P35928 (POLR_ELV) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names	Recommended name: RNA replicase polyprotein EC=2.7.7.48
Organism	Erysimum latent virus (ELV)
Taxonomic identifier	12152 [NCBI]
Taxonomic lineage	Viruses › ssRNA positive-strand viruses, no DNA stage › Tymovirales › Tymoviridae › Tymovirus
Virus host	Erysimum [TaxID: 65352]

Protein attributes

Sequence length	1748 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).
Sequence similarities	Belongs to the tymovirus NS35 RNA replicase polyprotein family. Contains 1 RdRp catalytic domain.

Ontologies

Keywords
Biological process	RNA replication
Ligand	ATP-binding Nucleotide-binding
Molecular function	Nucleotidyltransferase RNA-directed RNA polymerase Transferase
Gene Ontology (GO)
Biological process	RNA processing Inferred from electronic annotation. Source: InterPro transcription, DNA-dependent Inferred from electronic annotation. Source: InterPro viral genome replication Inferred from electronic annotation. Source: InterPro
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW RNA binding Inferred from electronic annotation. Source: InterPro RNA-directed RNA polymerase activity Inferred from electronic annotation. Source: UniProtKB-KW helicase activity Inferred from electronic annotation. Source: InterPro mRNA methyltransferase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1748	1748	RNA replicase polyprotein		PRO_0000222933
Regions
	Domain	1474 – 1580	107	RdRp catalytic
	Nucleotide binding	874 – 881	8	ATP By similarity

Sequences

	Sequence		Length	Mass (Da)
	P35928 [UniParc]. Last modified June 1, 1994. Version 1. Checksum: A9CA5DE87D64A3AA	FASTA	1,748	193,908
	10 20 30 40 50 60 MAFQLALDAL SSTTHRDSIS APLLDSSVSQ LQSSLELFPY TVPKELVPQL NRMGIQVSGL 70 80 90 100 110 120 TSTPHPHAAH KTLELNLLFN HWAKSCNVDS AVVFMKPSKF FKLQEKNSHF KSLHNYRLHP 130 140 150 160 170 180 HDSNRYPHPS TSLPTEKRFY IHDSLMYFTP HQISGLFESC PNLLSLYASL VVPPESSMTD 190 200 210 220 230 240 LSLNPDLYRY SIHKSTLHYT PEGHSAGSYN QPVNALDWLK ISAIQTPSLS LSVSVLESWG 250 260 270 280 290 300 PLHSLLIERS SQTQNPDSQK IKDLISFQTP QALILPNPDS LAVPLRHRLV PQKTYDALFT 310 320 330 340 350 360 YTRATRTLRT SDPAGFVRTQ SNKPEFNWVT SQAWDNLQTY ALLTASYRPP VSYTLHRSPL 370 380 390 400 410 420 TKLKELLTRN ALKLAAMASP ALTLAIFTTM TALNTNSSKA LSFSALKIHL LNPLTGPELL 430 440 450 460 470 480 HFQTSVLQQK NSAPLSQAEA KQELDKSAVP APSEHDSSAS QSTSLSLSAS SQLLSTEKHP 490 500 510 520 530 540 GSELSSKAIP VSTSCPSASK QLAPPLTAES HSSVNALLRK FLGPNSPQSN LDNYNLHLHP 550 560 570 580 590 600 ESFTLGWKRR PLLLDSHSSF LPSSCLQPPA SPSIAAAPHP LPPAQKPPRP PTTVPTPKPL 610 620 630 640 650 660 ASPSQTQAAQ PATQSPPSIP QTAPVTSLLP APLETDDSCA GPISTFQDLF PASYYPHTAN 670 680 690 700 710 720 FPCRSKIPGY LEAPYPPLDC MLVALSAQMP QSPQELWSAL NTLMPLSALT SPSLRVLGLG 730 740 750 760 770 780 TEELTALSYY YHFQAEIHSD NEIYRFGIQT ASTKLCLIRD SGPPAHFTAP DPLRAGSPPS 790 800 810 820 830 840 RSQTNENSLR RSLLGFRLNG NLLPIDQVHS FTSEPSRAKN LASNMKNGFD GILTTLAALS 850 860 870 880 890 900 SLSSGPSPRD RIFTLDGICD FALPKTVDLI HLSGFAGCGK THPIQQLLKT PHFHNFRVVT 910 920 930 940 950 960 PTTNLRSEWK SDMALPAHHN WRFSTWESAL LKHAEILVID EIYKLPRGYL DLSLIADPTV 970 980 990 1000 1010 1020 KLVILLGDPL QGEYHSTSAH SSNLRLSSEI PRLLPFIDYY CYWSYRVPKC VAKLFSLPCF 1030 1040 1050 1060 1070 1080 NPSEGFIKTT LDFFPSANNL VNSHSVVHIS EACGWNAVTI SSSQGCTFSD PAFIHLDRNT 1090 1100 1110 1120 1130 1140 ALLSPSNCLV ALTRSRSGVY FKGDFTFLSS LSGSSRMFSL AYSGQPIHLP DFFPEIVFQL 1150 1160 1170 1180 1190 1200 NMITAPLTKR SSSFRSGFQP NISSAPKIPA PPNLPCPPHI PTNYSKDVIV NNQALYGESL 1210 1220 1230 1240 1250 1260 ERRLSVLHLP PTRMTLHSDI NITAPSSSSF QPSDEPVPSD HTAVYPGFDF FTLAAHFLPA 1270 1280 1290 1300 1310 1320 HDPEVKEIEL KDQTSQQFPW LNLDFHISCQ TSSLISARHQ PGSDSTLLPA SLHKRLRFRP 1330 1340 1350 1360 1370 1380 TAAPYQITPS DSFLGNCLYR SWCQVYRRDP NVRLPFNEAL FLECIAVNDY AQLSSKTQAT 1390 1400 1410 1420 1430 1440 IVANASRSDP DWRHTFVKIF AKSQHKVNDG SIFGPWKACQ TLALMHDYVI LTLGPVKKYQ 1450 1460 1470 1480 1490 1500 RLFDQLERPS HIYYHAGNTP HDLRRWCSKH LETSHCTTND YTAFDQSQHG EAVVFEVLKM 1510 1520 1530 1540 1550 1560 RRLSIPENLI SLHVHLKTNV ETQFGPLTCM RLTGEPGTYD DNTDYNLAVL NLQYDLRKTP 1570 1580 1590 1600 1610 1620 TLVSGDDSYL SGTLSPRSNW PFVKELLHLR LKPSSLIDGL FCGYYLGPQG CIRNPLALFA 1630 1640 1650 1660 1670 1680 KLMIAEDDGS AFDKLPSYLT EFSIGHGLGD SLWQLLPSDL VLYQSACFDY FCRKATRSQK 1690 1700 1710 1720 1730 1740 ILLQPGLVDQ ETLDKIALSA KFISRPFYSM LSSHARSLIS TKFKLDSSLT TLQDPMVEFE LLPFSNVQ

References

[1]	"Comparisons of the genomic sequences of erysimum latent virus and other tymoviruses: a search for the molecular basis of their host specificities." Srifah P., Keese P., Weiller G., Gibbs A. J. Gen. Virol. 73:1437-1447(1992) [PubMed: 1607861] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.

Cross-references

Sequence databases
PIR	JQ1555.
RefSeq	NP_047920.1. NC_001977.1.
3D structure databases
ProteinModelPortal	P35928.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1493964.
Family and domain databases
InterPro	IPR000606. Helicase_domain_viral-like. IPR008043. Peptidase_C21. IPR007094. RNA-dir_pol_PSvirus. IPR002588. Tymovirus_MeTrfase. IPR001788. Tymovirus_RNA-dep_RNA_pol. [Graphical view]
Pfam	PF05381. Peptidase_C21. 1 hit. PF00978. RdRP_2. 1 hit. PF01443. Viral_helicase1. 1 hit. PF01660. Vmethyltransf. 1 hit. [Graphical view]
PROSITE	PS50507. RDRP_SSRNA_POS. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

POLR_ELV

Accession

Primary (citable) accession number: P35928

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 1, 1994
Last sequence update:	June 1, 1994
Last modified:	October 19, 2011
This is version 59 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Viral Protein Annotation Program