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P35913 (PDE6B_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 149. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta

Short name=GMP-PDE beta
EC=3.1.4.35
Gene names
Name:PDE6B
Synonyms:PDEB
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length854 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

This protein participates in processes of transmission and amplification of the visual signal. Necessary for the formation of a functional phosphodiesterase holoenzyme.

Catalytic activity

Guanosine 3',5'-cyclic phosphate + H2O = guanosine 5'-phosphate.

Cofactor

Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions By similarity.

Subunit structure

Oligomer composed of two catalytic chains (alpha and beta), an inhibitory chain (gamma) and the delta chain.

Subcellular location

Membrane; Lipid-anchor.

Involvement in disease

Retinitis pigmentosa 40 (RP40) [MIM:613801]: A retinal dystrophy belonging to the group of pigmentary retinopathies. Retinitis pigmentosa is characterized by retinal pigment deposits visible on fundus examination and primary loss of rod photoreceptor cells followed by secondary loss of cone photoreceptors. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well.
Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.12 Ref.13 Ref.14 Ref.15 Ref.16 Ref.17 Ref.18

Night blindness, congenital stationary, autosomal dominant 2 (CSNBAD2) [MIM:163500]: A non-progressive retinal disorder characterized by impaired night vision, often associated with nystagmus and myopia.
Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.9

Sequence similarities

Belongs to the cyclic nucleotide phosphodiesterase family.

Contains 2 GAF domains.

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: P35913-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: P35913-2)

The sequence of this isoform differs from the canonical sequence as follows:
     835-835: Missing.
Isoform 3 (identifier: P35913-3)

The sequence of this isoform differs from the canonical sequence as follows:
     2-279: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 851850Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta
PRO_0000023348
Propeptide852 – 8543Removed in mature form By similarity
PRO_0000023349

Regions

Domain71 – 220150GAF 1
Domain252 – 429178GAF 2

Sites

Active site5571Proton donor By similarity
Metal binding5611Divalent metal cation 1 By similarity
Metal binding5971Divalent metal cation 1 By similarity
Metal binding5981Divalent metal cation 1 By similarity
Metal binding5981Divalent metal cation 2 By similarity
Metal binding7181Divalent metal cation 1 By similarity

Amino acid modifications

Modified residue21N-acetylserine By similarity
Lipidation8511S-geranylgeranyl cysteine By similarity

Natural variations

Alternative sequence2 – 279278Missing in isoform 3.
VSP_044919
Alternative sequence8351Missing in isoform 2.
VSP_036884
Natural variant741R → C in RP40; autosomal recessive.
VAR_009283
Natural variant1001R → H in RP40. Ref.18
VAR_068361
Natural variant1661E → K. Ref.14
Corresponds to variant rs115775983 [ dbSNP | Ensembl ].
VAR_009284
Natural variant2121Y → H. Ref.14
VAR_009285
Natural variant2191Y → H in RP40; autosomal recessive.
Corresponds to variant rs62295357 [ dbSNP | Ensembl ].
VAR_009286
Natural variant2281L → H in RP40; autosomal recessive and autosomal dominant. Ref.14
VAR_009287
Natural variant2281L → I.
VAR_009288
Natural variant2581H → N in CSNBAD2. Ref.9
VAR_009289
Natural variant3201V → I. Ref.2 Ref.3 Ref.5 Ref.6 Ref.8 Ref.11
Corresponds to variant rs10902758 [ dbSNP | Ensembl ].
VAR_054868
Natural variant5271L → P in RP40; autosomal recessive.
VAR_009290
Natural variant5351I → N in RP40; autosomal recessive. Ref.17
VAR_009291
Natural variant5521R → Q in RP40; autosomal recessive. Ref.16
VAR_009292
Natural variant5571H → Y in RP40; autosomal dominant. Ref.12
VAR_006050
Natural variant5761G → D in RP40; autosomal recessive. Ref.13
VAR_006051
Natural variant6541E → D. Ref.5 Ref.8
Corresponds to variant rs17849286 [ dbSNP | Ensembl ].
VAR_054869
Natural variant6991L → R in RP40; autosomal recessive. Ref.15
VAR_006052
Natural variant7761D → N in RP40. Ref.18
Corresponds to variant rs141563823 [ dbSNP | Ensembl ].
VAR_068362
Natural variant8541L → R in RP40; autosomal recessive.
VAR_009293

Experimental info

Sequence conflict33 – 353AAA → GRG in CAA44569. Ref.1
Sequence conflict33 – 353AAA → GRG in CAA46932. Ref.2
Sequence conflict33 – 353AAA → GRG in AAB22690. Ref.3
Sequence conflict3151K → Q in CAA44569. Ref.1
Sequence conflict3201V → L in CAA44569. Ref.1
Sequence conflict3601A → R in CAA44569. Ref.1
Sequence conflict6981Y → I in CAA44569. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified April 14, 2009. Version 2.
Checksum: BB11A519BE88C9DF

FASTA85498,336
        10         20         30         40         50         60 
MSLSEEQARS FLDQNPDFAR QYFGKKLSPE NVAAACEDGC PPDCDSLRDL CQVEESTALL 

        70         80         90        100        110        120 
ELVQDMQESI NMERVVFKVL RRLCTLLQAD RCSLFMYRQR NGVAELATRL FSVQPDSVLE 

       130        140        150        160        170        180 
DCLVPPDSEI VFPLDIGVVG HVAQTKKMVN VEDVAECPHF SSFADELTDY KTKNMLATPI 

       190        200        210        220        230        240 
MNGKDVVAVI MAVNKLNGPF FTSEDEDVFL KYLNFATLYL KIYHLSYLHN CETRRGQVLL 

       250        260        270        280        290        300 
WSANKVFEEL TDIERQFHKA FYTVRAYLNC ERYSVGLLDM TKEKEFFDVW SVLMGESQPY 

       310        320        330        340        350        360 
SGPRTPDGRE IVFYKVIDYV LHGKEEIKVI PTPSADHWAL ASGLPSYVAE SGFICNIMNA 

       370        380        390        400        410        420 
SADEMFKFQE GALDDSGWLI KNVLSMPIVN KKEEIVGVAT FYNRKDGKPF DEQDEVLMES 

       430        440        450        460        470        480 
LTQFLGWSVM NTDTYDKMNK LENRKDIAQD MVLYHVKCDR DEIQLILPTR ARLGKEPADC 

       490        500        510        520        530        540 
DEDELGEILK EELPGPTTFD IYEFHFSDLE CTELDLVKCG IQMYYELGVV RKFQIPQEVL 

       550        560        570        580        590        600 
VRFLFSISKG YRRITYHNWR HGFNVAQTMF TLLMTGKLKS YYTDLEAFAM VTAGLCHDID 

       610        620        630        640        650        660 
HRGTNNLYQM KSQNPLAKLH GSSILERHHL EFGKFLLSEE TLNIYQNLNR RQHEHVIHLM 

       670        680        690        700        710        720 
DIAIIATDLA LYFKKRAMFQ KIVDESKNYQ DKKSWVEYLS LETTRKEIVM AMMMTACDLS 

       730        740        750        760        770        780 
AITKPWEVQS KVALLVAAEF WEQGDLERTV LDQQPIPMMD RNKAAELPKL QVGFIDFVCT 

       790        800        810        820        830        840 
FVYKEFSRFH EEILPMFDRL QNNRKEWKAL ADEYEAKVKA LEEKEEEERV AAKKVGTEIC 

       850 
NGGPAPKSST CCIL 

« Hide

Isoform 2 [UniParc].

Checksum: 1EE848D6E7BAB8BE
Show »

FASTA85398,237
Isoform 3 [UniParc].

Checksum: 4E0DA87B19325155
Show »

FASTA57666,626

References

« Hide 'large scale' references
[1]"Genomic organization and complete sequence of the human gene encoding the beta-subunit of the cGMP phosphodiesterase and its localisation to 4p16.3."
Weber B., Riess O., Hutchinson G., Collins C., Lin B., Kowbel D., Andrew S., Schappert K.T., Hayden M.R.
Nucleic Acids Res. 19:6263-6268(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Structural studies of cDNA and the gene for the beta-subunit of cGMP phosphodiesterase from human retina."
Khramtsov N.V., Feshchenko E.A., Suslova V.A., Terpugov B.E., Rakitina T.V., Atabekova N.V., Shmukler B.E., Lipkin V.M.
Bioorg. Khim. 18:1551-1554(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT ILE-320.
Tissue: Retinal rod cell.
[3]"The human beta-subunit of rod photoreceptor cGMP phosphodiesterase: complete retinal cDNA sequence and evidence for expression in brain."
Collins C., Hutchinson G., Kowbel D., Riess O., Weber B., Hayden M.R.
Genomics 13:698-704(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT ILE-320.
Tissue: Retina.
[4]"The human rod photoreceptor cGMP phosphodiesterase beta-subunit. Structural studies of its cDNA and gene."
Khramtsov N.V., Feshchenko E.A., Suslova V.A., Shmukler B.E., Terpugov B.E., Rakitina T.V., Atabekova N.V., Lipkin V.M.
FEBS Lett. 327:275-278(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
Tissue: Retina.
[5]"Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANTS ILE-320 AND ASP-654.
[6]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), VARIANT ILE-320.
Tissue: Hippocampus.
[7]"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. expand/collapse author list , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[8]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANTS ILE-320 AND ASP-654.
Tissue: Eye.
[9]"Heterozygous missense mutation in the rod cGMP phosphodiesterase beta-subunit gene in autosomal dominant stationary night blindness."
Gal A., Orth U., Baehr W., Schwinger E., Rosenberg T.
Nat. Genet. 7:64-68(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 197-297, VARIANT CSNBAD2 ASN-258.
[10]Erratum
Gal A., Orth U., Baehr W., Schwinger E., Rosenberg T.
Nat. Genet. 7:551-551(1994) [PubMed] [Europe PMC] [Abstract]
[11]"Organization of the gene for the beta-subunit of human photoreceptor cyclic GMP phosphodiesterase."
Suslova V.A., Suslov O.N., Kim E.E., Lipkin V.M.
Bioorg. Khim. 22:256-263(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 238-854, VARIANT ILE-320.
Tissue: Retinal rod cell.
[12]"Recessive mutations in the gene encoding the beta-subunit of rod phosphodiesterase in patients with retinitis pigmentosa."
McLaughlin M.E., Sandberg M.A., Berson E.L., Dryja T.P.
Nat. Genet. 4:130-134(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT RP40 TYR-557.
[13]"Mutations in the PDE6B gene in autosomal recessive retinitis pigmentosa."
Danciger M., Blaney J., Gao Y.Q., Zhao D.Y., Heckenlively J.R., Jacobson S.G., Farber D.B.
Genomics 30:1-7(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT RP40 ASP-576.
[14]"Screening of the PDE6B gene in patients with autosomal dominant retinitis pigmentosa."
Gao Y.Q., Danciger M., Zhao D.Y., Blaney J., Piriev N.I., Shih J., Jacobson S.G., Heckenlively J.H., Farber D.B.
Exp. Eye Res. 62:149-154(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT RP40 HIS-228, VARIANTS LYS-166 AND HIS-212.
[15]"A novel mutation in exon 17 of the beta-subunit of rod phosphodiesterase in two RP sisters of a consanguineous family."
Valverde D., Solans T., Grinberg D., Balcells S., Vilageliu L., Bayes M., Chivelet P., Besmond C., Goossens M., Gonzalez-Duarte R., Baiget M.
Hum. Genet. 97:35-38(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT RP40 ARG-699.
[16]"Identification of a novel R552Q mutation in exon 13 of the beta-subunit of rod phosphodiesterase gene in a Spanish family with autosomal recessive retinitis pigmentosa."
Valverde D., Baiget M., Seminago R., del Rio E., Garcia-Sandoval B., del Rio T., Bayes M., Balcells S., Martinez A., Grinberg D., Ayuso C.
Hum. Mutat. 8:393-394(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT RP40 GLN-552.
[17]"A novel homozygous Ile535Asn mutation in the rod cGMP phosphodiesterase beta-subunit gene in two brothers of a Japanese family with autosomal recessive retinitis pigmentosa."
Saga M., Mashima Y., Akeo K., Kudoh J., Oguchi Y., Shimizu N.
Curr. Eye Res. 17:332-335(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT RP40 ASN-535.
[18]"Next-generation genetic testing for retinitis pigmentosa."
Neveling K., Collin R.W., Gilissen C., van Huet R.A., Visser L., Kwint M.P., Gijsen S.J., Zonneveld M.N., Wieskamp N., de Ligt J., Siemiatkowska A.M., Hoefsloot L.H., Buckley M.F., Kellner U., Branham K.E., den Hollander A.I., Hoischen A., Hoyng C. expand/collapse author list , Klevering B.J., van den Born L.I., Veltman J.A., Cremers F.P., Scheffer H.
Hum. Mutat. 33:963-972(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANTS RP40 HIS-100 AND ASN-776.
+Additional computationally mapped references.

Web resources

Mutations of the PDE6A/B/G genes

Retina International's Scientific Newsletter

GeneReviews

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X62692 expand/collapse EMBL AC list , X62693, X62694, X62695 Genomic DNA. Translation: CAA44569.1.
X66142 mRNA. Translation: CAA46932.1.
S41458 mRNA. Translation: AAB22690.1.
BT009794 mRNA. Translation: AAP88796.1.
AK316054 mRNA. Translation: BAH14425.1.
AC107464 Genomic DNA. No translation available.
BC000249 mRNA. Translation: AAH00249.1.
X90587 expand/collapse EMBL AC list , X90588, X90589, X90590 Genomic DNA. Translation: CAA62215.1.
PIRA42828.
RefSeqNP_000274.2. NM_000283.3.
NP_001138763.1. NM_001145291.1.
NP_001138764.1. NM_001145292.1.
UniGeneHs.623810.
Hs.654544.

3D structure databases

ProteinModelPortalP35913.
SMRP35913. Positions 52-816.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid111184. 1 interaction.
STRING9606.ENSP00000420295.

Chemistry

BindingDBP35913.
ChEMBLCHEMBL2363066.

PTM databases

PhosphoSiteP35913.

Polymorphism databases

DMDM226693550.

Proteomic databases

PaxDbP35913.
PRIDEP35913.

Protocols and materials databases

DNASU5158.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000255622; ENSP00000255622; ENSG00000133256. [P35913-2]
ENST00000429163; ENSP00000406334; ENSG00000133256. [P35913-3]
ENST00000496514; ENSP00000420295; ENSG00000133256. [P35913-1]
GeneID5158.
KEGGhsa:5158.
UCSCuc003gao.4. human. [P35913-2]
uc003gap.3. human. [P35913-1]

Organism-specific databases

CTD5158.
GeneCardsGC04P000609.
H-InvDBHIX0031458.
HIX0031649.
HGNCHGNC:8786. PDE6B.
MIM163500. phenotype.
180072. gene.
613801. phenotype.
neXtProtNX_P35913.
Orphanet215. Congenital stationary night blindness.
791. Retinitis pigmentosa.
PharmGKBPA33134.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG242608.
HOGENOMHOG000007069.
HOVERGENHBG053539.
InParanoidP35913.
KOK13756.
OMAKSWVEYL.
OrthoDBEOG7BGHK1.
PhylomeDBP35913.
TreeFamTF316499.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.
REACT_116125. Disease.

Gene expression databases

ArrayExpressP35913.
BgeeP35913.
CleanExHS_PDE6B.
GenevestigatorP35913.

Family and domain databases

Gene3D1.10.1300.10. 1 hit.
InterProIPR003018. GAF.
IPR003607. HD/PDEase_dom.
IPR023088. PDEase.
IPR002073. PDEase_catalytic_dom.
IPR023174. PDEase_CS.
[Graphical view]
PfamPF01590. GAF. 2 hits.
PF00233. PDEase_I. 1 hit.
[Graphical view]
PRINTSPR00387. PDIESTERASE1.
SMARTSM00065. GAF. 2 hits.
SM00471. HDc. 1 hit.
[Graphical view]
PROSITEPS00126. PDEASE_I. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSPDE6B. human.
GeneWikiPDE6B.
GenomeRNAi5158.
NextBio19954.
PROP35913.
SOURCESearch...

Entry information

Entry namePDE6B_HUMAN
AccessionPrimary (citable) accession number: P35913
Secondary accession number(s): B7Z9T9 expand/collapse secondary AC list , E7ETT3, Q53XN5, Q9BWH5, Q9UD49
Entry history
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: April 14, 2009
Last modified: April 16, 2014
This is version 149 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 4

Human chromosome 4: entries, gene names and cross-references to MIM