Reviewed, UniProtKB/Swiss-Prot P35988 (PIV6_ADE12)

Names and origin

Protein names

Recommended name:
    Minor capsid protein 6
Alternative name(s):
    Minor capsid protein VI
Cleaved into the following chain:
    1- Recommended name:
            Protease cofactor

Gene names

Name:

PVI

Organism

Human adenovirus A serotype 12 (HAdV-12) (Human adenovirus 12)

Taxonomic identifier

28282 [NCBI]

Taxonomic lineage

Viruses › dsDNA viruses, no RNA stage › Adenoviridae › Mastadenovirus › Human adenovirus A

Virus host

Homo sapiens (Human) [TaxID: 9606]

Protein attributes

Sequence length	265 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Minor capsid protein that may act as a link between the external capsid and the internal DNA-protein core. The C-terminal domain may act as a protease cofactor which acts as an activator of the enzyme.
Subunit structure	The protease cofactor is a disulfide-linked homodimer By similarity.
Subcellular location	Virion Potential.
Sequence similarities	Belongs to the adenoviridae pVI family.

Ontologies

Keywords
Cellular component	Capsid protein Virion
PTM	Disulfide bond
Technical term	Direct protein sequencing
Gene Ontology (GO)
Cellular component	viral capsid Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Propeptide	1 – 33	33			PRO_0000036549
	Chain	34 – 254	221	Minor capsid protein 6		PRO_0000036550
	Peptide	255 – 265	11	Protease cofactor		PRO_0000036551
Sites
	Site	33 – 34	2	Cleavage; by adenovirus protease
	Site	254 – 255	2	Cleavage; by adenovirus protease
Amino acid modifications
	Disulfide bond	264		Interchain Potential

Sequences

	Sequence		Length	Mass (Da)
	P35988-1 [UniParc]. Last modified June 1, 1994. Version 1. Checksum: EE0A84BA12DC0943	FASTA	265	28,912
	10 20 30 40 50 60 MEDINFSSLA PRHGTRPYMG TWNEIGTSQL NGGAFNWNSI WSGLKNFGST IKTYGTKAWN 70 80 90 100 110 120 SQTGQMLRDK LKDQNFQQKV VDGLASGING VVDIANQAVQ KKIANRLEPR PDEVMVEEKL 130 140 150 160 170 180 PPLETVPGSV PTKGEKRPRP DAEETLVTHT TEPPSYEEAI KQGAALSPTT YPMTKPILPM 190 200 210 220 230 240 ATRVYGKNEN VPMTLELPPL PEPTIADPVG SVPVASVPVA STVSRPAVRP VAVASLRNPR 250 260 SSNWQSTLNS IVGLGVKSLK RRRCY

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Human adenovirus serotype 12 virion precursors pMu and pVI are cleaved at amino-terminal and carboxy-terminal sites that conform to the adenovirus 2 endoproteinase cleavage consensus sequence." Freimuth P., Anderson C.W. Virology 193:348-355(1993) [PubMed: 8438575] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 34-47 AND 255-265. Strain: Huie.
[2]	"Nucleotide sequence of human adenovirus type 12 DNA: comparative functional analysis." Sprengel J., Schmitz B., Heuss-Neitzel D., Zock C., Doerfler W. J. Virol. 68:379-389(1994) [PubMed: 8254750] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	L02237 Genomic DNA. Translation: AAA42516.1. X73487 Genomic DNA. Translation: CAA51890.1.
PIR	B45393.
RefSeq	NP_040923.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	1460858.
Family and domain databases
InterPro	IPR004243. McpVI. [Graphical view]
Pfam	PF02993. MCPVI. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
PMAP-CutDB	P35988.

Entry information

Entry name

PIV6_ADE12

Accession

Primary (citable) accession number: P35988

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 1, 1994
Last sequence update:	June 1, 1994
Last modified:	October 13, 2009
This is version 48 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Virus (Virus annotation project)