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Reviewed, UniProtKB/Swiss-Prot P35968 (VGFR2_HUMAN)

Last modified November 25, 2008. Version 100. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (8) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Vascular endothelial growth factor receptor 2
      Short name=VEGFR-2
    EC=2.7.10.1
Alternative name(s):
    Kinase insert domain receptor
    Protein-tyrosine kinase receptor Flk-1
    CD_antigen=CD309
Gene names
Name: KDR
Synonyms: FLK1
OrganismHomo sapiens (Human)
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length1356 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level.

General annotation (Comments)

Function

Receptor for VEGF or VEGFC. Has a tyrosine-protein kinase activity. The VEGF-kinase ligand/receptor signaling system plays a key role in vascular development and regulation of vascular permeability. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions.

Catalytic activity

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.

Subunit structure

Interacts with SHB upon VEGF activation. Interacts with HIV-1 Tat.

Subcellular location

Membrane; Single-pass type I membrane protein.

Sequence similarities

Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.

Contains 7 Ig-like C2-type (immunoglobulin-like) domains.

Contains 1 protein kinase domain.

Binary interactions

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1919 Potential
Chain20 – 13561337Vascular endothelial growth factor receptor 2
PRO_0000016771

Regions

Topological domain20 – 764745Extracellular Potential
Transmembrane765 – 78925 Potential
Topological domain790 – 1356567Cytoplasmic Potential
Domain46 – 11065Ig-like C2-type 1
Domain141 – 20767Ig-like C2-type 2
Domain224 – 32097Ig-like C2-type 3
Domain328 – 41487Ig-like C2-type 4
Domain421 – 548128Ig-like C2-type 5
Domain551 – 660110Ig-like C2-type 6
Domain667 – 75387Ig-like C2-type 7
Domain834 – 1162329Protein kinase
Nucleotide binding840 – 8489ATP By similarity

Sites

Active site10281Proton acceptor By similarity
Binding site8681ATP By similarity
Site11751Interaction with SHB By similarity

Amino acid modifications

Modified residue10541Phosphotyrosine
Modified residue10591Phosphotyrosine; by autocatalysis
Glycosylation461N-linked (GlcNAc...) Potential
Glycosylation661N-linked (GlcNAc...) Potential
Glycosylation961N-linked (GlcNAc...) Potential
Glycosylation1431N-linked (GlcNAc...) Potential
Glycosylation1581N-linked (GlcNAc...) Potential
Glycosylation2451N-linked (GlcNAc...) Potential
Glycosylation3181N-linked (GlcNAc...) Potential
Glycosylation3741N-linked (GlcNAc...) Potential
Glycosylation3951N-linked (GlcNAc...) Potential
Glycosylation5111N-linked (GlcNAc...) Potential
Glycosylation5231N-linked (GlcNAc...) Potential
Glycosylation5801N-linked (GlcNAc...) Potential
Glycosylation6131N-linked (GlcNAc...) Potential
Glycosylation6191N-linked (GlcNAc...) Potential
Glycosylation6311N-linked (GlcNAc...) Potential
Glycosylation6751N-linked (GlcNAc...) Potential
Glycosylation7041N-linked (GlcNAc...) Potential
Glycosylation7211N-linked (GlcNAc...) Potential

Natural variations

Natural variant21Q → R in a lung adenocarcinoma sample; somatic mutation.
VAR_042053
Natural variant1361V → M: dbSNP rs35636987.
VAR_042054
Natural variant2481A → G in a renal clear cell carcinoma sample; somatic mutation.
VAR_042055
Natural variant2751R → L in a colorectal cancer sample; somatic mutation.
VAR_036126
Natural variant2971V → I: dbSNP rs2305948.
VAR_022071
Natural variant4621L → V: dbSNP rs56286620.
VAR_042056
Natural variant4721Q → H: dbSNP rs1870377.
VAR_020353
Natural variant4821C → R: dbSNP rs34231037.
VAR_042057
Natural variant5391G → R: dbSNP rs55716939.
VAR_042058
Natural variant6891T → M: dbSNP rs34038364.
VAR_042059
Natural variant8141D → N: dbSNP rs35603373.
VAR_042060
Natural variant8481V → E: dbSNP rs1139776.
VAR_046679
Natural variant8731G → R in a colorectal cancer sample; somatic mutation.
VAR_036127
Natural variant9521V → I: dbSNP rs13129474.
VAR_046680
Natural variant10651A → T: dbSNP rs56302315.
VAR_042061

Experimental info

Sequence conflict21Q → E in AAC16450. Ref.2
Sequence conflict7721A → T in AAA59459 and CAA43837. Ref.3
Sequence conflict7871R → G in AAA59459 and CAA43837. Ref.3
Sequence conflict8351K → N in AAA59459 and CAA43837. Ref.3
Sequence conflict13471S → T in AAA59459 and CAA43837. Ref.3

Secondary structure

............................................ 1356
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P35968-1 [UniParc].

Last modified December 1, 2000. Version 2.
Checksum: 59E7C44B05CFEBB3

FASTA1,356151,527
        10         20         30         40         50         60 
MQSKVLLAVA LWLCVETRAA SVGLPSVSLD LPRLSIQKDI LTIKANTTLQ ITCRGQRDLD 

        70         80         90        100        110        120 
WLWPNNQSGS EQRVEVTECS DGLFCKTLTI PKVIGNDTGA YKCFYRETDL ASVIYVYVQD 

       130        140        150        160        170        180 
YRSPFIASVS DQHGVVYITE NKNKTVVIPC LGSISNLNVS LCARYPEKRF VPDGNRISWD 

       190        200        210        220        230        240 
SKKGFTIPSY MISYAGMVFC EAKINDESYQ SIMYIVVVVG YRIYDVVLSP SHGIELSVGE 

       250        260        270        280        290        300 
KLVLNCTART ELNVGIDFNW EYPSSKHQHK KLVNRDLKTQ SGSEMKKFLS TLTIDGVTRS 

       310        320        330        340        350        360 
DQGLYTCAAS SGLMTKKNST FVRVHEKPFV AFGSGMESLV EATVGERVRI PAKYLGYPPP 

       370        380        390        400        410        420 
EIKWYKNGIP LESNHTIKAG HVLTIMEVSE RDTGNYTVIL TNPISKEKQS HVVSLVVYVP 

       430        440        450        460        470        480 
PQIGEKSLIS PVDSYQYGTT QTLTCTVYAI PPPHHIHWYW QLEEECANEP SQAVSVTNPY 

       490        500        510        520        530        54