Curated1
Sequence conflicti1403N → S in AAO42638 (Ref. 5) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_057306216K → SRRTRHKELLDIKILRE in isoform H. Curated1
Alternative sequenceiVSP_0573071191T → TEMLSSP in isoform H. Curated1
Alternative sequenceiVSP_0051431549 – 1980Missing in isoform E. 2 PublicationsAdd BLAST432
Alternative sequenceiVSP_0573081632 – 1990Missing in isoform B and isoform H. 1 PublicationCuratedAdd BLAST359

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M80465 mRNA. Translation: AAA28484.1.
M80538 mRNA. Translation: AAA28952.1.
AE014298 Genomic DNA. Translation: AAF48072.3.
AE014298 Genomic DNA. Translation: AAS65319.2.
AE014298 Genomic DNA. Translation: AAS65320.2.
AE014298 Genomic DNA. Translation: ACL82919.1.
AE014298 Genomic DNA. Translation: AGB95296.1.
AE014298 Genomic DNA. Translation: AGB95297.1.
BT004474 mRNA. Translation: AAO42638.1.
BT126065 mRNA. Translation: ADY17764.1.
PIRiC41214.
D41214.
RefSeqiNP_001138187.1. NM_001144715.2. [P35992-2]
NP_001259453.1. NM_001272524.1. [P35992-6]
NP_001259454.1. NM_001272525.1. [P35992-2]
NP_727544.2. NM_167292.3. [P35992-1]
NP_996413.2. NM_206690.2. [P35992-5]
NP_996414.2. NM_206691.3. [P35992-5]
UniGeneiDm.7386.

Genome annotation databases

EnsemblMetazoaiFBtr0073522; FBpp0073369; FBgn0004370. [P35992-1]
FBtr0273235; FBpp0271743; FBgn0004370. [P35992-2]
FBtr0330392; FBpp0303418; FBgn0004370. [P35992-5]
FBtr0330393; FBpp0303419; FBgn0004370. [P35992-5]
FBtr0330394; FBpp0303420; FBgn0004370. [P35992-6]
FBtr0331406; FBpp0303823; FBgn0004370. [P35992-2]
GeneIDi32115.
KEGGidme:Dmel_CG1817.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M80465 mRNA. Translation: AAA28484.1.
M80538 mRNA. Translation: AAA28952.1.
AE014298 Genomic DNA. Translation: AAF48072.3.
AE014298 Genomic DNA. Translation: AAS65319.2.
AE014298 Genomic DNA. Translation: AAS65320.2.
AE014298 Genomic DNA. Translation: ACL82919.1.
AE014298 Genomic DNA. Translation: AGB95296.1.
AE014298 Genomic DNA. Translation: AGB95297.1.
BT004474 mRNA. Translation: AAO42638.1.
BT126065 mRNA. Translation: ADY17764.1.
PIRiC41214.
D41214.
RefSeqiNP_001138187.1. NM_001144715.2. [P35992-2]
NP_001259453.1. NM_001272524.1. [P35992-6]
NP_001259454.1. NM_001272525.1. [P35992-2]
NP_727544.2. NM_167292.3. [P35992-1]
NP_996413.2. NM_206690.2. [P35992-5]
NP_996414.2. NM_206691.3. [P35992-5]
UniGeneiDm.7386.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3S3EX-ray2.40A/B1250-1533[»]
3S3FX-ray2.70A/B1250-1533[»]
3S3HX-ray2.80A/B1250-1533[»]
3S3KX-ray3.20A/B1250-1533[»]
ProteinModelPortaliP35992.
SMRiP35992.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi58524. 5 interactors.
IntActiP35992. 5 interactors.
STRINGi7227.FBpp0303419.

Proteomic databases

PaxDbiP35992.
PRIDEiP35992.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0073522; FBpp0073369; FBgn0004370. [P35992-1]
FBtr0273235; FBpp0271743; FBgn0004370. [P35992-2]
FBtr0330392; FBpp0303418; FBgn0004370. [P35992-5]
FBtr0330393; FBpp0303419; FBgn0004370. [P35992-5]
FBtr0330394; FBpp0303420; FBgn0004370. [P35992-6]
FBtr0331406; FBpp0303823; FBgn0004370. [P35992-2]
GeneIDi32115.
KEGGidme:Dmel_CG1817.

Organism-specific databases

CTDi32115.
FlyBaseiFBgn0004370. Ptp10D.

Phylogenomic databases

eggNOGiKOG0791. Eukaryota.
COG5599. LUCA.
GeneTreeiENSGT00770000120452.
InParanoidiP35992.
KOiK05694.
OMAiPSSMICK.
OrthoDBiEOG091G00JF.

Enzyme and pathway databases

ReactomeiR-DME-6798695. Neutrophil degranulation.

Miscellaneous databases

ChiTaRSiPtp10D. fly.
GenomeRNAii32115.
PROiP35992.

Gene expression databases

BgeeiFBgn0004370.
ExpressionAtlasiP35992. baseline.
GenevisibleiP35992. DM.

Family and domain databases

CDDicd00063. FN3. 9 hits.
Gene3Di2.60.40.10. 12 hits.
3.90.190.10. 1 hit.
InterProiIPR003961. FN3_dom.
IPR013783. Ig-like_fold.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000242. PTPase_domain.
IPR016130. Tyr_Pase_AS.
IPR003595. Tyr_Pase_cat.
IPR000387. TYR_PHOSPHATASE_dom.
[Graphical view]
PfamiPF00041. fn3. 9 hits.
PF00102. Y_phosphatase. 1 hit.
[Graphical view]
PRINTSiPR00700. PRTYPHPHTASE.
SMARTiSM00060. FN3. 11 hits.
SM00194. PTPc. 1 hit.
SM00404. PTPc_motif. 1 hit.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 6 hits.
SSF52799. SSF52799. 1 hit.
PROSITEiPS50853. FN3. 9 hits.
PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPTP10_DROME
AccessioniPrimary (citable) accession number: P35992
Secondary accession number(s): A4V4B4
, B7Z142, F0JAM3, M9PEB6, M9PJI5, Q0KHT5, Q86NN9, Q8IR87, Q9VYW1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: January 7, 2015
Last modified: November 30, 2016
This is version 153 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Miscellaneous

This protein is translated by readthrough of a stop codon. Readthrough of the terminator codon TAG occurs between the codons for Arg-1631 and His-1633. There is currently no sequence that provides the identity of residue 1632.Curated

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.