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Protein

60S ribosomal protein L12

Gene

Rpl12

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Binds directly to 26S ribosomal RNA.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Keywords - Ligandi

RNA-binding

Enzyme and pathway databases

ReactomeiR-MMU-1799339. SRP-dependent cotranslational protein targeting to membrane.
R-MMU-72706. GTP hydrolysis and joining of the 60S ribosomal subunit.
R-MMU-975956. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
R-MMU-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Names & Taxonomyi

Protein namesi
Recommended name:
60S ribosomal protein L12
Gene namesi
Name:Rpl12
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:98002. Rpl12.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: MGI
  • cytosolic large ribosomal subunit Source: MGI
  • extracellular exosome Source: MGI
  • extracellular matrix Source: MGI
  • focal adhesion Source: MGI
  • membrane Source: MGI
  • nucleolus Source: MGI
  • nucleus Source: MGI
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001044571 – 16560S ribosomal protein L12Add BLAST165

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei38PhosphoserineCombined sources1
Modified residuei54N6-acetyllysineBy similarity1
Modified residuei165PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiP35979.
PaxDbiP35979.
PeptideAtlasiP35979.
PRIDEiP35979.

PTM databases

iPTMnetiP35979.
PhosphoSitePlusiP35979.
SwissPalmiP35979.

Expressioni

Gene expression databases

BgeeiENSMUSG00000038900.
CleanExiMM_RPL12.
ExpressionAtlasiP35979. baseline and differential.
GenevisibleiP35979. MM.

Interactioni

Protein-protein interaction databases

BioGridi234630. 3 interactors.
IntActiP35979. 6 interactors.
MINTiMINT-1870314.
STRINGi10090.ENSMUSP00000136144.

Structurei

Secondary structure

1165
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi7 – 9Combined sources3
Beta strandi11 – 18Combined sources8
Helixi29 – 32Combined sources4
Turni33 – 35Combined sources3
Helixi39 – 49Combined sources11
Turni50 – 55Combined sources6
Beta strandi56 – 65Combined sources10
Beta strandi68 – 70Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1WIBNMR-A2-79[»]
ProteinModelPortaliP35979.
SMRiP35979.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP35979.

Family & Domainsi

Sequence similaritiesi

Belongs to the ribosomal protein L11P family.Curated

Phylogenomic databases

eggNOGiKOG0886. Eukaryota.
COG0080. LUCA.
GeneTreeiENSGT00390000006922.
HOGENOMiHOG000082125.
HOVERGENiHBG007231.
InParanoidiP35979.
KOiK02870.
OMAiVYMRCTG.
OrthoDBiEOG091G0PW6.
PhylomeDBiP35979.
TreeFamiTF300123.

Family and domain databases

CDDicd00349. Ribosomal_L11. 1 hit.
Gene3Di1.10.10.250. 1 hit.
3.30.1550.10. 1 hit.
HAMAPiMF_00736. Ribosomal_L11. 1 hit.
InterProiIPR000911. Ribosomal_L11/L12.
IPR020783. Ribosomal_L11_C.
IPR020785. Ribosomal_L11_CS.
IPR020784. Ribosomal_L11_N.
[Graphical view]
PANTHERiPTHR11661. PTHR11661. 1 hit.
PfamiPF00298. Ribosomal_L11. 1 hit.
PF03946. Ribosomal_L11_N. 1 hit.
[Graphical view]
SMARTiSM00649. RL11. 1 hit.
[Graphical view]
SUPFAMiSSF46906. SSF46906. 1 hit.
SSF54747. SSF54747. 1 hit.
PROSITEiPS00359. RIBOSOMAL_L11. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P35979-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPPKFDPNEV KVVYLRCTGG EVGATSALAP KIGPLGLSPK KVGDDIAKAT
60 70 80 90 100
GDWKGLRITV KLTIQNRQAQ IEVVPSASAL IIKALKEPPR DRKKQKNIKH
110 120 130 140 150
SGNITFDEIV NIARQMRHRS LARELSGTIK EILGTAQSVG CNVDGRHPHD
160
IIDDINSGAV ECPAS
Length:165
Mass (Da):17,805
Last modified:June 16, 2003 - v2
Checksum:i7EEEC00C57193116
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti79A → G in AAA40066 (PubMed:8359697).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L04280 mRNA. Translation: AAA40066.1.
AK002973 mRNA. Translation: BAB22488.1.
AK008347 mRNA. Translation: BAB25619.1.
AK012349 mRNA. Translation: BAB28180.1.
AK012428 mRNA. Translation: BAB28232.1.
BC018321 mRNA. Translation: AAH18321.1.
BC081469 mRNA. Translation: AAH81469.1.
CCDSiCCDS15936.1.
PIRiJN0778.
RefSeqiNP_033102.2. NM_009076.3.
UniGeneiMm.250030.
Mm.381297.

Genome annotation databases

EnsembliENSMUST00000126610; ENSMUSP00000117461; ENSMUSG00000038900.
GeneIDi269261.
KEGGimmu:269261.
UCSCiuc008jhe.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L04280 mRNA. Translation: AAA40066.1.
AK002973 mRNA. Translation: BAB22488.1.
AK008347 mRNA. Translation: BAB25619.1.
AK012349 mRNA. Translation: BAB28180.1.
AK012428 mRNA. Translation: BAB28232.1.
BC018321 mRNA. Translation: AAH18321.1.
BC081469 mRNA. Translation: AAH81469.1.
CCDSiCCDS15936.1.
PIRiJN0778.
RefSeqiNP_033102.2. NM_009076.3.
UniGeneiMm.250030.
Mm.381297.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1WIBNMR-A2-79[»]
ProteinModelPortaliP35979.
SMRiP35979.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi234630. 3 interactors.
IntActiP35979. 6 interactors.
MINTiMINT-1870314.
STRINGi10090.ENSMUSP00000136144.

PTM databases

iPTMnetiP35979.
PhosphoSitePlusiP35979.
SwissPalmiP35979.

Proteomic databases

EPDiP35979.
PaxDbiP35979.
PeptideAtlasiP35979.
PRIDEiP35979.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000126610; ENSMUSP00000117461; ENSMUSG00000038900.
GeneIDi269261.
KEGGimmu:269261.
UCSCiuc008jhe.2. mouse.

Organism-specific databases

CTDi6136.
MGIiMGI:98002. Rpl12.

Phylogenomic databases

eggNOGiKOG0886. Eukaryota.
COG0080. LUCA.
GeneTreeiENSGT00390000006922.
HOGENOMiHOG000082125.
HOVERGENiHBG007231.
InParanoidiP35979.
KOiK02870.
OMAiVYMRCTG.
OrthoDBiEOG091G0PW6.
PhylomeDBiP35979.
TreeFamiTF300123.

Enzyme and pathway databases

ReactomeiR-MMU-1799339. SRP-dependent cotranslational protein targeting to membrane.
R-MMU-72706. GTP hydrolysis and joining of the 60S ribosomal subunit.
R-MMU-975956. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
R-MMU-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Miscellaneous databases

EvolutionaryTraceiP35979.
PROiP35979.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000038900.
CleanExiMM_RPL12.
ExpressionAtlasiP35979. baseline and differential.
GenevisibleiP35979. MM.

Family and domain databases

CDDicd00349. Ribosomal_L11. 1 hit.
Gene3Di1.10.10.250. 1 hit.
3.30.1550.10. 1 hit.
HAMAPiMF_00736. Ribosomal_L11. 1 hit.
InterProiIPR000911. Ribosomal_L11/L12.
IPR020783. Ribosomal_L11_C.
IPR020785. Ribosomal_L11_CS.
IPR020784. Ribosomal_L11_N.
[Graphical view]
PANTHERiPTHR11661. PTHR11661. 1 hit.
PfamiPF00298. Ribosomal_L11. 1 hit.
PF03946. Ribosomal_L11_N. 1 hit.
[Graphical view]
SMARTiSM00649. RL11. 1 hit.
[Graphical view]
SUPFAMiSSF46906. SSF46906. 1 hit.
SSF54747. SSF54747. 1 hit.
PROSITEiPS00359. RIBOSOMAL_L11. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRL12_MOUSE
AccessioniPrimary (citable) accession number: P35979
Secondary accession number(s): Q9CQK4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 16, 2003
Last modified: November 30, 2016
This is version 144 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. Ribosomal proteins
    Ribosomal proteins families and list of entries
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.