Reviewed, UniProtKB/Swiss-Prot P35986 (L2MU_ADE12)

Names and origin

Protein names

Recommended name:
    Late L2 mu core protein
Alternative name(s):
    pMu
    Protein X
      Short name=pX
    11 kDa core protein

Gene names

Name:

PX

Organism

Human adenovirus A serotype 12 (HAdV-12) (Human adenovirus 12)

Taxonomic identifier

28282 [NCBI]

Taxonomic lineage

Viruses › dsDNA viruses, no RNA stage › Adenoviridae › Mastadenovirus › Human adenovirus A

Virus host

Homo sapiens (Human) [TaxID: 9606]

Protein attributes

Sequence length	72 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	The role of the precursor might be to condense the viral prochromatin for encapsidation by virtue of the two basic domains By similarity.
Subcellular location	Virion Potential.
Sequence similarities	Belongs to the adenoviridae pX family.

Ontologies

Keywords
Cellular component	Core protein Virion
Developmental stage	Late protein
Ligand	DNA-binding
Technical term	Direct protein sequencing
Gene Ontology (GO)
Cellular component	viral nucleocapsid Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	DNA binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed; by host By similarity
	Propeptide	2 – 27	26			PRO_0000036522
	Peptide	28 – 42	15	Late L2 mu core protein Ref.1		PRO_0000036523
	Propeptide	43 – 72	30			PRO_0000036524
Sites
	Site	27 – 28	2	Cleavage; by adenovirus protease
	Site	42 – 43	2	Cleavage; by adenovirus protease

Sequences

	Sequence		Length	Mass (Da)
	P35986-1 [UniParc]. Last modified January 23, 2007. Version 2. Checksum: AB56A59BB2327B3F	FASTA	72	7,971
	10 20 30 40 50 60 MALTCRMRIP IPGYRGRPRR RKGLTGNGRF RRRSMRRRMK GGVLPFLIPL IAAAIGAVPG 70 IASVALQASR KN

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Human adenovirus serotype 12 virion precursors pMu and pVI are cleaved at amino-terminal and carboxy-terminal sites that conform to the adenovirus 2 endoproteinase cleavage consensus sequence." Freimuth P., Anderson C.W. Virology 193:348-355(1993) [PubMed: 8438575] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 28-42. Strain: Huie.
[2]	"Nucleotide sequence of human adenovirus type 12 DNA: comparative functional analysis." Sprengel J., Schmitz B., Heuss-Neitzel D., Zock C., Doerfler W. J. Virol. 68:379-389(1994) [PubMed: 8254750] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	L02237 Genomic DNA. Translation: AAA42515.1. X73487 Genomic DNA. Translation: CAA51889.1.
PIR	A45393.
RefSeq	NP_040922.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	1460868.
Family and domain databases
InterPro	IPR008393. Adenovirus_late_L2_mu_core. [Graphical view]
Pfam	PF05829. Adeno_PX. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
PMAP-CutDB	P35986.

Entry information

Entry name

L2MU_ADE12

Accession

Primary (citable) accession number: P35986

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 1, 1994
Last sequence update:	January 23, 2007
Last modified:	July 28, 2009
This is version 50 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Virus (Virus annotation project)