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Protein

60S ribosomal protein L18

Gene

Rpl18

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the large ribosomal subunit.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiR-MMU-1799339 SRP-dependent cotranslational protein targeting to membrane
R-MMU-72706 GTP hydrolysis and joining of the 60S ribosomal subunit
R-MMU-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
R-MMU-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Names & Taxonomyi

Protein namesi
Recommended name:
60S ribosomal protein L18
Gene namesi
Name:Rpl18
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:98003 Rpl18

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001327701 – 18860S ribosomal protein L18Add BLAST188

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki119Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei130PhosphoserineCombined sources1
Modified residuei158PhosphothreonineBy similarity1
Cross-linki164Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiP35980
PaxDbiP35980
PeptideAtlasiP35980
PRIDEiP35980

PTM databases

iPTMnetiP35980
PhosphoSitePlusiP35980
SwissPalmiP35980

Expressioni

Gene expression databases

BgeeiENSMUSG00000059070
CleanExiMM_RPL18
ExpressionAtlasiP35980 baseline and differential
GenevisibleiP35980 MM

Interactioni

Subunit structurei

Component of the large ribosomal subunit.By similarity

Protein-protein interaction databases

BioGridi202968, 5 interactors
CORUMiP35980
IntActiP35980, 4 interactors
MINTiP35980
STRINGi10090.ENSMUSP00000072320

Structurei

3D structure databases

ProteinModelPortaliP35980
SMRiP35980
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1714 Eukaryota
COG1727 LUCA
GeneTreeiENSGT00390000012976
HOGENOMiHOG000213425
HOVERGENiHBG000875
InParanoidiP35980
KOiK02883
OMAiKHHVKKG
OrthoDBiEOG091G07WU
PhylomeDBiP35980
TreeFamiTF300202

Family and domain databases

InterProiView protein in InterPro
IPR036227 L18e/L15P_sf
IPR000039 Ribosomal_L18e
IPR021131 Ribosomal_L18e/L15P
IPR021132 Ribosomal_L18e_CS
PANTHERiPTHR10934 PTHR10934, 1 hit
PfamiView protein in Pfam
PF17135 Ribosomal_L18, 1 hit
SUPFAMiSSF52080 SSF52080, 1 hit
PROSITEiView protein in PROSITE
PS01106 RIBOSOMAL_L18E, 1 hit

Sequencei

Sequence statusi: Complete.

P35980-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGVDIRHNKD RKVRRKEPKS QDIYLRLLVK LYRFLARRTN STFNQVVLKR
60 70 80 90 100
LFMSRTNRPP LSLSRMIRKM KLPGRENKTA VVVGTVTDDV RILEVPKLKV
110 120 130 140 150
CALRVSSRAR SRILKAGGKI LTFDQLALES PKGRGTVLLS GPRKGREVYR
160 170 180
HFGKAPGTPH SHTKPYVRSK GRKFERARGR RASRGYKN
Length:188
Mass (Da):21,645
Last modified:January 23, 2007 - v3
Checksum:i9489EFE201ABF7A1
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti59P → S in AAA40067 (PubMed:8359697).Curated1
Sequence conflicti109A → V in AAA40067 (PubMed:8359697).Curated1
Sequence conflicti115K → R in BAB24923 (PubMed:16141072).Curated1
Sequence conflicti116A → G in AAA40067 (PubMed:8359697).Curated1
Sequence conflicti147 – 150EVYR → DVFP in AAA40067 (PubMed:8359697).Curated4
Sequence conflicti155A → V in AAA40067 (PubMed:8359697).Curated1
Sequence conflicti160 – 162HSH → YSQ in AAA40067 (PubMed:8359697).Curated3
Sequence conflicti173 – 174KF → RL in AAA40067 (PubMed:8359697).Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L04128 mRNA Translation: AAA40067.1
AK007263 mRNA Translation: BAB24923.1
AK009044 mRNA Translation: BAB26043.1
AK010510 mRNA Translation: BAB26993.1
AK012580 mRNA Translation: BAB28332.1
BC082290 mRNA Translation: AAH82290.1
CCDSiCCDS39958.1
PIRiJN0779
RefSeqiNP_033103.2, NM_009077.2
UniGeneiMm.3459
Mm.422997

Genome annotation databases

EnsembliENSMUST00000072503; ENSMUSP00000072320; ENSMUSG00000059070
ENSMUST00000210640; ENSMUSP00000147816; ENSMUSG00000059070
GeneIDi19899
KEGGimmu:19899
UCSCiuc009gww.1 mouse

Similar proteinsi

Entry informationi

Entry nameiRL18_MOUSE
AccessioniPrimary (citable) accession number: P35980
Secondary accession number(s): Q9CQF1, Q9D987
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: January 23, 2007
Last modified: April 25, 2018
This is version 146 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health