P35908 (K22E_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Keratin, type II cytoskeletal 2 epidermal

Alternative name(s):
Cytokeratin-2e
Short name=CK-2e
Epithelial keratin-2e
Keratin-2 epidermis
Keratin-2e
Short name=K2e
Type-II keratin Kb2

Gene names

Name:	KRT2
Synonyms:	KRT2A, KRT2E

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	639 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Probably contributes to terminal cornification. Associated with keratinocyte activation, proliferation and keratinization. Ref.1 Ref.6
Subunit structure	Heterotetramer of two type I and two type II keratins. Associates with KRT10 By similarity.
Tissue specificity	Expressed in the upper spinous and granular suprabasal layers of normal adult epidermal tissues from most body sites including thigh, breast nipple, foot sole, penile shaft and axilla. Not present in foreskin, squamous metaplasias and carcinomas. Expression in hypertrophic and keloid scars begins in the deepest suprabasal layer. Weakly expressed in normal gingiva and tongue, however expression is induced in benign keratoses of lingual mucosa and in mild-to-moderate oral dysplasia with orthokeratinization. Ref.1 Ref.5 Ref.6
Developmental stage	Synthesized during maturation of epidermal keratinocytes and localized in the upper intermediate cells of fetal skin. Earliest expression is at 10 weeks in the developing embryo in the presumptive nail bed of developing digits, shifting to the proximal nail fold by 13.5 weeks. At 12.5 weeks, detected in scattered cells of the intermediate layer of trunk skin. At 19.3 weeks, regional expression patterns were observed in upper intermediate keratinocytes of cheek, trunk, dorsal and ventral knee, elbow and dorsal hand. Distal areas around the periumbilical region showed increased number of positive cells and by 15 weeks is expressed in small groups of cells in the fetal hair follicles. Ref.1 Ref.5
Involvement in disease	Ichthyosis bullosa of Siemens (IBS) [MIM:146800]: A rare autosomal dominant skin disorder displaying a type of epidermolytic hyperkeratosis characterized by generalized erythema and extensive blistering from birth. Large, dark gray hyperkeratoses are observed in later weeks. The skin of IBS patients is unusually fragile and has a tendency to shed the outer layers of the epidermis, producing localized denuded areas (molting effect). IBS usually improves with age so that in most middle-aged patients the hyperkeratosis and keratotic lichenification is limited to the flexural folds of the major joints. Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.2 Ref.9 Ref.10 Ref.11 Ref.12 Ref.13 Ref.14 Ref.15 Ref.16 Ref.17 Ref.18 Ref.19 Ref.20 Ref.21 Ref.22
Miscellaneous	There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).
Sequence similarities	Belongs to the intermediate filament family.

Ontologies

Keywords
Cellular component	Intermediate filament Keratin
Coding sequence diversity	Polymorphism
Disease	Disease mutation Ichthyosis
Domain	Coiled coil
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	keratinization Inferred from direct assay Ref.6. Source: UniProtKB keratinocyte activation Inferred from direct assay Ref.6. Source: UniProtKB keratinocyte migration Inferred from direct assay PubMed 15737202. Source: UniProtKB keratinocyte proliferation Inferred from direct assay Ref.6. Source: UniProtKB
Cellular_component	Golgi apparatus Inferred from direct assay. Source: HPA intermediate filament Traceable author statement Ref.1. Source: ProtInc keratin filament Inferred from electronic annotation. Source: InterPro
Molecular_function	structural constituent of cytoskeleton Traceable author statement Ref.1. Source: ProtInc
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 639	639	Keratin, type II cytoskeletal 2 epidermal		PRO_0000063715
Regions
	Region	1 – 177	177	Head
	Region	178 – 487	310	Rod
	Region	178 – 213	36	Coil 1A
	Region	214 – 232	19	Linker 1
	Region	233 – 324	92	Coil 1B
	Region	325 – 348	24	Linker 12
	Region	349 – 487	139	Coil 2
	Region	488 – 639	152	Tail
Sites
	Site	429	1	Stutter
Amino acid modifications
	Modified residue	62	1	Phosphoserine Ref.7
	Modified residue	579	1	Phosphoserine By similarity
Natural variations
	Natural variant	101	1	S → G. Ref.1 Ref.2 Corresponds to variant rs2634041 [ dbSNP | Ensembl ].		VAR_058293
	Natural variant	181	1	Q → P in IBS. Ref.10		VAR_003865
	Natural variant	182	1	I → N in IBS. Ref.16 Corresponds to variant rs61622714 [ dbSNP | Ensembl ].		VAR_010514
	Natural variant	186	1	N → D in IBS. Ref.20		VAR_010515
	Natural variant	186	1	N → K in IBS. Ref.21 Corresponds to variant rs61726457 [ dbSNP | Ensembl ].		VAR_017829
	Natural variant	186	1	N → Y in IBS. Ref.2 Corresponds to variant rs61726454 [ dbSNP | Ensembl ].		VAR_009185
	Natural variant	219	1	G → D. Corresponds to variant rs638043 [ dbSNP | Ensembl ].		VAR_058294
	Natural variant	465	1	E → D in IBS. Ref.19		VAR_031082
	Natural variant	465	1	E → K in IBS. Ref.19		VAR_031083
	Natural variant	476	1	E → K in IBS. Ref.2 Corresponds to variant rs56829062 [ dbSNP | Ensembl ].		VAR_009186
	Natural variant	476	1	E → V in IBS. Ref.17 Corresponds to variant rs60537449 [ dbSNP | Ensembl ].		VAR_031084
	Natural variant	477	1	I → N in IBS. Ref.18		VAR_031085
	Natural variant	479	1	T → P in IBS. Ref.13 Corresponds to variant rs61726453 [ dbSNP | Ensembl ].		VAR_009187
	Natural variant	484	1	L → P in IBS. Ref.10 Ref.22 Corresponds to variant rs61726451 [ dbSNP | Ensembl ].		VAR_010516
	Natural variant	487	1	E → D in IBS. Ref.11 Corresponds to variant rs61726450 [ dbSNP | Ensembl ].		VAR_003866
	Natural variant	487	1	E → K in IBS. Ref.9 Ref.10 Ref.11 Ref.12 Ref.14 Ref.15 Ref.22 Corresponds to variant rs61726449 [ dbSNP | Ensembl ].		VAR_003867
	Natural variant	488	1	E → K in IBS. Ref.12 Corresponds to variant rs61726452 [ dbSNP | Ensembl ].		VAR_031086
Experimental info
	Sequence conflict	108	1	F → FGGGSGF in AAC83410. Ref.1
	Sequence conflict	108	1	F → FGGGSGF in AAB81946. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	P35908 [UniParc]. Last modified June 16, 2009. Version 2. Checksum: B80526BAF70078A7	FASTA	639	65,433
	10 20 30 40 50 60 MSCQISCKSR GRGGGGGGFR GFSSGSAVVS GGSRRSTSSF SCLSRHGGGG GGFGGGGFGS 70 80 90 100 110 120 RSLVGLGGTK SISISVAGGG GGFGAAGGFG GRGGGFGGGS SFGGGSGFSG GGFGGGGFGG 130 140 150 160 170 180 GRFGGFGGPG GVGGLGGPGG FGPGGYPGGI HEVSVNQSLL QPLNVKVDPE IQNVKAQERE 190 200 210 220 230 240 QIKTLNNKFA SFIDKVRFLE QQNQVLQTKW ELLQQMNVGT RPINLEPIFQ GYIDSLKRYL 250 260 270 280 290 300 DGLTAERTSQ NSELNNMQDL VEDYKKKYED EINKRTAAEN DFVTLKKDVD NAYMIKVELQ 310 320 330 340 350 360 SKVDLLNQEI EFLKVLYDAE ISQIHQSVTD TNVILSMDNS RNLDLDSIIA EVKAQYEEIA 370 380 390 400 410 420 QRSKEEAEAL YHSKYEELQV TVGRHGDSLK EIKIEISELN RVIQRLQGEI AHVKKQCKNV 430 440 450 460 470 480 QDAIADAEQR GEHALKDARN KLNDLEEALQ QAKEDLARLL RDYQELMNVK LALDVEIATY 490 500 510 520 530 540 RKLLEGEECR MSGDLSSNVT VSVTSSTISS NVASKAAFGG SGGRGSSSGG GYSSGSSSYG 550 560 570 580 590 600 SGGRQSGSRG GSGGGGSISG GGYGSGGGSG GRYGSGGGSK GGSISGGGYG SGGGKHSSGG 610 620 630 GSRGGSSSGG GYGSGGGGSS SVKGSSGEAF GSSVTFSFR

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Characterization of human cytokeratin 2, an epidermal cytoskeletal protein synthesized late during differentiation." Collin C., Moll R., Kubicka S., Ouhayoun J.-P., Franke W.W. Exp. Cell Res. 202:132-141(1992) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, VARIANT GLY-101. Tissue: Thigh epidermis.
[2]	"Genomic organization and fine mapping of the keratin 2e gene (KRT2E): K2e V1 domain polymorphism and novel mutations in ichthyosis bullosa of Siemens." Smith F.J.D., Maingi C., Covello S.P., Higgins C., Schmidt M., Lane E.B., Uitto J., Leigh I.M., McLean W.H.I. J. Invest. Dermatol. 111:817-821(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS IBS TYR-186 AND LYS-476, VARIANT GLY-101.
[3]	"The finished DNA sequence of human chromosome 12." Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R. , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A. Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[5]	"Ontogeny and regional variability of keratin 2e (K2e) in developing human fetal skin: a unique spatial and temporal pattern of keratin expression in development." Smith L.T., Underwood R.A., McLean W.H.I. Br. J. Dermatol. 140:582-591(1999) [PubMed] [Europe PMC] [Abstract] Cited for: TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
[6]	"Expression of keratin K2e in cutaneous and oral lesions: association with keratinocyte activation, proliferation, and keratinization." Bloor B.K., Tidman N., Leigh I.M., Odell E., Dogan B., Wollina U., Ghali L., Waseem A. Am. J. Pathol. 162:963-975(2003) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, TISSUE SPECIFICITY.
[7]	"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle." Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M. Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-62, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[8]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[9]	"Ichthyosis bullosa of Siemens -- a disease involving keratin 2e." McLean W.H.I., Morley S.M., Lane E.B., Eady R.A.J., Griffiths W.A.D., Paige D.G., Harper J.I., Higgins C., Leigh I.M. J. Invest. Dermatol. 103:277-281(1994) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANT IBS LYS-487.
[10]	"Ichthyosis bullosa of Siemens is caused by mutations in the keratin 2e gene." Kremer H., Zeeuwen P., McLean W.H.I., Mariman E.C.M., Lane E.B., van de Kerkhof P.C.M., Ropers H.-H., Steijlen P.M. J. Invest. Dermatol. 103:286-289(1994) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANTS IBS PRO-181; PRO-484 AND LYS-487.
[11]	"Mutations in the rod domain of keratin 2e in patients with ichthyosis bullosa of Siemens." Rothnagel J.A., Traupe H., Wojcik S., Huber M., Hohl D., Pittelkow M.R., Saeki H., Ishibashi Y., Roop D.R. Nat. Genet. 7:485-490(1994) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANTS IBS ASP-487 AND LYS-487.
[12]	"A new keratin 2e mutation in ichthyosis bullosa of Siemens." Jones D.O., Watts C., Mills C., Sharpe G., Marks R., Bowden P.E. J. Invest. Dermatol. 108:354-356(1997) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANTS IBS LYS-487 AND LYS-488.
[13]	"A novel threonine-to-proline mutation at the end of 2B rod domain in the keratin 2e chain in ichthyosis bullosa of Siemens." Yang J.-M., Lee S., Bang H.-D., Kim W.-S., Lee E.-S., Steinert P.M. J. Invest. Dermatol. 109:116-118(1997) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANT IBS PRO-479.
[14]	"A glutamate to lysine mutation at the end of 2B rod domain of keratin 2e gene in ichthyosis bullosa of Siemens." Yang J.-M., Lee E.-S., Kang H.-J., Choi G.-S., Yoneda K., Jung S.-Y., Park K.-B., Steinert P.M., Lee E.-S. Acta Derm. Venereol. 78:417-419(1998) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANT IBS LYS-487.
[15]	"Ichthyosis bullosa of Siemens: report of a family with evidence of a keratin 2e mutation, and a review of the literature." Basarab T., Smith F.J., Jolliffe V.M., McLean W.H.I., Neill S., Rustin M.H., Eady R.A. Br. J. Dermatol. 140:689-695(1999) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANT IBS LYS-487.
[16]	"A novel mutation in the 1A domain of keratin 2e in ichthyosis bullosa of Siemens." Arin M.J., Longley M.A., Epstein E.H. Jr., Scott G., Goldsmith L.A., Rothnagel J.A., Roop D.R. J. Invest. Dermatol. 112:380-382(1999) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANT IBS ASN-182.
[17]	"Ichthyosis bullosa of Siemens resulting from a novel missense mutation near the helix termination motif of the keratin 2e gene." Moraru R., Cserhalmi-Friedman P.B., Grossman M.E., Schneiderman P., Christiano A.M. Clin. Exp. Dermatol. 24:412-415(1999) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANT IBS VAL-476.
[18]	"A novel mutation in the 2B domain of keratin 2e causing ichthyosis bullosa of Siemens." Irvine A.D., Smith F.J., Shum K.W., Williams H.C., McLean W.H.I. Clin. Exp. Dermatol. 25:648-651(2000) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANT IBS ASN-477.
[19]	"Hot spot mutations in keratin 2e suggest a correlation between genotype and phenotype in patients with ichthyosis bullosa of Siemens." Suga Y., Arin M.J., Scott G., Goldsmith L.A., Magro C.M., Baden L.A., Baden H.P., Roop D.R. Exp. Dermatol. 9:11-15(2000) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANTS IBS LYS-465 AND ASP-465.
[20]	"A novel asparagine-->aspartic acid mutation in the rod 1A domain in keratin 2e in a Japanese family with ichthyosis bullosa of Siemens." Takizawa Y., Akiyama M., Nagashima M., Shimizu H. J. Invest. Dermatol. 114:193-195(2000) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANT IBS ASP-186.
[21]	"New mutations in keratin 1 that cause bullous congenital ichthyosiform erythroderma and keratin 2e that cause ichthyosis bullosa of Siemens." Whittock N.V., Ashton G.H.S., Griffiths W.A.D., Eady R.A.J., McGrath J.A. Br. J. Dermatol. 145:330-335(2001) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANT IBS LYS-186.
[22]	"Ichthyosis bullosa of Siemens: its correct diagnosis facilitated by molecular genetic testing." Akiyama M., Tsuji-Abe Y., Yanagihara M., Nakajima K., Kodama H., Yaosaka M., Abe M., Sawamura D., Shimizu H. Br. J. Dermatol. 152:1353-1356(2005) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANTS IBS PRO-484 AND LYS-487.
+	Additional computationally mapped references.

Web resources

Human Intermediate Filament Mutation Database

GeneReviews

Wikipedia

Keratin-2A entry

Cross-references

Sequence databases
EMBL GenBank DDBJ	M99061 mRNA. Translation: AAC83410.1. AF019084 Genomic DNA. Translation: AAB81946.1. AC055715 Genomic DNA. No translation available. AC055716 Genomic DNA. No translation available. BC096294 mRNA. Translation: AAH96294.1. BC099643 mRNA. Translation: AAH99643.1. BC099644 mRNA. Translation: AAH99644.1.
IPI	IPI00021304.
PIR	A44861.
RefSeq	NP_000414.2. NM_000423.2.
UniGene	Hs.707.
3D structure databases
ProteinModelPortal	P35908.
ModBase	Search...
Protein-protein interaction databases
IntAct	P35908. 8 interactions.
MINT	MINT-1208580.
STRING	9606.ENSP00000310861.
PTM databases
PhosphoSite	P35908.
Polymorphism databases
DMDM	239938650.
Proteomic databases
PaxDb	P35908.
PeptideAtlas	P35908.
PRIDE	P35908.
ProMEX	P35908.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000309680; ENSP00000310861; ENSG00000172867.
GeneID	3849.
KEGG	hsa:3849.
UCSC	uc001sat.3. human.
Organism-specific databases
CTD	3849.
GeneCards	GC12M053038.
H-InvDB	HIX0036877.
HGNC	HGNC:6439. KRT2.
HPA	HPA006299.
MIM	146800. phenotype. 600194. gene.
neXtProt	NX_P35908.
Orphanet	455. Superficial epidermolytic ichthyosis.
PharmGKB	PA30227.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG146769.
HOGENOM	HOG000230976.
HOVERGEN	HBG013015.
InParanoid	P35908.
KO	K07605.
OMA	IFQAYIG.
OrthoDB	EOG44QT16.
PhylomeDB	P35908.
Gene expression databases
Bgee	P35908.
CleanEx	HS_KRT2.
Genevestigator	P35908.
GermOnline	ENSG00000172867. Homo sapiens.
Family and domain databases
InterPro	IPR016044. F. IPR001664. IF. IPR018039. Intermediate_filament_CS. IPR003054. Keratin_II. [Graphical view]
PANTHER	PTHR23239. PTHR23239. 1 hit. PTHR23239:SF18. PTHR23239:SF18. 1 hit.
Pfam	PF00038. Filament. 1 hit. [Graphical view]
PRINTS	PR01276. TYPE2KERATIN.
PROSITE	PS00226. IF. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	3849.
NextBio	15145.
SOURCE	Search...

Entry information

Entry name

K22E_HUMAN

Accession

Primary (citable) accession number: P35908
Secondary accession number(s): Q4VAQ2

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 1, 1994
Last sequence update:	June 16, 2009
Last modified:	May 1, 2013
This is version 121 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.